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combined-treatment
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  联合治疗
     Methods 45 rheumatism patients with depression and anxiety disorders were divided into 3 groups randomly: pharmacological group,combined-treatment group(cognitive and behavioral therapy combined with pharmacotherapy) and control group,15 patients in each group.
     方法选伴抑郁或焦虑的风湿病患者45例,随机分为3组,每组15例,对照组、药物治疗组及联合治疗组。 用抑郁和焦虑量表分别评估患者治疗前后的评分情况,比较单纯药物治疗和联合心理治疗的效果。
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  “combined-treatment”译为未确定词的双语例句
     Results The asthma incidence rate had markedly reduced in the combined-treatment group, when compared to the control group (X2=6.21, P<0.05).
     结果联合组哮喘发作率明显减少,与对照组比较有显著差异,X2=6.21,P<0.05;
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     The improvement rate of the FEV1% in the combined-treatment group was markedly better than that of the control group after 12 weeks: P<0.05.Conclusion Mental intervention plays an important clinical role in the treatment of bronchia asthmatic patients with anxiety.
     同时12周后肺功能FEV1预计值%改善联合组明显优于对照组,两组间有显著差异,P<0.05。
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     Effect Observation of Combined-treatment of Chronic Hepatitis B with Interferon and Thymopeptide
     干扰素联合胸腺肽治疗慢性乙肝疗效分析
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  相似匹配句对
     Combined treatment of pseudohermaphroditism
     21羟化酶缺乏致女性假两性畸形的内外科联合治疗
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     Combined treatment of urticaria
     三联疗法治疗慢性荨麻疹
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     L. P. treatment.
     L. P.
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     Treatment of combined endodontic-periodontal lesions
     牙髓牙周联合病变的治疗
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     It is combined with the bio-treatment and membrane filter.
     它是将污水的生物处理技术和膜过滤技术结合在一起的新型技术。
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  combined-treatment
Furthermore, at termination in the combined-treatment group there were significantly more improvers and remitters on the Hamilton Depression Scale and on the Global Index of Improvement and more improvers on the target problems ratings.
      
There were significantly more responders in the combined-treatment group than in the pharmacotherapy group.
      
Changes were particularly striking in the combined-treatment group.
      


(1)The present communication is a continuation of previous study of drugs on the pathologico-physiological reactions of the infected rabbits.The following indices of the reactions were used,namely:(1) erythrocyte sedimentation rate (ESR),(2) plasma fibrinogen content,(3) plasma gamma globulin content,(4) prothrombin time and (5)body weight. (2)It was shown that a full course of potassium antimony tartrate (PAT) could depress the abnormal rise of ESR of the infected rabbit.The effect was more striking in the...

(1)The present communication is a continuation of previous study of drugs on the pathologico-physiological reactions of the infected rabbits.The following indices of the reactions were used,namely:(1) erythrocyte sedimentation rate (ESR),(2) plasma fibrinogen content,(3) plasma gamma globulin content,(4) prothrombin time and (5)body weight. (2)It was shown that a full course of potassium antimony tartrate (PAT) could depress the abnormal rise of ESR of the infected rabbit.The effect was more striking in the early (i.e.7th day after inoculation) than the late treatment (i.e.33rd day after inoculation).This effect of PAT on the ESR was found to be in parallelism with its therapeutic effect.This method may be utilized for evaluation of drugs against schistosomiasis. (3)Neither PAT nor strychnine had any effect on the ESR of the normal rabbit.Strychnine was also found to have no significant effect on the ESR of the infected rabbit,but it could markedly modify the inhibitory effect of the PAT. (4)The therapeutic effect of half-course of PAT was found to be about 10—20% less marked than that of combined treatment with strychnine. Strychnine alone did not show any therapeutic effect.It was also found that the dose of strychnine used in our experiment did not increase the toxicity of PAT as shown by mice toxicity test. (5)The therapeutic dose of PAT showed no effect on the plasma fibrinogen content of the normal rabbit but it could bring the increased plasma fibrinogen content back to normal in the infected animal. (6)After a course of PAT in the infected animal,the double peak rise of the palsma gamma globulin content was distinctly suppressed as compared with the control group.On the contrary,the new drug,1:7-Bis (p-dimethylaminophenoxy) heptane (APH) did not show the same effect, probably indicating its weak action against schistosomiasis. (7)The body weight of the PAT treated group was found to be much higher than the non-treated group,However,the group treated with APH showed a continuous drop of body weight. (8)It has been found,as by others,that the APH showed high toxicity and low therapeutic effect in the experimental animals.From the fact that APH showed pronounced effect on ESR and plasma fibrinogen content of the infected animal,one could not yet decide,with the available data,whether these effects are due to its action on the schistosome or its eggs,or to its toxic action on the host.

