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ccn family
相关语句
  ccn家族
     Progress in the study of CCN family
     CCN家族研究进展
短句来源
     CTGF encodes a36-38 kDa cysteine-rich secreted polypeptide that is a member of an immediate earlygene family known as the CCN family.
     CTGF 是一种富含半胱氨酸的分泌性多肽,其分子量为36~38kD,属于即早基因CCN 家族。
短句来源
     The connective tissue growth factor is a member of an emerging gene family known as the CCN family, which is an exocrine-type cysteine-rich polypeptide, and i t is also the downstream effector of the transforming growth factorβ 1 and mediates the growth and migration of the vascular smooth muscular cell and the endothelium. The connective tissue growth factor plays an important role in the angiogenesis during wound repair, but its mechanism in tumor angiogenesis is sti ll poorly understood.
     结缔组织生长因子是即刻早期反应基因的家族成员之一 ,CCN家族中富含半胱氨酸的外分泌型多肽 ,是转化生长因子 β1的下游效应子 ,参与了血管平滑肌细胞和内皮细胞的生长、迁移 ,在创伤修复中参与了血管生成 ,但在肿瘤及其血管形成过程中的作用机制至今未明。
短句来源
     Connective tissue growth factor (CTGF) is a 38 kDa secreted polypeptide growth factor, belong to one of the members of the CCN family of immediate early genes. Now it has been shown to be synthesized by a variety of cells including fibrob-lasts, some vascular endothellal cells and vascular smooth muscle cells, epithelial cells, tumor cells, and chondrocytes.
     结缔组织生长因子(connective tissue growth factor,CTGF)是相对分子量为38kda的分泌性生长因子,属于即刻早期基因家族-CCN家族成员之一。
短句来源
  “ccn family”译为未确定词的双语例句
     Northern blotting was used to evaluate the mRNA expression of WISP3, a member of the CCN family, mRNA in the OBs.
     同时采用Northern杂交检测成骨细胞的WISP3表达情况。
短句来源
  相似匹配句对
     ANVANCES IN THE FAMILY OF CCN PROTEINS
     CCN蛋白家族研究进展
短句来源
     Progress in the study of CCN family
     CCN家族研究进展
短句来源
     family
     家庭·亲情
短句来源
     Family
     家人的团聚
短句来源
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  ccn family
CCN3 is a member of the CCN family of cell growth and differentiation regulators that play key roles during embryonic development, and are associated with severe human pathologies.
      
In contrast, another member of the CCN family, CCN2, promotes smooth muscle cell proliferation in vitro, and thus it was expected that its expression levels would be low in uninjured normal adult tissues.
      
The six proteins of the CCN family have important roles in development, angiogenesis, cell motility, proliferation, and other fundamental cell processes.
      
Fourth international workshop on the CCN family of genes: Abstracts and posters October 18-21, 2006
      
CCNs are expressed under conditions of cellular stress, and it has been suggested that some CCN family members utilize IRES-mediated translation initiation to facilitate this expression.
      
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The nov gene is a founding member of the expanding CCN family of genes, which encode proteins reported to be involved in a variety fundamental biological functions. Our previous studies have confirmed that nov gene might be involved in the acquisition of specific functions during postnatal development of rat central nervous system. The aim of this study is to reveal the relationship between nov expression and development, differentiation of brain during the evolution from lower vertebrate——fish to higher...

The nov gene is a founding member of the expanding CCN family of genes, which encode proteins reported to be involved in a variety fundamental biological functions. Our previous studies have confirmed that nov gene might be involved in the acquisition of specific functions during postnatal development of rat central nervous system. The aim of this study is to reveal the relationship between nov expression and development, differentiation of brain during the evolution from lower vertebrate——fish to higher vertebrate——mammals. Comparative distribution of nov mRNA positive neurons in the brain of Silver carp, chicken, cattle, dog and cat was studied by using in situ hybridization histochemistry. The results were as follows: a few of nov mRNA positive neurons were detected in dorsal motor nucleus of vagus, motor nucleus of the trigeminal nerve, anterior thalamic nucleus, posterior thalamic nucleus, dorsal hypothalamic nucleus and lateral hypothalamic nucleus of lower vertebrate Silver carp. In addition to the pons positive neurons were also found in cerebellum, most nucleus of thalamus and hypothalamus, and corpus striatum of chicken. Whereas a lot of nov mRNA positive neurons were widely localized in the brain of mammals—cattle, dog and cat, strong positive signal was found in pons, cerebellum, thalamus, hypothalamus and cerebrum of these species. Our results indicated that nov gene is very conservative during the evolution of brain from lower vertebrate—fish to higher vertebrate—mammals, and the expression of nov gene coincided with the development and structure and function differentiation of brain.

