The results demonstrated that:given orally,both aspirin(4\^4mg/kg) and Fufangdanshwenfang as different dosages(1\^2,2\^4,4\^8g/kg) could markedly counteract ADP inducing platelet aggregation and inhibit platelet adhesion in normal rabbits.
The degree of platelet adhesion and activation decreased with increasing content of MPC in copolymers:Comparing with other hydrophilic acrylate monomers having tethered(poly) ethylene glycol group such as HEMA,HPOEM_(360) and HPOEM_(526),MPC decreased platelet adhesion and activation on the copolymer surface more effectively.
Calcium dolesilate has been shown to significantly reduce platelet adhesiveness, inhibit platelet aggregation, reduce plasma and serum viscosity in rabbits.
Results Among 26,24 cases were from countryside and 23 cases had history of pregnancy induced hypertension syndrome(PIH),mainly characterized by subacute intracranial hypertension,increased blood viscosity and fibrinogen and strengthened platelet adhesiveness.
The most prominent or the most sensitive changes were β TG and platelet adhesive, the next were PF4 and TXB 2, and then platelet aggregation and 6 keto PGF 1α .
Results: (1)Before the experiment,PAgF and PAdF of each group has not sigrificant difference( P> 0.05 ),but at the experimental end,M group is higher than other three groups( P< 0.05 ).
Methods Fluorospectrophotometry was used to detect the 5-HT released by the rabbit platelets activated by PAF, Fura-2 fluorospectrophotometry was used to observe the PAF-induced increase in the level of free intraplatelet Ca 2+ of rabbit platelets, and spectrophotometry was used to detect the PAF-induced enhancement of adhesion of rabbit platelets.
Fistula clotting (16.5% of all patients) in hemodialysed patients (67 cases from 6 German centers) was found to be associated with a state of hypercoagulability characterized by increased platelet adhesiveness and increased thrombin production.
Platelet adhesiveness and the levels of two coagulation factors, fibrinogen and factor VIII, were studied in a series of diabetic and nondiabetic control subjects.
However, there were no accumulation and/or adherence of platelet aggregates of significant degree at the other parts of the circuit, namely venous and arterial tubings, venous colum and arterial reservoir.
Platelet adhesion (PAd) and %max of platelet aggregation (PAg) were examined in 67 cases of coronary heart disease (CHD) and 27 normal individuals (Ns). PAd was 44.1±10.4% in Ns, 66.6±7.8% (n=6) in acute myocardial infarction (AMI) (p<0.01) and 54.9±10.1% (n=10) in stable angina (SA) (p<0.05). PAg increased in unstable angina (UA) (77.33±15.98, n=6, p<0.01)in old myocardian infarction (OMI) (75.11±18.74%, n=9, p<0.01), in AMI over 3 days (70.17±15.72%, n=12, p<0.05) and in SA (68.23±12.76%, n=24, p<0.01) as...
Daphnetin is one of the constituents of Daphne koreana Nakai. A Carotid-jugular extracorporeal shunt was made in the rat. A 5 cm length of silk thread was placed in the shunt. Fifteen rain after the restoration of blood flow in the shunt, the wet weight of thrombus developed on the thread was measured.
Fourteen hypercoagulation parameters related to coagulation,anticoagulationplatelet functions,coagulation dynamics and blood rheology were determined in 10-109thromboangiitis obliterans (TAO) patients.The results showed that Ⅷ:Ag,PAdT,PAgT,HPF,whole blood and plasma viscosity and α_2-MG were elevated;fibrinogenelevated in the “Progressing Stage”;AT-Ⅲ declined;RBC electrophoresis time prolonged;and there were some hypercoagulation manifestations in thrombus elastogram.All theseindicated hyperocoagulation sta...