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fentanyl
相关语句
  芬太尼
     Midazolam and Fentanyl Interactions with Emulsified Isoflurane
     乳化异氟醚与咪唑安定和芬太尼的相互作用
短句来源
     SYNTHETIC STUDIES ON POTENTIAL ANALGESICS Ⅱ. THE SYNTHESIS OF FENTANYL
     镇痛药合成研究——Ⅱ.强效镇痛药芬太尼的合成
短句来源
     STUDIES ON POTENT ANALGESICS Ⅱ.Synthesis and Analgesic Activity of the Derivatives of 3-Methyl Fentanyl
     强效镇痛剂研究——Ⅱ.3-甲基芬太尼类衍生物的合成及镇痛活性
短句来源
     STUDIES ON CRYSTAL STRUCTURES AND STRUCTUREACTIVITY RELATIONSHIPS OF THE 4-SUBSTITUTED FENTANYL DERIVATIVES
     4-取代芬太尼类化合物的晶体结构和构效关系
短句来源
     Synthesis of 3-methyl [carbonyl-~(14)C] fentanyl
     3-甲[羧基-~(14)C]芬太尼的合成
短句来源
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  “fentanyl”译为未确定词的双语例句
     The effect onset time and the analgesia time of the Fentanyl group and the control group was respectively 5. 92±3. 11 min vs 8. 55±3. 62 min (P<0.05) and 193.76±59. 72 min vs 158. 45 ±50. 63 min (P<0. 05).
     实验组起效时间显著短于对照组(5.92±3.11minvs8.55±3.62min,P<0.05),维持时间显著长于对照组(193.76±59.72minvs158.45±50.63min,P<0.05);
短句来源
     The concentration of TNF-αand IL-1βin Ketamine and Fentanyl group were lower than control group,and the consentration of IL-10 were higher﹙P<0.05﹚;
     异丙酚组TNF-α、IL-1β浓度则明显高于对照组﹙P<0.05﹚,IL-10 浓度低于对照组( P<0.05);
短句来源
     There are 30 cases in Group D in which 0. 1% of bupivacaine (260 ml with the combination of 0. 6 mg of fentanyl and 10 mg of droperidol) with the speed of 5 ml per hour (5ml/h) is pumped into the extradural cavity.
     D组(30例):采用5ml/h速度泵入0.l%布比卡因260ml,内含分太尼0.6mg,氟哌啶10mg。
短句来源
     Ⅱ,Ⅲ,Ⅳ with mixture of fentanyl and droperidol 0.0125 mg/ml,0.025 mg/ml or 0.05mg/ml, group Ⅴ with mixture of fentanyl and azasetron 0.1 mg/ml .
     I组为对照组,、、组分别加入氟哌利多(0.0125mg/ml,0.025mg/ml,0.05mg/ml),V组加入万唯0.1mg/ml。
短句来源
     There are 30 and 10 cases in Croup B and C in which 0. 20% of bupivacaine with the combination of fentanyl (0. 3 mg) and droperidol (5 mg) is pump into the ex- tradural cavity.
     B组(30例)、C组(10例):泵入0.2%布比卡因260ml,内含分太尼0.3mg,氟哌啶5mg。
短句来源
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  相似匹配句对
     TRANSDERMAL FENTANYL
     芬太尼缓释透皮贴剂
短句来源
     ③Fentanyl group;
     ③芬太尼组;
短句来源
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  fentanyl
Demographic data, intraoperative consumption of fentanyl and phentolamine, preoperative hospital stay and postoperative ICU stay were compared.
      
The phaeochromocytoma group required significantly more fentanyl during surgery (370±87 vs.
      
Fentanyl, Na-pentobarbital and halothane influence myocardial infarct size
      
The anesthetics used were fentanyl, Na-pentobarbital, and halothane.
      
Under fentanyl, the BP was 143±3/91±2 mm Hg and HR 99±3/min.
      
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Fentanyl was synthesized by reductive alkylation of aniline with 1-benzoyl-4-piperidone as the key step.

