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substitute load
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The detailed structure of spectrum of atmospheric tides is obtained by the spectral analysis-and harmonic analysis from the microbarograph records in 1984 and 1985 years in Ta-Yuan region in Beijing. Substituting load Love numbers for tidal Love numbers and following relative formula of earth tides, the expressions of crustal strain and tilt resulted from atmospheric tides are derived. Using the tidal water level data in Ta-Yuan well in conjunction with barometric data in situ, the influence of barometric...

The detailed structure of spectrum of atmospheric tides is obtained by the spectral analysis-and harmonic analysis from the microbarograph records in 1984 and 1985 years in Ta-Yuan region in Beijing. Substituting load Love numbers for tidal Love numbers and following relative formula of earth tides, the expressions of crustal strain and tilt resulted from atmospheric tides are derived. Using the tidal water level data in Ta-Yuan well in conjunction with barometric data in situ, the influence of barometric pressure variations on water level in the well is analysed. The results of theoretic calculation are basically consistent with that analysed observations, especially, both results give that cubic dilatation of the crust produced by the atmospheric S2 tide is about 20 per cent of S2 tidal cubic dilatation.

根据北京塔院地区1984和1985年的微气压计记录采用频谱分析和调和分析两种方法得出了大气潮谱的详细结构;用负荷勒甫数代替潮汐勒甫数,仿照固体潮的有关公式,导出了大气潮引起的地壳应变和地倾斜公式;使用北京塔院井的水位观测资料结合当地的气压资料,分析了气压变化对深井水位的影响.理论计算和实测资料的分析结果基本相符,特别是两种结果都得出S_2大气潮引起的体膨胀约为S_2固体潮体膨胀的20%.

Objective:To study the new method of osteochondral autografts.Methods:Making 32 white healthy bigear adult rabbits as animal models,by the wedgeshaped with thick layers on osteochondral grafts,to finish unloaded cartilages substituted loaded cartilages.Results:The grafted cartilages can firmly unionize with their recepters,both the space and activity of cartilages being normal,the newly born cartilage tending to be normal.The result of the measurement of tritated thymidin incorporation those no obvious...

Objective:To study the new method of osteochondral autografts.Methods:Making 32 white healthy bigear adult rabbits as animal models,by the wedgeshaped with thick layers on osteochondral grafts,to finish unloaded cartilages substituted loaded cartilages.Results:The grafted cartilages can firmly unionize with their recepters,both the space and activity of cartilages being normal,the newly born cartilage tending to be normal.The result of the measurement of tritated thymidin incorporation those no obvious dedine of cartilage cells activity.Conclusion:Its resurfacing articular cartilage defects with unloaded cartilages substituted loaded cartilages is reliable.Therefore a new method is offered to the material choice of articular cartilage grafts.

目的:探讨自体骨软骨移植取材的新方法。方法 :选用健康成年大耳白兔32只 ,用楔形带厚层骨的骨软骨移植方法 ,取自体非负重区软骨替代负重区软骨进行修复试验。结果 :移植的软骨与受区牢固愈合 ,关节间隙正常 ,关节活动度正常 ,新生软骨为透明软骨。3H -胸腺嘧啶掺入法测试 :软骨细胞活性无明显降低。结论 :自体非负重区软骨替代负重区软骨修复关节软骨缺损疗效肯定 ,在关节软骨移植取材方面提供了新方法。

Objective To evaluate the effectiveness of the tissue-engineered bone substitute loaded with adenovirus mediated human bone morphogenetic protein-2 gene (Adv-hBMP-2)transfected bone marrow derived mesenchymal stem cells(BMSC)in the repair of diaphyseal segmental bone defect of large animal. Methods The right tibial bone defects (2.6 cm) model of 26 goats were established and divided into 5 groups: I.Adv-hBMP-2 transfected BMSC/calcined bone(CB) group ( n =9); II.adenovirus-β-galactosidase (Adv-βgal) gene...

