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drug release carrier
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  “drug release carrier”译为未确定词的双语例句
     Finally,the controlled release behavior of BH in polymer beads were studied and the release rate of BH kept almost constant after 24h. Release rate of BH was higher at pH 1.4 than that at pH 7.4.Conclusion: β-CDP beads may be an ideal controlled drug release carrier.
     BH在β-CDP微球中的释放速率存在明显的零级释放规律,且pH=1.4下的释放速率比pH=7.4下的快。 结论:β-环糊精聚合物微球是一理想的药物控释载体。
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  相似匹配句对
     drug release test;
     溶出物试验;
短句来源
     EXPERIMENTAL STUDY ON RELEASE RATE OF DRUG CARRIER MICROSPHERE
     载药微球释放规律的实验研究
短句来源
     Meantime, the rate of sustained release of the drug carrier in water was investigated.
     同时考察了装载阿司匹林的分子筛组装体在水溶液中的药物释放率。
     Temperature-sensitive Hydrogels Suitable for Drug Controlled-release Carrier
     药物缓释载体用温敏性水凝胶
短句来源
     Study of Carrier's Drug Release Rate Controlled by Ultrasound Irradiation
     影响β-TCP多孔陶瓷药物载体释药速度的因素分析
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Azopolymers can be used as a new type colonic-specific drug release carriers what have some characteristic of enzyme-controlled and accurate garget. Azopolymers were synthesised with MAA, MMA, DVAB/BMAAB monomers by radical polymerization in ethanol solution. Conditions of polymerization were studied. The results show that when mass of MAA and MMA is 7 g in 100 mL ethanol, percent of azo functional monmers mass is 2% relation to total mass of MAA and MMA , copolymers can dissolve in ethanol. The structure...

Azopolymers can be used as a new type colonic-specific drug release carriers what have some characteristic of enzyme-controlled and accurate garget. Azopolymers were synthesised with MAA, MMA, DVAB/BMAAB monomers by radical polymerization in ethanol solution. Conditions of polymerization were studied. The results show that when mass of MAA and MMA is 7 g in 100 mL ethanol, percent of azo functional monmers mass is 2% relation to total mass of MAA and MMA , copolymers can dissolve in ethanol. The structure of these azopolymers were also measured by UV, FT-IR, and()~( 13)C-NRM, λ__(max) of azopolymers of containing DVAB in UV is 342 nm shorter than λ_(max) 357 nm of DVAB. λ_(max) of azopolymers of containing BMAAB in UV does not change comparing with λ_(max) of BMAAB.

通过溶液聚合方法合成了含对二乙烯基偶氮苯(DVAB)和对二甲基丙烯酰胺偶氮苯(BMAAB)两种功能单体的可溶性共聚物。在合成聚合物时,单体固含量为7g/100mL乙醇,偶氮功能单体的含量为MAA、MMA总量的2%(质量)时,能得到可溶性聚合物。用UV、FT-IR、13C-NMR等现代分析方法表征了聚合物的结构,含DVAB的聚合物其最大紫外吸收波长为342nm,较DVAB的最大紫外吸收波长(357nm)短。而含BMAAB聚合物的最大吸收波长,在反应前后未发生变化。

AIM: To observe the degradation of the collagen material and its biocompatible in acoustic vesicles of guinea-pigs. METHODS: The study was conducted in Navy General Hospital of Chinese PLA from March to May 2005. Twenty white guinea pigs were selected and divided into 5 groups randomly, which were feigned operation group and collagen implantation 1, 2, 3, 4-week groups with 4 animals in each group. All animals were general anaesthesia through abdomen cavity. Their acoustic vesicles were open through retroauricular...

AIM: To observe the degradation of the collagen material and its biocompatible in acoustic vesicles of guinea-pigs. METHODS: The study was conducted in Navy General Hospital of Chinese PLA from March to May 2005. Twenty white guinea pigs were selected and divided into 5 groups randomly, which were feigned operation group and collagen implantation 1, 2, 3, 4-week groups with 4 animals in each group. All animals were general anaesthesia through abdomen cavity. Their acoustic vesicles were open through retroauricular sterile incision. BME-10X collagen membrane was implanted into every acoustic vesicle except these in the feigned operation group. The incision was closed, and the changes of praxiology of the animal action were observed after wakefulness. After 1, 2, 3, 4 weeks, the guinea-pigs were given general anaesthesia, the acoustic vesicles were opened again to observe the changes of the collagen membrane, then the animals were killed, the left acoustic vesicles were sliced to observe the degradation of collagen membrane and biocompitable with hematoxylin-eosin staining (HE). RESULTS: All the 20 experimental white guinea pig animals were involved in the result analysis. ①Observational result of animal ethology of every group after the collagen membrane implanted: All animals waked up after anaesthesia, no death. No animal paralyzed, twitched, vomited, incontinence of urine and feces or rotated, etc. The actions of the animals were active, and the response of the animals was agile. ②General observation of the degradation and biocompatible in the acoustic vesicles of guinea pigs: The collagen material was keeping its original shape after 1-week implantation and no neo-vessel grown into. Also, no neo-vessel was observed in the collagen material in auditory vesticle. No new tissue and vessel in the 2, 3-week group. In the 4-week group, the collagen material was dissolved and absorbed, there weren't any neo-tissue grown or liquid existed. ③Pathology examination on degradation and biocompatible of the collagen material in acoustic vesicles: There were some lymphocytes in collagen material in 1-week group, no foreign body giant cells. No granulation tissue grew in the acoustic vesicles; the lymphocytes were decreased in the 2-week group, and there were only a few lymphocytes in collagen material in the 3-week group.CONCLUSION: The collagen material is degraded and absorbed slowly along with the horary extension, and the vesicle membrane is normal, no node or granulation tissue forming. It indicates that the degradable collagen material has good biocompatibility, and can be used for controlled drug-release carrier in middle ear.

