助手标题  
全文文献 工具书 数字 学术定义 翻译助手 学术趋势 更多
查询帮助
意见反馈
   fentanyl 在 药学 分类中 的翻译结果: 查询用时:0.009秒
图标索引 在分类学科中查询
所有学科
药学
外科学
妇产科学
预防医学与卫生学
消化系统疾病
儿科学
肿瘤学
临床医学
心血管系统疾病
更多类别查询

图标索引 历史查询
 

fentanyl
相关语句
  芬太尼
    SYNTHETIC STUDIES ON POTENTIAL ANALGESICS Ⅱ. THE SYNTHESIS OF FENTANYL
    镇痛药合成研究——Ⅱ.强效镇痛药芬太尼的合成
短句来源
    STUDIES ON POTENT ANALGESICS Ⅱ.Synthesis and Analgesic Activity of the Derivatives of 3-Methyl Fentanyl
    强效镇痛剂研究——Ⅱ.3-甲基芬太尼类衍生物的合成及镇痛活性
短句来源
    STUDIES ON CRYSTAL STRUCTURES AND STRUCTUREACTIVITY RELATIONSHIPS OF THE 4-SUBSTITUTED FENTANYL DERIVATIVES
    4-取代芬太尼类化合物的晶体结构和构效关系
短句来源
    Synthesis of 3-methyl [carbonyl-~(14)C] fentanyl
    3-甲[羧基-~(14)C]芬太尼的合成
短句来源
    SYNTHESIS AND ANALGESIC ACTIVITY OF 4-N-PROPIONYL ANALOGS OF 4-METHOXYCARBONYL FENTANYL
    4-甲氧羰基芬太尼的4-N-丙酰基结构类似物的合成与镇痛活性
短句来源
更多       
  “fentanyl”译为未确定词的双语例句
    Objective 1. To determine the effect of morphine and fentanyl on expressions of subunit of nuclear factor-KB(NF-κKB)—p65 mRNA and content of p65 protein in human polymorphoneclear neutrophils(PMN) in vitro with or without LPS;
    1.对比观察不同阿片类药物对LPS刺激健康人离体中性粒细胞(PMN)核转录因子-κappaB(NF-κB)亚单位p65基因表达及p65蛋白含量的影响;
短句来源
    2. To observe the influence of exogenous opioids and fentanyl on apoptosis of human polymorphoneclear neutrophils(PMN) in vitro;
    2.观察不同阿片类药物对健康人离体PMN凋亡的影响;
短句来源
    The concentration of TNF-αand IL-1βin Ketamine and Fentanyl group were lower than control group,and the consentration of IL-10 were higher﹙P<0.05﹚;
    异丙酚组TNF-α、IL-1β浓度则明显高于对照组﹙P<0.05﹚,IL-10 浓度低于对照组( P<0.05);
短句来源
    2) Fentanyl 1. 9 μmol ·L-1 decreased the trachea contraction (P< 0. 05) ( 3) Pethidine 705 μmol·L-1 not only decreased markedly the trachea contraction (P < 0. 01), but also relaxed the trachea;
    Pet 705 μmol·L~(-1)不仅使其明显减弱(P<0.01),并可使之松弛;
短句来源
    Ca2+, Mg2+ATPase activity was inhibited slightly by either pethidine or fentanyl(Both P>005).
    这两种药物仅轻微地抑制Ca2+,Mg2+-ATPase活性。
短句来源
更多       
查询“fentanyl”译词为用户自定义的双语例句

    我想查看译文中含有:的双语例句
例句
为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法,我们为您准备了出自英文原文的大量英语例句,供您参考。
  fentanyl
Demographic data, intraoperative consumption of fentanyl and phentolamine, preoperative hospital stay and postoperative ICU stay were compared.
      
The phaeochromocytoma group required significantly more fentanyl during surgery (370±87 vs.
      
Fentanyl, Na-pentobarbital and halothane influence myocardial infarct size
      
The anesthetics used were fentanyl, Na-pentobarbital, and halothane.
      
Under fentanyl, the BP was 143±3/91±2 mm Hg and HR 99±3/min.
      
更多          


Fentanyl was synthesized by reductive alkylation of aniline with 1-benzoyl-4-piperidone as the key step.