Objective To evaluate the effectiveness of the tissue-engineered bone substitute loaded with adenovirus mediated human bone morphogenetic protein-2 gene (Adv-hBMP-2)transfected bone marrow derived mesenchymal stem cells(BMSC)in the repair of diaphyseal segmental bone defect of large animal. Methods The right tibial bone defects (2.6 cm) model of 26 goats were established and divided into 5 groups: I.Adv-hBMP-2 transfected BMSC/calcined bone(CB) group ( n =9); II.adenovirus-β-galactosidase (Adv-βgal) gene transfected BMSC/CB group ( n =6); III.untransfected BMSC/CB group ( n =6); IV.single CB group ( n =3); VI.untreated group ( n =2). The above tissue-engineered bone substitutes were implanted in the bone defects respectively except group VI. Roentgenography, histomorphometrical analysis and biomechanical measurement were studied at various times. Results X-ray: at 4~8 th weeks after implantation, more bony callus was found in the bone defects of group I. The complete healing rates of group I, II, III, IV, and V were 5/8, 1/5, 0/5, 0/2, 0/1 respectively at 26 th week after implantation. Histomorphometrical analysis showed much more new bony callus including cortical bone formed in group I than those of other groups. The compression strength of the implanted bone substitute of group I is significantly higher than those of group II and III. Conclusion The tissue-engineered bone substitute loaded with human BMP-2 gene transfected BMSC can repair diaphyseal segmental bone defect of large animal (goat).

目的 评价腺病毒介导的人骨形态发生蛋白 2 (Adv hBMP 2 )基因转染的组织工程化人工骨对大动物长骨干骨缺损的修复效果。方法 建立羊胫骨干骨缺损模型 (2 .6cm) ,单侧 (右 )植入体外构建的组织工程化骨 ,2 6只羊分为 5组 :(1)Adv hBMP 2转染的骨髓间充质干细胞 (BMSC)加煅烧骨 (CB)组 (9侧 ) ;(2 )腺病毒介导的 β 半乳糖苷酶 (Adv βgal)基因转染的BMSC加CB组 (6侧 ) ;(3)未转染的BMSC加CB组 (6侧 ) ;(4)单纯CB组 (3侧 ) ;(5 )未治疗组 (2侧 )。分期行X线、计量组织学检查和生物力学测定。结果 X线 :4~ 8周 ,Adv hBMP 2转染组的羊胫骨干骨缺损内有明显骨痂形成 ;2 6周 ,(1)、(2 )、(3)、(4)和 (5 )组的完全愈合率 ,分别为 5 / 8、1/ 5、0 / 5、0 / 2、0 / 1。计量组织学示 ,与其他组相比 ,1组的新生骨量最多 ,并有皮质骨形成 ;第 1组移植骨的压缩载荷和弹性模量明显大于其他各组。结论 hBMP 2基因修饰的组织工程化人工骨可以修复大动物 (羊 )负重骨 ...

目的 评价腺病毒介导的人骨形态发生蛋白 2 (Adv hBMP 2 )基因转染的组织工程化人工骨对大动物长骨干骨缺损的修复效果。方法 建立羊胫骨干骨缺损模型 (2 .6cm) ,单侧 (右 )植入体外构建的组织工程化骨 ,2 6只羊分为 5组 :(1)Adv hBMP 2转染的骨髓间充质干细胞 (BMSC)加煅烧骨 (CB)组 (9侧 ) ;(2 )腺病毒介导的 β 半乳糖苷酶 (Adv βgal)基因转染的BMSC加CB组 (6侧 ) ;(3)未转染的BMSC加CB组 (6侧 ) ;(4)单纯CB组 (3侧 ) ;(5 )未治疗组 (2侧 )。分期行X线、计量组织学检查和生物力学测定。结果 X线 :4~ 8周 ,Adv hBMP 2转染组的羊胫骨干骨缺损内有明显骨痂形成 ;2 6周 ,(1)、(2 )、(3)、(4)和 (5 )组的完全愈合率 ,分别为 5 / 8、1/ 5、0 / 5、0 / 2、0 / 1。计量组织学示 ,与其他组相比 ,1组的新生骨量最多 ,并有皮质骨形成 ;第 1组移植骨的压缩载荷和弹性模量明显大于其他各组。结论 hBMP 2基因修饰的组织工程化人工骨可以修复大动物 (羊 )负重骨 (胫骨 )的节段性缺损。

 
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