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chromosome fragility
相关语句
  染色体脆性
     Preliminary Investigation of Chromosome Fragility Sites with Clinical Situation in Mentally Retardation Children
     智力低下儿童染色体脆性部位与临床表现初步研究
短句来源
     Increased chromosome fragility and liability to cancer are the two major features of chromosome instability syndrome.
     染色体脆性增加与癌肿发病之间存在着有一定的关系,两者是染色体不稳定综合征的主要表现。
短句来源
     Objective: To explore relationship between the chromosome fragility sites and clinical situation among mentally retardation children.
     目的:探讨智力低下儿童染色体脆性部位与临床表现的关系。
短句来源
  “chromosome fragility”译为未确定词的双语例句
     Study on Chromosome Fragility in Patients with Viral Diseases
     病毒性疾病患者染色体脆裂性的研究
短句来源
     Study on the incidence of chromosome fragility in mental retardation.
     低智儿童常染色体脆性位点的研究
短句来源
     Conclusion: Abnormal methylation of chromosome fragility sites is related closely to clinical mentally retardation expression.
     脆性位点表达阴性94例(33.57%)。 结论:脆性位点的异常甲基化与智力低下临床表型有着密切的关系;
短句来源
     The more complex the chromosome fragility sites are, the lower mental retardation level of children is.
     脆性位点越多越复杂,患儿的智力低下的程度越低;
短句来源
     It is no direct relationship between degree of expression in same chromosome fragility sites and mental retardation level of children.
     同一脆性位点表达率的高低却与智力低下的程度无明显的正比关系。
短句来源
  相似匹配句对
     Study on the incidence of chromosome fragility in mental retardation.
     低智儿童常染色体脆性位点的研究
短句来源
     Study on Chromosome Fragility in Patients with Viral Diseases
     病毒性疾病患者染色体脆裂性的研究
短句来源
     were its chromosome markers.
     等为其标志染色体,未显示有完整Y染色体存在。
短句来源
     The X chromosome was normal.
     X染色体无变化。
短句来源
     On Financial Fragility
     论金融脆弱性
短句来源
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  chromosome fragility
Chromosome fragility and susceptibility of Bloom's syndrome fibroblasts to SV40 transformation
      
Chromosome fragility and susceptibility of Bloom's syndrome fibroblasts to SV40 transformation
      
Lymphocytes exposed to the radiomimetic agent, bleomycin, were arrested in methaphase and analyzed for chromosome fragility.
      
Since it is known that the tendency to develop cancer is closely related to chromosome breakage, we decided to investigate whether recombinant human growth hormone (rhGH) therapy can increase chromosome fragility.
      
Increased chromosome fragility in lymphocytes of short normal children treated with recombinant human growth hormone
      
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The chromosome fragility was studied in patients with hepatitis,measles,chicken pox and mumps as well as in normal subjects.The chromosome aberration frequency was increased when lymphocytes were cultured in medium deficient in folate and thymidine (MEM-FA).The chromosome fragility in patients with hepatitis was significantly higher than that of the normal subjects,while other patients showed no increase of it.A frequent breakpoint on chromosome 3pl4 was found when cells were cultured...

The chromosome fragility was studied in patients with hepatitis,measles,chicken pox and mumps as well as in normal subjects.The chromosome aberration frequency was increased when lymphocytes were cultured in medium deficient in folate and thymidine (MEM-FA).The chromosome fragility in patients with hepatitis was significantly higher than that of the normal subjects,while other patients showed no increase of it.A frequent breakpoint on chromosome 3pl4 was found when cells were cultured in MEM-FA.The total and 3pl4 break were variant at different times of the year.The mechanism of the increase of chromosome fragility in patients with hepatitis is discussed.

本文研究了若干种病毒性疾病患者的染色体脆裂性,初步探讨了染色体脆裂性的特点及其作为检测生物诱变因子更为敏感的指标的可能性。实验结果表明,MEM-FA中培养的细胞染色体自发畸变率显著高于完全培养基(MEM)。病毒性肝炎患者的染色体畸变率在两种培养基中有显著差异。流行性腮腺炎、水痘和麻疹组同对照相比没有明显差异。在MEM-FA中培养的淋巴细胞染色体畸变位点,以3p14最为多见。在不同季节染色体畸变率和3p14部位断裂频率上下波动。

Blood cell chromosomes of thirty patients with SLE were observed. Chromosome aberration including gap, breakage, minutes, fragment and polyploidy were found in 26 cases. The average rate of cell aberration was 4.13%. As compared with 0.8% in normal controls, there was significant difference (P<0.01). The aberration did not correlate with clinical and laboratory findings. Increased chromosome fragility and liability to cancer are the two major features of chromosome instability syndrome. Among the...

