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  renal
    Experiment Studies of Qichou Tang on Mechanisms in Rats of Chronic Renal Failure
    芪丑汤对衰大鼠作用机理的实验研究
短句来源
    The Effect of TNF-α on TEMT of Renal Interstitial Fibrosis and Inhibition Effect of Chinese Herbs Nourishing Kidney and Activing Blood on Transdifferentiation of Tubular Epithelium
    TNF-α对间质纤维化细胞表型变化的作用及补活血法中药对小管上皮细胞转分化的抑制作用
短句来源
    Effect of the Shenluotong on the Renal Tubular Epithelial-myofibroblast Transdifferentiation
    络通对小管上皮细胞表型转化及其相关调控因素的影响
短句来源
    Experimental Research of Effect of Shenshuaibaoshen Capsule on Mouse Renal Fibroblasts
    衰保胶囊对小鼠成纤维细胞影响的实验研究
短句来源
    Effect of Tujian Decoction on Protein Kinase C in Diabetic Rat Renal Cortex
    菟箭合剂对糖尿病大鼠皮质蛋白激酶C的影响
短句来源
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  kidney
    Effects and Mechanism of Active Site from Reimforcing Kidney Chinese Herbs on Bone Formation
    补中药醇提活性部位促成骨作用及机制
短句来源
    The Effect of TNF-α on TEMT of Renal Interstitial Fibrosis and Inhibition Effect of Chinese Herbs Nourishing Kidney and Activing Blood on Transdifferentiation of Tubular Epithelium
    TNF-α对间质纤维化细胞表型变化的作用及补活血法中药对小管上皮细胞转分化的抑制作用
短句来源
    The Study of the Protective Mechanism of Xiengyangkeli with Yohimbin on Kidney Yang Deficiency Animal
    兴阳颗粒配伍育亨宾对阳虚动物模型的干预作用及机理研究
短句来源
    Experiment Research on Formula of Nourishing Kidney Delaying the Premature Ovarian Failure (POF) of Menopausal Big Rats
    补复方延缓围绝经期大鼠卵巢衰老的实验研究
短句来源
    EFFECTS OF H-73-10 AND DTPA ON THE ULTRASTRUCTURE OF EPITHELIAL CELLS IN PROXIMAL CONVOLUTED TUBULES OF KIDNEY IN RATS
    H-73-10和DTPA对大鼠近曲小管上皮细胞超微结构的影响
短句来源
更多       
  the kidney
    Effect of Decoction for Warming the Kidney and Restoring Yang on Hepatic Ultrastructure of Rabbit Model with Yang Deficiency
    温助阳药对甲低阳虚模型兔肝组织超微结构的影响
短句来源
    Experimental Study of Effects on Tonifying the Kidney Yang by Pangshi Shenlong Ⅰ Oral Liquor (庞氏神龙1号口服液)
    庞氏神龙1号口服液补壮阳作用的实验研究
短句来源
    Results The peritoneal fluid with endometriosis model rats made sperm motile ratio and general hypo-osmotic ratio significantly lower than that of control group(P<0.05,P<0.01,P<0.01),herbs for invigorating the kidney to promote blood circulation could restore this change(P>0.05,P>0.05,P>0.01).
    结果与正常大鼠组相比,造模成功组腹腔液孵育后精子A级直线向前活动率及总活动率、总肿胀率均呈明显下降(P<0.05,P<0.01,P<0.01),经不同中药治疗后,补活血组上述指标基本恢复正常,与正常大鼠组相比均无显著差异(P>0.05,P>0.05,P>0.01)。
短句来源
    Objective: To illustrate the expressional distribution of heat shock protein70 (HSP70)in the kidney of acute renal injury rats caused by triptergium glycosides.
    目的:探讨雷公藤诱导的急性损伤大鼠模型中脏热休克蛋白70(HSP70)的分布及表达规律。
短句来源
    Result In the model group and UUOV,UUOB groups the content of protein and expressions of mRNA and ADM protein decreased obviously than those in the sham-operation group,and those in UUOB and UUOV groups were higher than those in the model group(P<0.05) but there was no significant difference between UUOB and UUOV groups. Conclusion Biejiajian Pills can up-regulate ADM protein and mRNA expressions in rats with renal interstitial fibrosis to protect the kidney.
    结果模型组及各治疗组大鼠脏中上腺髓质素组织蛋白含量、蛋白表达以及mRNA的基因表达较假手术组明显降低,鳖甲煎丸组、缬沙坦组的含量及表达均高于模型组(P<0.05?,但两组之间比较无显著性差异。结论鳖甲煎丸能够明显上调间质纤维化大鼠脏ADM的蛋白及mRNA的表达,对脏起到保护作用。
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  kideny
    The incorporation of ~3H-UdR(GSL 50mg/kg)into liver and kidney did not show significant difference(P>0.05). But the incorporation of ~3H-UdR (GSL 25mg/kg)into liver and kideny showed significant difference(P<0.01).
    GSL 25mg/kg,50mg/kg 对肝、组织蛋白合成亦均有增加作用(p<0.01和 p<0.05);
短句来源
    8 weeks after STZ injection, liver lesion w as evaluated using HE, oil red O staining and kideny lesion using PAS staining.
    8周后应用HE、油红O染色对肝组织、PAS染色对组织作病理检查。
短句来源
    The Effect of the Reinforcing the Kideny and Promoting Blood Circulation Decoction,the Invigorating Qi and Promoting Blood Circulation Decoctionon the ECG and Water Ratio of Aged Rats with Cerebral Ischemia
    补活血、益气活血方药对脑缺血老龄大鼠脑电图和脑含水量的影响
短句来源
    We also performed tissue detection of skin,brain,heart,liv- er,spleen,lung,kideny,testis(ovary).
    观察一般行为活动、食量、二便、皮肤粘膜、心率、心律、血像、肝功能,并作皮肤、脑、心、肝、脾、肺、、睾丸(或卵巢)组织学检查。
短句来源
    The jasmine tea,herbal medicine or tea added with herbal medicine not only significantly promoted the hyperplasis reactions of speen lymphocytes T and B,but also in-creased the activities of lymphocytes IL-2 and IL-3.Mechanism of protecting kideny functions by jasmine tea and tea added with herbal medicine was discussed.
    花茶、中药、复方茶均可显著促进小鼠脾T、B淋巴细胞增殖反应,而且都能增强小鼠脾淋巴细胞IL-2、IL-3的活性。 文中还对花茶和复方茶保护功能的机理进行了讨论。
短句来源
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      renal
    Investigations of their biodistribution in mice showed all five pseudo-peptide chelators (MGQ, MGGQ, MAGQ, MVGQ, MFGQ) are rapidly cleared from blood, mainly through renal clearance.
          
