Excess activation of NF-κB is associated with pathogenesis and processes of various acute and chronic inflammatory diseases such as autoimmune disease,allergy,rheumatoid arthritis,asthma,psoriasis,arterosclerosis,glomerulonephritis,graft rejection,enteronitis,cachexia,thyroid disease syndrome,gastritis associated with Helicobacterium pylori.
Benzoporpyrin derivative monoacid ring A (BPD-MA), a chlorin-type compound, is a new photosensitizer currently in phase I-LI clinical trials for the treatment of cutaneous malignancies , psoriasis and pathologic neovascularization. and other hyperplastic disease.
②There were significantly positive correlations between the expression of IL-22/S100A7 mRNA,IL-22/S100A8 mRNA,IL-22/S100A9 mRNA in the psoriasis vulgaris(r1=0.543,r2=0.774,r3=0.621,P<0.01).
Results: (1) The gene frequencies of HLA-A*0101-03, A*3001-04, B*5701, Cw*0602, Cw*0603/04/05, DRB1*0701/02 and DQB1*0201 were significantly increased in patients with psoriasis vulgaris than those in normal controls.
This work, utilizing bioinformatics analysis of transcriptomics data, demonstrated that the genes for transcription factor AP-1 components can be regarded as psoriasis candidate genes.
Analysis of clinical material obtained from the individuals (49 psoriasis patients and 357 individuals without this disease) representing three ethnic populations of Dagestan (Avars, Dargins, and Kumyks) was performed.
8-Methylpsoralen is of value in the treatment of idiopathic vitiligo and psoriasis. Starting from pyrogallic acid, it has been synthesized in 6 steps with an over-all yield of 5.8%.
8-Methylpsoralen is of value in the treatment of idiopathic vitiligo and psoriasis.Starting from pyrogallic acid,it has been synthesized in 6 steps with an over-all yield of 5.8%.
23 Cases of psoriasis vulgaris were treated with 8 Methoxypsoralen (supplied by the Hunan Pharmaceutical Research Institute) and UVA irradiation. The patients were divided into 3 groups. Group 1, 11 patient received 8 MOP, 0.7~0.8 mg/kg; Group 2, 9 patients, receivcd 8 mop, 0.6 mg/kg; Group 3, 3 patients, received 8 MOP 0.3 mg/kg. 2 hours before UVA radiation. The dosage of UVA irradiation began at 1 mpd. and gradually increased to 2mpd, i. e. for group 1 in 20 sirtings, for group 2 in 2~4 sittings, a...