Blood cell chromosomes of thirty patients with SLE were observed. Chromosome aberration including gap, breakage, minutes, fragment and polyploidy were found in 26 cases. The average rate of cell aberration was 4.13%. As compared with 0.8% in normal controls, there was significant difference (P<0.01). The aberration did not correlate with clinical and laboratory findings. Increased chromosome fragility and liability to cancer are the two major features of chromosome instability syndrome. Among the 26 cases, 2 cases had thyroid and gallbladder cancer respectively.

作者检查了30例SLE患者周围血的染色体,其中26例有染色体畸变,表现为裂隙、断裂、微小体、碎片和多倍体,总的细胞畸变率为4.13%,显著高于对照组畸变率(0.8%)(P<0.01),显示患者染色体脆性增加易断。畸变与临床表现及化验检查无明显关联。染色体脆性增加与癌肿发病之间存在着有一定的关系,两者是染色体不稳定综合征的主要表现。本组有2例伴有癌肿,一例为甲状腺癌,一例为胆囊癌。因此,作者认为SLE也是一种染色体不稳定综合征。

Retinoblastoma(Rb)is a malignant eye tumor of childhood and a desirable model for the genetic study of oncogenesis in human being. The results of genetic investigation of RB since 1982 in WCUMS were summerized in this paper. 1.Clinical genetic studies of RB The records of 327 patients with RB between 1958 and 1986 were reviewed.The clinical investiga- tion included the laterality of the involved eyes,the mean age at diagnosis,the secondary malignant neoplasm in survivors,the spontaneous regression of the tumor...

Retinoblastoma(Rb)is a malignant eye tumor of childhood and a desirable model for the genetic study of oncogenesis in human being. The results of genetic investigation of RB since 1982 in WCUMS were summerized in this paper. 1.Clinical genetic studies of RB The records of 327 patients with RB between 1958 and 1986 were reviewed.The clinical investiga- tion included the laterality of the involved eyes,the mean age at diagnosis,the secondary malignant neoplasm in survivors,the spontaneous regression of the tumor and RB in twins. 2.Cytogenetic studies of RB (1)Among 56 patients examined for chromosome constitution,4 cases showed abnormal or variant karyotypes:46,XY/46,XY,del(13)(q14.1 q14.3).46, XY,var(15)(p13,F55)mat.46,X,del(Y)(q12)pat. 46,XY,inv(9)(P13q13). (2)Chromosome fragility study in 14 RB patients and their parents showed an increased frequency of chromosome aberration in contrast with control group.Several chromosome fragile sites in RB patients were found. (3)The results of chromosomal study of solid tumor cells from 50 samples of RB showed that in all cases there were aberration of chromosome both in number and in structure.The commonest aber- ration was an i(6p)chromosome,and double minutes (DM),homogeneously staining regions(HSR)were found. 3.The esterase D(EsD)activity and phenotype of the red blood cells in 34 patients with RB were examined,but the EsD activity showed no differ- ence between the patients and the control groups. The same examinations performed in the RB tumor cells form 11 patients revealed that either one or both EsD alleles in tumor cells were inactivated,or that the tumor cells exhibited only one of the two isozvmic types of the EsD,but the red blood cells showed heterozygous at the EsD locus.These observations indicated that in RB tumor cells there were loss,inactivation or reduction to homozygosity at RB and EsD locus on 13q,this may be important for oncogenesis. 4.With the review of literature,it was thought that the Rb gene located at 13q14 may be a pair of allelic inhibitive genes which controls some potential cancer genes(proto-oncogene).If the allelic in hibi tive genes are inactivated or lost with some reasons, the cancer genes will be freed from the inhibitive gene,and cause the induction of RB.

视网膜母细胞瘤(简称 RB)是研究肿瘤遗传学的理想的天然模式。本文总结了自1982年以来对 RB 遗传学的研究。内容包括患病年龄、患病眼别、存活者的第二恶性肿瘤、肿瘤的自发消退、双生子患者等临床遗传学问题;RB 患者外周血淋巴细胞和肿瘤细胞染色体改变、染色体脆性部位等细胞遗传学问题;以及患者红细胞和瘤细胞酯酶 D 活性和表型改变等生化遗传学问题。对 RB 的发病机理进行了初步探讨,认为癌基因和抗癌基因平衡失调是 RB 为代表的一大类恶性肿瘤发病的关键。

 
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