    99mTc-MGGQ and 99mTc-MVGQ had high kidney uptake, quick blood clearance and high activity ratios of kidney to blood, thus showing potential application as renal imaging agents.
          
    Diabetic complications including nephropathy, neuropathy, and cataract are leading causes of end-stage renal diseases and neurological disorders.
          
    Within three months after transplantation, four recipients (7.14%) died due to small-for-size syndrome (one case), renal failure (one case) and multiple organ failure (two cases).
          
    Intra-abdominal hypertension is an independent cause of acute renal failure after orthotopic liver transplantation
          
    更多          
      kidney
    99mTc-MGGQ and 99mTc-MVGQ had high kidney uptake, quick blood clearance and high activity ratios of kidney to blood, thus showing potential application as renal imaging agents.
          
    Among the tested compounds, compounds 4d and 5a exhibited potent antifibrotic activity without harmful side effects on liver and kidney functions.
          
    Screening and evaluation of rat kidney aldose reductase inhibitory activity of some pyridazine derivatives
          
    We evaluated a series of 2H-pyridazine-3-one and 6-chloropyridazine analogues via an in vitro spectrophotometric assay for their ability to inhibit rat kidney AR.
          
    Preliminary evaluation of rat kidney aldose reductase inhibitory activity of 2-phenylindole derivatives: affiliation to antioxid
          
    更多          
      the kidney
    At the same time, the pharmacological stimulation of the sympathetic nervous system leads to an even more defective aldosterone reception by the kidney.
          
    The dystrophy developing in the kidney after cutting the sciatic nerve blocks the compensatory increase in specific accumulation of (3H)aldosterone in the cytoplasm of the renal tubular cells.
          
