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compound of tcm
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  相似匹配句对
     Progress on pharmacokinetics of compound prescriptions of TCM
     中药复方药代动力学研究进展
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     Applied study of large TCM compound recipe fingerprint
     大中药复方的色谱指纹图谱应用研究
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     Pharmacodynamic Study on TCM Compound Vagina Gel for Cervicitis
     中药复方阴道凝胶剂治疗宫颈炎的药效学研究
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     TCM SYSTEM
     TCM系统
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     And compound I was extracted.
     最后从30%乙醇的浓缩液中获单体化合物I。
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Object To apply microwave technique to the extraction of free anthraquinones from Rheum emodi Wall. and the methods of microwave extraction and traditional extraction were comparied. Methods The orthogonal test design was used to arrange sequent experiments to test the effect of the three main factors including microwave power, particle size of herb and extraction time on the extraction efficiency of free anthraquinones and to establish optimal extraction process. A parallel test was carried out using the...

Object To apply microwave technique to the extraction of free anthraquinones from Rheum emodi Wall. and the methods of microwave extraction and traditional extraction were comparied. Methods The orthogonal test design was used to arrange sequent experiments to test the effect of the three main factors including microwave power, particle size of herb and extraction time on the extraction efficiency of free anthraquinones and to establish optimal extraction process. A parallel test was carried out using the three different methods including the optimal extraction process, the traditional decocting method and the alcohol refluxing method. Results Particle size of herb and microwave power are the significant factors with P<0.01 and P<0.05 respectively. Time is an affective factor on the extraction of anthraquinones(0.05compounds of TCM.

目的 研究微波技术对大黄游离蒽醌浸出量的影响 ,并与传统提取方法做比较。方法 采用正交试验法考察微波输出功率、药材粒径、浸出时间 3个因素对提取效率的影响 ,优选大黄游离蒽醌的最佳浸出方案。以优选出的微波浸出方案为实验组 ,以常规煎煮法及乙醇回流法为对照组 ,进行平行实验。结果 药材粒径对大黄游离蒽醌浸出的影响高度显著 (P<0 .0 1) ,功率对大黄游离蒽醌浸出的影响显著 (P<0 .0 5 ) ,时间对大黄游离蒽醌的浸出有一定的影响 (0 .0 5

Based on generally analyzing the problems coming from the studies of1,2and3categories of new Chinese medicaments,the author makes an overall and systematical statement about the definition,characteristics and selecting steps and methods for small prescriptions of traditional Chinese medicine(TCM)in this article,and thinks that according to the situation in China,the theoretical characteristics of TCM and the objective demands,the study on the development of new Chinese medicaments must take the...

Based on generally analyzing the problems coming from the studies of1,2and3categories of new Chinese medicaments,the author makes an overall and systematical statement about the definition,characteristics and selecting steps and methods for small prescriptions of traditional Chinese medicine(TCM)in this article,and thinks that according to the situation in China,the theoretical characteristics of TCM and the objective demands,the study on the development of new Chinese medicaments must take the way of clearing up the syndromes of diseases first and then selecting medicinal materials to make up prescriptions;the principle of monarch,minister,assistant and envoy in the compounds of TCM should be perfected and normalized,on the basis of which the selection of medicinal materials for making up prescriptions can be carried out only;the heritage from the pharmacology of ancient traditional Chinese medical formulae should be explored systematically so as to develop new medicaments,and the methodology of how to overall establish and utilize the management system of the databases of ancient TCM prescriptions is expounded accordingly.In this article the author puts forward the basic principle and thinking of elaborate selection of medicinal materials for small prescriptions as well as an optimal method for the investigation of different preparation techniques and dosage proportion in order to realize the development of new Chinese medicaments by the way of proper programme,standardization,suitable quantity and scientific processes.

本文针对当前中药一、二、三类新药研究存在的问题,就中药精选小复方的定义和特点、筛选的步骤和方法进行了较全面系统的阐述,认为:根据国情和中医药理论特点,中药新药开发必须走先定病证再选药组方的研究之路;应完善和规范中药组合的君、臣、佐、使法则,且据以选药组方;应系统挖掘古方剂学遗产,探索全面建立和全方位利用古代方剂数据库管理系统,向古方剂要新药。本文提出了一种确立小复方具体药物精选的基本原则和思路,以及不同制备工艺、不同剂量配比最优化的考察方法,以求实现中药新药开发的程序化、规范化、定量化和科学化。

BACKGROUND:The biomechanical property(BP) of the bone is decided by its geometric structure and component material. Merely pursuing increase of the bone mineral density(BMD) might lead to deterioration of bone BP. However at present,some researches on therapeutic action on osteoporosis emphasize excessively medical influence to BMD,and the change in the holistic BP of the bone in osteoporotic zone and its mechanism still need to investigate deeply.OBJECTIVE:To probe into the action and its mechanism of “ the...

