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orthotopic bladder
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  原位膀胱
     HSVtk/GCV system inhibits the growth of an experimental rat orthotopic bladder cancer, showing anti-tumor effect.
     HSVtk/GCV系统能抑制大鼠原位膀胱肿瘤的生长,显示出抗肿瘤作用。
短句来源
     Conclusion Suicide-gene therapy using retroviral vector-mediated HSV-TK/GCV provides an effective method for treat-ing the experimental murine orthotopic bladder cancer by significantly inhibiting tumor growth.
     结论:经尿道膀胱灌注重组逆转录病毒载体可以向肿瘤转导 HSV-TK 基因。 HSV-TK/GCV 系统能抑制鼠原位膀胱肿瘤的生长。
短句来源
  原位新膀胱
     Nursing on radical cystectomy and an intestinal tract orthotopic bladder substitution
     全膀胱切除原位新膀胱术患者的护理
短句来源
     The author summarized nursing on radical cystectomy and an intestinal tract orthotopic bladder substitution.
     笔者报道全膀胱切除原位新膀胱术患者的护理。
短句来源
     According to nursing 63 patients with bladder cancer underwent radical cystectomy and an intestinal tract orthotopic bladder substitution,the authors argued that emphasis of nursing was intestinal tract preparation before operation,clysis of the intestinal tract orthotopic bladder after operation,conduits nursing and functional training of orthotopic neobladder.
     通过对63例根治性膀胱全切除、回肠/结肠原位新膀胱术患者的护理,提出护理重点在于术前肠道护理,术后原位新膀胱冲洗,预防吻合口瘘,各种管道的护理,新膀胱功能训练。
短句来源
  “orthotopic bladder”译为未确定词的双语例句
     METHODS: Human bladder cancer cell line T24 was inoculated into the bladders of 25 BALB/c nude mice to establish orthotopic bladder cancer model.
     方法:直视下经尿道机械损伤BALB/c裸鼠膀胱粘膜,将人膀胱癌细胞T24经尿道种植于25只裸鼠膀胱,建立荷人膀胱癌原位动物模型。
短句来源
     Bladder cancer radical operation of sparing the sexual function and orthotopic bladder substitution with sigmoid colon of removed the tube
     保留性功能膀胱癌根治性切除加去管化乙状结肠新膀胱术
短句来源
     Objective To explore the treatment mechanism of HSP70-peptides complexes (HSP70-PC) derived from autologous tumor after heated by non-invasive pelvic cavity regional moderate hyperthermia, we applied the protein to rats containing orthotopic bladder tumor.
     目的研究用来自亚高温盆腔区域热疗后原位大鼠膀胱肿瘤的热休克蛋白70-肽复合物(HSP70-PC)对原位大鼠膀胱肿瘤的治疗作用机制。
短句来源
     Objective: To investigate the effects of intravesical instillation of Utilins injection on orthotopic bladder tumor of rats, the serum levels of interleukin-6 (IL-6) and the weight of bladder tumor .
     目的:探讨乌体林斯膀胱灌注对大鼠血清白细胞介素-6(IL-6)和膀胱肿瘤生长的影响。
短句来源
     Methods: Orthotopic bladder tumors were established in rats by intravesical administration of MNU (N-mmethyl-noitrosourea).
     方法:用N-甲基-亚硝基脲(MNU)膀胱灌注建立大鼠原位膀胱癌模型。
短句来源
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  相似匹配句对
     Characteristics of urethra and bladder replacement with orthotopic cyno-ileum
     犬原位回肠构建全尿道、膀胱的实验方法特征
短句来源
     Model Development of Visible Orthotopic Mouse Bladder Tumor
     可视人膀胱肿瘤裸鼠原位移植模型的建立
短句来源
     Overactive Bladder
     膀胱过度活动症
短句来源
     Bladder hemangioma
     膀胱血管瘤的诊治
短句来源
     Orthotopic liver transplantation
     原位肝移植治疗终末期肝硬化
短句来源
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  orthotopic bladder
Whether an orthotopic bladder substitute shouldbe constructed in patients with locallyadvanced or lymph node positive bladder cancerremains a subject of debate.
      
