L"1, but the difference was not accord with the variance of plant whole tolerance. So the sensitivity of ALS was not the mode of drug tolerance of rice varieties. With the same metsulfuron-methyl concentration, ALS acthvity in vivo was far higher than ALS activity in vitro, which was accord with rice tolerance. This could explain that metsulfuron-methyl was metabolized strongly into inactive compounds, which might be the mechanism of tolerance of rice species to metsulfuron-methyl.
The main mechanism by which TSPG reverses the drug resistance of K562/A02 cells is decreasing the expression of mdr-1 mRNA, which then decreases P-gp, the product of mdr-1 mRNA.
The response to repeated exposure and the mechanism of tolerance depend on the strength of the initial effect of copper and the extent of heterogeneity of the initial cyanobacterial population.
Conclusion: Our study demonstrates that genome-wide gene expression profiling by using cDNA microarray technique is a valuable approach in obtaining molecular mechanism of drug resistance in cancer cells.