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血管抑素
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  angiostain
     A Study on the Expression, Mechanism and Intervention of Endostatin and Angiostain in Myocardial Infarction Rats
     心肌梗死大鼠内皮抑素、血管抑素的表达及其机制和干预研究
短句来源
     Although there remains some problems about their treatment for cancer, the studies of angiostain and endostain is likely to create a new therapeutic options.
     血管抑素与内皮抑素的发现与研究为恶性肿瘤的治疗开辟了新的道路
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  “血管抑素”译为未确定词的双语例句
     The carcinoma MVD was 52.2±6.6, 49.4±7.0, and 25.5±4.1 accordingly.
     肿瘤MVD :空白对照组 5 2 2± 6 6 ,空载体组 49 4± 7 0 ,血管抑素组 2 5 5± 4 1。
短句来源
     Study on Cloning Angiostatin Gene and Its Expressionin E.coli DH5α
     血管抑素基因克隆及在E.coli DH5α的表达
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     METHODS 21 Wistar rats were divided into IL-1α group,angiostatin group and normal control one randomly.
     方法选用Wistar大鼠21只,随机分为3组:A组:IL-1α组,B组:血管抑素组,C组:正常对照组,每组各7只大鼠。
短句来源
     The carcinoma weight of the control group, vector group, and angiostatin group was (6.0±0.7)g, (5.9±0.5)g, (2.1±0.5)g, respectively.
     肿瘤重量 :空白对照组 (6 0± 0 7)g,空载体组 (5 9± 0 5 )g ,血管抑素组(2 1± 0 5 )g;
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     Results: The detection range was 1 - 200 μg/L.
     结果:该ELISA方法检测人尿中血管抑素的检出范围为1~200μg/L。
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  相似匹配句对
     Research Status for Angiostatin
     血管抑素的研究近况
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     Progress in endostatin research
     血管内皮抑素研究进展
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     THE BLOOD VESSELS OF THYROID GLAND
     甲状腺的血管
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     Blood vessel net works
     血管网络
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Objective: To investigate the inhibitory effect of recombinant human angiostatin (rhAGN) on the xenografts of bearing human nasopharyngeal carcinoma. Methods: MTT method was used to examine the effect of rhAGN on the human dermal endothelial cell line HDMEC and human nasopharyneal carcinoma cell line CNE 1. The BALB/c nude mice subcutaneously bearing human nasopharyngeal carcinoma CNE 1 were injected subcutaneously with rhAGN every day for 30 days, and volume and weight of tumors were measured at the end of...

Objective: To investigate the inhibitory effect of recombinant human angiostatin (rhAGN) on the xenografts of bearing human nasopharyngeal carcinoma. Methods: MTT method was used to examine the effect of rhAGN on the human dermal endothelial cell line HDMEC and human nasopharyneal carcinoma cell line CNE 1. The BALB/c nude mice subcutaneously bearing human nasopharyngeal carcinoma CNE 1 were injected subcutaneously with rhAGN every day for 30 days, and volume and weight of tumors were measured at the end of the treatment. Results: (1) Over a concentration range from 0.5 to 2.0μ g/ml, rhAGN had no obvious inhibitory effect on the growth of CNE 1 cells in vitro, while it inhibited the growth of HDMEC in a dose dependent fasion. (2) The growth of CNE 1 xenografts was inhibited by 32.3% , 64.0% and 83.2% at rhAGN doses of 50 mg· (kg· d)- 1,100 mg· (kg· d)- 1 and 200 mg· (kg· d)- 1,respectively. Conclusions: The rhAGN can powerfully inhibit growth of endothelial cells in vitro and of CNE 1 xenografts in vivo, implicating that rhAGN has biological function against tumor growth.

目的:观察重组人血管抑素( recombinant human angiostatin,rhAGN)对鼻咽癌皮下移植瘤生长的抑制作用,探讨其应用价值。方法:应用 MTT法观察 rhAGN对 CNE 1鼻咽癌细胞和 HDMEC血管内皮细胞增殖的影响;建立 CNE 1鼻咽癌裸鼠皮下移植瘤模型,皮下注射不同剂量 rhAGN,治疗期为 30天,观察肿瘤体积和重量变化。 结果: (1)在 0.5μ g/ml、 1.0μ g/ml和 2.0μ g/ml测试浓度下,培养 72 h, rhAGN对 CNE 1细胞生长抑制率为 3.4%、 5.2%和 5.9%,对 HDMEC细胞生长抑制率为 39.4%、 65.3%和 89.7%; (2)rhAGN剂量为 50 mg· (kg· d)- 1、 100mg· (kg· d)- 1和 200mg· (kg· d)- 1时的抑瘤率分别为 32.3%、 64.0%和 83.2%。 结论: rhAGN在体外对 CNE 1细胞增殖无明显抑制作用,在体内能显著抑制 CNE 1鼻咽癌移植瘤的生长,具有潜在的应用前景。

AIM To explore the expression and effects of extra originated angiostatin K(1 3) [AK(1 3)] gene in human gliomas. METHODS AK(1 3) cDNA was linked with Ig kappa chain's secretive signal S to form SAK(1 3) by PCR. SAK(1 3) was inserted into polylinker sites of eukaryotic expression vector pcDNA3 to construct pcDNA SAK(1 3). The vector was transfected into human glioma SHG44 cells by lipofectamine and the positive clone was screened by G418. The biological characteristics of glioma cells before and after...

