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   mice scid 的翻译结果: 查询用时:0.008秒
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mice scid
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  “mice scid”译为未确定词的双语例句
     NE-2Z-H_5 was transplanted into the Scid mice of which immune system was reconstituted with the peripheral lymphocytes or thymus of the isogenetic mice and the BALB/c nude mice of which NK cells were inhibited with cyclophosphamide, The results showed that the growth speed and weight of the tumors were in order from high to low among groups of Scid mice, BALB/c nude mice with NK inhibit-ed,BALB/c nude mice, Scid mice with immune reconstitution.
     采用近系淋巴细胞输入或移植胸腺重建Scid小鼠免疫功能,以环磷酰胺抑制BALB/C裸鼠NK功能,然后移植CNE-2Z-H_5。 移植瘤生长速度及瘤重依次为:Scid小鼠组→NK功能抑制组→BALB/C裸鼠组→免疫重建组;
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     NOD/SCID mice, respectively.
     CD45+/CD3+/CD4+细胞的比例:A 组肝脏中人 CD45+/CD3+/CD4+细胞分别为
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     Breeding Diabetes Scid Mice with Streamline Cabinet
     应用层流柜饲养实验性糖尿病Scid小鼠体会
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     Mice were injected (i.m.)
     末次免疫后一周,眼眶取血后处死小鼠。
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     p stimulation in mice.
     (3)CDZ对未感染小鼠PMN的T哪一a和IL一lp分泌未见明显影响。
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  mice scid
Human prostate cancer cells which do not express αvβ3 or αIIbβ3 integrins were injected directly into human bone fragments previously implanted subcutaneously in SCID mice (SCID-human-bone model).
      
Rates of survival of neoplastic cells in the grafts were higher in nude-scid mice than in SCID and beige-scid mice (SCID mice 38%, nude-scid mice 55%, beige-scid mice 38%).
      


Objective: To study systematically the role of skeletal muscle cells in synthesizing, processing and secreting recombinant proteins in vitro . Methods: Primary murine myoblasts from SCID mice (SCID MB) and C2C12, a mouse myoblast cell line, were transfected with muscle specific (pdLMe4bAhⅨm) or non specific (LⅨSN) vectors encoding human factor Ⅸ (FⅨ). The capacities of the transgenic cells in producing recombinant FⅨ were compared in the levels of intracellular and secreted FⅨ...

Objective: To study systematically the role of skeletal muscle cells in synthesizing, processing and secreting recombinant proteins in vitro . Methods: Primary murine myoblasts from SCID mice (SCID MB) and C2C12, a mouse myoblast cell line, were transfected with muscle specific (pdLMe4bAhⅨm) or non specific (LⅨSN) vectors encoding human factor Ⅸ (FⅨ). The capacities of the transgenic cells in producing recombinant FⅨ were compared in the levels of intracellular and secreted FⅨ protein as well as FⅨ mRNA in primary muscle cells and C2C12 cells. Results: Both primary muscle cells and C2C12 cells can efficiently translate and process FⅨ protein. Myotubes derived from the SCID MB produced 2 000 ng FⅨ· (10 6 cells) -1 ·(24 h) -1 in culture with specific activity of 95%~103%. C2C12 cells can synthesize and process recombinant FⅨ as efficiently as primary muscle cells, but their secretion ability is less efficient in comparison with primary cells. Conclusion: The primary cells should be used in gene therapy related research projects and care should be taken while explaining the results derived from established cell lines.

目的:研究骨骼肌细胞作为基因治疗靶细胞,其合成、加工和分泌外源性蛋白质的功能。方法:应用骨骼肌细胞特异性和非特异性表达载体(pd L Me4b AhⅨm 和 LⅨ S N)转染联合免疫缺陷( S C I D)小鼠原代成肌细胞( S C I D M B)和 C2 C12 成肌细胞系,观察这两种细胞在合成、加工和分泌人凝血因子Ⅸ( FⅨ)蛋白质方面的异同。结果:在 S C I D M B中,pd L Me4b AhⅨm可表达的 FⅨ 达2 000 ng·10- 6 ·(24 h)- 1 ,凝血活性达 95% ~103% 。比较细胞内和培养上清液中的 FⅨ蛋白及细胞内 FⅨm R N A 丰度变化表明, C2 C12 细胞分泌 FⅨ的功能不如 S C I D M B,而合成、加工 FⅨ的能力与 S C I D M B相似。结论:原代小鼠骨骼肌细胞可高效表达、加工和分泌外源性基因产物;在以骨骼肌细胞作为靶细胞进行基因治疗研究时,应尽量应用原代细胞。本研究为临床应用骨骼肌细胞作为基因治疗靶细胞奠定了实验基础。

The sever combined immunodieficiency mice (Scid) was selected and injected infection larvae of wuchereria bancrofti for animal model established. The results showed that bancrofti filaria was easy infected scid and grow, develop into adults to continue producing microfilaria in Scid. The collecting rate of adult worms is as high as 14.8% around 6-30%. The microfilaria in circulation blood not only can be check up in all of Scid infected, adult worm also can be collected, meaning...

