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intracorporal process
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     This paper summarizes the mechanism of action,intracorporal process,antibiogram,resistance to drugs,clinical applications,untoward effects,medications and contraindications of Norfloxacin.
     对诺氟沙星的作用原理、体内过程、抗菌作用、耐药性、临床用途、不良反应、投药方法、用药注意事项等进行综述
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     CONCLUSION: After oral administration of volatile oil,intracorporal process of ligustilide in rabbit accords with 2-compartment model with 1 st order absorption,(2.6638) h and 108.88 h are obtained as t_(1/2α) and t_(1/2β) respectively.
     结论:兔口服当归挥发油后,藁本内酯在体内的药时过程为线性动力学过程,符合一级吸收二室模型,t1/2α为2.6638 h,t1/β为108.88 h。
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     m process.
     m工艺到SMIC流片。
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     In the process of the E.
     E.
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     STUDY ON THE INTRACORPORAL LEVELS OF SELENIUM IN PATIENTS WITH LARGE
     大肠癌患者体内硒水平的研究
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     Synthesis of JM221 and the Effect on Its Intracorporal and Extrinisic Antineoplastic Activity
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     Comparison of the effect of ureteral stents of extracorporeal and intracorporal drainage in renal transplantation
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This paper summarizes the mechanism of action,intracorporal process,antibiogram,resistance to drugs,clinical applications,untoward effects,medications and contraindications of Norfloxacin.

对诺氟沙星的作用原理、体内过程、抗菌作用、耐药性、临床用途、不良反应、投药方法、用药注意事项等进行综述

AIM: To study the pharmacokinetics of β Asarone in the volatile oil from Acorus. Tatarinowii Schott. in mice. METHODS: We developed a GC method for β Asarone determination in blood. The GC system consisted of HP 35 capillary column with Helium as carrier gas, oven starting temperature set at 30℃ , then was raised to 220℃ at a rate of 6℃/min , stayed for 5 minutes, injector temperature set at 250℃ , detector temperature at 320℃ . Injection volume was 2.0 μL with splitless inject mode....

AIM: To study the pharmacokinetics of β Asarone in the volatile oil from Acorus. Tatarinowii Schott. in mice. METHODS: We developed a GC method for β Asarone determination in blood. The GC system consisted of HP 35 capillary column with Helium as carrier gas, oven starting temperature set at 30℃ , then was raised to 220℃ at a rate of 6℃/min , stayed for 5 minutes, injector temperature set at 250℃ , detector temperature at 320℃ . Injection volume was 2.0 μL with splitless inject mode. Methanol was used as solvent and α naphthol as interior standard substance. CONCLUSION: The calibration curve in blood was linear in the range of 0.04μg/ml to 40μg/ml . The minimum detection limit was 0.04μg/ml . The recovery for β Asarone in blood was 95.3% with RSD 3.92% . After oral administration of volatile oil from Acorus. Tatarinowii Schott., the intracorporal process of β Asarone in mice accorded with 2 compartment model with 1st order absorption. 6.5min and 93.6min were obtained as t 1/2α and t 1/2β respectively.

目的 :研究石菖蒲挥发油中 β 细辛醚在小鼠体内的药物代谢动力学。 方法 :采用气相色谱法测定 β 细辛醚的血药浓度 ,色谱柱 :HP 35毛细管气相色谱柱 (内径 :0 .2 5mm ;长 :30m ;涂膜厚 :0 .2 5 μm) ;程序升温 :起始温度为 30℃ ,6℃ /min升至 2 2 0℃ ,保持 5min ;进样口温度 ;2 5 0℃ ;检测器温度 :32 0℃ ;进样量 :2 .0 μL;无分流进样 ;溶剂 :甲醇 ;载气 :氦气 ;柱头压 :5 .5× 1 0 4帕斯卡 ;内标物 :a 萘酚。结果与结论 :建立了用气相色谱法测定β 细辛醚血药浓度的方法 ,β 细辛醚与内标物的峰面积之比 (Y)与浓度 (C)之间的回归方程为 :Y =0 .0 1 889C +1 .75 5× 1 0 -3 (n =6 ,r =0 .9999)。线性范围 :0 .0 4 μg·mL-1 - 4 0 .0 μg·mL-1 。小鼠全血中最低检测浓度为 :0 .0 4 μg/mL。β 细辛醚在全血中的回收率为 :95 .3%,RSD为 3.92 %。小鼠口服石菖蒲挥发油后 ,β 细辛醚在体内的药时过程为线性动力学...

