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hospitals
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  医院
    Analysis of the Information on Drug Purchases of Domestic Hospitals in 1988
    1988年国内医院药品购入信息分析
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    Reconstruction of Air-Cleaning System for the Preparation Room of County-Level Hospitals
    浅谈县级医院制剂室的空气净化改造
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    Analysis of Drug Consumption Data of Military Hospitals
    军队医院药品消耗数据分析
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    SURVEY OF SUSCEPTIBILITY TO 16 NEWER ANTIBIOTICS IN HOSPITALS IN BEIJING
    北京4家医院对常用较新的16种抗生素的敏感性监测
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    The Mission of Hospitals and the Management Aim of Pharmacies
    医院的机构使命与医院药房的管理目标
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  “hospitals”译为未确定词的双语例句
    Discussion on the Feasibility of Establishing Central Preparation Room for Regional Hospitals
    对建立区域性医疗单位中心制剂室模式可行性的探讨
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    Evaluation for utilization of the agents of nervous system in the hospitals of Beijing in 1995 - 1996
    1995-1996北京地区神经系统用药评价
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    Analysis of the Drugs Used in Digestive System in the Hospitals of Six Cities around Changjiang River Basin in the First Half of the Year During 2002~2003
    长江流域6城市2002年和2003年上半年消化系统用药分析
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    Analysis of the situation of the drug- application for cardiovascular diseases in our hospitals from 2000 to 2003
    我院2000年~2003年心血管类药物应用情况及分析
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    Present situation on pharmaceutical information service in hospitals of Shanghai
    上海地区医疗机构开展药学咨询服务的现状与分析
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  hospitals
From September 2001 to 2003, a total of 1077 cases of SPH distributed in 135 hospitals all over the mainland of China were included for analysis.
      
The plasma aldosterone concentration (PAC) and plasma renin activity (PRA) levels were measured by radioimmunoassay in 902 hypertensive patients from out-patient clinics or hospitals.
      
Examination of 211 cases of schizophrenia earlier diagnosed in Daghestan psychiatric hospitals has shown that only 139 of them meet the DSM-IV criteria for schizophrenia.
      
A computer program based on the new algorithm has been developed and used by several hospitals.
      
This article determines and analyses persons in German hospitals and nursing homes who suffer from pressure ulcers but are not at risk.
      
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Cholesterol has been labeled with radioiodine by two methods: ( 1 ) mercura-tion of cholesterol and subsequent replacement of the chloromercuri group with 131I2;( 2) exchange of 6-iodo-cholesterol with radioactive iodide in aqueous butanolsolution. The radiochemical purity of the final product was demonstrated by paperchromatography and autoradiography.It was found that iodine was firmly bound in the iodinated cholesterol molecule. No appreciable loss of the label was observed and the original compound was recovered...

Cholesterol has been labeled with radioiodine by two methods: ( 1 ) mercura-tion of cholesterol and subsequent replacement of the chloromercuri group with 131I2;( 2) exchange of 6-iodo-cholesterol with radioactive iodide in aqueous butanolsolution. The radiochemical purity of the final product was demonstrated by paperchromatography and autoradiography.It was found that iodine was firmly bound in the iodinated cholesterol molecule. No appreciable loss of the label was observed and the original compound was recovered unchanged after refluxing for 3 hours the radioiodinated cholesterol in butanol solution containing either concentrated sodium ethoxide or hydrogen chloride.The labeled cholesterol resembles cholesterol itself in many respects. It crystallizes in pearly leaflets. It is precipitated by digitonin and gives intense red color with Zak's reagent. Its infrared absorption spectrum practically coincides with that of cholesterol in all of the main absorption bands.Above all, "the most interesting property of the radioiodinated cholesterol lies in its behavior in animal experiments. After being given intravenously to rabbits or rats together with unlabeled cholesterol, the labeled cholesterol appeared in plasma, liver and atherosclerotic plaques of the animal in such a manner that the changes in concentration of the two administered compounds closely paralleled to ,each other.Since the radioative isotope 131I is a cheap γ-emitter with relatively short half-life and its amount within the body can be easily measured from outside, this radioiodinated cholesterol might be useful as a diagnostic aid in clinical conditions involving cholesterol disturbance. As a matter of fact, it has already been used successfully in several Chinese hospitals as an imaging agent for adrenal visualization.

本文是试制一种适合于临床应用的胆固醇示踪物。研制成的I-6-碘代胆固醇在结晶形状,成色反应、沉淀反应及红外线吸收光谱等方面都和胆固醇很相似,且有很高的化学与生物稳定性。此标记物与胆固醇,同时给予家兔或大鼠后,在动物肝、血浆及血管壁动脉粥样硬化斑块中浓度的变化彼此平行。目前它巳用于临床,作为肾上腺显影剂。

6-131 I-cholesterol was prepared by the isotope exchange method. Effects of temperature and carrier amounts on the percentage of labeling were examined and the optimum labeling conditions ascertained.Both 19-131 I-and 6-161 I-cholesterol were synthesized for the purpose of comparison, the latter was proved to be superior in several aspects such as ease of preparation, simplicity of labeling procedure, high yield, constant quality and easy storage. 6-131 I-cholesterol was subjected to clinical trials in several...

