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   carnosine 在 肿瘤学 分类中 的翻译结果: 查询用时:0.008秒
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carnosine
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  肌肽
    THE INDUCTION APOPTOSIS OF HL-60 CELLS BY LOW MOLECULAR WEIGHT COMPOUNDS OF TAURINE,ORNITHINE AND CARNOSINE FROM NEW BORN CALF LIVER
    新生牛肝中三种低分子化合物牛磺酸、鸟氨酸、肌肽对HL-60细胞凋亡的诱导作用
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  相似匹配句对
    The Protective Effect of L-carnosine on the PC12 Cells Apoptosis Induced by Hydrogen Peroxide
    L-肌肽对H_2O_2诱导PC12细胞凋亡的保护作用的实验研究
短句来源
    THE INDUCTION APOPTOSIS OF HL-60 CELLS BY LOW MOLECULAR WEIGHT COMPOUNDS OF TAURINE,ORNITHINE AND CARNOSINE FROM NEW BORN CALF LIVER
    新生牛肝中三种低分子化合物牛磺酸、鸟氨酸、肌肽对HL-60细胞凋亡的诱导作用
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  carnosine
Effect of Carnosine on Self-Organization of Mitochondrial Assemblies in Rat Liver Homogenate
      
The effect of carnosine on self-organization of mitochondrial assemblies was studied in rat liver homogenate of quiescent and excited animals.
      
Carnosine was shown to prevent dissociation of assemblies during storage.
      
Prevention of disassembly of organelles by carnosine can serve as one of the mechanisms of carnosine-induced diminishing of muscle fatigue under prolonged work.
      
Carnosine protects erythrocytes from the oxidative stress caused by homocysteic acid
      
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Aim: Clinical studies stated that low molecular weight compounds(<1.0 kd) extracted from the new born calf liver could effectively inhibit the proliferation of tumor cells. In this report, we observed inhibition effects and their regulative mechanisms of taurine, ornithine, carnosine on the proliferation of HL-60 cells. Methods: Three active ingredients i.e. taurine, ornithine and carnosine were separated by ion-exchange chromatographic column and identified from the low molecular weight filtrate...

Aim: Clinical studies stated that low molecular weight compounds(<1.0 kd) extracted from the new born calf liver could effectively inhibit the proliferation of tumor cells. In this report, we observed inhibition effects and their regulative mechanisms of taurine, ornithine, carnosine on the proliferation of HL-60 cells. Methods: Three active ingredients i.e. taurine, ornithine and carnosine were separated by ion-exchange chromatographic column and identified from the low molecular weight filtrate of new born calf liver. MTT assay was used to test the survival rate of HL-60 cells and normal lymphocytes treated by the three ingredients. The various effects of the three compounds on HL-60 cells were respectively evaluated by agarose gel electrophoresis, ESR and immunohistochemical me(thods.) Results: These compounds effectively inhibited the proliferation of HL-60 cells and induced apoptosis which was determined by apoptotic changes in morphology and nuclear DNA degradation. Whereas no inhibition effects on normal lymphocytes were observed. In addition, the results of ESR showed that the activity of oxygen radical within HL-60 cells treated with there compounds decreased to trace level. Furthermore, in the immunohistochemical experiments, we found that the level of p45/skp2 in HL-60 cells decreased while the level of p27/kip increased. Conclusion: The taurine, ornithine and carnosine compounds can selectively suppress tumor cells proliferation by regulating the level of cell cycle proteins.

目的:研究三种新生牛肝源低分子化合物:牛磺酸、鸟氨酸、肌肽对HL60白血病细胞增殖的抑制作用并探讨其调控机理。方法:用MTT法分别检测三种活性成分作用后HL60细胞和正常人淋巴细胞的存活率。分别用琼脂糖凝胶电泳,顺磁共振ESR技术,免疫组化法测定其对HL60细胞的核DNA、氧自由基活性和细胞周期蛋白水平的影响。结果:三种化合物能够有效地抑制HL60细胞的增殖,而对正常的人淋巴细胞的生长没有抑制作用;三种化合物使HL60细胞的核DNA产生30kb片段,使HL60细胞内的氧自由基活性降至痕量水平,并下调HL60的p45/skp2的水平,而上调p27/kip的水平。结论:牛磺酸、鸟氨酸、肌肽能够通过调控细胞周期蛋白的水平而选择性的抑制肿瘤细胞的增殖。

 
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