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osteosarcoma tumor
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  成骨肉瘤
     Study on the pharmacodynamics of the adriamycin liposome conjugated MDP on UMR 106 osteosarcoma tumor model
     MDP-阿霉素脂质体交联物治疗大鼠成骨肉瘤的药效学研究
短句来源
     OBJECTIVE:To prepare adriamycin liposome conjugated with MDP (Methylenediphonate,MDP LADM) and observe its therapeutic effect on UMR106 osteosarcoma tumor model in rat, as well as comparing it with adriamycin liposome (LADM) and free adriamycin(ADM) .
     目的 :制备出 MDP-阿霉素脂质体交联物 (MDP-L ADM) ,观察 MDP-LADM治疗大鼠成骨肉瘤 UMR10 6模型的疗效 ,并与游离阿霉素 (ADM)及阿霉素脂质体 (L ADM)作比较。
短句来源
     Preparation of adriamycin liposomes conjugated with MDP and its targeting action on Sprague-Dawley rat osteosarcoma tumor model in vivo
     MDP-阿霉素脂质体的制备及其对大鼠成骨肉瘤的抗瘤作用
短句来源
     METHOD:The MDP was conjugated to the membrane of adriamycin liposome with tolylendiisocyanate(TDI). The model of UMR106 osteosarcoma tumor model in SD rat has been established.
     方法 :建立 SD大鼠 U MR10 6成骨肉瘤模型 ,将磷脂修饰后用1,4-二异氰基甲苯酯 (TDI)与 MDP交联 ,用改良的逆向蒸发法将其制备成阿霉素脂质体 -MDP交联物。
短句来源
  “osteosarcoma tumor”译为未确定词的双语例句
     Normal saline, The osteosarcoma tumor rats were divided into five groups at random so as to be injected with LADM,Lip+ADM,ADM and MDP ADM and observe the inhibitony effect. The concentration of ADM dispensed in relative organs was measured by HPLC method.
     将荷瘤大鼠随机分为五组 ,即生理盐水组、ADM组、游离 ADM+空白脂质体组、LADM组及 MDP-L ADM组 ,观察它们对大鼠的抑瘤作用。
短句来源
     HIF-1 play a very important role in angiogenesis of osteosarcoma through regulating the expression of VEGF. HIF-1 cooperates with p53 deletion or mutation taking part in the regulation of osteosarcoma tumor cells under hypoxia probably.
     结论骨肉瘤组织中存在HIF 1α的过表达 ,HIF 1部分地参与了骨肉瘤的演进 ,HIF 1通过调节VEGF的表达在骨肉瘤血管生成中发挥着重要作用 ;
短句来源
     Objective:To evaluate the inhibitory action of endostatin(ES) on human osteosarcoma tumor growth in nude mice and its possible mechanism.
     目的:观察内皮抑素(ES)对裸鼠骨肉瘤皮下移植模型血管生成和肿瘤生长的抑制作用及其机制。
短句来源
  相似匹配句对
     Osteosarcoma is the commonest primary malignant tumor of bone.
     骨肉瘤为最常见的原发于骨组织的恶性肿瘤,占骨恶性肿瘤的第一位。
短句来源
     Expression of cathepsin B in osteosarcoma and its relationship with tumor metastasis
     组织蛋白酶B在骨肉瘤中的表达及其与肿瘤侵袭转移的关系
短句来源
     Adiponectin and tumor
     Adiponectin与肿瘤
短句来源
     The Immunotherapy of Tumor.
     肿瘤的免疫治疗
短句来源
     Chemotherapy for Osteosarcoma
     骨肉瘤的辅助化疗
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  osteosarcoma tumor
Because of the difficulty of developing pairs of osteosarcoma cell lines and cytotoxic T lymphocytes (CTLs), no osteosarcoma tumor antigens that are useful for antiosteosarcoma immunotherapy have yet been identified.
      
Our data indicate that alendronate may have the potential to inhibit canine osteosarcoma tumor growth.
      
The sample population was composed of canine osteosarcoma tumor cells.
      
We sought to determine the mechanism for this escape using Ag201P and Ag201M cells, which are murine osteosarcoma tumor lines that express a functional HLA-A2/Kb molecule.
      