    Drug blockade of both neural and humoral transmission of the abnormal stimuli from the injured nerve to the kidney prevented development of trophic disorders as indicated by the status of the renal mineralocorticoid receptor system.
          
    Age-dependent dynamics of the kidney inner medullary 120-kDa protein content in vasopressin-deficient Brattleboro rats with di/di mutant genotype was studied in comparison with WAG rats with +/+ genotype and normal vasopressin expression.
          
    In the di/di rats dehydration had no effect on the kidney 120-kDa protein synthesis in all ages examined.
          
    更多          
      kideny
    Patients with bilateral renal carcinoma or malignancy in solitary kideny are best managed by radical nephretomy with subsequent dialysis and transplantation.
          
    Subsequently marked vescioureteral reflux to the right kideny was demonstrated on cystourethrography and the kidney was shown to have no function on a nuclear scan.
          
    No changes occurred in glomerular concentration in kideny tissue indicating a more marked increase of other kidney structures.
          


    The "Compound Mixture of Two Fairies" (Ⅰ) has been used as a hypotensive drug. One of its chief ingredients is Phellodendron chinense (Ⅱ). Berberis spp. (Ⅲ)contains also much berbcrine. Hence Ⅱhas been substituted by Ⅲ in making the Compound Mixture Ⅳ. In this paper Ⅱand Ⅲ were studied in the form of fluidextracts. The dosages used were expressed in terms of crude drugs. The intraperitoneal LD_(50) in mice were 2.7 g/kg for Ⅱ and 3.1 g/kg for Ⅲ. Intraperitoneal injections in anesthetized cats produced, in...

    The "Compound Mixture of Two Fairies" (Ⅰ) has been used as a hypotensive drug. One of its chief ingredients is Phellodendron chinense (Ⅱ). Berberis spp. (Ⅲ)contains also much berbcrine. Hence Ⅱhas been substituted by Ⅲ in making the Compound Mixture Ⅳ. In this paper Ⅱand Ⅲ were studied in the form of fluidextracts. The dosages used were expressed in terms of crude drugs. The intraperitoneal LD_(50) in mice were 2.7 g/kg for Ⅱ and 3.1 g/kg for Ⅲ. Intraperitoneal injections in anesthetized cats produced, in 90 minutes, an average “% of hypotensive areas”of -30%for Ⅰ(4g/kg),—30% forⅡ(2g/kg),—42% for Ⅲ(2g/kg), and —32% for Ⅳ(4g/kg). Six renal hypertensive dogs were fed Ⅳ 15—30 g/kg/day for 20 days. There were no remarkable changes in blood pressure, EKG, BSP retention, and blood NPN. Three normal dogs were fed daily Ⅳ 45 g/kg for 3 weeks. Abnormal alteration was not found in EKG, liver and kidney function tests, nor was toxic sign noticed in the microscopic examinations. Sixteen water-soluble portions from different fractions of Ⅲ were screened over by single intravenous injections in anesthetized cats, 2—3 cats for each portion. Six of them yielded an average“%of hypotensive areas” exceeding —30%. Since Ⅲ is abundant in China and low in toxicity, it seems to be a promising source of hypotensive drugs.

    复方二仙合剂降压有效,其中以黄蘗的降压作用較強。三顆針是小蘗科植物,与黄蘗同为小蘗碱的資源植物,来源充沛。本文試驗其毒性与疗效。小白鼠腹腔注射1次三顆針或黃蘗流浸膏,观察3天的LD_(50)各为3.1与2.7克生药/公斤,相差不显著。麻醉猫腹腔注射三顆針或黄蘗流浸膏2克/公斤,90分钟內平均降压面积百分比:三顆針組为-42%,黃蘗組为-30%,相差显著。而注射針仙合剂(三顆針代黄蘗加入二仙合剂)或二仙合剂4克/公斤,90分钟內的平均降压面积百分比均为-30%左右。 腎型高血压狗每天灌服針仙合剂15—30克/公斤,共20天,血压变化不明显。心电图、肝对磺溴酞鈉的排泄机能及全血非蛋白氮量的測定,无明显改变。正常狗每天灌服針仙合剂45克/公斤,3周后,检查心电图、肝及腎机能无异常,其中1狗內脏作組織切片,无明显中毒現象。对麻醉猫靜脉注射由三顆針提取的不同部位的水溶液2—10毫克/公斤,篩过16种成分,其中6种的平均降压面积百分比超过-30%。三顆針药源广、口服毒性小,是一种較有希望的降压药源。

