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| | AIM To evaluate the injury of interventional thermotherapy on liver tissue at 60℃ through hepatic artery. METHODS 200 mL saline at 60℃ was perfused through hepatic artery in 30 minutes. Liver function was checked before perfusion and 1,3, 5 and 7 days after the perfusion. RESULTS DSA indicated a little dilation of hepatic artery and delayed image of hepatic parenchyma. ALT, AST became abnormal (ALT 10 times, AST 3 times ) after the perfusion but reversed in a week, while BIL, ALB, γ GT ind... | | 目的 研究 6 0℃灌注液经肝动脉行灌注性热疗后 ,肝功各项指标的变化情况 ,为临床灌注性热化疗提供安全数据 .方法 经犬肝动脉 (n=10 )灌注入 6 0℃生理盐水 2 0 0m L ,30 min灌完 .分别于灌注前及灌注后 1,3,5 ,7d检查肝功的动态变化情况 .结果 DSA示肝动脉扩张 ,肝实质显影延迟 ;AL T,AST于灌注后开始升高 (AL T 10倍、AST 3倍 ) ,之后逐渐恢复 ,1wk后全部恢复正常 ,而胆红素、白蛋白及 γ-GT则无明显变化 .结论 经肝动脉 6 0℃介入性热疗对肝脏损伤轻微 ,临床应用此温度下的灌注性热化疗是安全的 | | 文摘来源 | | Objective: This study was designed to investigate the influence of interventioinal thermotherapy at different temperature (45,50,55,60,65℃)on liver and kidney function of dog, intrahepatic temperature, and hepatic histology of dog Method: A total of 180 ml saline at different temperature(45, 50, 55, 60, 65℃) were respectively perfused through hepatic artery of a dog within 30 minutes. Changes of the liver and kidney function of the dog were observed by hepatic puncture pathological findings. Results: ... | | 目的:以犬为研究对象,研究不同温度(45℃,50℃,55℃,60℃,65℃)的热灌注液经肝动脉灌注对犬肝内温度、肝组织学及肝、肾功能的动态影响,为介入性热化疗的临床应用提供实验依据。方法:经犬肝动脉分别灌注入45℃、50℃、55℃、60℃、65℃生理盐水180 ml,持续30 min。观察并比较热灌注前后肝脏穿刺活检及肝、肾功能的动态变化情况。结果:1.45℃、50℃、55℃、60℃、65℃肝动脉热灌注时,肝内中心测得的温度分别为(37.9±0.5)℃、(38.6±0.3)℃、(40.5±0.3)℃、(42.1±0.5)℃和(45.8±0.6)℃,谷丙转氨酶(alanine aminotransferase,ALT)、谷草转氨酶(aspartate transaminase,AST)于60℃灌注后24 h开始升高,72 h达到高峰(P< 0.01),168 h后逐渐下降,216 h后恢复正常;总胆红素(total bilirubin,T-BIL)、白蛋白(albumin,ALB)、γ-谷氨酰基转移酶(γ-glutamyltransferase,γ-GT)无明显变化(P< 0.05)。2.肝组织可见一过性淋巴细... | | 文摘来源 | | Objective To evaluate the injury of interventional thermotherapy on Liver tissue at 60℃ throngh hepatic artery.Methods 200ml saline at 60℃ was perfused through hepatic artery in 30 minutes .Liver function and the biopsy of liver tissue were checked before and after perfusion .Results ALT, AST became abnormal after perfusion but recovered in a week, while BIL, ALB, γ GT indicated no significant changes at all. The biopsy of liver tissue also showed reversible changes.Conclusion Interventional... | | 目的 研究 6 0℃的灌注液经肝动脉行灌注性热疗后 ,肝脏活检及肝功各项指标的变化情况 ,为临床灌注性热化疗提供安全数据。方法 经犬肝动脉灌注入 6 0℃生理盐水 2 0 0 ml,30分钟灌完。比较灌注前后肝脏穿刺活检及肝功的动态变化情况。结果 谷丙、谷草转氨酶于灌注后开始升高 ,之后逐渐恢复 ,一周后全部恢复正常 ,而胆红素、白蛋白、γ- GT则无明显变化。肝脏活检也呈可逆性变化。结论 经肝动脉 6 0℃灌注液介入性热疗对肝脏损伤轻微 ,临床应用此温度下的灌注性热化疗是安全的。 | | 文摘来源 | |   | | << 更多相关文摘 |
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