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postmenopausal breast cancer
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  绝经后乳腺癌
     After further adjustment for BMI, weight gain since age 20 was significantly associated to an increased risk for postmenopausal breast cancer (RR = 1.61, 95% CI: 1.09-2.37).
     调整BMI后,20岁后体重增加会显著增加绝经后乳腺癌危险(RR=1.61,95%CI:1.09-2.37)。
短句来源
     nm23-H1 gene may take part in lymphatic metastasis in postmenopausal breast cancer patients.
     而nm23-H1可能参与绝经后乳腺癌的转移。
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     Results:E and P were found decreased and T and PRL increased in postmenopausal breast cancer patients.
     结果:与绝经前患者比较,绝经后乳腺癌患者P、T明显降低,LH、FSH水平升高,PRL变化不明显。
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     [Conclusion] p53 may play an role in the carcinogenesis of breast cancer in premenopausal patients by the regulation of endocrine system,and could promote lymphatic metastasis in postmenopausal breast cancer patients.
     [结论]p53可能参与绝经前妇女乳腺癌的发生,可能促进绝经后乳腺癌的转移;
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     Risk factors of endometrial polyps in postmenopausal breast cancer patients treated with tamoxifen
     绝经后乳腺癌患者服用他莫昔芬发生子宫内膜息肉危险因素的探讨
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  “postmenopausal breast cancer”译为未确定词的双语例句
     Comparison between transvaginal ultrasonographic and hysteroscopic endometrial findings in postmenopausal breast cancer tamoxifen-treated patients
     经阴道超声与宫腔镜检查诊断绝经后服用他莫昔芬妇女子宫内膜病变的比较
短句来源
     Objective To evaluate the efficacy and side effects of Levonorgestrel-releasing intrauterine device (LNG-IUD,Mirena) in the treatment of tamoxifen-stimulated endometrium lesions of postmenopausal breast cancer patients.
     目的 探讨释放左旋 18甲基炔诺酮宫内节育器 (LNG -IUD ,Mirena)对服用三苯氧胺的乳腺癌患者子宫内膜病变的疗效和不良反应。
短句来源
     Objective:To evaluate risk factors of endometrial polyps in postmenopausal breast cancer patients treated with tamoxifen.
     目的:探讨绝经后因乳腺癌服用他莫昔芬(TAM)与子宫内膜息肉发生的相关性。
短句来源
     Conclusion:Various factors,such as longer duration of tamoxifen treatment (>2 years) or larger cumulative tamoxifen dose(>15g),heavier body weight,may contribute to the development of endometrial polyps in postmenopausal breast cancer patients treated with tamoxifen.
     结论:肥胖,长期服用TAM超过2年或累计剂量超过15g是绝经后妇女服用TAM发生子宫内膜息肉的高危因素。
短句来源
     Methods Forty-six postmenopausal breast cancer patients receiving 20 mg/d TAM for at least six months were examined by hysteroscopy and endometrial biopsy,and eighteen age-matched,non-hormonally treated patients with atrophic endometrium post vaginal hysterectomy because of uterine prolapse served as control groups.
     方法选择46例绝经后因乳腺癌服用TAM超过6个月妇女的子宫内膜为研究组,同时选择18例绝经后妇女的萎缩型子宫内膜作为对照组。
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  相似匹配句对
     Letrozole in the treatment of postmenopausal advanced breast cancer.
     来曲唑治疗绝经后晚期乳腺癌临床观察
短句来源
     Exemestane in postmenopausal patients with advanced breast cancer
     依西美坦片治疗绝经妇女晚期乳癌的临床研究
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     A study on the effect of HRT to the breast in postmenopausal women
     激素替代疗法对绝经后妇女乳腺的影响
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     Arimidex for the Treatment of Advanced Breast Cancer in Postmenopausal Women
     瑞宁得治疗绝经后晚期乳腺癌分析
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     Lentaron for Postmenopausal Women with Advanced and Recurrent Breast Cancer
     兰他隆治疗绝经后晚期和复发性乳腺癌患者的疗效观察
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  postmenopausal breast cancer
Tamoxifen and megestrol acetate for postmenopausal breast cancer
      
Aim: To compare the effects of tamoxifen and megestrol acetate on liver proteins, androgens, and glucocorticoids during adjuvant treatment for postmenopausal breast cancer.
      