The sever combined immunodieficiency mice (Scid) was selected and injected infection larvae of wuchereria bancrofti for animal model established. The results showed that bancrofti filaria was easy infected scid and grow, develop into adults to continue producing microfilaria in Scid. The collecting rate of adult worms is as high as 14.8% around 6-30%. The microfilaria in circulation blood not only can be check up in all of Scid infected, adult worm also can be collected, meaning 100% of scid was successful for infected with bancrofti filaria. It indicated that due to immunodeficiency of Tand B lymphatic cells of Scid mice for antibody producing, it is a valuable laboratory animal with following characters easy infected, high microfilarial density, high collected rate of worm. It is good laboratory animal model for bancrofti filaria.

采用人工感染法,对严重联合免疫缺陷小鼠(Scid 小鼠) 进行夜现周期性斑氏丝虫实验感染研究。结果表明,斑氏丝虫经人工感染后能在Scid 小鼠体内发育成熟并产生微丝蚴,且虫体回收率较高为6~30% ,平均14-8% 。感染的10 只小鼠均在外周血中检获出微丝蚴,及解剖收集到成虫,感染成功率高达100% 。作者认为Scid 小鼠由于T、B淋巴细胞功能缺如,不能产生相应的抗丝虫感染抗体,是一种易于感染成功、潜伏期短、微丝蚴密度及成虫回收率高的较理想的实验动物。

AIM To explore the model characteristics of human hepatocarcinoma cells growing in various strains of different immunodeficient mice. METHODS The human hepatocarcinoma cells cultured in vitro were inoculated into va rious strains of different immunodeficient mice (B lymphocyte deficient mice-CBA/N, T lymphocyte deficient mice-BALB/c nu, T and B lymphocytes combined deficient mice-SCID and immunoreconstituted BALB/c PBL SCID, CBA/N PBL SCID. normal immune...

AIM To explore the model characteristics of human hepatocarcinoma cells growing in various strains of different immunodeficient mice. METHODS The human hepatocarcinoma cells cultured in vitro were inoculated into va rious strains of different immunodeficient mice (B lymphocyte deficient mice-CBA/N, T lymphocyte deficient mice-BALB/c nu, T and B lymphocytes combined deficient mice-SCID and immunoreconstituted BALB/c PBL SCID, CBA/N PBL SCID. normal immune mice-BALB/c as controls) and their growths in the mice were surveyed. RESULTS There were no carcinoma growth in BALB/c and immunoreconstituted SCID mice with BALB/c mice peripheral blood lymphocytes (CBA/N PBL SCID); tumor growth in CBA/N mice was different with different cells inoculation sites; but there were 100% carcinoma growth in SICD, nude and immunoreconstituted SCID mice with CBA/N (CBA/N PBL SCID). CONCLUSION SCID mice are ideal animals for establishing hepatocarcinoma model and for studying tumor immunity. T lymphocytes play a main role in rejection to tumor.

目的 探讨人类肝癌细胞 972 4在不同免疫缺陷小鼠的生长及模型特点 .方法 体外培养人类肝癌细胞 972 4;接种到不同免疫力小鼠 (B缺陷的 CBA/ N,T缺陷的 BAL B/ c裸鼠 ,T,B缺陷的 C.B- 17SICD小鼠及免疫重建的 SCID小鼠 .免疫正常的 BAL B/ c作为对照组 )皮下、肝内、腹腔 ,观察其生长特性 .结果  BAL B/ c小鼠和用 BAL B/ c外周淋巴细胞免疫重建的 SCID(BAL B/ c- PBL - SCID)不成瘤 ;CBA/ N小鼠随接种数量和途径不同而有不同的表现 ;BAL B/ c裸鼠 ,SCID小鼠和 CBA/ N小鼠外周淋巴细胞重建的 SCID(CBA/N- PBL- SCID) 10 0 %成瘤 .结论  SCID小鼠是建立肝癌模型的最佳小鼠 ,也是进行肿瘤免疫研究最佳模型动物 ;T细胞在异种瘤移植排斥中起主要作用

 
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