In this report, we have demonstrated that a significant proportion of osteosarcoma tumor samples have deletions in the MTAP gene.
      
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OBJECTIVE:To prepare adriamycin liposome conjugated with MDP (Methylenediphonate,MDP LADM) and observe its therapeutic effect on UMR106 osteosarcoma tumor model in rat, as well as comparing it with adriamycin liposome (LADM) and free adriamycin(ADM) . METHOD:The MDP was conjugated to the membrane of adriamycin liposome with tolylendiisocyanate(TDI).The model of UMR106 osteosarcoma tumor model in SD rat has been established. Normal saline, The osteosarcoma tumor rats were divided into five...

OBJECTIVE:To prepare adriamycin liposome conjugated with MDP (Methylenediphonate,MDP LADM) and observe its therapeutic effect on UMR106 osteosarcoma tumor model in rat, as well as comparing it with adriamycin liposome (LADM) and free adriamycin(ADM) . METHOD:The MDP was conjugated to the membrane of adriamycin liposome with tolylendiisocyanate(TDI).The model of UMR106 osteosarcoma tumor model in SD rat has been established. Normal saline, The osteosarcoma tumor rats were divided into five groups at random so as to be injected with LADM,Lip+ADM,ADM and MDP ADM and observe the inhibitony effect. The concentration of ADM dispensed in relative organs was measured by HPLC method. RESULTS:The average encapsulation rate of adriamycin was 92.3% and conjugation rate of MDP was 70.2%.Compared with the ADM group?Lip+ADM group and LADM group, the survival time in MDP LADM group was prolonged significantly, respectirely ( P <0.01). The inhibition of tumor growth was increased significantly ( P <0.01, P <0.01 and P <0.05). CONCLUSION:The adriamycin liposome conjugated with MDP not only lower the side effect, but also improved therapeutic effect significantly than ADM?Lip+ADM and LADM in the treatment of osteosarcoma tumor.

目的 :制备出 MDP-阿霉素脂质体交联物 (MDP-L ADM) ,观察 MDP-LADM治疗大鼠成骨肉瘤 UMR10 6模型的疗效 ,并与游离阿霉素 (ADM)及阿霉素脂质体 (L ADM)作比较。方法 :建立 SD大鼠 U MR10 6成骨肉瘤模型 ,将磷脂修饰后用1,4-二异氰基甲苯酯 (TDI)与 MDP交联 ,用改良的逆向蒸发法将其制备成阿霉素脂质体 -MDP交联物。将荷瘤大鼠随机分为五组 ,即生理盐水组、ADM组、游离 ADM+空白脂质体组、LADM组及 MDP-L ADM组 ,观察它们对大鼠的抑瘤作用。用高效液相色谱测定阿霉素在骨组织及其它器官中的含量。结果 :MDP-阿霉素脂质体交联物对阿霉素包裹率为 92 .3 % ,MDP交联率为 70 .2 % ,对 SD大鼠 UMR10 6成骨肉瘤模型的抑瘤作用明显高于阿霉素 (P<0 .0 1)和阿霉素脂质体 (P<0 .0 5 ) ,治疗后大鼠生存期明显延长 (P<0 .0 1) ,阿霉素在骨组织中的含量明显增加。结论 :MDP-阿霉素脂质体交联物可明显提高阿霉素脂质体对骨肿瘤的治疗作用 ,降低其不良反应

Purpose To detect the expression of hypoxia-inducible factor 1α (HIF-1α) and VEGF, p53 and CD34 in osteosarcoma and to investigate their association with angiogenesis and prognosis of osteosarcoma under hypoxia.. Methods Immunohistochemical staining (S-P method) was used to detect HIF-α and VEGF, p53 and CD34 expression in 46 cases of osteosarcoma which had complete follow-up data. Spearman coeffcient of correlation was used to test correlation between HIF-1α and VEGF, p53, MVD. Follow-up data were collected...

