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type polioviruses
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  “type 2 polioviruses”译为未确定词的双语例句
     Results During 1996 to 2002,the number of type 2 polioviruses is larger than type 1 and type 3 isolated in AFP cases,and there were significant differences between the number of type 2 and type 1 or type 3,so type 2 poliovirus is preponderant.
     型内鉴定显示与疫苗病毒有差异者,进行VP1区基因核苷酸序列的测定和分析。 结果中国1996~2002年从AFP病例中分离的脊灰疫苗病毒Ⅱ型比Ⅰ型和Ⅲ型多,差异有显著的统计学意义,是优势病毒株。
短句来源
     Among type 2 polioviruses,70 strains were identified as typical strains by PCR-RFLP ITD method,13 strains were identified as Non-Sabin like(NSL) viruses or Double-reactive viruses(DRV) by ELISA and no wild polioviruses were detected.
     在Ⅱ型脊灰病毒中,PCR-RFLP型内鉴定方法检测出Ⅱ型疫苗变异脊灰病毒70株,ELISA型内鉴定方法检测出Ⅱ型双反应(DRV)株13株,全部排除脊灰野病毒。
短句来源
  相似匹配句对
     type 2 C.
     2类型以台湾立花桔为代表;
短句来源
     Type 2, the O.
     O .
短句来源
     2?
     2?
短句来源
     2).
     2).当m≥4时,都是色唯一图;
短句来源
     Molecular Evolution of Polioviruses
     脊髓灰质炎病毒的分子进化
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  type polioviruses
Sabin Type 2 Polioviruses with Intertypic Vaccine/Vaccine Recombinant Genomes
      


Seven of the thirteen vaccine-related typepolioviruses isolated in China were identified as recombinant strains by PCR-RFLP and sequencing analysis was made in 1994. With Transgenic mice test and Temperature-sensitive multiplication test (Rct-marker), most of them showed higher neurovirulence and higher ability of growth at 39.8℃ than Sabin2 vaccine strain but lower than that of MEF strain. However, the neurovirulence of the 7 isolates is not completely correlated with biological characteristics...

Seven of the thirteen vaccine-related typepolioviruses isolated in China were identified as recombinant strains by PCR-RFLP and sequencing analysis was made in 1994. With Transgenic mice test and Temperature-sensitive multiplication test (Rct-marker), most of them showed higher neurovirulence and higher ability of growth at 39.8℃ than Sabin2 vaccine strain but lower than that of MEF strain. However, the neurovirulence of the 7 isolates is not completely correlated with biological characteristics of Rct-marker. Partial genomic sequences of 5′non-coding region and VP1 region of these viruses were also examined. It was found that all recombinants have a transition from C to G at neucleotide position 481, some of them have T to A or T to C transition at position 2909, but non of them has mutation at position 2908 which is considered previously as one of the important points with type Ⅱ poliovirus neurovirulence.

对1994年中国分离的13株脊髓灰质炎Ⅱ型疫苗相关株进行了PCR-RFLP分析,发现7株为重组病毒,毒力较疫苗株有回复。在Ⅱ型脊髓灰质炎病毒基因序列上,对于神经毒力有重要影响的第481位核苷酸发生了突变(C→G),另一个被视为重要位点的第2908位核苷酸无一发生变化,反而在第2909位核苷发生了高频率的点突变,意味着2909位点在中国Ⅱ型疫苗相关株的自然变异中可能起着重要作用。根据转基因小鼠实验和温度敏感实验(Rct-marker),脊髓灰质炎病毒的神经毒力大小并不与温度敏感实验所显示的毒力特征呈正相关性。

In order to strengthen the virologic surveillance of poliomyelitis in China, since 1992 the polio laboratory network has been established. In the past six years, more than 1383 poliovirus isolates were isolated and the characteristics of these isolates were analyzed. 1. Wild polioviruses circulated in the mainland of China before 1994, and all of the wild polioviruses were type 1 except one type 3 wild virus was isolated in Xinjiang. 2. The wild type 1 epidemic strains were divided into three genotypes by...

