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   rb tumor suppressor gene 的翻译结果: 查询用时:0.143秒
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rb tumor suppressor gene
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  “rb tumor suppressor gene”译为未确定词的双语例句
     To investigate the correlation between Rb tumor suppressor gene and bladder and renal cell carcinoma,the gene in primary RCC, baldder carcinoma and cell lines Were analyzed by northern blot,One RCC and two bladder carcinoma cell lines showed noramal Rb expression.
     对正常肾和肾细胞癌组织,正常膀胱粘膜和膀胱移行细胞癌组织以及肾癌细胞和膀胱癌细胞株BIU-87和E-J中的抗癌基因Rb进行Northernblot分析。 肾和膀胱癌细胞都表达正常的RbmRNA。
短句来源
     Objective: To investigate the mutation of RB tumor suppressor gene in Wilms tumor and to explore the relationship between RB mutation and the pathogenesis of Wilms tumor.
     目的:调查肾母细胞瘤中RB基因突变,探讨RB基因突变与肾母细胞瘤发生的关系。
短句来源
     Conclusion The infiltrating growth and onset of keloid might be related to the mutation or loss of Rb tumor suppressor gene.
     结论:瘢痕瘤的发生或其侵袭性生长失控可能与Rb 肿瘤抑制基因突变或缺失有关。
短句来源
     To explore the expression of Rb tumor suppressor gene in the esophageal carcinoma from a high_incidence area,Jieyang,Guangdong province,and to investigate its clinic significance.
     目的]研究广东揭阳地区食管癌高发现场患者的抑癌基因Rb蛋白表达的情况及其意义。
短句来源
  相似匹配句对
     RB Gene and Tumor Suppression .
     RB基因与肿瘤抑制
短句来源
     Mutation of RB Gene in Wilms- Tumor
     肾母细胞瘤中RB基因突变的研究
短句来源
     Expression of p16 and Rb in Epithelial Ovarian Tumor
     抑癌基因p16及Rb在上皮性卵巢肿瘤中的表达及其意义
短句来源
     The expression of Rb and p53 were more correlated with the progression of tumor.
     而Rb、p53基因表达多与肿瘤的发展过程相关。
短句来源
     Advances in the study of tumor suppressor genes Rb and P53
     抑癌基因Rb与P53的研究进展
短句来源
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  rb tumor suppressor gene
Expression of the RB tumor suppressor gene, whose function is putatively in controlling cell growth, may be regulated by S-phase specific inhibitors of DNA synthesis that are commonly used in cell synchronization and cancer chemotherapy.
      
RB tumor suppressor gene expression responds to DNA synthesis inhibitors
      
Children with constitutional deletion of the long arm of chromosome 13 are at risk for retinoblastoma (RB) due to loss of the RB tumor suppressor gene.
      
The cyclin D1 protein forms a complex with CDK-4 or -6, and this complex phosphorylates and thereby inactivates the RB tumor suppressor gene product.
      
One specific example of this phenomenon is the RB tumor suppressor gene located on chromosome 13q14.
      
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To investigate the correlation between Rb tumor suppressor gene and bladder and renal cell carcinoma,the gene in primary RCC, baldder carcinoma and cell lines Were analyzed by northern blot,One RCC and two bladder carcinoma cell lines showed noramal Rb expression.One of 13 RCC,and two hing-grade bladder carcinomas lacked Rb mRNA expression. None of the low-grade carcimomas showed an altration in Rb gene,The result suggests that the loss of Rb gene corrclates with...

To investigate the correlation between Rb tumor suppressor gene and bladder and renal cell carcinoma,the gene in primary RCC, baldder carcinoma and cell lines Were analyzed by northern blot,One RCC and two bladder carcinoma cell lines showed noramal Rb expression.One of 13 RCC,and two hing-grade bladder carcinomas lacked Rb mRNA expression. None of the low-grade carcimomas showed an altration in Rb gene,The result suggests that the loss of Rb gene corrclates with bladder carcinoma and is more frequent in high-grade ones Rb loss might have a role in certain renal cell carcinoma.

对正常肾和肾细胞癌组织,正常膀胱粘膜和膀胱移行细胞癌组织以及肾癌细胞和膀胱癌细胞株BIU-87和E-J中的抗癌基因Rb进行Northernblot分析。肾和膀胱癌细胞都表达正常的RbmRNA。1/13例肾癌组织和2/8例膀胱癌组织中发现Rb基因缺失。此2例Rb缺失的膀胱癌均为低分化肿瘤,在分化较高的膀胱癌中未发现Rb基因缺失。结果表明,Rb基因缺失与膀胱癌的关系密切,同时与肿瘤的分化程度有关。结合文献对Rb抗癌基因与泌尿系肿瘤的关系及其在肿瘤发生中的作用进行讨论。

The alterations of multiple genes andtheir carcinogenic mechanism in cervical carcinomawere studies by molecular hybridization,PCR andPCR-ASO techaniques. The G→T point mutation inthe 12th coden of Ha-ras was detected in cervical carci-nomas with mutation frequency of 18.2%(8/44),andthe amplification rate of Ha-ras gene was 45%(9/20).The c-erb B2 was amplified 3-30 fold with an amplifica-tion rate of73.3%(11/15)in cervical carcinomas and5 cancerous samples showed gene rearrangement.Theelevated...