The use of absorbable staples may allow to reduce the operating time of orthotopic bladder replacement.
      
We present our functional experience with orthotopic bladder replacement in female patients dependent on the urethral resection line.
      
In contrast, a small anatomical capacity is unlikely to respond to conservative therapy, but is associated with a high probability of successful orthotopic bladder substitution.
      
A large capacity indicates the potential for conservative treatment and may be regarded as a negative predictor for the outcome of orthotopic bladder substitution.
      
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To study the feasibility of the treatment of bladder carcinoma with high intensity focused ultrasound (HIFU) through a transabdominal approach in T_(739), mice,a model of orthotropic transplantation bladder transitional cell cancer was established by implanting BTT_(739). cells of bladder transitional cell cancer in syngenic mice. Using this model,Bladder carcinoma was treated with a HlFU device. The survival time(day),the survival curve change,mean tumor volume and weight,and microscopic pathology and ultrastructure...

To study the feasibility of the treatment of bladder carcinoma with high intensity focused ultrasound (HIFU) through a transabdominal approach in T_(739), mice,a model of orthotropic transplantation bladder transitional cell cancer was established by implanting BTT_(739). cells of bladder transitional cell cancer in syngenic mice. Using this model,Bladder carcinoma was treated with a HlFU device. The survival time(day),the survival curve change,mean tumor volume and weight,and microscopic pathology and ultrastructure of the treated zone were investigated. The results showed that mice survival time of treated group (22. 90± 4. 78 days) was significant longer than that of control group (14. 10±3. 52 days) (P <0. 01). HIFU can reduce the tumor weights greatly (P <0. 01). Histological observation showed direct thermal cytotoxic coagulative necrosis in the treated zone,and HIFU could decrease load of carcinoma signficantly. HIFU could be used focally to ablate mice orthotopic bladder carcinoma and the next step will be to determine whether this type of therapy can be adapted to the treatment of human bladder carcinoma.

为探索高能聚焦超声(HIFU)经腹治疗小鼠膀胱肿瘤的可行性,采用同系移植技术建立小鼠膀胱可移植性移行细胞癌模型,观察:①HIFU对膀胱荷瘤鼠生存期的影响;②荷瘤鼠生存曲线的变化;③HIFU对荷瘤鼠肿瘤体积及肿瘤重量的影响;④靶区肿瘤组织以及邻近组织超微结构变化。结果荷瘤鼠生存时间治疗组为22.90±4.78d,对照组为14.10±3.52d,两组有非常显著性差异(P<0.01);HIFU可导致肿瘤组织凝固性坏死,明显减轻肿瘤负荷。认为HIFU可以治疗小鼠膀胱肿瘤,为下一步临床研究奠定了理论基础。

Objective To evaluate the urodynamic status of lower urinary tract undergone ileocolonic orthotopic bladder substitution.Methods Eleven cases with ileocolonic orthotopic bladder substitution were detected with the cystometry and the rest urethral pressure profile.The pressure and the compliance of the sack,and the resistance of the outlet as well,were detected.Results The capacity of the sack was 518.5±184.3ml,and the pressure of storage and voiding were respectively (26.7±6.6)cm H 2O,( 36.2...

Objective To evaluate the urodynamic status of lower urinary tract undergone ileocolonic orthotopic bladder substitution.Methods Eleven cases with ileocolonic orthotopic bladder substitution were detected with the cystometry and the rest urethral pressure profile.The pressure and the compliance of the sack,and the resistance of the outlet as well,were detected.Results The capacity of the sack was 518.5±184.3ml,and the pressure of storage and voiding were respectively (26.7±6.6)cm H 2O,( 36.2 ±14.9)cm H 2O.The sack had high compliance,following with low compliance.The pressure of the bladder neck was (78.6± 17.9 )cm H 2O,and the maximum pressure of the urethral was (108.4±32.7)cm H 2O.Conclusion The sack of the ileocolonic orthotopic bladder can store normally,and the dysuria relates to the low pressure of the sack and the high resistance of the anastomose.

