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phosphodiesterase
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  5’磷酸二酯酶
     Enzymology characters of acidic phosphomonoesterase,5' phosphodiesterase and nuclease in malt root were studied. Amount of 5' nucleotide and RNA hydrolytic efficiency were used as standard. The conditions (pH,temperature,time and RNA:malt root) of RNA hydrolysis were obtained.
     研究麦芽根中酸性磷酸单酯酶 ,5’ 磷酸二酯酶及核酸水解酶的酶学特性 ,以 5’ 核苷酸和核酸水解率为指标 ,初步确定了核糖核酸 (RNA)在麦芽根作用下水解为单核苷酸的最适条件 :温度、PH值、时间及RNA与麦芽根用量比等
短句来源
  相似匹配句对
     THE PREPARATION OF IMMOBLLIZED 5'-PHOSPHODIESTERASE
     固定化5′-磷酸二酯酶的制备
短句来源
     5..
     5.活性氧参与乙烯的形成。
短句来源
     (5) .
     (5).
短句来源
     Advances in Type 5 Phosphodiesterase Inhibitors
     磷酸二酯酶5抑制剂的研究进展
短句来源
     Optimization of the fermentation conditions of 5'-Phosphodiesterase
     5'-磷酸二酯酶发酵培养条件的优化
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  phosphodiesterase
A previous study showed that DA-8159, a potent type 5 phosphodiesterase inhibitor, enhanced the relaxation of the smooth muscles in the normal rabbit corpus cavernosum.
      
The expression of Pγ in this tissue may be related to its ability to interact the type 5 phosphodiesterase (PDE-5), which is the predominant cGMP binding protein in lung.
      
The emerging role for type 5 phosphodiesterase inhibition in heart failure
      
Type 5 phosphodiesterase inhibition in heart failure and pulmonary hypertension
      
The physiological actions of cGMP are terminated by the hydrolysis of the 3 5 bond by the type 5 phosphodiesterase.
      
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Various metallic ions have different effects on the activity of ribonuclease of Esckerichia colt. Among the divalent cations, Mg~(++)is not only non-inhibitory but is required for enzyme action. The results of Elson and of Spahr & Hollingworth that Mg~(++)inhibits the E. coli RNase could not be confirmed. Calcium ion essentially resembles Mg~(++), Co~(++)has only slightly stimulatory effect, whereas Ni~(++)exerts strong inhibition. The monovalent Na~+ is stimulatory.In the presence of Mg~(++), Ca~(++)or Na~+,...

Various metallic ions have different effects on the activity of ribonuclease of Esckerichia colt. Among the divalent cations, Mg~(++)is not only non-inhibitory but is required for enzyme action. The results of Elson and of Spahr & Hollingworth that Mg~(++)inhibits the E. coli RNase could not be confirmed. Calcium ion essentially resembles Mg~(++), Co~(++)has only slightly stimulatory effect, whereas Ni~(++)exerts strong inhibition. The monovalent Na~+ is stimulatory.In the presence of Mg~(++), Ca~(++)or Na~+, SRNA is degraded much slower than the high-molecular-weight RNA(HRNA)by either E. coli RNase or the bovine pancreatic RNase. Unlike the E. coli enzyme, the bovine pancreatic RNase can act without Mg~(++)and under such condition, SRNA can be degraded as fast as HRNA(sometimes even faster). However, when Mg~(++)is included in the incubation mixture, the rate of degradation of SRNA becomes much slower. On the other hand, HRNA is degraded even faster. This excludes the possibility that the slower degradation of SRNA is due to the inhibitory effect of Mg~(++)on pancreatic RNase. The protect effect of Mg~(++)on SRNA against degradation is observed even when the incubation temperature is raised to 60°C. Thus, we propose that the secondary structure of SRNA is responsible for its resistance to enzymic degradation and Mg~(++)has a profound stabilizing effect on its secondary structure.It has also been found that when RNA is added during precipitation with the uranyl acetate reagent, the acid soluble ultraviolet absorption becomes smaller. In other words, some of the acid soluble nucleotides are co-precipitated with RNA by this treatment. This may explain at least partially the observation that SRNA"inhibits"the enzymic degradation of HRNA both noticed by us and by Zillig.The stabilizing effect of Mg~(++)on the secondary structure of SRNA and in turn on the resistance of SRNA to enzymic degradation may have some bearing on the slow and incomplete degradation of SRNA by polynucleotide phosphorylase and snake venom phosphodiesterase since these enzymes all require Mg~(++)for activity.The physiological significance of the resistance to enzymic degradation of SRNA is briefly discussed.