目的 :研究石菖蒲挥发油中 β 细辛醚在小鼠体内的药物代谢动力学。 方法 :采用气相色谱法测定 β 细辛醚的血药浓度 ,色谱柱 :HP 35毛细管气相色谱柱 (内径 :0 .2 5mm ;长 :30m ;涂膜厚 :0 .2 5 μm) ;程序升温 :起始温度为 30℃ ,6℃ /min升至 2 2 0℃ ,保持 5min ;进样口温度 ;2 5 0℃ ;检测器温度 :32 0℃ ;进样量 :2 .0 μL;无分流进样 ;溶剂 :甲醇 ;载气 :氦气 ;柱头压 :5 .5× 1 0 4帕斯卡 ;内标物 :a 萘酚。结果与结论 :建立了用气相色谱法测定β 细辛醚血药浓度的方法 ,β 细辛醚与内标物的峰面积之比 (Y)与浓度 (C)之间的回归方程为 :Y =0 .0 1 889C +1 .75 5× 1 0 -3 (n =6 ,r =0 .9999)。线性范围 :0 .0 4 μg·mL-1 - 4 0 .0 μg·mL-1 。小鼠全血中最低检测浓度为 :0 .0 4 μg/mL。β 细辛醚在全血中的回收率为 :95 .3%,RSD为 3.92 %。小鼠口服石菖蒲挥发油后 ,β 细辛醚在体内的药时过程为线性动力学过程 ,符合一级吸收二室模型 ,t1 /2α为6 .5min ,t1 /2 ( β) 为 93.6min。

AIM: To study the pharmacokinetics of ligustilide in the volatile oil from Angelica Sinensis(Oliv.) Diels in the rabbit. METHODS: HPLC method for ligustilide determination in the blood was developed.The HPLC system consisted of C_(18) column using MeOH-H_2O(65∶35,v/v) as mobile phase at a flow rate of 1.0 mL/min and UV detection at 236 nm. RESULTS: Linear calibration curves were obtained over the concentration range of 0.40 μg·mL~(-1)~10.00 μg·mL~(-1) for ligustilide.The minimum limit detection was 0.40 μg·mL~(-1).The...

AIM: To study the pharmacokinetics of ligustilide in the volatile oil from Angelica Sinensis(Oliv.) Diels in the rabbit. METHODS: HPLC method for ligustilide determination in the blood was developed.The HPLC system consisted of C_(18) column using MeOH-H_2O(65∶35,v/v) as mobile phase at a flow rate of 1.0 mL/min and UV detection at 236 nm. RESULTS: Linear calibration curves were obtained over the concentration range of 0.40 μg·mL~(-1)~10.00 μg·mL~(-1) for ligustilide.The minimum limit detection was 0.40 μg·mL~(-1).The recovery of ligusitilide in blood was 90.90% with RSD 2.74%. CONCLUSION: After oral administration of volatile oil,intracorporal process of ligustilide in rabbit accords with 2-compartment model with 1 st order absorption,(2.6638) h and 108.88 h are obtained as t_(1/2α) and t_(1/2β) respectively.

目的:研究当归挥发油中藁本内酯在家兔体内的药物代谢动力学。方法:采用高效液相色谱法测定藁本内酯的血药浓度。色谱柱:L ichrosorb C18高效液相色谱柱(150 mm×4.6 mm,5μm粒径),流动相为甲醇-水(65∶35),流速1.0 mL/m in,检测波长236 nm,柱温为室温,灵敏度:0.02 AUFS。结果:建立了用高效液相色谱法测定藁本内酯血药浓度的方法,藁本内酯峰面积(Y)与浓度(C)之间的回归方程为:Y=1 635.2C-397.58(n=5,r=0.997 3)。线性范围:0.40~10.00μg.mL-1。兔全血中最低检测浓度为:0.40μg.mL-1。藁本内酯在全血中的回收率为:90.90%,RSD为2.74%。结论:兔口服当归挥发油后,藁本内酯在体内的药时过程为线性动力学过程,符合一级吸收二室模型,t1/2α为2.6638 h,t1/β为108.88 h。

 
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