目的 评估回结肠正位膀胱术后的下尿路储尿囊及流出道尿动力学状况。方法 对 11例回结肠正位膀胱术患者术后进行储尿囊及流出道的充盈性测压和静态压力图测定 ,检测储尿囊的压力、顺应性 ,以及流出道的压力和阻力状态。结果  11例患者储尿囊容量、储尿压、排尿压分别为 :(5 18.5± 184 .3)ml,(2 6 .7± 6 .6 )cmH2 O ,(36 .2± 14 .9)cmH2 O ,储尿囊的顺应性为先高顺应后低顺应。膀胱颈压为 (78.6± 17.9)cmH2 O ,最大尿道压为 (10 8.4± 32 .7)cmH2 O。流出道压力中吻合口压力偏高。结论 回结肠正位膀胱术储尿囊可正常储尿 ,术后排尿困难与储尿囊的低压及吻合口的高压状态有关。

Objective:To improve the specificity and positive predictive value of NMP22 for diagnosing bladder transitional cell carcinoma.Methods:A total of 196 patients considered at risk of bladder cancer were asked to submit a single voided urine sample. Each urine sample was examined cytology, urinalysis, culture and NMP22 protein assay, etc. All pltients underwent cystoscopy.Results:In the 196 patients, there were 41 bladder transitional cell carcinoma patients(BTCC) who had been diagnosed by histology. NMP22 was...

Objective:To improve the specificity and positive predictive value of NMP22 for diagnosing bladder transitional cell carcinoma.Methods:A total of 196 patients considered at risk of bladder cancer were asked to submit a single voided urine sample. Each urine sample was examined cytology, urinalysis, culture and NMP22 protein assay, etc. All pltients underwent cystoscopy.Results:In the 196 patients, there were 41 bladder transitional cell carcinoma patients(BTCC) who had been diagnosed by histology. NMP22 was detected in 33( 80.5%) cases of 41 BTCC, whereas cytology was identified only in 11( 26.8%) cases. In the 67 patients with incresased NMP22 values, the 33 identified tumors were accompenied by 34 false-positive values, so the specificity was 78.1% and positive predictive value was 49.3%. These false positive results were owing to urinary inflammation or infection, urinary calculi, foreign body in urinary tract, orthotopic bladder replacement, other genitourinary cancer and urinary tract instrumentation, and so on. The specificity and positive predictive values of NMP22 can improved to 96.2% and 91.7% respectively with the exclusion of above 6 factors. Conclusions:Exclusion of the categories of false positive results can improve the specificity and positive predictive value of NMP22,enhance the clinical use of this urinary tumor marker.

目的 :探讨尿核基质蛋白 (NMP2 2 )在膀胱癌诊断中的特异性和阳性预测值价值。方法 :对 196例临床怀疑膀胱癌的患者 ,在膀胱镜检查前留取新鲜自排尿 ,每个尿标本均行尿细胞学、尿常规、尿培养和NMP2 2检测。所有患者均行膀胱镜检查。结果 :196例中 ,病理检查证实膀胱癌 4 1例 ,其他疾病 15 5例。 4 1例膀胱癌患者中 ,检测出NMP2 2 33例 (80 .5 % ) ,而尿细胞学检测阳性仅为 11例 (2 6 .8% )。在 6 7例NMP2 2异常者中 ,除 33例诊断为膀胱癌外 ,假阳性为 34例 ,故特异性和阳性预测值分别为 78.1%和 4 9.3%。假阳性结果主要出现在泌尿系感染或炎症、泌尿系结石、泌尿系异物、肠道代膀胱、其他泌尿生殖系肿瘤和器械操作 6种情况 ,排除这 6种干扰因素后 ,NMP2 2检测的特异性和阳性预测值分别升高至 96 .2 %和 91.7%。结论 :排除干扰因素能明显改善NMP2 2诊断膀胱癌的特异性和阳性预测值 ,提高其临床应用价值。

 
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