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polymeric immunoglobulin
相关语句
  多聚免疫球蛋白
     Expression of Polymeric Immunoglobulin Receptor (PIGR/SC) in the Tumor Tissues and the Plasma Levels of Lung Cancer Patients
     多聚免疫球蛋白受体(PIGR/SC)的肺癌组织表达和血浆水平分析研究
短句来源
     Human immortal epithelial cell line-Hacat cells without expression of CR2(complement receptor 2, CR2) and polymeric immunoglobulin receptor(pIgR) were co-cultivated with marmoset lymphocyte line-B95-8 cells producing EBV for infection by cell-to-cell contacting.
     选用产EB病毒的绒猴淋巴细胞B95-8系和补体受体2型(complementreceptor2,CR2)与多聚免疫球蛋白受体(polymericimmunoglobulinreceptor,pIgR)表达阴性的人永生化上皮细胞Hacat系共培养,进行细胞接触感染实验。
短句来源
     Objective To study the gene expression profile of human polymeric immunoglobulin receptor gene (hpIgR)-transfected mouse nasopharyngeal epithelial cells transformed with n, n'-dinitrosoperazine (TMNE) before and after EBV infection using cDNA array and investigate the role of Epstein-Barr virus (EBV) infection in the tumorigenesis of nasopharyngeal carcinoma (NPC).
     目的应用cDNA阵列技术研究转染人多聚免疫球蛋白受体(hpIgR)的二亚硝基哌嗪(n, n'-dinitrosoperazine, DNP)转化的小鼠鼻咽上皮(TMNE)细胞系在EBV感染前后基因表达谱差异,探索EBV在鼻咽癌发病过程中的作用及鼻咽癌的发病机制。
短句来源
     Establishment of transgenic mouse models carrying human polymeric immunoglobulin receptor gene
     人多聚免疫球蛋白受体转基因鼠的建立
短句来源
     BACKGROUND & OBJECTIVE: Polymeric immunoglobulin receptor (pIgR) gene plays a central role in immune response, and is closely related to Epstein-Barr virus (EBV) infection. Therefore, it is an ideal candidate gene for research on genetic susceptibility of nasopharyngeal carcinoma (NPC).
     背景和目的:多聚免疫球蛋白受体(polymericimmunoglobulinreceptor,pIgR)基因在机体免疫应答过程中发挥重要作用,并且与EB病毒(Epstein鄄Barrvirus,EBV)的感染途径密切相关,因而是研究鼻咽癌(nasopharyngealcarcinoma,NPC)遗传易感性的理想候选基因。
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  “polymeric immunoglobulin”译为未确定词的双语例句
     The mutation of mismatch repair genes is also reported to be related to this process. We selected four genes which have significant different expression in cancer tissue compared to normal tissue from differentially expressed 86 genes by methods of suppression subtractive hybridization combined with cDNA microarray. They are gene of heat shock lOkDa protein 1 (HSPE1 HSP10) , SRY-box9 (SOX9), polymeric immunoglobulin receptor ( PIGR) and eukaryotic translation elongation factor 1 delta , EEF1 —delta.
     我们利用抑制性消减杂交结合cDNA芯片技术,筛选出86个差异表达的基因片段,选择其中四个基因,分别为heat shock 10kDa protein 1(HSPE1 HSP10)基因、SRY-box9(SOX9)基因、polymeric immunoglobulin receptor(PIGR)和真核细胞延长因子—1 delta(eukaryotic translation elongation factor1 delta,EEF1—delta)基因。
短句来源
     Difference in gene expression profile of human polymeric immunoglobulin receptor-transfected mouse nasopharyngeal epithelial cells before and after EBV infection
     转染人pIgR的小鼠鼻咽上皮细胞在EBV感染前后基因表达谱差异
短句来源
  相似匹配句对
     The Polymeric Effect
     高分子效应
短句来源
     Polymeric Flocculants
     高分子絮凝剂
短句来源
     Correlation of Polymeric Immunoglobulin Receptor Gene Polymorphisms to Susceptibility of Nasopharyngeal Carcinoma
     多聚免疫球蛋白受体基因的多态性与鼻咽癌易感性的关系
短句来源
     Establishment of transgenic mouse models carrying human polymeric immunoglobulin receptor gene
     人多聚免疫球蛋白受体转基因鼠的建立
短句来源
     Immunoglobulin Gene Superfamily
     免疫球蛋白基因超家族
短句来源
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  polymeric immunoglobulin
The polymeric immunoglobulin receptor (PIGR) mediates transport of IgA and IgM antibodies across mucosal and glandular epithelia.
      