BACKGROUND:The biomechanical property(BP) of the bone is decided by its geometric structure and component material. Merely pursuing increase of the bone mineral density(BMD) might lead to deterioration of bone BP. However at present,some researches on therapeutic action on osteoporosis emphasize excessively medical influence to BMD,and the change in the holistic BP of the bone in osteoporotic zone and its mechanism still need to investigate deeply.OBJECTIVE:To probe into the action and its mechanism of “ the kidney tonifying compound of the Traditional Chinese Medical (TCM) ” on BP of cortical bone in ovariectomized osteoporotic model rats.DESIGN:Completely randomized controlled experiment based on experimental animals. SETTING:Laboratory of Biomedical Engineering,Luoyang Hospital and Institute of Traditional Chinese Orthopedics and Traumatology in Henan Province.MATERIALS:The experiment was completed from November 2000 to July 2001 at Research Laboratory of Biomedical Engineering, Luoyang Institute of Traditional Chinese Orthopedics and Traumatology of Henan Province.The healthy Wistar female rats aged 10 months, weighing(350± 20) g.METHODS:Fifty Whistar female rats aged 10 months were randomly divided into 5 groups: the normal,model,premarin treated,xianling gubao treated and migu capsule treated with 10 in each group.The normal group was only given sham operation and the other four groups were ovariectomized.The rats after operation were fed normally for ninety days. Since the 91st day after operation, the rats had been given the medicines for 90 days and then killed. The thighbones were taken out, then BMD,femoral geometry sizes and BP were determined. MAIN OUTCOME MEASURES:① The primary sequel was the comparison of the parameters of femoral BP.② The secondary sequel was the changes in parameters of femoral geometric structure,area of cortical bone and BMD of every midsectional fomur. RESULTS:Femoral BP worsened significantly, its mechanical intensity reduced,its external diameter diminished, cortical bone area decreased and femoral BMD lowered in osteoporotic model rats. In comparison with the above,in “ the kidney tonifying compound of TCM " groups(migu capsule group and xianling gubao group) femoral BP raised significantly,its mechanical intensity advanced,its external diameter augmented,cortical bone area aggrandized and femoral BMD enhanced. CONCLUSION:“ The kidney tonifying compound of TCM " can improve BP of the cortical bone(thighbone) in ovariectomized osteoporosis rats. Its primary mechanism of action is that the TCM compound prescription could enhance“ the mechanism of biomechanical response and regulation"(MBRR) of macrostructure of cortical bone, consequently increase femoral external diameter, aggrandize cortical bone area and enhance BMD in ovariectomized rats.

背景:骨的生物力学性能优劣,取决于骨的结构和骨的材料。片面追求骨矿密度的提高,可能会引起骨生物力学性能的恶化。目前对骨质疏松治疗作用的不少研究过分强调了药物对骨矿密度的影响,对骨质疏松部位骨的整体生物力学性能的变化及其机制的研究还有待深入。设计:以实验动物为研究对象的完全随机对照的实验研究。目的:探讨补肾中药复方对去卵巢骨质疏松模型大鼠皮质骨(股骨)生物力学性能的作用及其相关的机制。单位:河南省洛阳正骨研究所生物医学工程实验室。材料:实验于2000-11/2001-06在河南省洛阳正骨研究所生物医学工程实验室完成。10月龄Wistar雌性大鼠50只,体质量(350±20)g。方法:将50只10月龄Wistar雌性大鼠随机分为5组:正常对照组、模型对照组、密骨胶囊组、仙灵骨葆组和倍美力组,每组10只。正常对照组做假手术,其余4组做卵巢切除术。术后正常饲养90d,第91天开始给药,连续用药90d,处死,测定股骨的骨矿密度、几何尺寸和股骨的生物力学性能。主要观察指标:①主要结局为股骨力学性能参数的比较。②次要结局为股骨几何结构参数、皮质骨面积和股骨各平面骨矿密度的变化。结果:模型大鼠股骨的生物力学性能明显下降,骨强...

背景:骨的生物力学性能优劣,取决于骨的结构和骨的材料。片面追求骨矿密度的提高,可能会引起骨生物力学性能的恶化。目前对骨质疏松治疗作用的不少研究过分强调了药物对骨矿密度的影响,对骨质疏松部位骨的整体生物力学性能的变化及其机制的研究还有待深入。设计:以实验动物为研究对象的完全随机对照的实验研究。目的:探讨补肾中药复方对去卵巢骨质疏松模型大鼠皮质骨(股骨)生物力学性能的作用及其相关的机制。单位:河南省洛阳正骨研究所生物医学工程实验室。材料:实验于2000-11/2001-06在河南省洛阳正骨研究所生物医学工程实验室完成。10月龄Wistar雌性大鼠50只,体质量(350±20)g。方法:将50只10月龄Wistar雌性大鼠随机分为5组:正常对照组、模型对照组、密骨胶囊组、仙灵骨葆组和倍美力组,每组10只。正常对照组做假手术,其余4组做卵巢切除术。术后正常饲养90d,第91天开始给药,连续用药90d,处死,测定股骨的骨矿密度、几何尺寸和股骨的生物力学性能。主要观察指标:①主要结局为股骨力学性能参数的比较。②次要结局为股骨几何结构参数、皮质骨面积和股骨各平面骨矿密度的变化。结果:模型大鼠股骨的生物力学性能明显下降,骨强度降低;股骨干外径变细,股骨中段骨皮质面积减少,骨矿密度有所下降。补肾中药复方?

 
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