The alterations of multiple genes andtheir carcinogenic mechanism in cervical carcinomawere studies by molecular hybridization,PCR andPCR-ASO techaniques. The G→T point mutation inthe 12th coden of Ha-ras was detected in cervical carci-nomas with mutation frequency of 18.2%(8/44),andthe amplification rate of Ha-ras gene was 45%(9/20).The c-erb B2 was amplified 3-30 fold with an amplifica-tion rate of73.3%(11/15)in cervical carcinomas and5 cancerous samples showed gene rearrangement.Theelevated copies of c-myc gene with amplification rate of91.7%(11/12)were observed in cervical carcinomas.The study of HPV16 viral gene showed that the exis-tence of HPV16 DNA seauence was Dositively associat-ed whth c-myc gene amplification in cervical canceroussamples. The p53 and Rb tumor suppressor genes ab-sence of deletion were observed in the 12 specimens ofcervical carcinorna investigated. As mentioned above,the study on alteration and carcinogenic mechanism ofmultiple genes indicated that 3 oncogenes and HPV16viral gene were activated or integrated throygh differ-ent mechanisms and they played roles in co-carcino-genesis. The integration of HPV16 gene might promotethe c-myc gene at the carly stage in carcinogenesis ofcervical carcinoma, while the alteration of Ha-ras andc-erb B2 gene might be rniddle-late event. As for theroles of the p53 and Rb tumor suppresor gene in cervi-cal carcinoRenesis need further researches.

应用核酸分子杂交、PCR、PCR-ASO杂交等技术,对人宫颈癌中Ha-ras等三种癌基因、HPV16病毒基因及P53、Rb抑癌基因等多基因变化及其致癌机理进行了研究。结果表明:①宫颈癌中存在Ha-ras第12位密码子G→T点突变,突变率为18.2%(8/44),并有Ha-ras基因扩增,扩增率为45%(9/20);②c-erbB2基因在宫颈癌中的扩增率为73.3%(11/15),5例伴有重排;③c-myc基因在宫颈癌中的扩增率为91.7%(11/12);④HPV16E6/E7为引物的PCR检测结果,宫颈癌中的阳性率为80.5%(33/41);⑤12例宫颈癌中未发现P58、Rb基因缺失。上述多基因致癌机理的研究表明,人宫颈癌中Ha-ras、c-myc、c-erbB2经点突变、扩增、重排而被激活,在癌变中起着协同致癌作用。HPV16基因的整合可能启动c-myc,为癌变的起始因素,而Ha-ras、c-erbB2的基因改变可能为中、晚期事件,抑癌基因P53、Rb的作用尚需进一步研究。

Objective: To investigate the mutation of RB tumor suppressor gene in Wilms tumor and to explore the relationship between RB mutation and the pathogenesis of Wilms tumor. Methods: Twenty-five samples of Wilms- tumor were screened for mutation from exon 1 to 27 of RB gene by multiplex PCRSSCP and DNA sequencing. Results: Of the 25 cases, 5 displayed homozygous deletions, and 4 showed abnormal SSCPband shifts. In the other 2 samples, one (W28) showed a basic change...

Objective: To investigate the mutation of RB tumor suppressor gene in Wilms tumor and to explore the relationship between RB mutation and the pathogenesis of Wilms tumor. Methods: Twenty-five samples of Wilms- tumor were screened for mutation from exon 1 to 27 of RB gene by multiplex PCRSSCP and DNA sequencing. Results: Of the 25 cases, 5 displayed homozygous deletions, and 4 showed abnormal SSCPband shifts. In the other 2 samples, one (W28) showed a basic change in the 2nd base of codon 756 (an A to C transversion). The other (W31) showed a basic change at the 28th position of intron 26 (a C to T transversion). Conclusion: The mutation of RB gene is involved in the oncogenesis of Wilms tumor. This suggests that alterations of multigenes may be involved in the oncogenesis of Wilms tumor.

目的:调查肾母细胞瘤中RB基因突变,探讨RB基因突变与肾母细胞瘤发生的关系。方法:采用多重PCR-SSCP法结合DNA测序对肾母细胞瘤的手术标本进行RB基因全部外显子的突变筛查。结果:25例肾母细胞瘤中5例显示有缺失,4例检出SSCP电泳迁移率的改变,2例经测序证实为单碱基置换。其中1例(W28)为第756个密码子的第2个碱基发生A→C的颠换,另1例(W31)为第26内含子距5′端28个碱基处发生T→C的转换。结论:RB基因突变涉及肾母细胞瘤的发生,提示肾母细胞瘤的发生为多次遗传改变积累的结果。

 
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