(1)各种金属离子对大腸杆菌RNase活力的影响不同,Mg~++不仅沒有抑制作用而且是大腸杆菌RNase表現活力的必需因素。Ca~(++)与Ag~(++)相似,Co~(++)对酶活力影响較小,而Ni~(++)則有抑制作用。(2)在Mg~(++)、Ca~(++)或Na~+等存在下,大腸杆菌RNase和牛胰RNase降解SRNA的速度远比HRNA为慢;利用Mg~(++)对这两种RNase活力的影响不同,在Mg~(++)存在与否下,比較SRNA与HRNA降解速度的結果指出,SRNA的二級結构是其酶解緩慢的主要原因,而Mg~(++)等金属离子对稳定其二級結构起着重要的作用。这种作用在60℃仍然存在。(3)SRNA影响RNase对HRNA的降解。这种現象可能用酸溶性核苷酸与RNA一起沉淀的作用解释,但也不能完全排除两个結构相似底物(SRNA与HRNA)同时存在相互竞爭的可能性。(4)对SRNA不能为其他核酸降解酶完全降解或降解速度緩慢的原因及其生理意义进行了討論。

The conditions for the reaction of ENA with FDNB was reported, and the relation between the degree of degradation of the RNA and the amount of DNP group combined was studied.The combining site of DNP-in S-RNA was studied by means of ultraviolet absorption spectra, and degradation by RNase and snake venom phosphodiesterase. The results suggested that DNP group combined only with the phosphomonoester of the terminal 5'-phospho guanosine of S-RNA.The possibilities of using the amount of DNP-combined for the...

The conditions for the reaction of ENA with FDNB was reported, and the relation between the degree of degradation of the RNA and the amount of DNP group combined was studied.The combining site of DNP-in S-RNA was studied by means of ultraviolet absorption spectra, and degradation by RNase and snake venom phosphodiesterase. The results suggested that DNP group combined only with the phosphomonoester of the terminal 5'-phospho guanosine of S-RNA.The possibilities of using the amount of DNP-combined for the calculation of chain length and molecular weight of S-RNA and using the DNP-as a label for the pG……terminal of S-RNA to facilitate the nucleotide sequence analysis from that end are suggested.

(一)本工作报告了FDNB与RNA的作用条件,并研究了不同断裂程度的RNA和FDNB的反应。(二)对DNP-在大肠杆菌S-RNA分子中的结合位置通过紫外线吸收光谱和牛胰RNase以及蛇毒磷酸双酯酶的降解作用做了探讨,由实验结果推断:DNP-似结合在S-RNA末端5′-G核苷酸的磷酸单酯上。(三)本文说明DNP-的结合量可以用来计算S-RNA的链长及分子量;也可以利用DNP-标记pG末端,以便利于该末端核苷酸排列顺序的研究。

The changes of tyrosine transaminase activity (TAT) and nucleotide 5'-phosphodiesterase activity (5'-NPDase) during foetal development and carcinogenesis in rats and in human beings were observed. Results so far obtained indicate that (1) a higher positive rate of the fastest moving isoenzyme band for 5'-NPDase has been noted in AFP (-) patients with liver cancer, and (2) TAT, 5'-NPDase and AFP may be taken together as good markers for the study of gene expression during liver caroinogenesis and foetal...

The changes of tyrosine transaminase activity (TAT) and nucleotide 5'-phosphodiesterase activity (5'-NPDase) during foetal development and carcinogenesis in rats and in human beings were observed. Results so far obtained indicate that (1) a higher positive rate of the fastest moving isoenzyme band for 5'-NPDase has been noted in AFP (-) patients with liver cancer, and (2) TAT, 5'-NPDase and AFP may be taken together as good markers for the study of gene expression during liver caroinogenesis and foetal development.

本文测定了大鼠及人体胚胎发育和癌变过程中TAT和5′-NPDase活力变化,所得结果表明: (一)5′-NPDase快速同工酶区带在甲胎蛋白(AFP)阴性肝癌患者血清中阳性率较高。(二)TAT,5′-NPDase和AFP也许可作为研究癌、胚以及肝癌癌变过程中基因表达的三个互补生化指标。

 
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