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antiarrhythmic
相关语句
  抗心律失常
    STUDY ON SYNTHESIS AND ANTIARRHYTHMIC ACTIVITY OF DERIVATIVES OF 1,2,3,4-TETRAHYDROISOQUINOLINES AND 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINES
    1,2,3,4—四氢异喹啉和1—苄基—1,2,3,4—四氢异喹啉类衍生物的合成及其抗心律失常活性研究
短句来源
    Resolution of(±)Mexiletine—A New Antiarrhythmic Agent
    抗心律失常新药—(±)慢心律的拆分
短句来源
    The Actions of B_(7601),——A New Synthetic Anticholinergic Drug on Cardiovascular System and its Antiarrhythmic Effect
    新抗胆硷类药物—B_(7601)对心血管系统及抗心律失常作用的研究
短句来源
    PHARMACODYNAMIC ANALYSIS OF ANTIARRHYTHMIC AGENT GALLANILIDE (603)
    抗心律失常药棓酰苯胺(603)的药效动力学分析
短句来源
    SYNTHESIS OF ANTIARRHYTHMIC GALLANILIDEC603) DERIVATIVES
    抗心律失常药棓酰苯胺(603)衍生物的合成
短句来源
更多       
  抗心律失常
    STUDY ON SYNTHESIS AND ANTIARRHYTHMIC ACTIVITY OF DERIVATIVES OF 1,2,3,4-TETRAHYDROISOQUINOLINES AND 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINES
    1,2,3,4—四氢异喹啉和1—苄基—1,2,3,4—四氢异喹啉类衍生物的合成及其抗心律失常活性研究
短句来源
    Resolution of(±)Mexiletine—A New Antiarrhythmic Agent
    抗心律失常新药—(±)慢心律的拆分
短句来源
    The Actions of B_(7601),——A New Synthetic Anticholinergic Drug on Cardiovascular System and its Antiarrhythmic Effect
    新抗胆硷类药物—B_(7601)对心血管系统及抗心律失常作用的研究
短句来源
    PHARMACODYNAMIC ANALYSIS OF ANTIARRHYTHMIC AGENT GALLANILIDE (603)
    抗心律失常药棓酰苯胺(603)的药效动力学分析
短句来源
    SYNTHESIS OF ANTIARRHYTHMIC GALLANILIDEC603) DERIVATIVES
    抗心律失常药棓酰苯胺(603)衍生物的合成
短句来源
更多       
  抗心律失常药
    PHARMACODYNAMIC ANALYSIS OF ANTIARRHYTHMIC AGENT GALLANILIDE (603)
    抗心律失常药棓酰苯胺(603)的药效动力学分析
短句来源
    SYNTHESIS OF ANTIARRHYTHMIC GALLANILIDEC603) DERIVATIVES
    抗心律失常药棓酰苯胺(603)衍生物的合成
短句来源
    STUDIES ON ANTIARRHYTHMIC AGENTS, ⅡSYNTHESES OF 1-P-METHYLPHENYL-2-SUBSTITUTED TETRAHYDROISOQUINOLINE DERIVATIVES
    抗心律失常药研究Ⅱ——1-对甲苯基-2-取代四氢异喹啉衍生物的合成
短句来源
    SYNTHESIS OF ANALOGS OF BW A256C,A NOVEL ANTIARRHYTHMIC AGENT
    新型抗心律失常药BWA256C类似物的合成
短句来源
    ELECTROPHYSIOLOGICAL EFFECTS OF ANTIARRHYTHMIC DRUG UK-68798 ON DIFFERENT AV NODAL CELLS IN RABBIT HEART
    抗心律失常药UK-68798对家兔心脏房室结区不同细胞的电生理作用
短句来源
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  “antiarrhythmic”译为未确定词的双语例句
    ANTIARRHYTHMIC EFFECT OF 4-{3', 5'-BIS [(N-PYRRO LIDINYL)METHYL]-4'-HYDROXYANILINO} QUINAZOLINE (CHANGROLIN) ON ACONITINE-INDUCED ARRHYTHMIA IN RATS
    4-{3′,5′-双-[(N-吡咯烷基)甲基]-4′-羟苯胺基}喹唑啉(常咯啉)抗乌头硷诱发大鼠心律失常的作用
短句来源
    Antiarrhythmic action and α1-and α2-adrenoceptor blocking effect of β-MNDI
    β-萘甲基6,7二甲氧基异喹啉抗实验性心律失常及对α_1和α_2受体的阻断作用
短句来源
    Antiarrhythmic effects of 1-(2,6-dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino) propane hydrochloride during coronary artery occlusion and reperfusion in cats and rats
    1-(2,6-二甲基苯氧基)-2-(3,4-二甲氧基苯乙胺基)丙烷盐酸盐对麻醉猫、大鼠心肌缺血再灌注所致心律失常的作用
短句来源
    Antiarrhythmic effects of piperaquine phosphate in experimental arrhythmias
    磷酸喹哌抗实验性心律失常作用
短句来源
    ANTIARRHYTHMIC EFFICACY OF MORICIZINE HCI AND CLINICAL SIGNIFICANCE OF ITS SERUM CONCENTRATION
    盐酸莫雷西嗪临床疗效及血药浓度的临床意义
短句来源
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  antiarrhythmic
Preliminary administration of glibenclamide (0.3 mg/kg), an inhibitor of KATP channels, blocks the antiarrhythmic effect of DALDA and DPDPE.
      