    The LD_(50) in mice was found to be 19.4 g/kg and 0.98±0.075 g/kg respectively for the infusion and crude extract of Chou-wu-tung, given by intravenous injections. The subacute toxicity is negligible when the infusion was crally administered to rats (0.25—2.5 g/kg/day) for 60 days, except that some animals showed quietness, slight fall of systolic pressure and soft stool. No apparent toxic effects were observed. A crude extract and infusion of Chou-wu-tung, when injected intravenously at respective dosages...

    The LD_(50) in mice was found to be 19.4 g/kg and 0.98±0.075 g/kg respectively for the infusion and crude extract of Chou-wu-tung, given by intravenous injections. The subacute toxicity is negligible when the infusion was crally administered to rats (0.25—2.5 g/kg/day) for 60 days, except that some animals showed quietness, slight fall of systolic pressure and soft stool. No apparent toxic effects were observed. A crude extract and infusion of Chou-wu-tung, when injected intravenously at respective dosages of 50—100 mg/kg and 150 mg/kg, produced primary and secondary falls of blood pressure on anaesthetized rats and dogs, but with intramuscular injection or oral administration, only the secondary fall of blood pressure was apparent. This hypotensive effect might last for 2—3 hours. Intravenous injection of the decoction to anaesthetized animals produced only primary fall of blood pressure, the infusions of alcohol, ether and ,chloroform, given by the same route, did not lower the blood pressure. Twenty-eight renal hypertensive rats were divided into three groups, the first (11 rats) and the second (7 rats) groups were treated with the infusion at respective dosages of 0.5 g/kg/day and 5 g/kg/day, and the third (10 rats) with the crude extract at 50 mg/kg/day. The drug was given to all the rats for 2 weeks by oral administration. Hypotensive effect was observed in 3—10 days after medication, and became more remarkable in the second week of the therapeutic period or the first week after cessation of medication; the blood pressure dropped 57.4%. The blood pressure in most rats returned in 2 weeks, and in some rats in 2—4 days or 4 weeks after the stopping of medication.

    1.本文就臭梧桐的一般性质作了实验性研究,结果证明其降血压成分易溶于水,难溶或不溶于乙醚、乙醇和氯仿,对热稳定,在碱性溶液中可被氯化钙沉淀出来。臭梧桐降血压效果可因产地而不同。开花前的和新鲜的臭梧桐降血压作用分别较开花后的和经长时间保存的要强。 2.臭梧桐毒性甚小,其热浸剂和提出物给小鼠静脉注射时半数致死量分别为19.4克/公斤和0.98±0.075克/公斤。给大鼠每天用热浸剂(0.25—2.5克/公斤)灌胃经60天,除少数动物出现安静、轻度收缩压下降和大便变稀外,未发现其他毒性反应。 3.臭梧桐提出物(50—100毫克/公斤)和热浸剂(150毫克/公斤)给麻醉大鼠和狗静脉注射时,可引起两度血压下降,但肌肉注射或经口给药,仅引起第二度降血压作用,其作用可维持2—3小时。静脉注射煎剂(麻醉大鼠和狗实验)仅出现第一度降血压作用,经口给药时无效。乙醚、乙醇和氯仿的浸出液不论静脉注射或经口给药,均不引起麻醉动物的血压下降。给型高血压大鼠每天经口投予臭梧桐热浸剂(0.5—5克/公斤)和提出物(50毫克/公斤)时,给药的第3—10天卽口出现血压下降,在给药的第二周和停药后的第一周,血压下降最明显,最大降血压...

