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expression proteomics
相关语句
  表达蛋白质组学
     Technique of Expression Proteomics and Progress of Studies on Esophageal Cancer Proteomics
     表达蛋白质组学技术及其在食管癌研究中的进展
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  “expression proteomics”译为未确定词的双语例句
     The difference of proteome of hearts was detected by expression proteomics between rats in Group HF+SERCA and those in HF group at 30 days after gene transfer.
     分析比较基因转导30天组中HF和HF+SERCA2a亚组大鼠的心肌蛋白质组表达的差异;
短句来源
     The proteome difference from rat hearts between Groups HF+SERCA2a and HF was detected by expression proteomics.
     比较HF组和HF+SERCA2a组大鼠心肌蛋白质组表达的差异;
短句来源
     With the completion of the human genome sequence project and the quick development of revelant techniques, proteomics is an emerging research area about the global protein profiles and their dynamic changes in cell. Technically, proteomics can be classified into two types. The first type is protein expression proteomics.
     随着人类基因组测序计划(human genome sequence project)的完成及蛋白质组学相关技术的迅速发展。
短句来源
     Content and methods of functional genomics are reviewed, including gene expression profile, genomic diversity, model organism,genomic comparation and evolution studied by microarray, serial analysis of gene expression, proteomics, bioinformatics , and so on.
     综述了功能基因组学研究的内容和方法,主要包括应用微点阵、基因表达系列分析(SAGE)、蛋白质组、生物信息学等方法来研究基因组表达概况、基因组多样性、模式生物体等
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  expression proteomics
Current proteome investigations are basically focused on two major areas, expression proteomics and functional proteomics.
      
These properties are described through studies of the growth phase and growth rate control of macromolecular synthesis, stress resistance and global gene expression (proteomics).
      


Proteomics means the large-scale analysis of all the proteins encoded by the genome. It can be divided into expression proteomics and functional proteomics. Neuroscience in particular is poised to benefit from new proteomic tools in light of its high complexity. This article outlines the application of expression and functional proteomics in the field of neuroscience.

蛋白质组学是指对基因组编码的所有蛋白质进行大规模分析的一门学科,它分为表达蛋白质组 学和功能蛋白质组学。新的蛋白质组学工具将为高度复杂的神经科学的研究提供便利。作者简述了表达 蛋白质组学和功能蛋白质组学在这一领域的应用。

Objective To study the therapy effect of adeno-associated viral gene transfer of sarcoplasmic reticulum Ca~ 2+ -ATPase 2a (SERCA2a)on chronic congestive heart failure (HF) in 30 days, and the possible mechanism of the therapy effect.Methods The rats were divided into four groups: control group, HF group, Group HF+EGFP, and Group HF+SERCA2a.HF rats were obtained by creating descending aortic constriction. 0.9% sodium chloride solution, recombinant adeno-associated virus carrying enhanced green fluorescent protein...

Objective To study the therapy effect of adeno-associated viral gene transfer of sarcoplasmic reticulum Ca~ 2+ -ATPase 2a (SERCA2a)on chronic congestive heart failure (HF) in 30 days, and the possible mechanism of the therapy effect.Methods The rats were divided into four groups: control group, HF group, Group HF+EGFP, and Group HF+SERCA2a.HF rats were obtained by creating descending aortic constriction. 0.9% sodium chloride solution, recombinant adeno-associated virus carrying enhanced green fluorescent protein gene (rAAV2.eGFP) and recombinant adeno-associated virus carrying SERCA2a gene (rAAV2.SERCA2a), were respectively delivered to pericardium of HF rats in different groups by intrapericardial injection with a trans-diaphragmatic approach. 30 days after gene transfer, hemodynamic parameters,SERCA2a protein expression and SERCA2a activity were analyzed. The proteome difference from rat hearts between Groups HF+SERCA2a and HF was detected by expression proteomics. Electrophoretic separation and quantitation of cardiac myosin heavy chain isoforms of hearts in different groups were performed at 30 days. Results At 30 days, left ventricular function improved significantly in HF rats infected with rAAV2.SERCA2a (LVSP 146.52±13.86 vs 97.91±12.13,LVEDP 7.88±2.88 vs 21.15±3.57,LV +dp/dt 11 206.16±1730.11 vs 5948.93±1283.43,LV -dp/dt -8249.54 ± 1076.09 vs -4497.50±652.12;P< 0.05). The recovered cardiac function in Group HF+SERCA2a rats was comparable to control rats, and had lower LV-weight/Body-weight ratio (2.46±0.17 vs 2.71±0.24, P<0.05). Overexpression of SERCA2a increased both the protein content (0.39 ±0.11 vs 1.11±0.18, P<0.05) and activity (228.62±25.11 vs 82.55 ±14.13, P<0.05) up to nonfailing levels. Expressions of some energy metabolic enzymes in hearts of Group HF+SERCA2a were much higher than those of HF group. They included creatine kinase-muscle, enolase beta, fructose-bisphosphate aldolase, mitochondrial H~+-ATP synthase alpha subunit, electron transfer flavoprotein alpha-subunit, H~+-transporting ATP synthase and heart fatty acid binding protein. Downregulation of α-MHC and upregulation of β-MHC in failing hearts were observed. Gene transfer of SERCA2a could increase the expression of α-MHC [(74.48±3.74)% vs (53.57±2.30)%, P<0.05], and decrease the expression of β-MHC [(25.52±3.74)% vs (46.43 ±2.30)%, P<0.05] in HF rats. The expression profiles of α-MHC and β-MHC and the ratio of α-MHC/β-MHC were similar to those in controls. Conclusions Adeno-associated viral gene transfer of SERCA2a can enhance SERCA2a functions, maintain calcium homeostasis, improve cardiac energy metabolism, and normalize the expression of cardiac myosin heavy chain isoforms in HF rats. As a result, the ventricular systolic and diastolic functions can be improved significantly, and the hypertrophy of the heart may be reduced in clinic. Adeno-associated viral gene transfer of SERCA2a demonstrated good therapy effects on HF rats.