用地高辛标记的cRNA探针原位杂交组织化学方法研究了鲢、鸡、牛、犬和猫脑肾母细胞瘤过度表达基因阳性神经元的比较发育。结果显示 ,低等脊椎动物鲢脑仅有少量novmRNA阳性神经元 ,分布于延髓的迷走神经背核、三叉神经背核、丘脑前核、丘脑后核、下丘脑背侧核、下丘脑外侧核。鸡脑阳性神经元除广泛分布于脑干外 ,小脑、丘脑的多数核团、下丘脑的背侧核、腹侧核和后核以及大脑纹状体等多数脑区也有一定分布。哺乳动物牛、犬和猫脑中novmRNA阳性神经元广泛分布 ,在脑干、小脑、间脑和大脑都检测到强烈阳性信号。以上结果表明 ,在从低等脊椎动物到高等脊椎动物的进化过程中nov基因的表达也从低级中枢向高级中枢扩展 ,提示该基因的表达与脑的种系发育、脑功能的分化平行相关。

The connective tissue growth factor is a member of an emerging gene family known as the CCN family, which is an exocrine-type cysteine-rich polypeptide, and i t is also the downstream effector of the transforming growth factorβ 1 and mediates the growth and migration of the vascular smooth muscular cell and the endothelium. The connective tissue growth factor plays an important role in the angiogenesis during wound repair, but its mechanism in tumor angiogenesis is sti ll poorly understood....

The connective tissue growth factor is a member of an emerging gene family known as the CCN family, which is an exocrine-type cysteine-rich polypeptide, and i t is also the downstream effector of the transforming growth factorβ 1 and mediates the growth and migration of the vascular smooth muscular cell and the endothelium. The connective tissue growth factor plays an important role in the angiogenesis during wound repair, but its mechanism in tumor angiogenesis is sti ll poorly understood. The breast is abundant in connective tissue matrix, especi ally higher in breast carcinoma, so the connective tissue growth factor probably plays an important role throughout the biological course of breast carcinoma.

结缔组织生长因子是即刻早期反应基因的家族成员之一 ,CCN家族中富含半胱氨酸的外分泌型多肽 ,是转化生长因子 β1的下游效应子 ,参与了血管平滑肌细胞和内皮细胞的生长、迁移 ,在创伤修复中参与了血管生成 ,但在肿瘤及其血管形成过程中的作用机制至今未明。乳腺组织中含有丰富的纤维结缔组织基质 ,尤其在乳腺癌中结缔组织生长因子含量明显增高 ,故它很可能参与了乳腺癌的各种生物学全过程

Objective To explore the proliferation, differentiation, and gene expression profile of the osteoblasts (OBs) of patient with spondyloepiphyseal dysplasia tarda with progressive arthropathy (SEDT-PA). Methods OBs from the head of femur of a SEDT-PA patient resected during operation were cultured. ELISA was used to examine the bone-specific alkaline phosphatase (BAP), osteocalcin (OC), and osteoprotegrin (OPC) in the lysate of OBs. The proliferation and survival of the OBs were evaluated with MTT method and 3H-TDR...

