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scid mouse
相关语句
  scid鼠
     (3)24 hrs after transplantation with 1×10~7/0.2 ml BALL-1 into each NOD/SCID mouse,24 mice were divided into 4 study groups:control group;
     (3)每组6只NOD/SCID鼠在每只鼠接种1×107/0.2 ml BALL-1后24 h按如下分组进行实验:①对照组; ②HA14-1组,经尾静脉注射灭菌HA14-1 25 mg.
短句来源
     Dotted or small focal expressions were found in SCID mouse liver when detecting the human serum albumin with mouse anti-human albumin antibody after transplantation of the stem cells in 3 months.
     SCID鼠移植细胞3个月后用鼠抗人白蛋白抗体检测小鼠肝脏中的人白蛋白,可见有点状或小灶状表达。
短句来源
     RECONSTITUTION OF HUMAN IMMUNE SYSTEM IN SCID MOUSE WITH INTRAPERITONEAL INJECTION OF FETAL LIVER CELLS
     用人胎肝细胞重建SCID鼠人免疫系统
短句来源
     Methods: Human ovarian carcinoma SKOV3 cells were injected intraperitoneally into female SCID mouse to establish a transplantation model of human ovarian carcinoma.
     方法 :SCID鼠腹腔注射人 SKOV3卵巢癌细胞 1× 10 7个 /只 ,饲养在无特定病原体环境中 ,观察其生物学特性。
短句来源
     In animal experiments, human ovarian carcinoma in a SCID mouse model was devised, and the potential of irradiated NK 92 as immunotherapy for ovarian carcinoma was evaluated.
     建立人卵巢癌SCID鼠肿瘤模型,观察输注经照射后的NK92细胞对荷瘤鼠的治疗效果。
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  scid小鼠
     Results It was found that every SCID mouse had an observable tumor at 6~10 days after injection (5/5 mice) and the average period of tumor formation was about 7.4±1.3 days.
     结果接种SCID小鼠后6~10d成瘤,成瘤率为5/5只,潜伏期平均(7.4±1.3)d。
短句来源
     Establishment of Human Acute Myeloid Leukemia Model in the SCID Mouse
     人急性早幼粒细胞白血病SCID小鼠模型的建立
短句来源
     Establishment of a SCID Mouse Model for Synergistic Anti-tumor Effect of Human IL-12 and B 7-1
     人IL-12和B7-1基因对HuPBL-SCID小鼠模型中人源肿瘤的协同抑制作用
短句来源
     Establishment and identification of humanized SCID mouse model
     人源化SCID小鼠模型的建立及其鉴定
短句来源
     The percentage of parasitied erythrocyted (PPE) in the BO RB SCID mouse was 15% (24h), and maxium parasitemias was 6.3% in vitro.
     B.ovata在 BO- RBC- SCID小鼠体内染虫率可达 15 %以上 ,体外培养最高染虫率为 6 .3%。
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  “scid mouse”译为未确定词的双语例句
     Cotransplantation of hUC-MSC from umbilical cord blood(UCB) resulted a significant increment of human UCB mononuclear cells(MNC)~ in NOD/SCID mouse bone marrow as compared with the infusion of UCB alone \(145±59)/1×10~ 5 vs (298±72)/1×10~ 5 ;
     在hUC-MSC共移植情况下,流式细胞仪检测和荧光显微镜下细胞计数均发现人脐带血MNC在小鼠骨髓中的含量与单独脐带血移植相比较有显著提高〔(145±59)/1×105vs(298±72)/1×105;
短句来源
     Humanized SCID Mouse:A Small Animal Model for HIV Research
     SCID-hu小鼠:HIV研究的小型动物模型
短句来源
     In our preclinical study, As_2O_3 has been implicated as a promising anticancer agent in inducing apoptosis and differentiation of NPC xenografts in Scid mouse.
     在我们的前期工作中表明传统中药三氧化二砷(As_2O_3)能够诱导鼻咽癌移植瘤分化与凋亡。
短句来源
     Establishment of human breast cancer metastasis SCID mouse model by orthotopic transplantation and study of its biological features
     免疫双缺陷鼠人乳腺癌转移模型的生物学特性研究
短句来源
     Bcl-2 antisense oligonucleotides suppress HL-60 cell growth in a SCID mouse model
     Bcl-2反义硫代磷酸寡脱氧核苷酸抑制HL-60细胞在重度联合免疫缺陷鼠中生长的研究
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  scid mouse
In vivo analysis using a SCID mouse virulence model showed a consistently measurable attenuated phenotype for all three m136 mutants.
      
Modulation of adhesion molecules by cytokinesin vivo using human/severe combined immunodeficient (SCID) mouse chimeras
      
Reproducible animal models of lung cancer bone metastasis, like NK-cell depleted SCID mouse model with SCB-5 cells, are useful to explore the molecular mechanism and search of molecular targets.
      