目的研究腺相关病毒为载体的心肌肌浆网Ca2+-ATPase2a(sarcoplasmicreticulumCa2+-ATPase,SERCA2a)基因转导对慢性心力衰竭(HF)大鼠的治疗作用,并探讨其多种可能的机理。方法采用腹主动脉缩窄术建立HF大鼠模型,应用经腹心包腔内注射术分别将生理盐水、携带eGFP基因和携带SERCA2a基因的重组腺相关病毒导入HF、HF+EGFP和HF+SERCA2a组大鼠心脏。于导入30天,检测各组大鼠的心脏功能、SERCA2a蛋白表达和活性;比较HF组和HF+SERCA2a组大鼠心肌蛋白质组表达的差异;检测各组大鼠心肌肌球蛋白重链(MHC)亚型的表达。结果HF大鼠心脏内转导入SERCA2a基因30天,心脏收缩和舒张功能达到对照组大鼠水平,并且HF+SERCA2a组左室重/体重比值显著降低;SERCA2a蛋白表达和活性明显升高至对照组大鼠水平;多种能量代谢酶表达明显增加;α-MHC、β-MHC的表达以及α-MHC/β-MHC恢复至对照组大鼠水平。结论以重组腺相关病毒2作为载体,SERCA2a基因转导可以增强衰竭心脏的SERCA2a功能,增加心脏能量代谢,纠正MHC亚型的异常表达;在...

目的研究腺相关病毒为载体的心肌肌浆网Ca2+-ATPase2a(sarcoplasmicreticulumCa2+-ATPase,SERCA2a)基因转导对慢性心力衰竭(HF)大鼠的治疗作用,并探讨其多种可能的机理。方法采用腹主动脉缩窄术建立HF大鼠模型,应用经腹心包腔内注射术分别将生理盐水、携带eGFP基因和携带SERCA2a基因的重组腺相关病毒导入HF、HF+EGFP和HF+SERCA2a组大鼠心脏。于导入30天,检测各组大鼠的心脏功能、SERCA2a蛋白表达和活性;比较HF组和HF+SERCA2a组大鼠心肌蛋白质组表达的差异;检测各组大鼠心肌肌球蛋白重链(MHC)亚型的表达。结果HF大鼠心脏内转导入SERCA2a基因30天,心脏收缩和舒张功能达到对照组大鼠水平,并且HF+SERCA2a组左室重/体重比值显著降低;SERCA2a蛋白表达和活性明显升高至对照组大鼠水平;多种能量代谢酶表达明显增加;α-MHC、β-MHC的表达以及α-MHC/β-MHC恢复至对照组大鼠水平。结论以重组腺相关病毒2作为载体,SERCA2a基因转导可以增强衰竭心脏的SERCA2a功能,增加心脏能量代谢,纠正MHC亚型的异常表达;在临床方面表现为显著改善心脏收缩和舒张功能,可能能够减轻心脏肥厚等病理性结构改变。

 
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