Purpose To detect the expression of hypoxia-inducible factor 1α (HIF-1α) and VEGF, p53 and CD34 in osteosarcoma and to investigate their association with angiogenesis and prognosis of osteosarcoma under hypoxia.. Methods Immunohistochemical staining (S-P method) was used to detect HIF-α and VEGF, p53 and CD34 expression in 46 cases of osteosarcoma which had complete follow-up data. Spearman coeffcient of correlation was used to test correlation between HIF-1α and VEGF, p53, MVD. Follow-up data were collected to perform survival curve analysis. Results Expression of HIF-1α was observed in 14(30.4%)cases. Patients with expression of HIF-1α had a higher VEGF and p53 expression and metastasis rate since surgery compared with those with no expression. Patients with expression of HIF-1α had a significantly shorter one-year survival and overall survival rate since surgery compared with those with no expression. HIF-1α expression was found significant association with VEGF and p53 expression, but no correlation with MVD. Conclusion There is HIF-1α overexpression in osteosarcoma. HIF-1 is involved in the progression of osteosarcoma partly. HIF-1 play a very important role in angiogenesis of osteosarcoma through regulating the expression of VEGF. HIF-1 cooperates with p53 deletion or mutation taking part in the regulation of osteosarcoma tumor cells under hypoxia probably. There is an intimate correlation between the expression of HIF-1α in osteosarcoma and its unfavorable prognosis. HIF-1α expression is an useful parameter to evaluate prognosis of osteosarcoma.

目的 检测缺氧诱导因子 1α(HIF 1α)及VEGF、p5 3、CD34在骨肉瘤的表达 ,探讨其与缺氧情况下骨肉瘤血管生成和预后的关系。方法 采用免疫组织化学S P法检测 4 6例有完整随访资料的骨肉瘤病例中HIF 1α、VEGF、p5 3、CD34的表达。用Spearman分析各指标间的相关性 ,并结合临床资料进行生存曲线分析。结果  4 6例骨肉瘤标本中有 14例 (30 4 % )表达HIF 1α ;HIF 1α表达组VEGF、p5 3表达强度及术后转移率均高于HIF 1α不表达组 ;HIF 1α表达组患者术后 1年生存率及总生存率均显著低于HIF 1α不表达组。HIF 1α表达与VEGF、p5 3表达之间存在显著相关性 ;HIF 1α表达与微血管密度(MVD)之间无相关性。结论骨肉瘤组织中存在HIF 1α的过表达 ,HIF 1部分地参与了骨肉瘤的演进 ,HIF 1通过调节VEGF的表达在骨肉瘤血管生成中发挥着重要作用 ;HIF 1和p5 3缺失或突变可能协同参与了缺氧对骨肉瘤肿瘤细胞的调节 ,HIF 1α表达与骨肉瘤的不良预后密切相关 ,是评估骨肉瘤患者预后的重要指标

Objective:To evaluate the inhibitory action of endostatin(ES) on human osteosarcoma tumor growth in nude mice and its possible mechanism.Methods:The inhibitory role of ES on endothelial cell migration induced by osteosarcoma cell line 9901 was observed using a transwell model.Thirty Balb/c nu/nu mice implanted with osteosarcoma were randomly divided into the control,ES low dose(0.75 mg/Kg.d) and ES high dose(1.5 mg/Kg.d) groups.ES was injected intratumorally and around the tumor,once...

Objective:To evaluate the inhibitory action of endostatin(ES) on human osteosarcoma tumor growth in nude mice and its possible mechanism.Methods:The inhibitory role of ES on endothelial cell migration induced by osteosarcoma cell line 9901 was observed using a transwell model.Thirty Balb/c nu/nu mice implanted with osteosarcoma were randomly divided into the control,ES low dose(0.75 mg/Kg.d) and ES high dose(1.5 mg/Kg.d) groups.ES was injected intratumorally and around the tumor,once a day for 14 days.The tumor volumes were measured and the tumor inhibition rate(TIR) was calculated.The percentages of necrotic tissue,microvessel density,proliferation index(PI) and apoptotic index(AI) were detected by pathohistologic observation and immunohistochemical staining.The mice were sacrificed 3 h after EF5 injection via tail vein,and then the hypoxia of tumor cells and microvessels was observed using laser confocal microscopy.Results:Both the low dose(350 ng/ml) and high dose(700 ng/ml) ES groups showed a marked inhibition of endothelial cell migration induced by osteosarcoma cells,while the high dose showed much stronger inhibition than the low dose(P<0.01) .The tumor volume was significantly different among the 3 groups.The TIR in the high dose and the low dose groups were 35.8% and 22.9%,respectively.In the control group,the ES low dose group and the ES high dose group,the percentage of necrotic tissue was 2.40%,4.68% and 9.52%,the PI was 66.44%,46.11% and 25.11%,and the AI was 2.69%,7.58% and 11.53%,respectively(P<0.01) .Much less green fluorescence(microvessel) and stronger red fluorescence(hypoxia) were apparent in the tumors treated with ES when observed with laser confocal microscopy.Conclusions:The results show that ES markedly inhibits endothelial cell migration in vitro and significantly restrains the growth and development of osteosarcoma in vivo.The mechanism may be due to anti-angiogenesis properties associated with hypoxia in the tumor and apoptosis of tumor cells.

