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naproxen
相关语句
  萘普生
    Studies on the Pharmacokinetics of Naproxen
    国产萘普生体内动力学研究
短句来源
    A Study on Resolution Method of Naproxen Using The 1-threo-1- (p-Nitrophenyl) -2-Amino-1, 3-Propanediol as Resolution Agent
    萘普生的1-threo-1-对硝基苯基-2-氨基-1,-3-丙二醇拆分研究
短句来源
    PHARMACODYNAMIC STUDY OF NAPROXEN AND NAPROXEN SODIUM SUPPOSITORIES
    萘普生栓及萘普生钠栓的药效学研究
短句来源
    Study on the bioavailability of naproxen sodium and its pharmacokinetics in healthy volunteers
    萘普生钠片剂和胶囊剂生物利用度及药物动力学研究
短句来源
    ASSAY OF NAPROXEN SODIUM BY ULTRAVIOLET SPECTROPHOTOMETRY
    紫外分光光度法测定萘普生钠含量
短句来源
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  “naproxen”译为未确定词的双语例句
    Clinical evaluation of analgesic effect of naproxen/codeine tablet in open trial
    萘普待因镇痛效果开放试验临床评价
短句来源
    In conclusion, the proper proportion of these co-solvents, solubility of Naproxen should be more than 50mg/ml.
    选择适当配比的上述两种复合溶媒,其溶解量均在50mg/ml以上。
短句来源
    The biologic half-life of naproxen tablet and two suppositories were 13. 66±2. 53 h 15.11±2. 37 h;
    15.11±2.37h;
短句来源
    Aqueous solution of naproxen sodium has characteristic absorption peak at wave length 266nm, which was discovered in this experiment. Assay of naproxen sodium as the concentration of naproxen sodium range from 10μg/ml to 50μg/ml in agreement with the law of Beer. The correlation coefficient is 0.9996(γ=0.9996, P<0.01).
    本实验发现普生钠水溶液在波长266nm处有特征吸收峰,浓度在10μg/ml~50μg/ml符合Beer定律,γ=0.9996(P<0.01).
短句来源
    The time to maximum plasma concentration of naproxen for SR tablets and conventional tablets averaged (6.5±1.9) h, (2.3±0.8) h.
    缓释片与普通片的达峰时间(tmax)分别为(6.5±1.9)h和(2.3±0.8)h。
短句来源
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  naproxen
Study on the Binding Characteristic of S-Naproxen Imprinted Polymer and the Interactions between Templates and Monomers
      
S-naproxen imprinted polymer was prepared with acrylamide as a functional monomer, 1,4-butanediyl diacrylate as a new kind of crossliner, and 2,4,6-trimethylbenzoylphenyl-phosphinic acid ethyl ester as photoinitiator.
      
Binding experiments showed that the S-naproxen imprinted polymer had better recognition capability for the template than that of a blank polymer.
      
The adsorption distribution coefficient KD of S-naproxen on molecularly-imprinted polymer was 153.2 g/mL, and the separation factor was 1.95 when the initial concentration of substrate was 2.0 mmol/L.
      
The conditions are found for the alkalimetric determination of naproxen and ketoprofen with the end-point detection using thymol blue.
      
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This paper is to report our study on the effects of indomethacin, fenbufen, ksto profen, naproxen and doxamethasone on the number of leucocytes, the phagocytosis of macrophages and the intracellucar cAMP level in the peptone induced peritoneal exudate of mouse and on the comparison of thses drugs with dexametha-sone.Under therapeutic dosage, indomethacin and ketoprofen could significantly decrease the number of leucocytes in the exudate (P<0.01),but the effects of fenbufen and naproxen were of no...

This paper is to report our study on the effects of indomethacin, fenbufen, ksto profen, naproxen and doxamethasone on the number of leucocytes, the phagocytosis of macrophages and the intracellucar cAMP level in the peptone induced peritoneal exudate of mouse and on the comparison of thses drugs with dexametha-sone.Under therapeutic dosage, indomethacin and ketoprofen could significantly decrease the number of leucocytes in the exudate (P<0.01),but the effects of fenbufen and naproxen were of no statistical significance. Dexamethasone was also effective to reduce the leucocyte number (P<0.05). The four NSAIDs tested and dexamethasone all could inhibit both the percentage and index of the macro-phage phagocytosis in the exudate (P<0.01).The changes of cAMP in leucocytes were estimated with RIA- It was found that the intracellular cAMP level could be markedly increased by fenbufen (P<0.01)and ketoprofen (P<0.05).It seems that the anti-inflammatory effects of these drugs may be mediated partly through the elevated content of cAMP in leucocytes.

本实验研究了消炎痛、芬布芬、酮布洛芬、萘普生及地塞米松对小白鼠腹腔渗出液白细胞数量和巨噬细胞吞噬功能的影响。在治疗剂量下,消炎痛和酮布洛芬均使渗出液中白细胞数量显著地减少(P<0.01);芬布芬和萘普生虽有减少,但无统计学意义;地塞米松亦有效地使白细胞减少(P<0.05)。所试药物均显著地抑制巨噬细胞的吞噬功能,降低吞噬率(P<0.01)和吞噬指数(P<0.01)。此外还用放射免疫测定法测定了细胞内cAMP含量的变化,芬布芬和酮布洛芬显著地增加细胞内cAMP含量(P<0.05)。这提示其抗炎作用可能部分通过细胞内cAMP含量的升高而介导的。

Naproxen has been resolved from dl-2-(6-methoxy-2-Naphthyl) propionic acid by 1-threo-1(p-Nitro phenyl)-2-amino-1, 3-propanediol. The resolution yield in a single run is 25~28%. [α] D: more than+62~0(c=1/100, CHCl~3).Result showed that The proportion of the resolntion agent to racemic mixture and temperature condition is important factor on the resolution yields and optical purity.

作者用生产氯霉素的中间体—左旋氨基醇拆分d1-2-(6-甲氧基-2-萘基丙酸,首次成功地得到(+)-s-2-(6-甲氧基-2-萘基)丙酸即萘普生(Naproxen)。并研讨了温度、拆分剂用量等因素对拆分的影响。

This primarily report is to deal with the solubility and stability of Naproxen in the solutions of different basic substance arid solubility in defferent solvents and co-solvents, we draw some graphs of solubilization phases of Naproxen in the system of PEG400, alcohol, water and in the system of PEG400, Dimethy sulfoxide and waster. It may be helpful to select satisfied proportion of co-solvent and determine what degree can be diluted. In conclusion, the proper proportion of these co-solvents, solubility...

This primarily report is to deal with the solubility and stability of Naproxen in the solutions of different basic substance arid solubility in defferent solvents and co-solvents, we draw some graphs of solubilization phases of Naproxen in the system of PEG400, alcohol, water and in the system of PEG400, Dimethy sulfoxide and waster. It may be helpful to select satisfied proportion of co-solvent and determine what degree can be diluted. In conclusion, the proper proportion of these co-solvents, solubility of Naproxen should be more than 50mg/ml.

本文对萘普生在不同碱性药物的溶液中的溶解性能和稳定性以及在不同溶媒和复合溶媒的溶解性能进行了初步的研究。绘制了萘普生在聚乙二醇_(400)、乙醇、水系统和在二甲基亚砜、PEG400、水系统中的助溶相图,对选择合理的复合溶媒配比,了解溶液的可稀释程度具有一定的指导意义。选择适当配比的上述两种复合溶媒,其溶解量均在50mg/ml以上。

 
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