(一)本文报告了药物对于血吸虫病病兔及正常家兔的红血球沉降率,血浆纤维蛋白,丙种球蛋白,凝血酶元时值及体重的影响。(二)酒石酸锑钾的治疗,无论在家兔患病的早期或后期,均可抑制其血沉的加速,而以早期治疗的抑制作用更为显著。同时这个抑制血沉的作用与治疗后的成虫发育率是符合的。因此利用这种方法,可以考虑作为研究一些治疗血吸虫病药物的疗效指标。(三)酒石酸锑钾及士的宁本身对正常家兔的血沉并不引起改变,士的宁对于病兔的血沉也无明显作用,但士的宁可以影响酒石酸锑钾对病兔血沉的抑制作用。 (四)半疗程剂量酒石酸锑钾并用士的宁之疗效较单独应用半疗程剂量酒石酸锑钾者为高(10—20%),而单独应用士的宁并无任何疗效,轻度激动量士的宁也不增加酒石酸锑钾的毒性。(五)酒石酸锑钾的治疗剂量对于正常家兔之血浆纤维蛋白元无明显影响,但能使病兔增高之血浆纤维蛋白元回复正常。(六)酒石酸锑钾的治疗可以使病兔的丙种球蛋白在一定时期内保持在接近正常值范围内,这一抑制作用与感染对照组相比,甚为明显,而氨苯氧烷却无此作用,这一点可能与疗效是有关系的。(七)酒石酸锑钾治疗后的病兔之体重较感染对照组病兔显著增高,而经氨苯氧烷治疗后之病兔,其体重仍日见减...

(一)本文报告了药物对于血吸虫病病兔及正常家兔的红血球沉降率,血浆纤维蛋白,丙种球蛋白,凝血酶元时值及体重的影响。(二)酒石酸锑钾的治疗,无论在家兔患病的早期或后期,均可抑制其血沉的加速,而以早期治疗的抑制作用更为显著。同时这个抑制血沉的作用与治疗后的成虫发育率是符合的。因此利用这种方法,可以考虑作为研究一些治疗血吸虫病药物的疗效指标。(三)酒石酸锑钾及士的宁本身对正常家兔的血沉并不引起改变,士的宁对于病兔的血沉也无明显作用,但士的宁可以影响酒石酸锑钾对病兔血沉的抑制作用。 (四)半疗程剂量酒石酸锑钾并用士的宁之疗效较单独应用半疗程剂量酒石酸锑钾者为高(10—20%),而单独应用士的宁并无任何疗效,轻度激动量士的宁也不增加酒石酸锑钾的毒性。(五)酒石酸锑钾的治疗剂量对于正常家兔之血浆纤维蛋白元无明显影响,但能使病兔增高之血浆纤维蛋白元回复正常。(六)酒石酸锑钾的治疗可以使病兔的丙种球蛋白在一定时期内保持在接近正常值范围内,这一抑制作用与感染对照组相比,甚为明显,而氨苯氧烷却无此作用,这一点可能与疗效是有关系的。(七)酒石酸锑钾治疗后的病兔之体重较感染对照组病兔显著增高,而经氨苯氧烷治疗后之病兔,其体重仍日见减轻。(八)氨苯氧烷有较高的毒性,但疗效甚低,它对病兔的血沉及纤维蛋白元所出现的抑制作用,究竟属于对血吸虫或其虫卵的作用,抑系对于病兔机体的毒性作用,目前还不能肯定。

The effects of combined treatment of Sb-71 with some metal salts such as cupric sulfate, magnesium sulfate, zinc sulfate, cupric chloride, magnesium chloride and zinc chloride were investigated in mice bearing Ehrlich ascites carcinoma. It was found that simultaenous administrations of Sb-71 (15 mg/kg) and cupric sulfate (1.5-3 mg/kg) produced a marked potentiation of inhibition of the growth of the carcinoma, and prolonged significantly the survival time of the mice. The density and the total number of ascites...