Background: In postmenopausal breast cancer (BC) patients, tamoxifen (TAM)is frequently used in first-line therapy, and for those relapsing under TAM,aromatase inhibitors would be the drug of choice.
      
Clinical efficacy and endocrine activity of vorozole in postmenopausal breast cancer patients.
      
Aim:We aimed to study the importance of erbB2 status in earlystage postmenopausal breast cancer for patients who participated in a trialof five vs.
      
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To clarify the relationship between the hormone levels in postmenopausal breast cancer patients and cancer growth and development,the influence and modulating effect of Yiqiyangxue herbs on the hormone levels.Methods:The expression levels of estriol(E 3),progesterone(P),testosterone(T),follicle stimulating hormone(FSH),luteotropic hormone (LH)and Prolactin(PRL)were studied with methods of RIA.Results:E and P were found decreased and T and PRL increased in postmenopausal breast cancer patients.The...

To clarify the relationship between the hormone levels in postmenopausal breast cancer patients and cancer growth and development,the influence and modulating effect of Yiqiyangxue herbs on the hormone levels.Methods:The expression levels of estriol(E 3),progesterone(P),testosterone(T),follicle stimulating hormone(FSH),luteotropic hormone (LH)and Prolactin(PRL)were studied with methods of RIA.Results:E and P were found decreased and T and PRL increased in postmenopausal breast cancer patients.The hormone levels of postmenopausal patients have changed after chemotherapy.Conclusion:Chemotherapy could influence the function of the endocrine system.Yiqiyangxue herbs could exert synergistic effects to chemotherapy in regulating the endocrine system.

目的:探讨绝经后乳腺癌患者内分泌功能变化及中药益气养血颗粒对它们的调节作用。方法:采用放射免疫分析法对82 例乳腺疾病患者的性激素孕酮(P)、雌三醇(E3)、睾酮(T) 和促性腺激素促卵泡生成素(FSH) 、促黄体生成素(LH)及催乳素(PRL) 进行检测研究,同时给予化疗和中药治疗。结果:与绝经前患者比较,绝经后乳腺癌患者P、T明显降低,LH、FSH水平升高,PRL变化不明显。与良性对照组比较,各激素水平明显异常。化疗后患者P降低,LH、FSH水平升高,T、PRL变化不明显,服用益气养血颗粒后P水平升高,T水平下降。结论:绝经后乳腺癌患者内分泌功能明显异常,化疗对绝经后患者的治疗作用同样对机体内分泌机制产生影响,益气养血颗粒对患者激素水平具有调节作用,与化疗对内分泌机制的影响具有协同作用。

Objective:We con du cted a prospective,nonrandomized study of a group of women with breast cancer w ith a baseline benign endometrium who were already on TAM or who were scheduled to start TAM and evaluated the endometrial pathology during following-up period .Methods:Patients were evaluated every6months with endometrial biopsy.Result s:Eighty women were enrolled and67patients were evaluated.The67patients ha d a total of200en-dometrial biopsy.Sixty patients still had normal endometr ium.Two premenopausal patients...

Objective:We con du cted a prospective,nonrandomized study of a group of women with breast cancer w ith a baseline benign endometrium who were already on TAM or who were scheduled to start TAM and evaluated the endometrial pathology during following-up period .Methods:Patients were evaluated every6months with endometrial biopsy.Result s:Eighty women were enrolled and67patients were evaluated.The67patients ha d a total of200en-dometrial biopsy.Sixty patients still had normal endometr ium.Two premenopausal patients had simple hyperplasia and the endometrium retu rn to normal after TAM discontinuted.One post-menopausal patient had complex hyperplasia with atypia.Another postmenopausal patient had mas-sive hemorrhag e and underwent operation,the endometrial pathology was proliferative polyp an d simple cysto-hyperplasia.Seven patients had endometrial polyp.Conclusion:T he result of this study shows that simple hyperplasia,complex hyperplasia and polyp can develop in the pre-and postmenopausal breast cancer patients with lon g time TAM treated.Endometrial carcinoma was not found in the group.Whether TAM stimulates the development of endometriosis is not clear.Ac-cording to th is study,endometriosis may be caused by TAM for a long time in the post-menop ausal patient.

