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This paper is to report the result of using ELISA to detect HBsAg-IgM complex in the serum of patients with viral hepatitis B. A series of serum samples of 35 patients,including 29 acute,2 subacute severe and 4 chronic active cases were tested. 28 normal individuals were also tested as control.HBsAg-IgM complex was discovered in the sera of all the patients in the first one or two weeks of hospitalization. It disappeared from the sera of 24 patients (among whom 10 have been followed up for more than 3 to 6 months)... This paper is to report the result of using ELISA to detect HBsAg-IgM complex in the serum of patients with viral hepatitis B. A series of serum samples of 35 patients,including 29 acute,2 subacute severe and 4 chronic active cases were tested. 28 normal individuals were also tested as control.HBsAg-IgM complex was discovered in the sera of all the patients in the first one or two weeks of hospitalization. It disappeared from the sera of 24 patients (among whom 10 have been followed up for more than 3 to 6 months) who recovered completely after 4 weeks of treatment. The disappearance of the complex occurred long before the clearance of HBsAg and the returning to normal levels of other biochemical parameters. In 5 cases of acute hepatitis with the tendency to be chronic and in those subacute and chronic cases,HBsAg-IgM complex delayed to disappear and could be found in the sera even 6 months later. All the normal controls were negative.It is suggested that the detection of HBsAg-IgM complex in the serum of hepatitis B patient may be used not only as a criterion to evaluate the prognosis of acute cases but also as an index to determine whether the patient is suffering an active disease process. 本文初步报告用国内较易推广的ELISA法检测急性乙型病毒性肝炎血清中HBsAg/IgM复合物的结果。简要介绍实验方法。系列检测35例乙肝患者的标本(包活急肝29例,急性亚急性重症2例,慢活肝4例),全部被检患者均于入院后1~2周内检测到HBsAg/IgM复合物,24例急肝痊愈者(包括随访3~6月以上的10例)都在住院的4周内转阴,远较血清HBsAg和其他生化指标恢复为早;5例有慢性顿向的急肝和亚急性重症及慢活肝患者的HBsAg/IgM复合物迟迟不消失,甚至长达半年以上。28例正常人群全阴性。结合文献初步讨论本实验的临床意义,认为本实验不但可早期判断急性乙肝患者的转归,而且还可考虑作为确定乙肝现症患者的指征。 The influence of psychological Factors on the course of disease in one hundred andeighty patients with acute hepatitis B has been analized.The results showed that the inci-dence of mishaps in patients with a course of disease over 6 months(80 cases)was notablyhigher than that cured within 6 months (100 cases).(P<0. 05).in a period of time from oneyear before the onset to one year after recovery of disease. Examination according to Zeng′sself-measured table on melancholia,the former scored evidently higher than... The influence of psychological Factors on the course of disease in one hundred andeighty patients with acute hepatitis B has been analized.The results showed that the inci-dence of mishaps in patients with a course of disease over 6 months(80 cases)was notablyhigher than that cured within 6 months (100 cases).(P<0. 05).in a period of time from oneyear before the onset to one year after recovery of disease. Examination according to Zeng′sself-measured table on melancholia,the former scored evidently higher than the latter, indi-cating that psychological condition is a unique factor influencing the course of disease in hep-atitis B and emphasis should be put on it. 分析180例急性乙型病毒性肝炎患者的心理状态对其病程的影响。结果病前及病后一年负性生活事件发生率,在病程迁延6个月以上组(80例)显著高于6个月以内治愈组(100例),P<0.05;Zung氏抑郁自评量表的调查,前者得分显著高于后者,P<0.05。表明心理状态乃是对乙肝患者病程有影响的独立因素,应予以重视。 Sixty five cases of acute hepatitis B divided into two groups, icteric and nonicteric,havebeen analysed and compared.The results showed that the number of the 3 series of cellularelements blood decreased to varying degrees. The decrease in blood platelets was promi-nent with significant difference(P<0. 001)and was positively related to serum bilirubin(P>0.01).There was no relationship between the increase of GPT and blood platelets. In cas-es with positive reactions on 3 items(HBsAg,anti HBC and HBeAg)of the... Sixty five cases of acute hepatitis B divided into two groups, icteric and nonicteric,havebeen analysed and compared.The results showed that the number of the 3 series of cellularelements blood decreased to varying degrees. The decrease in blood platelets was promi-nent with significant difference(P<0. 001)and was positively related to serum bilirubin(P>0.01).There was no relationship between the increase of GPT and blood platelets. In cas-es with positive reactions on 3 items(HBsAg,anti HBC and HBeAg)of the hepatitis B in-dices, the platelet count decreased markedly with significant difference(P<0.01). 本文总结了急性乙型病毒性肝炎65例,分黄疸组和无黄疸组两组对比。结果表明两组血象三系细胞不同程度减少,而黄疸组以血小板减少为著,有显著差异性(P<0.001),并与血清脸红素呈正相关(r=0.41)。谷丙转氨酶升高与血小板无相关性(P>0.01)。乙肝标志物呈三项阳性者(HBsAg、抗HBC、HBeAg)血小板明显减少,有差异性(P<0.01)。
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