The technique of surgical orthotopic implantation (SOI) has allowed the development of clinically relevant metastatic models of human cancer in immunodeficient rodents such as the nude and SCID mouse.
      
Therefore, the scid mouse that allows disseminated growths for a number of human tumors, particularly hematologic disorders and malignant melanoma, can be used preferentially for the investigation of such malignancies.
      
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Mice with severe combined immunodeficiency (SCID) disease are deficient for both T and B lymphocyte functions because of impairment of lymphoiesis. To ensure SCID mice to survive, we raised them in a plastic film isolator in which specific-pathogen-free (SPF) condition was kept, free of 12 viruses and 17 bacteria considered as common pathogens of mice, as well as endoparasites and ectoparasites.Body weights of the SCID mice 4 and 8 weeks old were the same as those of the control...

Mice with severe combined immunodeficiency (SCID) disease are deficient for both T and B lymphocyte functions because of impairment of lymphoiesis. To ensure SCID mice to survive, we raised them in a plastic film isolator in which specific-pathogen-free (SPF) condition was kept, free of 12 viruses and 17 bacteria considered as common pathogens of mice, as well as endoparasites and ectoparasites.Body weights of the SCID mice 4 and 8 weeks old were the same as those of the control group of BALB/c mice. Average litter size of the SCID mice was 3.4, slightly smaller than that of BALB/c mice, but their non-productive rate and weaned-to-born ratio were comparable to those of BALB/c mice, i. e. 27.2% and 73.5%, respectively.Circulating lymphocytes of SCID mice only comprised a small fraction of the total leukocytes of peripheral blood (10-24%), while neutrophils were 76-88%. Conversely, in BALB/c mice, lymphocytes were 75-87% and neutrophils 15-25%. Theymus glands of the SCID mice were abnormally small, and their relative weight was only about 6% of that of BALB/c mice. SCID thymus was found to consist of a rudimentary medulla without cortex and contained few lymphocytes, predominated by epithelioid cells and fibroblasts. Relative weight of SCID spleen was about 30% of that of BALB/c mice. SCID spleen follicles were empty, virtually devoid of lymphocytes, occupied by reticular cells. But red pulp of SCID spleens was normal as in BALB/c mice. SCID lymph nodes were extremely small, only 1/3-1/4 of normal size of BALB/c mice. SCID lymph nodes showed no clear cortex structure, devoid of paracortical area, lacking follicles. The whole structure of SCID lymph nodes was poorly populated by lymphocytes, but predominated by reticular cells. SCID lymphoid tissues in submucosa of small intestines were undeveloped. The follicular-like sites were mainly composed of reticular cells without lymphocytes.The SCID mice may be sued to study lymphoid differentiation, and serve as an in vivo test system for transplanted tumors and normal tissues.

SCID小鼠是一种T和B淋巴细胞严重缺陷的动物,是肿瘤学和免疫学等学科研究的很有用的模型。 将SCID小鼠饲养于塑料薄膜隔离器内,保持无特定病原体状态。其平均每窝产仔数为3.4只,不育率为27.2%,离乳率为73.5%。该小鼠胸腺无皮质结构,髓质保留,缺乏淋巴细胞;脾脏内滤泡呈淋巴细胞脱空状态;淋巴结皮质区不明显,整个淋巴结呈淋巴细胞脱空状态;小肠粘膜下淋巴样组织无淋巴细胞聚集。外周血淋巴细胞仅占白细胞总数的10-24%。该小鼠基本符合免疫学试验要求。

The super severe combined immunodeficient mice(superscid)is a newly established mouse strain which was constructed by introducing the bg gene into C.B-17 scid mice.To identify its cellular immunologic haracteristics,we examined the T、natural killer(NK)and lymphokine-activated killer (LAK)cell activity in this mouse strain.The NK cell activity was studied by measuring the cytotoxicity to NK sensitive cell(YAC-1)and the influence of poly Ⅰ-C on it.The LAK cell activity was examined by...

The super severe combined immunodeficient mice(superscid)is a newly established mouse strain which was constructed by introducing the bg gene into C.B-17 scid mice.To identify its cellular immunologic haracteristics,we examined the T、natural killer(NK)and lymphokine-activated killer (LAK)cell activity in this mouse strain.The NK cell activity was studied by measuring the cytotoxicity to NK sensitive cell(YAC-1)and the influence of poly Ⅰ-C on it.The LAK cell activity was examined by measuring the cytotoxicity aganist NK resistant cell(p815).

