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mesencephalic precursor
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  中脑前体细胞
     ②Mesencephalic precursor cells were more possible to differentiated into dopaminergic neurons than cortex precursor cells.
     ②中脑前体细胞比皮质前体细胞更有可能分化成多巴胺神经元。
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  “mesencephalic precursor”译为未确定词的双语例句
     Conclusions:Dividing human mesencephalic precursor cells can be isolated and expanded in vitro in the presence of reduced atmospheric oxygen, and striatal tissue induces some of these cells into TH-ircells.
     结论 :低氧分压更适于中脑神经祖细胞的体外扩增 ,纹状体培养上清对中脑祖细胞向多巴胺能神经元的分化及成熟具有促进作用
短句来源
     Of which the number of dopaminergic neurons differentiated from mesencephalic precursor cells increased by 8 times and that of cortexes also increased which was only equal to the increasing number of differentiated non-dopaminergic neurons.
     其中中脑前体细胞分化成的多巴胺神经元数增加8倍,皮质前体细胞分化成多巴胺神经元数也有增加,但仅与分化成的非多巴胺神经元增加相平行。
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  相似匹配句对
     PRECURSOR-DERIVED CERAMICS
     先驱体陶瓷
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     Mining Earthquake and Its Precursor
     矿震及其前兆初探
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     Primary mesencephalic hemorrhage
     原发性中脑出血
短句来源
     ②Mesencephalic precursor cells were more possible to differentiated into dopaminergic neurons than cortex precursor cells.
     ②中脑前体细胞比皮质前体细胞更有可能分化成多巴胺神经元。
短句来源
     MICROANATOMY OF THE MESENCEPHALIC VEINS OF THE CHINESE
     国人中脑静脉的显微解剖
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  mesencephalic precursor
Thus, we established that nestin-GFP was a useful and reliable marker for mesencephalic precursor cells.
      
Mesencephalic precursor cells derived from the developing midbrain appear to be a good candidate cell source for dopaminergic precursors.
      
Here, we used the nestin-GFP transgene to visualize and identify mesencephalic precursor cells in the ventricular zone.
      
As a first step toward isolating VZ precursors from the midbrain, we devised a method for labeling live mesencephalic precursor cells.
      


Objective Ventral mesencephalic dopaminergic precursors from rat embryos at young embryonic stages were cultured in vitro. The yields of dopaminergic neurons (DNs) determined the optimal research material for the subsequent study on cell transplantation as a treatment of Parkinson's disease. Methods Ventral mesencephalic precursors from rat embryos at different embryonic stages (from E10, E11, E12) proliferated with bFGF for 7 days and differentiated for the next 7 days in the special differentiation...

Objective Ventral mesencephalic dopaminergic precursors from rat embryos at young embryonic stages were cultured in vitro. The yields of dopaminergic neurons (DNs) determined the optimal research material for the subsequent study on cell transplantation as a treatment of Parkinson's disease. Methods Ventral mesencephalic precursors from rat embryos at different embryonic stages (from E10, E11, E12) proliferated with bFGF for 7 days and differentiated for the next 7 days in the special differentiation medium containing L-ascorbic acid-2-phosphate sesquimagnesium salt (AA-2P). The yields of DNs were compared by means of immunofluorescence staining. Results The total cell numbers in E10, E11 and E12 cultures increased about 76.39 times, 59.67 times and 51.85 times, respectively. The ratio of DNs versus the total cell population in E11, E10 and E12 cultures decreased sequentially and significantly. The ratio of DNs versus all the neurons in E11 culture was significantly higher than those in E10 and E12 cultures. Conclusion Ventral mesencephalic precursors from E11 rat embryos are the optimal research material, which can in vitro supply enormous cell resources for the study of cell transplantation.

