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obligatory carrier
相关语句
  肯定携带者
     Subjects: 43 cases 21-OHD patients (SW 8 cases, SV 26 cases, NC 21OHD 8 cases), 33 cases of obligatory carrier (parents of patients) and 20 normal controls.
     对象:43例21—OHD病人,包括9例失盐型病人,26例单纯男性化病人,8例非经典型病人。 另有肯定携带者(患者父母)33例,正常对照20例。
短句来源
     Method:33 obligatory carrier of 21-OHD and 34 normal controls were studied as following: CYP21 gene was amplified into fragment 1(exon1→exon3) and fragment 2(exon3→exon10) through gene specific PCR with specific primers.
     方法33例肯定携带者及34例正常对照者基因组DNA作模板,用特定引物特异性扩增CYP21成两个片段,片段1从Exon1→Exon3,片段2从Exon3→Exon10。
短句来源
     Basal serum 17-OHP of obligatory carrier was 1.9±1.25 ng/ml for female, 2.58±1.36 ng/ml for male.
     肯定携带者17-羟孕酮(17-OHP)基础值女性为1.90±1.25ng/ml,男性为2.58±1.36ng/ml。
短句来源
  “obligatory carrier”译为未确定词的双语例句
     Basal serum 17-OHP level of obligatory carrier is higher than normal value and serum cortisol level is not significantly different from normal value.
     血清17-OHP均值显著高于正常均值。 血清F与正常均值无显著差异,血清F与血清17-OHP显著相关。
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  相似匹配句对
     The Carrier
     浅谈催化反应中活性组分的载体
短句来源
     Identification of the carrier
     承运人识别的法律问题
短句来源
     On the features of obligatory adjunct
     试论必具性附加状语的特征
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Objective:The corrective surgery and psychological counseling in treatment of classical 21-OHD has relationship with rehabilitation medicine.Therefore,a gene specific polymerase chain reaction(PCR) test was developed to investigate characteristics of CYP21 mutations in Chinese carrier of 21-hydroxylase deficiency.Method:33 obligatory carrier of 21-OHD and 34 normal controls were studied as following: CYP21 gene was amplified into fragment 1(exon1→exon3) and fragment 2(exon3→exon10) through gene specific...

Objective:The corrective surgery and psychological counseling in treatment of classical 21-OHD has relationship with rehabilitation medicine.Therefore,a gene specific polymerase chain reaction(PCR) test was developed to investigate characteristics of CYP21 mutations in Chinese carrier of 21-hydroxylase deficiency.Method:33 obligatory carrier of 21-OHD and 34 normal controls were studied as following: CYP21 gene was amplified into fragment 1(exon1→exon3) and fragment 2(exon3→exon10) through gene specific PCR with specific primers. Second round PCRs were carried out using fragment 1 and 2 as template, and PCR products were digested by restrictive enzymes to analyze mutations.Result:The most frequent mutation in 26 cases of 21-OHD was I172N(19.2%),i2g(13.5%)and Del(11.5%).Basal serum 17-OHP of obligatory carrier was 1.9±1.25 ng/ml for female, 2.58±1.36 ng/ml for male. Serum cortisol level was 13.60±4.49μg/dl and 12.2±6.27μg/dl for female and male respectively.Conclusion:This is the first report about genotype of Chinese carriers of 21-OHD.The most frequent mutation in Chinese obligatory carriers of 21-OHD is I172N,i2g and Del.Basal serum 17-OHP level of obligatory carrier is higher than normal value and serum cortisol level is not significantly different from normal value.

目的经典型21-羟化酶缺乏症(21-hydroxylasedeficiency,21-OHD)患者假两性畸形的手术矫形和心理治疗均与康复医学相关,通过研究中国人21-OHD携带者基因突变和临床表型特点有利于该病的防治。方法33例肯定携带者及34例正常对照者基因组DNA作模板,用特定引物特异性扩增CYP21成两个片段,片段1从Exon1→Exon3,片段2从Exon3→Exon10。用片段1和片段2为模板进行第二轮PCR,用特定限制性内切酶消化后经琼脂糖凝胶电泳鉴定突变。结果26例肯定携带者中最常见的突变为I172N(19.2%),i2g(13.5%)和Del(11.5%)。肯定携带者17-羟孕酮(17-OHP)基础值女性为1.90±1.25ng/ml,男性为2.58±1.36ng/ml。血清皮质醇女性为13.60±4.49μg/dl,男性为12.2±6.27μg/dl。结论中国人21-OHD携带者最常见的突变为I172N、i2g和Del。血清17-OHP均值显著高于正常均值。血清F与正常均值无显著差异,血清F与血清17-OHP显著相关。

 
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