In order to strengthen the virologic surveillance of poliomyelitis in China, since 1992 the polio laboratory network has been established. In the past six years, more than 1383 poliovirus isolates were isolated and the characteristics of these isolates were analyzed. 1. Wild polioviruses circulated in the mainland of China before 1994, and all of the wild polioviruses were type 1 except one type 3 wild virus was isolated in Xinjiang. 2. The wild type 1 epidemic strains were divided into three genotypes by gene analysis of their VP1-coding regions, and the main genotype was further divided into two sub-groups: sub-group A and B. The sub-group B was recombinant of wild type poliovirus genome with vaccine type genome, the homology between sub-group Aand Bwas 90%. 3. The National Immunization Days (NIDs) had been set up for children under the age of 4 since the winter of 1993, the reported immunization coverage rate was 95%, the children with two rounds of supplemental immunization at the first NIDs were about 80 millions during 1993-1994. The poliomyelitis cases decreased greatly in 1994, the domestic wild-type poliovirus has not been isolated since October of 1994. 4. Four wild polioviruses were isolated from the children with Myamma nationality in Yunnan Province in 1995 and 1996. The children were at onset of paralysis before they went to Yunnan Province to see a doctor.The genotype of the wild polioviruses were different from that of Chinese domestic strains. So these wild-type polioviruses were imported from abroad. 5. The type of the polioviruses isolated from AFP cases has changed significantly while the polio cases decreased greatly in 1994. Type 2 poliovirus increased, and the recombination was found among the type 1, type 2 and type 3 isolates. 6. The type 1 recombinant which was vaccine type genome in VP1 and wild type genomein 3D found in 1993 was different from the recombinant found in 1991. The above-mentioned recombinants were no longer found after 1994, but the recombination between different vaccine genotypes was found frequently. These suggested that when a wild poliovirus and avaccine strain infected an identical cell at the same time, the recombinant might occur in the nature. Whether a new polio-derived strain will occur or not when a poliovirus and a non-polio enterovirus infected the same cell is under studying. The risk of occurring recombinants which were resulted from the combined use of different types or sorts of attenuated vaccines should be considered. 7. The type 2 recombinant strains have been isolated in 14 provinces of China, since its first detection in 1993. The neurovirulence of this kind of recombinant was increasing as shown by transgenic mice, and the children with zero-dose of OPV may suffer residual paralysis when they were infected by this kind of recombinant strain. The number of type 2 vaccine strain isolated from AFP patients in 1997 was more than before, while that isolated from contacts was low. Summarizing these findings, we suggest that the type 2 recombinant or vaccine-derived strain might be the cause of some AFP cases. But we have had no epidemiologic evidence yet that these kinds of viruses will cause an epidemic, which needs further investigation.

中国大陆1994年以前有脊髓灰质炎(脊灰)野病毒流行,除新疆外均为Ⅰ型野病毒。经VP1片段的基因分析,流行的Ⅰ型野病毒可分为3个亚型,其中主要亚型又可分为A、B两簇,B簇为野病毒和疫苗病毒的重组株,A、B簇间同源性为90%。1993年冬起,在全国开展强化免疫日活动,4岁以下儿童报告的免疫覆盖率达95%。1993/1994年,第1次强化免疫儿童约8000万,1994年脊灰病例明显减少,当年10月后未再分离到本土脊灰野病毒。1995、1996年我国从云南省分离到4株野病毒,患儿均系缅甸籍儿童,在缅甸发病后来中国求医。分离的野病毒与中国本土野病毒的基因型不同,故为输入病例。1994年在脊灰病例明显减少的同时,从急性弛缓性麻痹(AFP)病例中分离到的脊灰病毒的型别发生了明显改变,Ⅱ型增多,而且在Ⅰ、Ⅱ、Ⅲ型分离的病毒中都出现了不同形式的重组株。与1991年发现的野病毒与疫苗病毒重组株不同,1993年发现了VP1区为疫苗株病毒基因片段,3D区为野病毒片段的Ⅰ型重组株。1994年后未再发现上述疫苗病毒与野病毒的重组。但同时发现了不同型别之间的疫苗重组株。重组株的发现,说明了自然界脊灰野病毒可与疫苗病毒或不同型别的疫苗株?

Objective:To explore the relationship between poliomyelitis epidemics and wildvirus characteristics.Methods:Two patients were clinically diagnosed as poliomyelitis,one in Anyue County,1991 and one in Huidong County,1992.Two virus strains were isolated in the stool samples,and the two isolates were detected by microtitration neutralization,Polymerase Chain Reaction Restriction Fragment Length Polymorphism(PCR-RFLP),and neucleotide sequence analysis.Results:They were all typepolioviruses by microtitration...

Objective:To explore the relationship between poliomyelitis epidemics and wildvirus characteristics.Methods:Two patients were clinically diagnosed as poliomyelitis,one in Anyue County,1991 and one in Huidong County,1992.Two virus strains were isolated in the stool samples,and the two isolates were detected by microtitration neutralization,Polymerase Chain Reaction Restriction Fragment Length Polymorphism(PCR-RFLP),and neucleotide sequence analysis.Results:They were all typepolioviruses by microtitration neutralization,and interpreted as wildviruses by PCR-RFLP.Nucleotide sequence analysis were performed and they showed significant differences from Sabin Ⅰ,they were confirmed as polio wildviruses.There were 20 neucleotide differences in sequences between the two isolates.Conclusions:In different places and times,there were differences in the sequences of epidemic strains.The outbreak of polio in Sichuan was related to difference of nucleotide sequence in strains,but current use of trivalent oral polio vaccine could effectively prevent the infection of poliovirus.Routine immunization and national immunization day activities were powerful measures to prevent and eradicate poliomyelitis.

目的 :探索脊髓灰质炎 (脊灰 )流行与野毒株性状的关系。方法 :选择了 1991年安岳县和 1992年会东县各一例临床诊断为脊灰的患者 ,从其粪便标本中各分离出一株病毒 ,用微量中和试验进行血清学鉴定 ,PCR— RFL P法进行型内鉴定 ,对 VP1区 30 0个核苷酸进行测序。结果 :血清学定型均为脊灰 型病毒 ,经 PCR— RFL P法检测 ,判为野病毒。核酸序列分析证实两株病毒与 Sabin 有明显差异为野病毒。两毒株间核酸序列不完全一致 ,有 2 0个核苷酸的差异。结论 :不同年份、不同地方流行株间的序列有差异。四川省脊灰流行与毒株间核酸序列的差异有关。但我国现行疫苗 OPV能有效预防我省脊灰 ,基础免疫和强化免疫是预防和消灭脊灰的有力武器

 
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