目的体外培养小胎龄的胎鼠腹侧中脑神经前体细胞,根据多巴胺能神经元产量,确定较好的研究对象,为细胞移植治疗帕金森病奠定基础。方法取不同胎龄胎鼠(E10、E11、E12)的腹侧中脑神经前体细胞,体外加碱性成纤维细胞生长因子扩增7d后用含AA-2P的分化增养液培养7 d,行免疫荧光染色比较多巴胺能神经元形成情况。结果E10、E11、E12细胞经培养后细胞总数分别增加76.39倍、59.67倍、51.85倍。多巴胺能神经元占所有细胞的比例在E11、E10、E12依次显著降低。对于多巴胺能神经元占所有神经元的比例,E11显著高于E10和E12。结论来自胎龄11 d的胎鼠腹侧中脑神经前体细胞是较好的体外培养对象,可为细胞移植研究提供较为充足的细胞资源。

Objective:To study of the method about dissection, proliferation and differentiation of mesencephalic progenitor cells in vitro. Methods:Neurosphere method was used to expand the mesencephalic progenitor cell clones in vitro in 3% atmospheric oxygen. Striatal culture conditioned media was used to induce the mesencephalic progenitor cells differentiated into mature DA neurons.Results:The mesencephalic progenitor cells were successfully expanded in vitro using the epidermal growth factor (EGF) and fibroblast growth...

Objective:To study of the method about dissection, proliferation and differentiation of mesencephalic progenitor cells in vitro. Methods:Neurosphere method was used to expand the mesencephalic progenitor cell clones in vitro in 3% atmospheric oxygen. Striatal culture conditioned media was used to induce the mesencephalic progenitor cells differentiated into mature DA neurons.Results:The mesencephalic progenitor cells were successfully expanded in vitro using the epidermal growth factor (EGF) and fibroblast growth factor-2(FGF-2) in 3% atmospheric oxygen. Following incubation in differentiation media containing striatal culture conditioned media, up to 2% of the precursor cells converted into TH-immunoreactive (TH-ir) cells, which exhibited mature morphological and functional properties of dopamine neurons in culture. Conclusions:Dividing human mesencephalic precursor cells can be isolated and expanded in vitro in the presence of reduced atmospheric oxygen, and striatal tissue induces some of these cells into TH-ircells.

目的 :探讨人类中脑祖细胞体外分离、培养及向多巴胺能神经元诱导分化的方法。方法 :利用neuro sphere法 ,在低氧分压的情况下建立中脑祖细胞克隆 ,并用纹状体培养上清对其进行诱导分化 ,观察TH阳性神经元的分化比率及成熟度。结果 :中脑来源的神经祖细胞克隆 ,能以neurosphere形式生长 ,低氧分压对其克隆生长具有促进作用 ;纹状体培养上清可增加TH阳性神经元的分化比率 ,并能使TH阳性细胞具有更成熟的多巴胺能神经元的形态特征。结论 :低氧分压更适于中脑神经祖细胞的体外扩增 ,纹状体培养上清对中脑祖细胞向多巴胺能神经元的分化及成熟具有促进作用

Objective To investigate the optimal time points for transplantation with in vitro cultured dopaminergic neurons as a potential treatment of Parkinson’s disease. Methods After the ventral mesencephalic precursors from E11 rat embryos were expanded for 7 days in vitro, they were harvested respectively from day 0 to day 7 in the period of induced differentiation. Then the cells were seeded again and cultured for another 7 days. The final survival of dopaminergic neurons determined the optimal time points...

Objective To investigate the optimal time points for transplantation with in vitro cultured dopaminergic neurons as a potential treatment of Parkinson’s disease. Methods After the ventral mesencephalic precursors from E11 rat embryos were expanded for 7 days in vitro, they were harvested respectively from day 0 to day 7 in the period of induced differentiation. Then the cells were seeded again and cultured for another 7 days. The final survival of dopaminergic neurons determined the optimal time points for moving cells in vitro and, possibly, for transplantation in vivo. Result The survival rate of dopaminergic neurons moved on day 0 and day 1 in the period of induced differentiation was significantly higher than that at other time points. Conclusion The optimal time points for transplantation are found possibly to be day 0 and day 1 in the period of differentiation after the expansion of ventral mesencephalic precursors from E11 rat embryos.

目的 探索体外培养的多巴胺能神经细胞的最佳移植时机,为细胞移植治疗帕金森病奠定基础。方法 体外扩增E11胎鼠腹侧中脑神经前体细胞7 d后,分别在诱导分化期开始0、1、2、3、4、5、6、7 d时收获细胞,重新接种后再培养7 d。根据多巴胺能神经元生存率高低,初步决定出最佳移植时机。结果 在诱导分化期开始0 d和1 d传代细胞后,多巴胺能神经元的生存率显著高于其他时间点。结论 E11胎鼠腹侧中脑神经前体细胞体外扩增后诱导分化0 d和1 d时,可能是最佳移植时机。

 
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