超重症联合免疫缺陷小鼠(B.C.B-17scid-beige)是将自然杀伤细胞(NK)缺陷基因(bg 基因)导入重症联合免疫缺陷病小鼠(C.B-17scid)体内得到的一种新品系小鼠.为确定该鼠基本细胞免疫特征,我们测定了该鼠 T、NK 和淋巴因子激活的杀伤细胞(LAK)等的功能,以及聚肌胞(poly I-C)对该鼠 NK 细胞活性的影响。该小鼠脾淋巴细胞不能针对 T 细胞有丝分裂原刀豆蛋白(ConA)的刺激而产生增殖反应。同正常对照小鼠相差非常显著(P<0.01)。该鼠 NK 细胞活性(对 YAC-1细胞杀伤活性)明显低于亲代 scid 小鼠和正常小鼠(P<0.01),经聚肌胞(100μg/只)预先刺激后该鼠 NK 细胞活性未见增加.而亲代 scid 小鼠则有明显增加。该鼠脾脏细胞经白细胞介素—2刺激后,LAK 细胞活性(对 P815细胞杀伤活性)明显低于亲代 scid 小鼠和正常小鼠(P<0.01)。上述结果表明 B、C、B-17scid-beige 小鼠是一种 T、NK和 LAK 细胞联合免疫缺陷小鼠,该鼠 B 细胞功能也是缺陷的(详见它文)。上述缺陷是 scid 基因和 bg 基因共同作用的结果,该动...

超重症联合免疫缺陷小鼠(B.C.B-17scid-beige)是将自然杀伤细胞(NK)缺陷基因(bg 基因)导入重症联合免疫缺陷病小鼠(C.B-17scid)体内得到的一种新品系小鼠.为确定该鼠基本细胞免疫特征,我们测定了该鼠 T、NK 和淋巴因子激活的杀伤细胞(LAK)等的功能,以及聚肌胞(poly I-C)对该鼠 NK 细胞活性的影响。该小鼠脾淋巴细胞不能针对 T 细胞有丝分裂原刀豆蛋白(ConA)的刺激而产生增殖反应。同正常对照小鼠相差非常显著(P<0.01)。该鼠 NK 细胞活性(对 YAC-1细胞杀伤活性)明显低于亲代 scid 小鼠和正常小鼠(P<0.01),经聚肌胞(100μg/只)预先刺激后该鼠 NK 细胞活性未见增加.而亲代 scid 小鼠则有明显增加。该鼠脾脏细胞经白细胞介素—2刺激后,LAK 细胞活性(对 P815细胞杀伤活性)明显低于亲代 scid 小鼠和正常小鼠(P<0.01)。上述结果表明 B、C、B-17scid-beige 小鼠是一种 T、NK和 LAK 细胞联合免疫缺陷小鼠,该鼠 B 细胞功能也是缺陷的(详见它文)。上述缺陷是 scid 基因和 bg 基因共同作用的结果,该动物为建立人—免疫缺陷动物模型提供了一种更为理想的受体小鼠,并为基础免疫学研究提供了一种新的研究工具。

Cloned CNE-2Z variants cells(CNE-2L2 and CNE2L4)in suspension form were injected into subcutaneous costal region of SCID mice(severe combined immunodeficiency mice)and BALB/c(nu/nu)nude mice.All tumor bearing mice were sacrified on 56th day after transplantation.The results indicate that CNE2L2 tranplanted into SCID mice is a highly metastatic variant which produced lymphatic metastasis in 100%(7/7)of the cases and lung metastasis in 71%(5/7)of the cases, while CNE2L4 transplanted...

Cloned CNE-2Z variants cells(CNE-2L2 and CNE2L4)in suspension form were injected into subcutaneous costal region of SCID mice(severe combined immunodeficiency mice)and BALB/c(nu/nu)nude mice.All tumor bearing mice were sacrified on 56th day after transplantation.The results indicate that CNE2L2 tranplanted into SCID mice is a highly metastatic variant which produced lymphatic metastasis in 100%(7/7)of the cases and lung metastasis in 71%(5/7)of the cases, while CNE2L4 transplanted into SCID mice is a low metastatic variant which produced lung metastasis in 13%(1/8)of the cases and no lymphatic metastasis is found.The results also indicate that SCID mice can benefit the expression of metastasis phenotype of the transplanted cells,and suggest that SCID mice can be a more suitable in vivo model compared to BALB/c(nu/nu)nude mice for study the cancer biological characters.This experiment also shows that the tumor cell number inoculated into subcutaneous costal region are related to the expression of metastasis phenotype higher rate of metastasis result from more numbers of cells transplanted subcutaneously.

将人类鼻咽癌不同克隆株的细胞悬液移植在严重联合免疫缺陷(SCID)小鼠和BALB/c(un/un)裸小鼠的颈背侧皮下,56d后处死全部动物进行观察。结果发现,在SCID小鼠体内移植后CNE2L2为高转移克隆株,其淋巴结转移率为100%,肺转移率为71%;而CNE2L4为低转移克隆株,其肺转移率为13%,淋巴结未见癌转移。这是从1个细胞母系中新筛选出的1个高转移和1个低转移的癌细胞克隆株。实验结果还显示,同BALB/c(un/un)裸小鼠相比,SCID小鼠的恶性表型的表达能力高。另外,皮下移植时肿瘤细胞的数量可能与转移表型的表达有相关性,移植的瘤细胞数越多,转移率越高,反之亦然。

 
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