Objective To explore the proliferation, differentiation, and gene expression profile of the osteoblasts (OBs) of patient with spondyloepiphyseal dysplasia tarda with progressive arthropathy (SEDT-PA). Methods OBs from the head of femur of a SEDT-PA patient resected during operation were cultured. ELISA was used to examine the bone-specific alkaline phosphatase (BAP), osteocalcin (OC), and osteoprotegrin (OPC) in the lysate of OBs. The proliferation and survival of the OBs were evaluated with MTT method and 3H-TDR incorporation. Flow cytometry was used to observe the cell cycle. Northern blotting was used to evaluate the mRNA expression of WISP3, a member of the CCN family, mRNA in the OBs. Gene differential expression microarray was used to determine the cDNA expression. Osteoblasts from the head of femur of a patient about the same age with fracture of femur neck was used as control. Results~The cultured OBs from the SEDT-PA patient showed a higher survival capacity (0.86±0.04 vs 0.71±0.10) and more 3H-TDR incorporation (1363±350 vs 867±128). The expressions of OC and OPG were down-regulated to the 1/4.3 and 1/4.69 of the control respectively. There was no significant difference in the expression of BAP. WISP3 was very lowly expressed in the OBs of the SEDT-PA patient. In comparison with the normal control, there were up-regulation of 22 genes, including those coding chemotactic factors and inflammatory factors, and down-regulation of 16 genes in the OBs of the SEDT-PA patient with a synthetic effect of more rapid proliferation of OBs and reduction of synthesis of extracellular matrix, resulting in osteopenia. Conclusion Not significantly different between SEDT-PA patient and normal person, the WISP3 expression may not be a direct factor of SEDT-PA.

目的探讨晚发型脊柱骨骺发育不良伴进行性骨关节病(SEDT PA)患者WISP3基因突变所造成的软骨及周围骨组织病变和可能的发病机制。方法从SEDT PA患者及正常同龄个体的股骨头松质骨分离成骨细胞进行体外培养,对培养的成骨细胞进行细胞增殖、骨特异性碱性磷酸酶(BAP)、骨钙素、护骨素测定,利用cDNA表达芯片进行基因表达谱分析,并用免疫组织化学方法对基因芯片进行验证。比较SEDT PA患者及正常对照的成骨细胞在细胞增殖、分化及基因表达谱等方面的改变。同时采用Northern杂交检测成骨细胞的WISP3表达情况。结果与正常人成骨细胞相比,SEDT PA患者成骨细胞的增殖能力较强(0.86±0.04vs0.71±0.10),氚胸腺嘧啶(3H TDR)的掺入量明显较高(1363cpm±350cpmvs867cpm±128cpm)。SEDT PA患者的成骨细胞骨钙素的表达水平明显低于正常同龄人(3.62ng/μg蛋白±0.3ng/μg蛋白vs0.85ng/μg蛋白±0.06ng/μg蛋白),护骨素的表达明显低于正常同龄人(9.43pg/μg蛋白±0.41pg/μg蛋白vs1.98pg/μg蛋白±0.03pg/μg蛋白...

目的探讨晚发型脊柱骨骺发育不良伴进行性骨关节病(SEDT PA)患者WISP3基因突变所造成的软骨及周围骨组织病变和可能的发病机制。方法从SEDT PA患者及正常同龄个体的股骨头松质骨分离成骨细胞进行体外培养,对培养的成骨细胞进行细胞增殖、骨特异性碱性磷酸酶(BAP)、骨钙素、护骨素测定,利用cDNA表达芯片进行基因表达谱分析,并用免疫组织化学方法对基因芯片进行验证。比较SEDT PA患者及正常对照的成骨细胞在细胞增殖、分化及基因表达谱等方面的改变。同时采用Northern杂交检测成骨细胞的WISP3表达情况。结果与正常人成骨细胞相比,SEDT PA患者成骨细胞的增殖能力较强(0.86±0.04vs0.71±0.10),氚胸腺嘧啶(3H TDR)的掺入量明显较高(1363cpm±350cpmvs867cpm±128cpm)。SEDT PA患者的成骨细胞骨钙素的表达水平明显低于正常同龄人(3.62ng/μg蛋白±0.3ng/μg蛋白vs0.85ng/μg蛋白±0.06ng/μg蛋白),护骨素的表达明显低于正常同龄人(9.43pg/μg蛋白±0.41pg/μg蛋白vs1.98pg/μg蛋白±0.03pg/μg蛋白),而BAP的表达未发生明显改变;WISP3基因的表达极低。cDNA表达芯片分析结果发现,与正常对照比较,SEDT PA患者的成骨细胞有22个基因表达明显上调,16个基因表达明显下调,这些基因包括有成骨细胞的标记分子、细胞外基

 
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