目的:观察内皮抑素(ES)对裸鼠骨肉瘤皮下移植模型血管生成和肿瘤生长的抑制作用及其机制。方法:Transwell双室模型观察ES对骨肉瘤细胞9901诱导内皮细胞迁徙的影响;随机将30只骨肉瘤荷瘤裸鼠分为对照组、ES低剂量组[0.75mg(kg·d)-1]和高剂量组[1.5mg(kg·d)-1],瘤体及瘤体周围注射ES,1次/d,连续给药14d,观察肿瘤生长情况,计算抑瘤率。肿瘤组织进行病理学观察及免疫组化染色,计数坏死组织百分比,微血管密度以及细胞增殖和凋亡指数;动物处死前3个小时尾静脉注射EF5,激光共聚焦显微镜观察组织缺氧及血管标记。结果:ES低剂量组(350ng·ml-1)和高剂量组(700ng·ml-1)对内皮细胞迁徙有明显抑制作用,且高剂量组明显高于低剂量组(P<0.01);高剂量组和低剂量组平均瘤重明显小于对照组,抑瘤率分别为35.83%和22.92%(P<0.01);正常对照组、低剂量组、高剂量组的坏死百分比分别为2.40%、4.68%和9.52%(P<0.01),细胞增殖指数(PI)分别为66.44%、46.11%和25.11%(P<0.01),细胞凋亡指数(AI)分别为2.69%、7.58%...

目的:观察内皮抑素(ES)对裸鼠骨肉瘤皮下移植模型血管生成和肿瘤生长的抑制作用及其机制。方法:Transwell双室模型观察ES对骨肉瘤细胞9901诱导内皮细胞迁徙的影响;随机将30只骨肉瘤荷瘤裸鼠分为对照组、ES低剂量组[0.75mg(kg·d)-1]和高剂量组[1.5mg(kg·d)-1],瘤体及瘤体周围注射ES,1次/d,连续给药14d,观察肿瘤生长情况,计算抑瘤率。肿瘤组织进行病理学观察及免疫组化染色,计数坏死组织百分比,微血管密度以及细胞增殖和凋亡指数;动物处死前3个小时尾静脉注射EF5,激光共聚焦显微镜观察组织缺氧及血管标记。结果:ES低剂量组(350ng·ml-1)和高剂量组(700ng·ml-1)对内皮细胞迁徙有明显抑制作用,且高剂量组明显高于低剂量组(P<0.01);高剂量组和低剂量组平均瘤重明显小于对照组,抑瘤率分别为35.83%和22.92%(P<0.01);正常对照组、低剂量组、高剂量组的坏死百分比分别为2.40%、4.68%和9.52%(P<0.01),细胞增殖指数(PI)分别为66.44%、46.11%和25.11%(P<0.01),细胞凋亡指数(AI)分别为2.69%、7.58%和11.53%(P<0.01)。激光共聚焦观察ES治疗组绿色荧光量减少,血管稀疏;肿瘤细胞缺氧增加,呈弥漫的强红色。结论:ES可显著地抑制骨肉瘤细胞诱导的内皮细胞迁徙,以及人骨肉瘤的生长和发展,且呈剂量依赖效应,其可能机制为抑制血管生成,增加肿瘤细胞缺氧和凋亡。

 
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