AIM To explore the expression and effects of extra originated angiostatin K(1 3) [AK(1 3)] gene in human gliomas. METHODS AK(1 3) cDNA was linked with Ig kappa chain's secretive signal S to form SAK(1 3) by PCR. SAK(1 3) was inserted into polylinker sites of eukaryotic expression vector pcDNA3 to construct pcDNA SAK(1 3). The vector was transfected into human glioma SHG44 cells by lipofectamine and the positive clone was screened by G418. The biological characteristics of glioma cells before and after transfection were compared. The activity of AK(1 3) protein expressed by the SHG44 cells was examined by the endotheliocyte inhibition assay, immunofluorescence assay and immnohistochemistry. When the tumor cells were implanted into the nude mice, the influence of AK(1 3) protein to the human glioma growth was confirmed by some kind of tests. RESULTS The biological characteristics of glioma cells were not influenced by the extra originated AK(1 3) expression. The protein was able to inhibit the endothelial growth in vitro . The tumorigenesis of glioma cells in nude mice was greatly reduced and the tumor inhibition rate was 76.8%. CONCLUSION The human glioma growth can be withheld by the tumor's self expression of AK(1 3) protein. The mechanism is that the tumor angiogenesis is so suppressed that its necrosis happens.

目的 探讨外源性血管抑素 K(1- 3)基因[angiostatin K(1- 3) ,AK(1- 3) ]在人脑胶质瘤中的表达及其作用 .方法 应用 PCR法 ,使人 Ig kappa链分泌信号肽序列S加装在 AK(1- 3)基因上 - SAK(1- 3) ;构建 SAK(1- 3)基因的真核表达载体 pc DNA- SAK(1- 3) .经脂质体法将其转染入SHG44人脑胶质瘤细胞 ,行 G418筛选获得转基因瘤细胞克隆 ,比较转基因和未转基因的瘤细胞生物学特性 .以免疫荧光、免疫组化和内皮细胞抑制实验检测瘤细胞表达的 AK(1-3)蛋白及其活性 .应用裸鼠皮下致瘤性实验 ,结合 SHG44瘤组织的各项检测 ,确定肿瘤表达 AK(1- 3)蛋白对人脑胶质瘤生长的影响 .结果 外源性 AK(1- 3)的表达不影响 SHG44瘤细胞的生物学特性 ,它能在体外抑制内皮细胞生长 ;表达AK(1- 3)的胶质瘤细胞体内致瘤性显著下降 ,抑瘤率为 76 .8% .结论 肿瘤表达的 AK(1- 3)蛋白能抑制其自身生长 ,该机制是通过抑制胶质瘤的血管生成 ,进而导致肿瘤局部缺血坏死实现的

Objective To study the antitumor effect of angiostatin on LA795 adenocarcinoma cells inoculated on T 739 mice Methods Affinity chromatography purified plasminogen was digested by pancreatic elastase and angiostatin was obtained by purifying the digestion with affinity chromatography and dialysis T 739 mice were inoculated with LA795 cells Angiostatin was given to part of inoculated and uninoculated mice by intraperitoneal injection fourteen days after the inoculation The treatment lasted...

Objective To study the antitumor effect of angiostatin on LA795 adenocarcinoma cells inoculated on T 739 mice Methods Affinity chromatography purified plasminogen was digested by pancreatic elastase and angiostatin was obtained by purifying the digestion with affinity chromatography and dialysis T 739 mice were inoculated with LA795 cells Angiostatin was given to part of inoculated and uninoculated mice by intraperitoneal injection fourteen days after the inoculation The treatment lasted 20 days and the size of tumor, survival period, behavior of the mice and pathology of lungs, livers and kidneys were observed Results The size of tumor decreased from (2 35±0 26) cm to (0 97±0 34) cm after angiostatin treatment The number of metastases in lung was significantly fewer in angiostatin treated mice than in untreated ones, which lived much shorter No obvious side effects were observed Conclusion Angiostatin markedly inhibits the growth and metastasis of LA795 cells on T 739 mice and no obvious side effects of angiostatin were found during the treatment

目的 观察血浆源性血管抑素 (angiostatin)对T739小鼠LA795细胞癌 (肺腺癌细胞 )生长、转移的抑制作用。方法 用亲和层析方法得到的血浆纤维溶酶原经胰蛋白酶消化、层析柱亲和层析、透析 ,得到纯化的血管抑素 ;以LA795细胞接种于T739小鼠 ;接种后第 15日起腹腔内注射血管抑素共2 0d ,观察动物行为 ,测量荷瘤鼠肿块直径 ,记录生存期 ,另设未治疗对照组及观察血管抑素副作用对照组 ,行肺、肝、肾脏病理学检查。结果 接受血管抑素治疗的小鼠肿瘤肿块直径由治疗前的 (2 3 5±0 2 6)cm减小到治疗后的 (0 97± 0 3 4)cm ,肺表面转移灶数目明显少于未治疗组 ,生存期明显延长 ,未见明显副作用。结论 血管抑素能显著抑制T739小鼠LA795细胞肿瘤肿块生长、转移 ,未观察到明显副作用。

 
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