    1.本文就臭梧桐的一般性质作了实验性研究,结果证明其降血压成分易溶于水,难溶或不溶于乙醚、乙醇和氯仿,对热稳定,在碱性溶液中可被氯化钙沉淀出来。臭梧桐降血压效果可因产地而不同。开花前的和新鲜的臭梧桐降血压作用分别较开花后的和经长时间保存的要强。 2.臭梧桐毒性甚小,其热浸剂和提出物给小鼠静脉注射时半数致死量分别为19.4克/公斤和0.98±0.075克/公斤。给大鼠每天用热浸剂(0.25—2.5克/公斤)灌胃经60天,除少数动物出现安静、轻度收缩压下降和大便变稀外,未发现其他毒性反应。 3.臭梧桐提出物(50—100毫克/公斤)和热浸剂(150毫克/公斤)给麻醉大鼠和狗静脉注射时,可引起两度血压下降,但肌肉注射或经口给药,仅引起第二度降血压作用,其作用可维持2—3小时。静脉注射煎剂(麻醉大鼠和狗实验)仅出现第一度降血压作用,经口给药时无效。乙醚、乙醇和氯仿的浸出液不论静脉注射或经口给药,均不引起麻醉动物的血压下降。给型高血压大鼠每天经口投予臭梧桐热浸剂(0.5—5克/公斤)和提出物(50毫克/公斤)时,给药的第3—10天卽口出现血压下降,在给药的第二周和停药后的第一周,血压下降最明显,最大降血压作用可达原值的57.4%。多数高血压大鼠的血压在停药后的第二周恢复,少数在停药的2—4天或4周后恢复。

    The absorption, distribution and excretion of anthraquinone derivatives in animals and in human beings receiving single oral, intramuscular or intravenous doses were studied. The anthraquinone derivatives tested were easily absorbed and excreted. The peak blood levels were reached within 2—3 hours after oral ingestion. Thereafter, the concentration fell gradually. After intramuscular injection, the peak was reached within 30 minutes, the concentration fell rapidly and then maintained a nearly constant level...

    The absorption, distribution and excretion of anthraquinone derivatives in animals and in human beings receiving single oral, intramuscular or intravenous doses were studied. The anthraquinone derivatives tested were easily absorbed and excreted. The peak blood levels were reached within 2—3 hours after oral ingestion. Thereafter, the concentration fell gradually. After intramuscular injection, the peak was reached within 30 minutes, the concentration fell rapidly and then maintained a nearly constant level for 4 hours. By the intravenous injection the peak was reached within 5 minutes. The concentration dropped quickly in the first 30 minutes. At the end of 1 hour, anthraquinone derivatives were not detectable in the blood. Among the anthraquinone derivatives studied, rhein was more easily absorbed than emodin. Anthraquinone derivatives were excreted by the bowel, urine and bile. The total excretion was about 46.2% of ingested does. About 23.4% was found in the feces and 22.8% in the urine. The excretion lasted 2 days. About 88% of that excreted in feces occurred in the first day and about 61% of that excreted in urine appeared in the first8 hours. Anthraquinone derivatives were distributed mainly in the liver and kidneys afterabsorption. No detectable amount was found in heart, spleen, lungs and brain.

    本文以人体和动物(家兔及小鼠)实验,一次口服和注射(肌肉及静脉)大黄蒽醌衍生物,以观察其在体内的吸收、排泄和分布的情况。实验结果表明,蒽醌衍生物在体内易于吸收。口服时血中浓度在2—3小时内即达最高峯,其后慢慢下降,与注射比较,高峯较低,但持续时间较长。肌肉注射半小时内即达最高峯,其后迅速下降,在4小时内可维持一定水平。静脉注射5分钟内即达特高高峯,但维持时间极短,1小时内仅余痕迹。大黄酸似乎比大黄素更易于吸收。蒽醌衍生物在体内易由粪、尿和胆汁中排泄。由粪排出总量占摄入量的23.4%,其中88%是在第一天排出,排出可持续2—3天。尿及胆中蒽醌衍生物浓度分别以6—8及4—6小时为最高,由尿排出总量占摄入量的22.8%,以2—4小时内为最高,在前8小时内排出者占61%,由尿排出可持续2天。由尿及粪排出总和占摄入量的46.2%,说明有一半多可能在体内破坏。蒽醌衍生物在各组织和脏器的分布以肝和为最多,心、脾、肺和脑等没有测到。口服时肝和均在2小时内达最高峯,肌肉注射则在半小时内达最高峯,尤其是脏。

     
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