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   5 '-cyclic-nucleotide-phosphodiesterase 在 药学 分类中 的翻译结果: 查询用时:0.309秒
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-cyclic-nucleotide-phosphodiesterase
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  “5 '-cyclic-nucleotide-phosphodiesterase”译为未确定词的双语例句
    The Mechanism of Inhibiton of Calmodulin-Dependent Cyclic Nucleotide Phosphodiesterase by Dihydropyridine Calcium Antagonists
    二氢吡啶类钙拮抗剂对钙调素依赖性环核苷酸磷酸二酯酶的抑制机理
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    The effects of API_(0134) extracted from andrographis paniculata on the activities of calmodulin/calmodulin dependent cyclic nucleotide phosphodiesterase
    API_(0134)对钙调素及其依赖性环核苷酸磷酸二酯酶的作用
短句来源
    The effects of API0134 on activity and kinetic parameters of calmodulin-independent cyclic nucleotide phosphodiesterase
    API 0134对钙调素非依赖型环核苷酸磷酸二酯酶的影响
短句来源
    Benzylisoquinoline compounds antagonized calmodulin ( CaM ) to inhibit the activity of CaM-dependent cyclic nucleotide phosphodiesterase ( CaM-PDE ) .
    苄基异喹啉类化合物拮抗钙调素(CaM),对环核苷酸磷酸二酯酶(CaM-PDE)产生抑制作用。
短句来源
    Using the reactive system of calmodulin-independent cyclic nucleotide phosphodiesterase (PDE-Ⅱ), The effects of API0134 on the activity and kinetic parameters of PDE-Ⅱ were observed.
    采用钙调素非依赖型环核苷酸磷酸二酯酶(PDE-Ⅱ)测定方法,观察API0134对PDE-Ⅱ的作用。
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Benzylisoquinoline compounds antagonized calmodulin ( CaM ) to inhibit the activity of CaM-dependent cyclic nucleotide phosphodiesterase ( CaM-PDE ) . The anti-CaM ability was relevant to the hydrophobicity of non-polar terminus in the antagonist molecule. The antagonistic potency increased with the increase of hydrophobicity while the anti-CaM ability did not change whether the polar terminus is tertiary amine or quaternary amine. As far as our knowledge goes, compound D3, with IC54 value 2.8 μmol/L, was the...

Benzylisoquinoline compounds antagonized calmodulin ( CaM ) to inhibit the activity of CaM-dependent cyclic nucleotide phosphodiesterase ( CaM-PDE ) . The anti-CaM ability was relevant to the hydrophobicity of non-polar terminus in the antagonist molecule. The antagonistic potency increased with the increase of hydrophobicity while the anti-CaM ability did not change whether the polar terminus is tertiary amine or quaternary amine. As far as our knowledge goes, compound D3, with IC54 value 2.8 μmol/L, was the most potent CaM antagonist among benzylisoquinoline compounds according to the PDE assay system.

苄基异喹啉类化合物拮抗钙调素(CaM),对环核苷酸磷酸二酯酶(CaM-PDE)产生抑制作用。它们的拮抗能力与分子中非极性端的疏水性相关,增强疏水性能增强拮抗性;极性端为叔胺或季铵离子时,抗CaM性基本不变;在受试的化合物中,D_3的抗CaM活性最强,IC_(50)值为2.8μmol/L。

Using Calmodulin (CaM)-dependent cyclic nucleotide Phosphodiesterase we found that Mexiletinum (Mex) could inhibit the activity of the enzyme activated by CaM (IC_(50)=1000μM), but not inhibit the basal activity, and the increase of the amounts of CaM in the reaction system could reduce the inhibition. The results suggest that the inhibition be through the interaction of Mex and CaM. This may relate to the amphipathic nature of Mex.

本文应用脑依赖于钙调素的环核苷酸磷酸二酯酶,发现慢心律能抑制钙调素激活址该酶活性,IC_(60)=1000μm,而对酶的基础活性无抑制作用,增加反应体系中的钙调素量能减弱慢心律的抑制作用。实验提示慢心律是通过与钙调素相互作用而抑制其对靶酶的激活,这可能与慢心律的两性分子特性有关。

Using the reactive system of calmodulin-independent cyclic nucleotide phosphodiesterase (PDE-Ⅱ), The effects of API0134 on the activity and kinetic parameters of PDE-Ⅱ were observed. The activity of PDE-Ⅱ was considerably inhibited by API0134 at concentration of more than 50 mg·L-1.and the IC50 was 213 mg· L-1. No change of the Km and decrease of Vmax suggest that the inhibitory effect of API0134 on PDE-Ⅱ activity is incompetitive.

采用钙调素非依赖型环核苷酸磷酸二酯酶(PDE-Ⅱ)测定方法,观察API0134对PDE-Ⅱ的作用。API0134浓度50mg·L-1时明显抑制PDE一Ⅱ活性,半效抑制浓度为213mg·L-1。酶促动力学分析表明:API0134存在时,PDE-Ⅱ的Km值不变,为1.92×10-4mol·L-1,而Vmax值则随API0134剂量增大而减小,提示API0134为PDE-Ⅱ的非竞争性抑制剂。

 
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