Down-regulation of the polymeric immunoglobulin receptor in non-small cell lung carcinoma: correlation with dysregulated express
      
Characterization of the human polymeric immunoglobulin receptor(PIGR) 3'UTR and differential expression ofPIGR mRNA during colon
      
The polymeric immunoglobulin receptor (pIgR) transports dimeric IgA (dIgA) across epithelial cells lining mucosal and glandular tissues, including the mammary gland.
      
Corrigendum - Over-expression of the murine polymeric immunoglobulin receptor gene in the mammary gland of transgenic mice
      
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Objective To establish transgenic mouse models carrying human polymeric immunoglobulin receptor (pIgR) gene to render the mice prone to EBV infection in normal condition, thereby to facilitate the study of the role of Epstein-Barr virus (EBV) in the pathogenesis of nasopharyngeal carcinoma. Method By means of microinjection, pIgR gene under the regulation by kerotinocyte-specific promoter ED-L2 was introduced into the pronuclei of mouse zygote, which was transferred into pseudo- pregnant...

Objective To establish transgenic mouse models carrying human polymeric immunoglobulin receptor (pIgR) gene to render the mice prone to EBV infection in normal condition, thereby to facilitate the study of the role of Epstein-Barr virus (EBV) in the pathogenesis of nasopharyngeal carcinoma. Method By means of microinjection, pIgR gene under the regulation by kerotinocyte-specific promoter ED-L2 was introduced into the pronuclei of mouse zygote, which was transferred into pseudo- pregnant female mice to induce nasopharynx-specific pIgR expression in the founder mice. Result Six out of the 16 founder mice (37.5%) was tested by PCR to be pIgR-positive, while Southern blotting identified only 2 positive mice. Conclusion Transgenic mice harboring pIgR gene can be used potentially as a new model for studying the pothogenesis of nasopharyngeal carcinoma by EBV.

目的构建携带有多聚免疫球蛋白受体(pIgR)的转基因鼠,使其能以近乎自然的状态感染EBV,观察EBV在鼻咽部病变过程中的作用。方法采用角质上皮特异性启动子ED-L2调控的pIgR基因,用显微注射方法将其导入受精卵中,使该基因能在F0代转基因鼠鼻咽部特异性表达。结果PCR检测F0代pIgR基因阳性率达37.5%(6/16),Southern杂交F0代pIgR基因阳性率为12.5%(2/16)。结论表达多聚免疫球蛋白受体的转基因动物有望成为研究EBV病毒致病机制的一种新的动物模型。

Human immortal epithelial cell line-Hacat cells without expression of CR2(complement receptor 2, CR2) and polymeric immunoglobulin receptor(pIgR) were co-cultivated with marmoset lymphocyte line-B95-8 cells producing EBV for infection by cell-to-cell contacting. After a week, all the B95-8 cells were removed to keep only Hacat cells, and an ameliorated method was applied to determine whether the former was eradicated or not. When there were no contaminated B95-8 cells in those residual Hacat cells, EBV...

