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microsomes
相关语句
  微粒体
    Study on the Metabolism of Imrecoxib in Rat Liver Microsomes
    艾瑞昔布在大鼠肝微粒体内的代谢研究
短句来源
    25-Hydroxylation of [3H]-Vitamin D3 in Liver Microsomes
    肝微粒体内~3H-D_3的25羟化作用
短句来源
    Study on the Physicochemical Properties of Rat Liver Microsomes with Various Activity of Aryl Hydrocarbon Hydroxylase (AHH)
    诱导芳香烃羟化酶活性不同的大鼠肝微粒体理化特性研究
短句来源
    Toxicological application of luminol-dependent chemiluminescence assay in hepatic microsomes and reconstitutedcytochrome P450 enzyme system
    3-氨基苯二酰肼发光法在微粒体和重组细胞色素P450酶系中的毒理学应用(英文)
短句来源
    STUDY ON THE INTERACTIONS BETWEEN TETRAMETHYLPYRAZINE PHOSPHATE AND LIVER MICROSOMES IN RATS
    磷酸川芎嗪与大鼠肝微粒体相互作用的研究
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  “microsomes”译为未确定词的双语例句
    Induction of Cytochrome P-450 in Rat Liver Microsomes by CTPTD Treatment
    CTPTD对大鼠肝细胞色素P-450的诱导作用
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    Relationship of the pathway of metabolic conversion of 2,4,5-trifluoroaniline into carbon monoxide and the structure-activity of trihaloanilines by rat hepatic microsomes
    2,4,5-三氯苯胺体外代谢生成一氧化碳的途径与三卤苯胺的构效关系研究
短句来源
    Conclusions ODV shows no effect on CYP450 content and CYP3A4 activity,but can inhibit CYP2D6 activity in liver microsomes.
    结论ODV对CYP450含量和CYP3A4活性无影响,但对CYP2D6活性有抑制作用。
短句来源
    Effect of Proton Pump Inhibitor-Pantoprazole on P450 in Rat Liver Microsomes
    质子泵抑制剂盘托拉唑对大鼠肝药酶中P450的影响
短句来源
    Objective: To study the Stereoselectivity in trans-tramadol [( ±)-trans T] metabolism and trans-O-demethyltramadol [( ±)-Ml] formation in rat liver microsomes in vitro.
    目的:研究手性药物反式曲马朵[(±)-trans T]代谢及其活性代谢物反式O-去甲基曲马朵[(±)-M1]生成的立体选择性。
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  microsomes
Differences in TPO concentrations in mitochondria, microsomes, and supernatant fluid depending on thyroid pathology and tissue storage conditions were found.
      
The immunochemical properties of TPO were studied under variable conditions and a new method for isolating the protein from the microsomes, mitochondria, and cytosol of thyroid glands of patients with diverse thyroid diseases was developed.
      
Effect of Glycine and Strychnine on Cl--Activated Mg2+-ATPase from Bream Brain Microsomes (Abramis bramaL.)
      
A receptor-dependent pathway of glycine and strychnine action on Cl--activated Mg2+-ATPase from bream brain microsomes is proposed.
      
Effect of Modulators of Protein Kinase C Activity on Ca2+ Transport in Retinal Rod Microsomes
      
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The last step in the biosynthesis of vitamin C has been shown to be carried out enzymatically by a particulate preparation from rat liver.In the presence of oxygen and glutathione,L-gulono-or L-galactono-γ-lactone is oxidized to L-ascorbic acid. When the mitochondria and the microsomes are separated by means of differential centri- fugation,the enzyme activity is found in both fractions but is much higher in the microsomes. In the particulate form,the enzyme is insensitive to inhibitors such as cyanide,azide,iodoacetate,...

The last step in the biosynthesis of vitamin C has been shown to be carried out enzymatically by a particulate preparation from rat liver.In the presence of oxygen and glutathione,L-gulono-or L-galactono-γ-lactone is oxidized to L-ascorbic acid. When the mitochondria and the microsomes are separated by means of differential centri- fugation,the enzyme activity is found in both fractions but is much higher in the microsomes. In the particulate form,the enzyme is insensitive to inhibitors such as cyanide,azide,iodoacetate, arsenite and atebrin but is stimulated by 2,4-dinitrophenol. Upon treatment with sodium desoxycholate,the microsomes can be partially solubilized.The solubilized enzyme can be purified 5—6 fold by adsorption on alumina C_γ gel and precipitation by ammonium sulfate at 0.2 saturation.The partially purified enzyme still requires oxygen for its action and is incapable of utilizing ferricytochrome c as acceptor or artificial hydrogen acceptors such as ferricyanide,methylcne blue and 2:6-dichlorophenol indophenol.It still acts only on the lactones and cannot utilize the acid form of the substrates.With the iemoval of most of the substances capable of oxidizing ascorbic acid, glutathione is no longer a necessary factor in the reaction medium.Its addition,however, slightly enhances the reaction.This and the facts that p-chloromercuribenzoate strongly inhibits it while metal-chelating agents such as 8-hydroxyquinoline and thiocyanate enhance its activity show that the enzyme probably contains essentiai-SH-groups.The enzyme action is still in- sensitive to cyanide,being only slightly depressed by very high concentration of KCN(10~1M). The inhibitory effect,however,is more marked upon incubation in the absence of the substrate. The ()nzyme is also inhibited by BAL but not by atebrin,arsenite or fluoride,while 2,4-dinitro- phenol has a markedly stimulating effect.Inhibitors that are known to affect catalase activity, such as hydroxylamine and azide have an inhibitory effect on our enzyme only when gluta- thione is absent.It is suggested that in the oxidation of the substrate,H_2O_2 is produced and normally is immediately decomposed by catalase which accompanies our enzyme and proves to be very difficult to remove completely.In the presence of inhibitors which act on catalase, however,H_2O_2 accumulates resulting in either the oxidation of ascorbic acid or inactivation of the enzyme or both.Glutathione,if present,protects both the product and the enzyme from destruction.The action of KCN which,in addition to its strong effect on catalase,also protects L-ascorbic acid,is not influenced by glutathione in the same way.The enzyme shows a decided requirement for inorganic phosphate which can only be partially replaced by metal chelating agents such as versene(ethylene diamine tetraacetic acid). Work on the further purification of the enzyme and detailed investigation on its nature and action is still in progress.