目的:随访口服三苯氧胺的乳腺癌患者,观察在随访期内发生的子宫内膜病理改变类型。方法:80例乳腺癌患者口服三苯氧胺20mg/日,每隔6个月作双合诊检查及子宫内膜活体组织检查。结果:可评价患者共67例,共行200次子宫内膜活检,60例仍为正常子宫内膜表现,TAM应用中位持续时间30个月。2例绝经前患者子宫内膜活检表现为单纯性增生过长,1例绝经后患者表现为萎缩性子宫内膜与复合性增生过长并存,1例绝经后患者切除子宫,术后内膜病理表现为增生性息肉、单纯性囊性增生。7例患者发生子宫内膜息肉。结论:长期口服三苯氧胺在绝经前后患者中均能发生子宫内膜单纯性增生过长、复合性增生过长及息肉改变,未见有癌的发生。

The association between physical activity and site specific cancer risk is elaborated in relation to whether any dose response association between physical activity and cancer is observed and whether any possible mechanisms can be interpreted in the association. Observational studies in latter five years were reviewed that have examined the independent effect of the volume of occupational physical activity (OPA) and/or leisure time physical activity(LPA)on site specific cancer risk.The evidence of cohort...

The association between physical activity and site specific cancer risk is elaborated in relation to whether any dose response association between physical activity and cancer is observed and whether any possible mechanisms can be interpreted in the association. Observational studies in latter five years were reviewed that have examined the independent effect of the volume of occupational physical activity (OPA) and/or leisure time physical activity(LPA)on site specific cancer risk.The evidence of cohort and case control studies were reviewed with the confounding effects such as diet, body weight, and parity included as a covariate in the analyses.A protective effect of physical activity was observed in the majority of site specific cancer such as breast cancer, endometrial cancer, colon cancer and lung cancer. A crude graded inverse dose response effect of physical activity on breast cancer was suggested in 6 studies of 12 studies with a positive protective effect conclusion.This association between physical activity and breast cancer risk is possibly dependent on age at exposure, age at diagnosis, menopausal status and other effect modifiers, e.g., body mass index. An observed inverse association with a dose response relationship between physical activity and colon cancer was identified in the majority of the studies. No significant evidence of a protective effect between physical activity and prostate and testicular cancer was suggested in latter studies. Data concerning carcinoma of other cancers are required.A protective effect of physical activity on site specific cancer risk with a dose response association between physical activity and colon and pre and postmenopausal breast cancer supported by identified biological mechanisms has been observed. The complicated nature of the physical activity variable, combined with lack of knowledge regarding possible biological mechanisms operating between physical activity and cancer, warrants further studies including controlled clinical randomized trials.

运动与恶性肿瘤风险之间的联系是否存在可见的剂量反应关系,是否能阐明其生物学机制。将近五年的有关职业劳动和/或休闲体育活动对各种恶性肿瘤风险作用的观察性研究进行回顾,包括队列研究和病例对照研究。在回顾运动与恶性肿瘤风险联系的研究结果时,包括饮食、体重在内的各种混杂因素被标化,在此基础上发现运动对于乳腺癌、结肠癌、子宫内膜癌和肺癌等具有保护作用。在12项报道运动对乳腺癌具有保护作用的研究中有6项研究结果提示运动与乳腺癌之间呈负相关。这种联系可能依赖于患者的暴露年龄、诊断年龄、绝经状况和其他因素如体重指数等。负相关的剂量反应关系也出现在大部分的关于结肠癌的研究结果中。对于前列腺癌和睾丸肿瘤的研究没有提示运动对其具有保护作用。运动与其他肿瘤的联系尚需更多的研究资料。运动对乳腺癌和结肠癌具有保护作用,并呈负相关,这种联系的生物学机制也被发现。但运动的复杂多样性以及相关生物学机制的认识匮乏,决定了需要更多的临床随机对照的试验性研究。

 
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