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bioactive small molecule
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  “bioactive small molecule”译为未确定词的双语例句
     2. Creation of NIH Bioactive Small Molecule Library, Image and Screening Centers, Key point is Cheminformatics and development of high specificity/high sensitivity probes to improve detection.
     2.建立分子库和分子图像及筛选中心,开展化学信息学研究和分子图像探针合成关键设备研制。
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  相似匹配句对
     The Fabrication of Small Molecule OLED
     小分子OLED器件的制作
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     Small.
     Small、为正品。
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     Application of carrier molecule PaP3.30 in fusion expression of small bioactive peptides
     承载分子PaP3.30在小分子活性肽融合表达中的应用
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     Biological Active Small Molecule Peroxynitrite
     生物活性小分子过亚硝酸根
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     Objective:To screen and clone a carrier molecule for the expression of small bioactive peptides at high levels.
     目的 :筛选并克隆一个承载分子 ,研究其在肽抗生素及其他小分子活性肽融合表达中的应用。
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  bioactive small molecule
Bioactive small molecule inhibitors of the cell's replication machinery are currently being exploited as cellular probes and novel therapeutics.
      


As part of our investigations on bioactive small molecules, the crystal structure of 1-methylsi-latrane was redetermined in order to provide more reliable geometry fot quantum chemistry calcu-latons. The crystal is monoclinic. P21/n, a = 7. 606(1), b=12.150(1), c=9. 779(1) A,β= 91.64(1)°, V = 903. 4A3, Z=4, Dc= 1. 392gcm-3, F(000) = 408,μ(MoKa) = 2. 208cm-1, R = 0. 044 for 1510 observed reflections. The redetermination, resulting in bond distances and angles with e. s. d' s of 0. 002 - 0. 004A and 0. 1...

As part of our investigations on bioactive small molecules, the crystal structure of 1-methylsi-latrane was redetermined in order to provide more reliable geometry fot quantum chemistry calcu-latons. The crystal is monoclinic. P21/n, a = 7. 606(1), b=12.150(1), c=9. 779(1) A,β= 91.64(1)°, V = 903. 4A3, Z=4, Dc= 1. 392gcm-3, F(000) = 408,μ(MoKa) = 2. 208cm-1, R = 0. 044 for 1510 observed reflections. The redetermination, resulting in bond distances and angles with e. s. d' s of 0. 002 - 0. 004A and 0. 1 - 0. 2° respectively, confirmed the quasi C3 point group symmetry of the molecule. The study of the nature of Si - N bonding in silatranes.RSi(OCH2CH2)3N (R=CH3,F,Cl,Br,I) with SCC-DV-Xa method was carrted out, and the feature of Si-N bonding was discussed in detail.

精确测定了1—甲基杂氮硅三环的X光晶体结构,并用量子化学SCC—DV—X_a法对杂氮硅三环类化合物RSi(OCH_2CH_2)_3N(R=CH_3,F,Cl,Br,I)中硅氮成键本质进行了研究。计算结果证明硅氮间形成的配键中除σ键外还存在微弱的π键,硅原子的3d轨道在成键中起一定的作用。 晶体学参数:C_7H_(15)NO_3Si,M_r=189.3,单斜晶系,空间群P2_1/n,a=7.606(1),b=12.150(1),c=9.779(1),β=91.64(1)°,V=903.4,Z=4,D_c=1.392gcm~(-3),F(000)=408,μ(MoK_a)=2.208cm~(-1)。1510个可观察衍射参与最小二乘修正,最终偏离因子R=0.044。

Chemical genomics is a new paradigm in which chemistry is utilized early in the development process along with other tools such as genomics,proteomics,combinatorial chemistry and cell-based screening to accelerate the drug development process.The recent use of chemical genomics to identify bioactive small molecules that interact with specific proteins has had a tremendous impact on both the functional analysis of genes and drug development.The recent review highlights the applicatioin of chemical genomics...

Chemical genomics is a new paradigm in which chemistry is utilized early in the development process along with other tools such as genomics,proteomics,combinatorial chemistry and cell-based screening to accelerate the drug development process.The recent use of chemical genomics to identify bioactive small molecules that interact with specific proteins has had a tremendous impact on both the functional analysis of genes and drug development.The recent review highlights the applicatioin of chemical genomics in drug discovery and development.

化学基因组学作为药物发现的新模式 ,组合了基因组学、蛋白质组学、组合化学及细胞筛选等领域的新技术 ,加快了新药研发的过程。本文介绍了化学基因组学研究的方法学及典型的技术平台 ,评述了化学基因组学在基因、蛋白质功能分析研究的概况及其应用于新药发现中的进展。

National Institutes of Health (NIH) is one of the world's foremost medical research and management centers. It issued the roadmap and strategy for future 10-year's medical research on September 2003. The new pathways to discovery including: 1. Building blocks, biological pathways, and networks. Key point is Proteomics and Metabolomics. 2. Creation of NIH Bioactive Small Molecule Library, Image and Screening Centers, Key point is Cheminformatics and development of high specificity/high sensitivity probes...

National Institutes of Health (NIH) is one of the world's foremost medical research and management centers. It issued the roadmap and strategy for future 10-year's medical research on September 2003. The new pathways to discovery including: 1. Building blocks, biological pathways, and networks. Key point is Proteomics and Metabolomics. 2. Creation of NIH Bioactive Small Molecule Library, Image and Screening Centers, Key point is Cheminformatics and development of high specificity/high sensitivity probes to improve detection. 3. Structural Biology research field. 4. Bioinformatics and Computational Biology research areas. 5. Nanomedicine research field. One of the research strategy is building research teams of the future, supporting high-risk research, interdisciplinary research and public-private partnerships. The other research strategy is re-engineering the clinical research, including translational research, clinical workforce training and building clinical research networks. Future molecular medicine will benefit from the roadmap, also the roadmap and strategy will be great helpful for medical research and management in our country.

美国国立卫生院(NationalInstitutesofHealth,NIH)是当今世界上最著名的医学领域研究和管理机构。2003年9月该机构公布了未来10年能导致生命科学原创发现的重点研究领域和研究战略。重点研究领域包括:1.生物学通道和网络研究,重点是蛋白组学和代谢组学研究。2.建立分子库和分子图像及筛选中心,开展化学信息学研究和分子图像探针合成关键设备研制。3.结构生物学研究领域。4.生物信息学和计算生物学研究领域。5.纳米医学研究领域。研究战略之一是加强未来医学研究队伍建设,重点支持高风险研究,建立多学科交叉研究队伍和建立政府和私人机构的合作联系。研究战略之二是重铸临床研究,重点加快科学发现向临床应用转化的研究,加强临床工作人员的培训和建立临床研究网络。NIH确定的研究领域和研究战略对加速分子医学革命的到来有重要意义,对我国生命科学研究和宏观管理具有极大的参考价值。

 
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