从1-苯甲酰基-4-哌啶酮(Ⅳ_c)开始,经四步反应,合成了强效镇痛药芬太尼。用类似方法,还合成了芬太尼中苯乙基被苯甲酰乙基置换的类似物。

Since introduction of a methyl group in the 3-position of piperidine ring of 4-phenylpiperidine analgesics and replacement of phenylethyl group in the 1-position of piperidine ring of fentanyl by some substituents can enhance analgesic activity, we already synthesized some 3-methyl derivatives of fentanyl e. g., N-[1-(2-phenylethyl)-3-methyl-4-piperidyl]-N-phenylpropanamide(7209, simply named as 3-methyl fentanyl) and others (7207, 7222, 7210). In view of their higher analgesic activity than...

Since introduction of a methyl group in the 3-position of piperidine ring of 4-phenylpiperidine analgesics and replacement of phenylethyl group in the 1-position of piperidine ring of fentanyl by some substituents can enhance analgesic activity, we already synthesized some 3-methyl derivatives of fentanyl e. g., N-[1-(2-phenylethyl)-3-methyl-4-piperidyl]-N-phenylpropanamide(7209, simply named as 3-methyl fentanyl) and others (7207, 7222, 7210). In view of their higher analgesic activity than that of fentanyl, studies on derivatives of 3-methyl fentanyl were further performed. Pharmacological results showed that some compounds in this series have extremely potent analgesic activity with typical morphine-like action. The structure-activity relationships of these compounds are discussed, compound N-[1-(2-hydroxy-2-phenylethyl]-3-methyl-4-piperidyl]-N-phenylpropanamide (7302) was found to be the most potent analgesic agent in this series. Its analgesic ED_(50) value was 0.0022mg/kg and the analgesic activity was 28 times more potent than that of fentanyl and 6318 times than morphine.

本文报道了N-[1-(β-苯乙基)-3-甲基-4-哌啶基]-N-丙酰苯胺(7209)和N-[1-(β-羟基-β-苯乙基)-3-甲基-4-哌啶基]-N-丙酰苯胺(7302)等一系列3-甲基芬太尼类衍生物的合成及镇痛活性。绝大部分该类衍生物均具有典型的吗啡样镇痛活性,是一类结构较简单、易于合成、镇痛作用极强的麻醉镇痛剂。化合物7302的ED_(50)为0.0022mg/kg(ip,小鼠,热板法),比芬太尼强28倍,竟达吗啡的6318倍,为我们至今合成该类衍生物中作用最强者。

In the present paper, we report the preparation of a series of Fentanyl derivatives which are N-[1-(β-arylalkyl)-4-piperidyl]-N-propionyl aniline, N-[1-(β-phenylet-hyl)-4-piperidyl]-N-amidoaniline, N-[1(-β-phenylethyl)-4-piperidyl]-E-propionylary-lamine, N-[1-(β-arylethyl)-4-tropyl]-N-propionyl aniline and N-1-(β-arylethyl)-4-pyrrolidinyl]-N-propionyl aniline. A total of 22 compounds were synthesized.Pharmacological results showed that most of the compounds in these series possessed morphine-like effects...

In the present paper, we report the preparation of a series of Fentanyl derivatives which are N-[1-(β-arylalkyl)-4-piperidyl]-N-propionyl aniline, N-[1-(β-phenylet-hyl)-4-piperidyl]-N-amidoaniline, N-[1(-β-phenylethyl)-4-piperidyl]-E-propionylary-lamine, N-[1-(β-arylethyl)-4-tropyl]-N-propionyl aniline and N-1-(β-arylethyl)-4-pyrrolidinyl]-N-propionyl aniline. A total of 22 compounds were synthesized.Pharmacological results showed that most of the compounds in these series possessed morphine-like effects in laboratory animals with potencies levels 2~150 times those of morphine.

本文报道了芬太尼类衍生物的化学结构与镇痛活性之间的关系。分别改变了芬太尼中的哌啶环1位氮原子的取代基,N-酰芳胺基及哌啶环等部分结构。药理试验结果表明,大部分化合物均具有吗啡样镇痛活性,其镇痛强度分别为吗啡的2~150倍左右。

 
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