从1-苯甲酰基-4-哌啶酮(Ⅳ_c)开始,经四步反应,合成了强效镇痛药芬太尼。用类似方法,还合成了芬太尼中苯乙基被苯甲酰乙基置换的类似物。

Since introduction of a methyl group in the 3-position of piperidine ring of 4-phenylpiperidine analgesics and replacement of phenylethyl group in the 1-position of piperidine ring of fentanyl by some substituents can enhance analgesic activity, we already synthesized some 3-methyl derivatives of fentanyl e. g., N-[1-(2-phenylethyl)-3-methyl-4-piperidyl]-N-phenylpropanamide(7209, simply named as 3-methyl fentanyl) and others (7207, 7222, 7210). In view of their higher analgesic activity than...

Since introduction of a methyl group in the 3-position of piperidine ring of 4-phenylpiperidine analgesics and replacement of phenylethyl group in the 1-position of piperidine ring of fentanyl by some substituents can enhance analgesic activity, we already synthesized some 3-methyl derivatives of fentanyl e. g., N-[1-(2-phenylethyl)-3-methyl-4-piperidyl]-N-phenylpropanamide(7209, simply named as 3-methyl fentanyl) and others (7207, 7222, 7210). In view of their higher analgesic activity than that of fentanyl, studies on derivatives of 3-methyl fentanyl were further performed. Pharmacological results showed that some compounds in this series have extremely potent analgesic activity with typical morphine-like action. The structure-activity relationships of these compounds are discussed, compound N-[1-(2-hydroxy-2-phenylethyl]-3-methyl-4-piperidyl]-N-phenylpropanamide (7302) was found to be the most potent analgesic agent in this series. Its analgesic ED_(50) value was 0.0022mg/kg and the analgesic activity was 28 times more potent than that of fentanyl and 6318 times than morphine.

本文报道了N-[1-(β-苯乙基)-3-甲基-4-哌啶基]-N-丙酰苯胺(7209)和N-[1-(β-羟基-β-苯乙基)-3-甲基-4-哌啶基]-N-丙酰苯胺(7302)等一系列3-甲基芬太尼类衍生物的合成及镇痛活性。绝大部分该类衍生物均具有典型的吗啡样镇痛活性,是一类结构较简单、易于合成、镇痛作用极强的麻醉镇痛剂。化合物7302的ED_(50)为0.0022mg/kg(ip,小鼠,热板法),比芬太尼强28倍,竟达吗啡的6318倍,为我们至今合成该类衍生物中作用最强者。

In the present paper, we report the preparation of a series of Fentanyl derivatives which are N-[1-(β-arylalkyl)-4-piperidyl]-N-propionyl aniline, N-[1-(β-phenylet-hyl)-4-piperidyl]-N-amidoaniline, N-[1(-β-phenylethyl)-4-piperidyl]-E-propionylary-lamine, N-[1-(β-arylethyl)-4-tropyl]-N-propionyl aniline and N-1-(β-arylethyl)-4-pyrrolidinyl]-N-propionyl aniline. A total of 22 compounds were synthesized.Pharmacological results showed that most of the compounds in these series possessed morphine-like effects...

In the present paper, we report the preparation of a series of Fentanyl derivatives which are N-[1-(β-arylalkyl)-4-piperidyl]-N-propionyl aniline, N-[1-(β-phenylet-hyl)-4-piperidyl]-N-amidoaniline, N-[1(-β-phenylethyl)-4-piperidyl]-E-propionylary-lamine, N-[1-(β-arylethyl)-4-tropyl]-N-propionyl aniline and N-1-(β-arylethyl)-4-pyrrolidinyl]-N-propionyl aniline. A total of 22 compounds were synthesized.Pharmacological results showed that most of the compounds in these series possessed morphine-like effects in laboratory animals with potencies levels 2~150 times those of morphine.

本文报道了芬太尼类衍生物的化学结构与镇痛活性之间的关系。分别改变了芬太尼中的哌啶环1位氮原子的取代基,N-酰芳胺基及哌啶环等部分结构。药理试验结果表明,大部分化合物均具有吗啡样镇痛活性,其镇痛强度分别为吗啡的2~150倍左右。

 
<< 更多相关文摘    
图标索引 相关查询

 


 
CNKI小工具
在英文学术搜索中查有关fentanyl的内容
在知识搜索中查有关fentanyl的内容
在数字搜索中查有关fentanyl的内容
在概念知识元中查有关fentanyl的内容
在学术趋势中查有关fentanyl的内容
 
 

CNKI主页设CNKI翻译助手为主页 | 收藏CNKI翻译助手 | 广告服务 | 英文学术搜索
版权图标  2008 CNKI-中国知网
京ICP证040431号 互联网出版许可证 新出网证(京)字008号
北京市公安局海淀分局 备案号:110 1081725
版权图标 2008中国知网(cnki) 中国学术期刊(光盘版)电子杂志社