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 Two functional parameters evaluated by NBT dye reduction and YC rosette formation and a morphological change assessed by WrightGiemsa stain of HL60 cells were used to determine the extent of HL60 cell differentiation induced by retinoids and DMSO. Studies revealed that under the action of retinoic acid(RA) and its two new synthetic analogs, 4(ethoxycarbophenyl) retiamide(RI) and 4(hydroxycarbophenyl) retiamide (RII), HL60 cells could be induced to differentiate to more mature cells with functional... Two functional parameters evaluated by NBT dye reduction and YC rosette formation and a morphological change assessed by WrightGiemsa stain of HL60 cells were used to determine the extent of HL60 cell differentiation induced by retinoids and DMSO. Studies revealed that under the action of retinoic acid(RA) and its two new synthetic analogs, 4(ethoxycarbophenyl) retiamide(RI) and 4(hydroxycarbophenyl) retiamide (RII), HL60 cells could be induced to differentiate to more mature cells with functional characteristics of granuloeytes. When HL60 cells were incubated with 10~(6)M of RⅠ and RⅡ for 6 days, 42.3% and 43.6% of the eells were capable of reducing NBT; 20.7% and 14.9% could form YC rosettes with yeast ceils covered by human C_3 complement. DMSO was also shown to be active in the induction of both functional differentiation phenotypes. However, the expression of C_3 complement receptor was much earlier than the emergence of NBT reduction capacity under its induction. It is resonable to speculate that the induction machanism of retinoids and DMSO is somewhat different. Both retinoids and DMSO could induce HL60 cells into morphologically more mature myeloid cells including myeloeytes, metamyelocytes and banded neutrophils. However, only a few cells matured into fully segmented ones. The induction of differentiation of HL60 cells by all of the drugs tested was found to be associated with a reduction of the number of viable ceils. Since this phenomenon appeared later than cell differentiation, it may be related with the change of growth characteristics of differentiated cells.  本文研究了新维甲酸衙生物——维胺酯(RⅠ)和维胺酸(RⅡ)对人早幼粒白血病细胞(HL60)的分化诱导作用,并与维甲酸(RA)和二甲基亚砜(DMSO)进行了比较。HL60细胞经RⅠ和RⅡ处理后,细胞对NBT染料还原能力增强,细胞表面出现C_3补体受体等中性粒细胞的分化特征,但作用比RA弱。DMSO诱导上述分化性状出现时间不同,提示维甲酸类药物与DMSO诱导分化的机制可能不同。上述药物均可使HL60细胞形态按粒系途径向较成熟的方向发展,但变化出现较晚。  Applying the graphic scieace to the geometrical design about level luffing of the double link jib with a rigid pitman, this paper advances the followings: 1. The equivalent expressions for extracting size parameters of the jib; 2. The r_1line, a binding of the pitman articulaton of the jib lever; 3. The rtarget curve, a means to check up the levelness of luffing and adjust the parameters evaluated automatically. Given in the paper is a concrete instance of computation, which proves the feasibility... Applying the graphic scieace to the geometrical design about level luffing of the double link jib with a rigid pitman, this paper advances the followings: 1. The equivalent expressions for extracting size parameters of the jib; 2. The r_1line, a binding of the pitman articulaton of the jib lever; 3. The rtarget curve, a means to check up the levelness of luffing and adjust the parameters evaluated automatically. Given in the paper is a concrete instance of computation, which proves the feasibility and conspicuous advantages of the method advanced.  对于刚性拉杆组合臂架的水平变幅几何设计,本文运用图学工具,提出了: 1.求解臂架尺寸参数的等效关系式; 2.象鼻架拉杆铰点的约束条件:r_1线; 3.自动校核变幅水平性及调整待求参数的手段:r目标曲线。文中举出一个计算实例,表明本法可行并有其突出优点。  In this article the assessment model for the dose equavalent of the radioactive materials disposed into the sea and received by public individial via various routes is presented. The differential equation group describing the kinematic behavior of radionuelides in the sea environment is derived. The Derived Limit Concentration (DLC) of radionuclides in sea water is calculated for the equilibrium condition. The local fisherman serves as the critical group, a third of yearly dose equavalent limit for these individuals... In this article the assessment model for the dose equavalent of the radioactive materials disposed into the sea and received by public individial via various routes is presented. The differential equation group describing the kinematic behavior of radionuelides in the sea environment is derived. The Derived Limit Concentration (DLC) of radionuclides in sea water is calculated for the equilibrium condition. The local fisherman serves as the critical group, a third of yearly dose equavalent limit for these individuals (i.e. 1.7 mSv/a) is taken as dose limit in ocean environment contaminated with radioactive materials. The parameter evaluating approach and its significance is also discussed. The DLC calculated by specific activity approach and the applicability of resultant values and its safety are given. Finally, the calculated DLC is compared with the maximum permissible caneentration (MPC) as published in literatures for sea water and also with the limit concentration of radionuclides in fresh water.  本文提出了放射性物质排入海洋后经由各种途径对人照射的评价模式。导出了描述放射性核素在海洋体系中动力学行为的微分方程组,并就平衡条件推算出放射性核素在海水中的限制浓度。关键居民组为当地渔民,取公众个人年剂量当量限值的1/3(即1.7mS_v/a)作为海洋环境引起的照射限值。讨论了参数的估算和取值方法。文中还给出了用比活度法算出的限制浓度值。讨论了所给结果的适用性和安全裕量。本文的结果还与文献报道的相应结果以及露天水源的限制浓度作了比较。   << 更多相关文摘 
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