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   peripheral tolerance 在 基础医学 分类中 的翻译结果: 查询用时:0.195秒
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peripheral tolerance
相关语句
  外周耐受
    The exosomes produced by immature DCs can maintain peripheral tolerance,while exosomes produced by mature DCs can stimulate effector T cells. Therefore the exosomes play a important role in inducing immune tolerance.
    非成熟DC(iDC)产生的外染色体能够维持外周耐受,而成熟DC(mDC)产生的外染色体能够刺激效应性T细胞,因此外染色体在诱导免疫耐受中发挥着重要作用。
短句来源
  “peripheral tolerance”译为未确定词的双语例句
    PD-L and PD-1 interaction involves in maintenance of peripheral tolerance.
    PD-1也参与了一系列疾病的发病。
短句来源
    Part2: Deficiency in both central and peripheral tolerance is essential for the development of MLDS-DM To further study the role of abnormal immunotolerance mechanism in the development of diabetes , the makeup and function of cells in thymus was observed and the frequency and function of CD4+CD25+Treg with immunoregulatory function in the spleen was detected. Ⅰ.
    说明模型鼠胸腺功能异常可能是导致自身反应T 细胞和CD4~+CD25~+Treg 的胸腺选择异常的原因。
短句来源
    Objective: Recent researches showed that dendritic cells can either initiate T cell immunoreaction or promote peripheral tolerance depending on their state of maturaton. Tolerogenic dendritic cells(Tol-DC) have been defined by immature phenotype and the ability to inhibit T cell responses. RelB is a critical nuclear transcription factor NF- κB family member required for myeloid DC maturation.
    树突状细胞(dendritic cell,DC)具有激活免疫应答或诱导免疫耐受的功能,未成熟状态的树突状细胞倾向于诱导免疫耐受产生,被称为“致耐受DC(tolerogenic dendritic cell,Tol DC)”。
短句来源
    Studies show that engagement of PD-l can downregulate the immune response of activated T,B cells, and its biological significance in sustaining peripheral tolerance.
    研究证实,增强PD-1的信号可以下调已活化的T、B细胞在外周组织中的应答,在维持外周T、B细胞耐受中发挥重要的作用。
短句来源
    More recent studies have shown that Foxp3 is not only a key intracellular marker but also a crucial developmental and functional factor for CD4+CD25+ regulatory T cells. The active suppression by regulatory T cells has been considered to be a fifth mechanism of peripheral tolerance, except for clonal anergy, split tolerance, clonal ignorance and AICD.
    目前研究证实该基因特异性表达于固有CD4~+CD25~+调节性T细胞,并在该细胞的发育和功能维持中起重要作用,是CD4~+CD25~+调节性T细胞特异性标志物之一,并作为转录抑制因子参与免疫应答的调控。
短句来源
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  peripheral tolerance
One is that tumors induce peripheral tolerance of tumor-specific CD8+ T cells.
      
Experimental animal models for autoimmunity have demonstrated the existence and crucial role of CD4+CD25+ T regulatory (Tr) cells in suppressing autoreactive T cells and promoting peripheral tolerance.
      
However, the recovery of the first graft was not associated with antigen-specific peripheral tolerance.
      
In the experimental colitis model NK1.1+ lymphocytes play a dual role: In the presence of peripheral tolerance they may be accountable for keeping the high CD4+IL-4+/CD4+IFN-γ+ ratio and disease alleviation.
      
IL-2, through its pivitol role in activation-induced cell death (AICD), is involved in peripheral tolerance through the elimination of self-reactive T cells.
      
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As one of population of antigen presenting cells, Oendntic cells (DCs) not only can stimulate immune response of T cells but also play an important role in the establishment of both central as well as peripheral tolerance. The DCs in the thymus have )been subdivided into two populations, lymphoid DCs and myeloid DCs. They can induce negative selection of effective T cells and positive selective of regulatory T cells. This review will discuss the origin of mtrathymic DCs and Us mechanisms of inducing immune...

As one of population of antigen presenting cells, Oendntic cells (DCs) not only can stimulate immune response of T cells but also play an important role in the establishment of both central as well as peripheral tolerance. The DCs in the thymus have )been subdivided into two populations, lymphoid DCs and myeloid DCs. They can induce negative selection of effective T cells and positive selective of regulatory T cells. This review will discuss the origin of mtrathymic DCs and Us mechanisms of inducing immune tolerance.

树突状细胞作为一类重要的抗原提呈细胞,不仅能激发免疫应答,而且在中枢免疫耐受和外周免疫耐受中发挥着重要作用。胸腺中树突状细胞分为淋巴源性和髓源性,参与效应性T细胞的阴性选择和调节性T细胞的阳性选择过程。本文就胸腺内树突状细胞的来源、特点以及在中枢耐受中的机制作一综述。

CD4~(+)CD25~(+)T regulatory cells(Treg) are an indispensable subset of T cells involved in immunoregulation.It is thought that Treg cells play a critical role in peripheral tolerance,especially in maternal immunotolerance to the fetus.Treg cells can exert their immunosuppression through many mechanisms,further maintain immunotolerance.The text reviewed derivation of CD4~(+)CD25~(+)T regulatory cells,roles of their surface markers and secreted cytokines and early pregnancy.

CD4+CD25+调节性T细胞是一类在免疫调节中不可缺少的T细胞群,并且认为它在外周耐受尤其是在母胎免疫耐受中起重要作用。它可通过许多途径来发挥免疫抑制作用,从而维持免疫耐受。该文综述了CD4+CD25+调节性T细胞的产生机制、它的表面标记和分泌的细胞因子所起的作用以及它与早期妊娠的关系。

The capacities of antigen-presenting dendritic cells (DCs) in functions of both tolerance and immunity is now well documented.The T cell activation capacities of the DCs in different stages of maturation and activation are different.The exosomes produced by DCs can induce the immune tolerance mediated by T cell's and are antigenic.The exosomes produced by immature DCs can maintain peripheral tolerance,while exosomes produced by mature DCs can stimulate effector T cells.Therefore the exosomes play a important...

The capacities of antigen-presenting dendritic cells (DCs) in functions of both tolerance and immunity is now well documented.The T cell activation capacities of the DCs in different stages of maturation and activation are different.The exosomes produced by DCs can induce the immune tolerance mediated by T cell's and are antigenic.The exosomes produced by immature DCs can maintain peripheral tolerance,while exosomes produced by mature DCs can stimulate effector T cells.Therefore the exosomes play a important role in inducing immune tolerance.

大量研究证实具有抗原递呈作用的树突状细胞(DC)能够诱导免疫耐受,处于不同成熟阶段不同活化条件下的DC激活T细胞的能力不同。进一步研究发现DC产生的外染色体能够诱导T细胞免疫耐受,具有免疫原性。非成熟DC(iDC)产生的外染色体能够维持外周耐受,而成熟DC(mDC)产生的外染色体能够刺激效应性T细胞,因此外染色体在诱导免疫耐受中发挥着重要作用。

 
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