The antiarrhythmic effect of the adaptation is mediated by stimulation of μ ORs and mitochondrial KATP channels.
      
The obtained data suggest that the antiarrhythmic and cytoprotective effects observed after δ-OR stimulation can be realized through the changes in Ca2+ transport at the level of the sarcoplasmic reticulum
      
The cardioprotective, inotropic, and antiarrhythmic effects of U-50.488, a selective agonist of κ1 opioid receptors (κ1 ORs), was studied using the model of 45-min total ischemia and 30-min reperfusion of isolated rat heart.
      
Diaryldihydropyrimidine-2-ones, a Prospective Group of Antiarrhythmic Agents
      
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Intravenous injections of changrolin followed by or concomitant with injections of aconitine could retard the onset of aconitineinduced arrhythmia. If changrolin was given after the onset of arrhythmia, the antiarrhythmic effect of changrolin would be weaker. Neither bilateral vagotomy nor intravenous injections of hexamethonium modified the antiarrhythmic effect of changrolin. The dose thresholds for ventricular premature beats, ventricular tachycardia and ventricular fibrillation during intravenous...

Intravenous injections of changrolin followed by or concomitant with injections of aconitine could retard the onset of aconitineinduced arrhythmia. If changrolin was given after the onset of arrhythmia, the antiarrhythmic effect of changrolin would be weaker. Neither bilateral vagotomy nor intravenous injections of hexamethonium modified the antiarrhythmic effect of changrolin. The dose thresholds for ventricular premature beats, ventricular tachycardia and ventricular fibrillation during intravenous infusion of aconitine at constant rate were all raised by a premedication of changrolin, and further augmented by a previous reserpinization. Administrations of changrolin into the lateral cerebral ventricle also retarded the onset of arrhythmia induced by a subsequent intracerebral introduction of aconitine.On the sciatic nerves of rats changrolin manifestated only a very mild local anaesthetic action, which was obviously different from that of lidocaine.

大鼠静注常咯啉再注射乌头硷,或同时用常咯啉和乌头硷,明显推迟乌头硷引起的心律紊乱。先静注乌头硷出现心律失常后,再注射常咯啉,抗心律失常作用较弱。剪断二侧迷走神经,或静注六烃季铵,都不影响常咯啉抗静注乌头硷所致心律失常的疗效。从静脉恒速注射乌头硷,记录室性早搏、室性心动过速和心室颤动阈值。预先静脉注射常咯啉明显提高这三种阈值。利血平化加常咯啉组,这些阀值也比对照组明显提高,与常咯啉组相比,仅显著提高心室颤动阈值。脑室内注射常咯啉后,再脑室内注射乌头硷,明显推迟心律失常出现时间。常咯啉对大鼠坐骨神经的局麻作用甚微,这与利多卡因有明显不同。

Changrolin, 4-{3′, 5′-Bis [(Pyrrolidinyl) methyl]-4′-Hydroxy-anilino} quinazoline, is an antiarrhythmic drug. Its intracellular distribution in myocardium of rabbits has been studied by differential centrifugation. The components of cells were fractionated into three parts, nuclear, mitochondrial and supernatant fraction. Most of the drug was found in the supernatant fraction. Next is the nuclear fraction. Physico-chemical studies demonstrate that the binding of Changrolin to the nuclear fraction is a...