Human immortal epithelial cell line-Hacat cells without expression of CR2(complement receptor 2, CR2) and polymeric immunoglobulin receptor(pIgR) were co-cultivated with marmoset lymphocyte line-B95-8 cells producing EBV for infection by cell-to-cell contacting. After a week, all the B95-8 cells were removed to keep only Hacat cells, and an ameliorated method was applied to determine whether the former was eradicated or not. When there were no contaminated B95-8 cells in those residual Hacat cells, EBV infection was detected and confirmed by Polymerase Chain Reaction (PCR) and in situ Hybridization(ISH), respectively. The results showed that the ameliorated method was sensitive, simple and convenient for detecting the contamination of B95-8 cells, and the Hacat cells can be effectively infected by EBV when co-cultivated with B95-8 cells, suggesting that there is a new pathway other than cell-to-cell fusing and CR2 or pIgR mediating for EBV to infect epithelial cells. This study simplified the method of infection via cell-to-cell contacting, and laid the foundation for establishing the model with EBV to spontaneously and effectively infect epithelial cells.

选用产EB病毒的绒猴淋巴细胞B95-8系和补体受体2型(complementreceptor2,CR2)与多聚免疫球蛋白受体(polymericimmunoglobulinreceptor,pIgR)表达阴性的人永生化上皮细胞Hacat系共培养,进行细胞接触感染实验。一周后去除B95-8细胞,仅留Hacat细胞,并以自行改进的方法鉴定前者是否得以彻底去除。在证实没有B95-8残留后,PCR和原位杂交分别检验剩余Hacat细胞中EB病毒的感染结果。实验结果表明:改进的方法能够灵敏和简便地判断B95-8细胞的污染与否,并且与B95-8细胞接触共培养的Hacat细胞能被EB病毒有效地感染,后者暗示了EB病毒对上皮细胞可能存在细胞融合和CR2或pIgR介导之外新的感染途径。本研究在一定程度上简化了前人的细胞接触感染方法,也为建立天然的EB病毒自发有效地感染上皮细胞的模型奠定了基础。

Objective To study the gene expression profile of human polymeric immunoglobulin receptor gene (hpIgR)-transfected mouse nasopharyngeal epithelial cells transformed with n, n'-dinitrosoperazine (TMNE) before and after EBV infection using cDNA array and investigate the role of Epstein-Barr virus (EBV) infection in the tumorigenesis of nasopharyngeal carcinoma (NPC). Methods The total RNAs of hpIgR-transfected TMNE cells before and after EBV infection were extracted, reversely transcribed, and labeled...

Objective To study the gene expression profile of human polymeric immunoglobulin receptor gene (hpIgR)-transfected mouse nasopharyngeal epithelial cells transformed with n, n'-dinitrosoperazine (TMNE) before and after EBV infection using cDNA array and investigate the role of Epstein-Barr virus (EBV) infection in the tumorigenesis of nasopharyngeal carcinoma (NPC). Methods The total RNAs of hpIgR-transfected TMNE cells before and after EBV infection were extracted, reversely transcribed, and labeled with α -32P-dATP. The cDNA probes were hybridized to the AtlasTM mouse cancer array 1.2, and the signals analyzed by AtlasImageTM software. Results Twenty-five genes differentially expressed in cells before and after EBV infection, including 23 up-regulated genes and 2 down-regulated genes. Conclusions The gene expression profile of hpIgR-transfected TMNE cells may change after EBV infection, suggesting that these genes are probably involved in the tumorigenesis and progression of NPC.

目的应用cDNA阵列技术研究转染人多聚免疫球蛋白受体(hpIgR)的二亚硝基哌嗪(n, n'-dinitrosoperazine, DNP)转化的小鼠鼻咽上皮(TMNE)细胞系在EBV感染前后基因表达谱差异,探索EBV在鼻咽癌发病过程中的作用及鼻咽癌的发病机制。方法提取转染hpIgR 的TMNE细胞在EBV感染前后的总RNA,逆转录成α-32P-dATP标记的cDNA探针,与AtlasTM mouse cancer array 1.2 阵列膜进行杂交。利用AtlasImageTM 软件分析基因表达差异。结果共有25个基因表达水平发生了改变,有23个基因表达上调,2个基因表达下调。结论EBV感染可使转染细胞的多个基因表达发生改变,这些基因可能与鼻咽癌的发生、发展有关。

 
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