目的:观察可降解的胶原基材料在豚鼠听泡内的降解过程及其生物相容性情况。方法:实验于2005-03/05在解放军海军总医院完成。选取白豚鼠20只,随机分为5组:假手术组、胶原基植入1,2,3,4周组,4只/组。全部白豚鼠腹腔麻醉后,无菌条件下取左侧耳后切口,打开听泡。除假手术组外,其余各组均植入BME-10X医用胶原膜,缝合手术切口,待豚鼠全麻清醒后观察其行为学变化。胶原基植入1,2,3,4周组分别于胶原基植入1,2,3,4周时,麻醉后在手术显微镜下打开听泡,观察胶原材料的大体变化。处死动物,取其左侧听泡,切片苏木精-伊红染色后对胶原基材料在听泡内的降解及生物相容性进行观察。结果:实验选用白豚鼠20只,全部进入结果分析。①胶原基材料植入后各组动物行为学观察结果:各组动物全麻后均清醒,未出现死亡。胶原基材料植入后未出现瘫痪、抽搐、呕吐、尿便失禁、原地打转等不良反应,行为活跃,反应敏捷。②各组胶原基材料在听泡内降解及生物相容性的大体观察:胶原基植入1周组植入的胶原材料大致保持了植入前形状,无新生血管长入,听泡内黏膜无明显新生血管增生;胶原基植入2,3周组无肉眼可见的新生组织及血管长入;胶原基植入4周组听泡内的胶原材...

目的:观察可降解的胶原基材料在豚鼠听泡内的降解过程及其生物相容性情况。方法:实验于2005-03/05在解放军海军总医院完成。选取白豚鼠20只,随机分为5组:假手术组、胶原基植入1,2,3,4周组,4只/组。全部白豚鼠腹腔麻醉后,无菌条件下取左侧耳后切口,打开听泡。除假手术组外,其余各组均植入BME-10X医用胶原膜,缝合手术切口,待豚鼠全麻清醒后观察其行为学变化。胶原基植入1,2,3,4周组分别于胶原基植入1,2,3,4周时,麻醉后在手术显微镜下打开听泡,观察胶原材料的大体变化。处死动物,取其左侧听泡,切片苏木精-伊红染色后对胶原基材料在听泡内的降解及生物相容性进行观察。结果:实验选用白豚鼠20只,全部进入结果分析。①胶原基材料植入后各组动物行为学观察结果:各组动物全麻后均清醒,未出现死亡。胶原基材料植入后未出现瘫痪、抽搐、呕吐、尿便失禁、原地打转等不良反应,行为活跃,反应敏捷。②各组胶原基材料在听泡内降解及生物相容性的大体观察:胶原基植入1周组植入的胶原材料大致保持了植入前形状,无新生血管长入,听泡内黏膜无明显新生血管增生;胶原基植入2,3周组无肉眼可见的新生组织及血管长入;胶原基植入4周组听泡内的胶原材料已完全溶解吸收,听泡内无新生纤维组织条索,无积液。③各组胶原基材料在听泡内降解及生物相容性的病理检查:胶原基植入1周组可见少量淋巴细胞浸润,未见异物巨细胞,听泡内黏膜无肉芽组织增生;胶原基植入2周组的淋巴细胞浸润继续减轻;至胶原基植入3周组仅见少量淋巴细胞。结论:随着植入时间的延长,胶原材料在豚鼠听泡内逐渐被降解吸收,周围黏膜无结节和肉芽组织形成。提示可降解的胶原基材料具有良好的生物相容性,可以做为中耳控释给药的载体材料。

As drug release carriers,chitosan has played an important role in the less administration frequency,low toxicity,and cure efficiency enhancement.In this article,the recent progress in the preparation and properties of chitosan-based release carriers has been reviewed,including nanoparticle,microsphere,tablet,film,and gel.Furthermore,their advance in the future was also introduced briefly.

壳聚糖作为药物缓释载体在减少给药次数,降低药物毒副作用,提高药物疗效等方面具有重要作用。本文综述了壳聚糖作为药物缓释载体的研究进展,主要包括壳聚糖纳米粒子、微球、片、膜和凝胶等的制备和缓释特性,并对其发展趋势进行了展望。

 
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