(一)用差示离心方法,由大白鼠肝得到的颗粒体制剂在谷胱甘肽的保护作用下,有将 L-古罗糖酸-或 L-半乳糖酸-γ-内酯氧化为 L-抗坏血酸的作用,活力大部存在于微粒体。(二)利用脱羟胆盐处理微粒体可使之成为局部溶解的酶制剂,经氧化铝凝胶 C_r 吸附,硫酸铵沉淀续加纯化,活力提高5—6倍。(三)对于酶作用的一般情况和一些因素对它的影响,我们作了一些观察。(四)比较并讨论了我俩所得结果与其他工作者所报告者的异同。

The mutagenicity of Alkyl phenoxy-polyethoxy ethanol(74 1)contraceptive films wastested on mutant Salmonella and E.coli microsome system.The Salmonella Typhimuriumstrain TA 1535,TA 1537,TA 1538,TA 98 and TA 100 were mutants requiring histidineand E.coli strains WP 2,WP 2 UVrA,CM-891,ND-160 and MR2-102 were mutantsrequiring trytophane and thiamine.The microsomes were isolated from rat liver.Bothspot tests and plate tests were conducted,and known carcinogens MNNG and 2 AAF wereused as positive references.Results...

The mutagenicity of Alkyl phenoxy-polyethoxy ethanol(74 1)contraceptive films wastested on mutant Salmonella and E.coli microsome system.The Salmonella Typhimuriumstrain TA 1535,TA 1537,TA 1538,TA 98 and TA 100 were mutants requiring histidineand E.coli strains WP 2,WP 2 UVrA,CM-891,ND-160 and MR2-102 were mutantsrequiring trytophane and thiamine.The microsomes were isolated from rat liver.Bothspot tests and plate tests were conducted,and known carcinogens MNNG and 2 AAF wereused as positive references.Results of the experimentation showed that the“74 1”contraceptive films and all blanktests consistantly gave negative results,while the known carcinogenic references gave posi-tive results.

用鼠伤寒沙门氏菌组氨酸缺陷型和大肠杆菌突变株及大鼠肝微粒体酶,做活化和非活化平皿点试法和掺入法诱变试验,以检测烷苯聚醇醚(代号741)避孕药膜有无致突变/致癌性。用已知化学致癌物(MNNG,2AAF)做阳性诱变对照。结果:“741”避孕药膜与对照一致,为阴性结果。而已知化学致癌物仍呈现阳性结果。

The effects of coke oven gas flyash extract, anthracene, pyrene, benz (a)anthracene, dibenz (a, b) anthracene on benzo(a)Pyrene (BaP) mutagenicity and metabolism were studied. The results indicated that the combined mutagenic activities of BaP and flyash extract or PAHs were antagonistic towards Salmonella typhimurium TA 100. The results of high-pressure liquid chromatography analysis indicated that the above mentioned PAHs had the function of inhibiting the formation of 7,8-diol-BaP and detoxifying metabolites...

The effects of coke oven gas flyash extract, anthracene, pyrene, benz (a)anthracene, dibenz (a, b) anthracene on benzo(a)Pyrene (BaP) mutagenicity and metabolism were studied. The results indicated that the combined mutagenic activities of BaP and flyash extract or PAHs were antagonistic towards Salmonella typhimurium TA 100. The results of high-pressure liquid chromatography analysis indicated that the above mentioned PAHs had the function of inhibiting the formation of 7,8-diol-BaP and detoxifying metabolites under the effect of 3-methylchol-anthrene induced rat liver microsomes. The inhibition was most likely due to the competition between BaP and PAH for the same eytoehrome P-450, which led to the inhibition of aryl hydrocarbon hydroxylase activity. Furthermore, the metabolites of PAHs also inhibited epoxide hydrase activity.

本文报告了焦炉尾气飘尘及几种多环芳烃(PAH)与苯并(a)芘(BaP)对鼠伤寒沙门氏菌/微粒体系统的联合致突变作用及其机理的研究。 沙门氏菌致突变试验的结果发现高剂量尾气飘尘提取物(相当于1.1m~3尾气飘尘)与BaP(40μM)联合时,致突变作用呈拮抗现象。用3-甲基胆蒽诱导大鼠肝微粒体BaP代谢产物为指标所进行的高压液相色谱分析表明,这四种PAH抑制了BaP近致癌物7,8-二氢二羟和灭活代谢产物的生成。四种PAH都抑制了芳烃羟化酶的活性,这最可能是由于不同的PAH在细胞色素P-450同一结合部位的竞争。而且,四种PAH经代谢后还抑制了环氧化物水化酶的活性。

 
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