The effects of combined treatment of Sb-71 with some metal salts such as cupric sulfate, magnesium sulfate, zinc sulfate, cupric chloride, magnesium chloride and zinc chloride were investigated in mice bearing Ehrlich ascites carcinoma. It was found that simultaenous administrations of Sb-71 (15 mg/kg) and cupric sulfate (1.5-3 mg/kg) produced a marked potentiation of inhibition of the growth of the carcinoma, and prolonged significantly the survival time of the mice. The density and the total number of ascites carcinoma cells were considerably decreased than those in the group treated with Sb-71 alone. Cupric sulfate alone at dosages of 1.5-3 mg/kg/day had no therapeutic effect on Ehrlich ascites carcinoma. Magnesium sulfate, zinc sulfate, cupric chloride and magnesium chloride did not influence the carcinostatic activity of Sb-71, whereas zinc chloride showed some antagonistic action against the therapeutic effect of Sb-71.

本文研究了sb-71与几种金属盐合并治疗小白鼠Ehrlich腹水癌的疗效,結果发現用硫酸銅3毫克/公斤、硫酸鋅20毫克/公斤、硫酸鎂30毫克/公斤、氯化鎂30毫克/公斤及氯化銅2.5毫克/公斤与sb-71 30毫克/公斤合并治疗小白鼠Ehrlich腹水癌时,疗效无明显变化,但硫酸銅与sb-71合并治疗組的动物一般情况較好,腹水出現較晚、腹水量亦少。用上述金属盐与sb-71 15毫克/公斤合并治疗时发現硫酸銅1.5,3毫克/公斤能显著地提高sb-71对小白鼠Ehrlich腹水癌的疗效,动物的生存时間較单用sb-71組延长,腹水量、瘤細胞浓度、瘤細胞总数亦显著減少.硫酸銅本身无治疗作用;亦不影响sb-71的毒性.在sb-71 30毫克/公斤治疗小自鼠Ehrlich腹水癌的同时投給氯化鋅3,6毫克/公斤,后者明显地拮抗Sb-7l的疗效,动物生存时間明显地短于单用sb-71組。

In our previous reports,sinomenine was found to possess analgesic activity,and its site of ac- tion was determined to be central.The present work deals with the development of tolerance to its analgesic action and the possibility of cross tolerance between sinomenine and morphine.Ex- periments were made in mice,using the hot- plate method.Drugs were injected daily,and pain threshold was measured every 2-3 days. Tolerance was gradually developed to the analgesic action of either sinomenine given sin- gly in daily...

In our previous reports,sinomenine was found to possess analgesic activity,and its site of ac- tion was determined to be central.The present work deals with the development of tolerance to its analgesic action and the possibility of cross tolerance between sinomenine and morphine.Ex- periments were made in mice,using the hot- plate method.Drugs were injected daily,and pain threshold was measured every 2-3 days. Tolerance was gradually developed to the analgesic action of either sinomenine given sin- gly in daily doses of 100mg/kg or sinomonine (100mg/kg daily) combined with promethazine (25 mg/kg daily),taking about 10 days to reach their maximums,when the analgesic action prac- tically disappeared altogether.In the case of morphine the tolerance developed more rapidly, reaching its maximum in about 6 days.No cross tolerance was observed between sinomenine and morphine. After daily administration of sinomenine for 16 days,the mice suffered higher mortality than those given saline or morphine,and those given combined treatment with sinomenine and prome- thazine had a mortality still higher.Thus it has been shown that the development of tolerance in mice to the analgesic action of sinomenine is not accompanied by a tolerance to its lethal action as that of morphine.And slso the combined use of sinomenine and promethazine gives a syner- gistic toxicity,but,on the other hand,its mark- edly potentiated analgesia far exceeding that of morphine or sinomenine alone leaves a leeway to greatly reduce the toxicity by appropriate reduction of dosages.

1.用小鼠热板法试验,每日连续腹腔注射防己碱100毫克/公斤,经10天后,镇痛作用消失,但吗啡在15毫克/公斤时,连用6天即丧失其镇痛效能,说明防己碱耐受的产生较吗啡为缓慢。合用异丙嗪25毫克/公斤,虽明显加强防己碱100毫克/公斤的镇痛作用,但并不影响防己碱耐受的产生。2.防己碱与吗啡间不存在交叉耐受性。3.连续应用防己碱16天后,动物死亡率显较对照组与吗啡组为高,而加用异丙嗪的合并用药组的死亡率更高。可见小白鼠对防己碱镇痛作用产生耐受的同时,对其致死作用并不耐受,而有积蓄现象。防己碱与异丙嗪合并应用时,其致死作用则有协同现象。另一方面,合并用药的镇痛效果大大超过防己碱或吗啡,因此在等效剂量时有可能大大降低其毒性。

 
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