6-131 I-cholesterol was prepared by the isotope exchange method. Effects of temperature and carrier amounts on the percentage of labeling were examined and the optimum labeling conditions ascertained.Both 19-131 I-and 6-161 I-cholesterol were synthesized for the purpose of comparison, the latter was proved to be superior in several aspects such as ease of preparation, simplicity of labeling procedure, high yield, constant quality and easy storage. 6-131 I-cholesterol was subjected to clinical trials in several hospitals. Results of studies show that 6-131 I-cholesterol is also a good adrenal scanning agent.

本文以胆固醇为原料,合成和标记了6-~(131)I胆固醇。结果表明,6-~(131)I胆固醇是一种良好和安全的肾上腺扫描剂。鉴于6-~(131)Ⅰ胆固醇的实际应用意义,我们比较系统地研究了6-I胆固醇同位素交换的各种影响因素。如载体浓度对标记率的影响,计算和验证了在不同载体浓度下交换平衡可能达到的极限值。浴温对反应速度的影响以及同位素交换的动力学特征。确定了比放为2mCi/mg的最佳标记条件,并研究了6-~(131)I胆固醇在不同温度和不同辐射剂量下的热稳定性和辐射稳定性。研究表明6-I胆固醇能在空气存在的条件下回流碘化及标记。产品也可在室温下保存。较国外报道的19-~(131)Ⅰ胆固醇具有生产工艺简便,产额高,产品质量稳定,热稳定性和辐射稳定性好,以及便于使用和保存等优点。

Experiments were conducted on fiftymale rabbits to identify the concomi-tant changes both of the EEG and thebehavior as an epileptic pattern causedby the adminstration of Coriaria Lac-tone and to find out an adequate doseof this drug to induce a high frequencyof epileptic seizure with a low mor-tality rate. Coriaria Lactone, manufactured bythe pharmaceutical laboratory of Si-chuan Medical College, is an activeconstituent of Loranthus on Coriariasinica Maxim, a medicinal herb, whichhas long been known having...

Experiments were conducted on fiftymale rabbits to identify the concomi-tant changes both of the EEG and thebehavior as an epileptic pattern causedby the adminstration of Coriaria Lac-tone and to find out an adequate doseof this drug to induce a high frequencyof epileptic seizure with a low mor-tality rate. Coriaria Lactone, manufactured bythe pharmaceutical laboratory of Si-chuan Medical College, is an activeconstituent of Loranthus on Coriariasinica Maxim, a medicinal herb, whichhas long been known having beneficialeffect on some form of psychosis intraditional Chinese medicine and wasrecently demonstrated effective for thetreatment of schizophrenia by psychia-trists in our and other hospitals. Anepileptic-like convulsion was usuallyfound in those patients using the drugas a cure. In our previous experimentsthe effects of Coriaria Lactone onbehavior and EEG of the rabbit wereobserved.It was found that the Coria-ria Lactone caused convulsion andEEG changes which were much thesame as those of the epileptic patients,and there seemed to be a dose-depen-dent effect. These findings raised thepossibility of inducing epileptic seizureby Coriaria Lactone. In our present work,further observa-tions were made. Thus, when theexperimental animal was conscious andunrestrained the EEG of the animalwas recorded by telemetric methodwhich made the simultaneous observa-tion of both EEG and behavior seizurespossible. The fifty rabbits, weighing2.0-2.8 kg, were divided arbitrarilyinto four groups, three of which weredesigned for testing the optimum dosageand the remaining one for examiningthe possibility that conventional anti-epileptics, sodium phenobarbital, couldantagonize the effects induced by theoptimum dosage. The results were: 1. In group of 2mg/kg dosage therewas no effect. In group of 3mg/kg dosage the effect was significant: therate of seizure was 100%, i.e. all theanimals tested in this group had aseizure, with a death rate of 13.3%,whereas in group of 4mg/kg dosagethe death rate was 66.7% which muchhigher than that of the former group(P<0.01 ) though the rate of seizure(100% ) was the same. From thesedata it showed that 3 mg/kg could bethe optimum dosage of Coriaria Lac-tone for inducing an epileptic seizure. 2. The seizure revealed by EEG re-cording and behavior observation (insome cases cinematograph was taken)showed typical epileptic characteris-tics. On the other hand, this CoriariaLactone-caused seizure was antagonizedby preinjection of sodium phenobarbital(50mg/kg) 2 hours before the injectionof Coriaria Lactone. Thereby, it wasshown from both the obverse and thereverse sides that Coriaria Lactonewas an effective agent for inducingepileptic seizure. 3. Repeated injections of Coriaria Lac-tone (3mg/kg ) induced correspondingrepeated seizures when the dosage usedand the time interval chosen weresuitable. This suggested that the accu-mulation action of Coriaria Lactonewas not significant in the body. Although a researcher in his experi-ment may observe the behavior and EEGrecord separately, we think it best torecord both the indices at the sametime because antiepileptic drugs affectthe behavior and EEG of epilepsyseizure differently. Some drugs havea depressant effect on EEG seizurewhile others do not affect the beha-vioral seizure. Still some others justact in the reverse manner. In our pre-sent experiment we observed both thebehavioral and EEG seizure patternsby Coriaria Lactone at the same time. In our investigation an easy andeffective model of animal was offered.

本文报告以家兔作为实验动物,用马桑内酯造成癫痫模型。所用方法简便可靠。本模型可用于探索马桑内酯治疗精神分裂症的作用机理,也可用于探索癫痫发生机理及筛选抗癫痫药物。

 
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