Changrolin, 4-{3′, 5′-Bis [(Pyrrolidinyl) methyl]-4′-Hydroxy-anilino} quinazoline, is an antiarrhythmic drug. Its intracellular distribution in myocardium of rabbits has been studied by differential centrifugation. The components of cells were fractionated into three parts, nuclear, mitochondrial and supernatant fraction. Most of the drug was found in the supernatant fraction. Next is the nuclear fraction. Physico-chemical studies demonstrate that the binding of Changrolin to the nuclear fraction is a rather "physical" process. Part of the drug in the supernatant fraction has been proved to be associated with the cytoplasmic proteins.

常咯啉(4-{3′,5′-Bis[(N-pyrrolidinyl)metbyl]-4′-Hydroxyaniline}quinazoline)。是一个有效抗心律失常药 用差离心法研究了该药在家兔心肌亚细胞部位,核、线粒体和上清液三部分的分布。发现上清液部位药物分布最多,其次是核部分。各种物化试验证明,常咯啉分布到核部分似乎是一个“物理”过程。上清液中约6.8%药物和细胞浆蛋白结合。

Changrolin is 4-{3', 5'-bis [(N-pyrrolidinyl) methyl]-4'-hydroxyanilino}-quinazoline. It was found in our Institute to be a new antiarrhythmic drug. In anesthetized dogs, intravenous injection of 30 mg/kg (2mg/kg/min) did not cause a significant reduction of the total peripheral resistance, but the blood pressure, left ventricular systolic pressure and cardiac output were lowered significantly, The work of the left ventricle was weakened. A widening of the QRS complex and a prolongation of the P-R and...

Changrolin is 4-{3', 5'-bis [(N-pyrrolidinyl) methyl]-4'-hydroxyanilino}-quinazoline. It was found in our Institute to be a new antiarrhythmic drug. In anesthetized dogs, intravenous injection of 30 mg/kg (2mg/kg/min) did not cause a significant reduction of the total peripheral resistance, but the blood pressure, left ventricular systolic pressure and cardiac output were lowered significantly, The work of the left ventricle was weakened. A widening of the QRS complex and a prolongation of the P-R and Q-Tc intervals on EKG were observed. After cessation of the medication these indices tended to restore. Ghangrolin exhibited a cardio-vagal blocking effect but showed no adrenergic blocking action. Ouabain induced ventricular tachycardia in anesthetized dogs could be reverted to supra-ventricular or sinus rhythm, by intravenous drip of changrolin 4 mg/min for 120 minutes. This reversion occurred when the dose reached 4.5±2.1 mg/kg (±SD) while the concentration of changrolin in plasma was about 0.61±0.29 μg/ml. The concentration of changrolin in plasma rose to 0.89±0.23 μg/ml at 15 minutes and to 2.19±0.16 μg/ml at 120 minutes.The cardiovascular actions of changrolin were thus similar to that of quinidine.

常咯啉是我所发现的一个新的抗心律失常药。麻醉狗静注常咯啉30mg/kg(2mg/kg/min),对总外周血管阻力减低不显著,血压、左心室内收缩压和心输出量显著降低,左心室作功亦减弱。心电图出现QRS增宽,P-R和Q-Tc间期延长。但停药后一些指标能趋于回复。常咯啉具有心脏迷走神经阻滞作用,而无肾上腺素能受体的阻滞作用。麻醉狗静脉滴注4mg/min共120分钟,可使哇巴因所引起的室性心动过速转为室上性或窦性节律。常咯啉的有效剂量为4.5±2.1mg/kg((?)±SD),血浆中的有效浓度为0.61±0.29μg/ml。滴注15分钟血浆中的浓度升至0.89±0.23μg/ml,至120分钟为2.19±0.16μg/ml。本文结果提示常咯啉对心电图和血流动力学作用基本上与奎尼丁的作用相似。

 
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