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尿轻链
相关语句
  urinary bene-jones protein
     There was a positive correlation between IL-6 and serum calcium or C-reactive protein(P<0.01), and there was a positive correlation between VEGF and serum Cr or urinary Bene-Jones protein λ (P<0.01).
     VEGF与血肌苷,尿轻链λ存 在密切的关系(P<0.01); IL 6与血钙,C反应蛋白存在密切的关系(P<0.01)。
短句来源
     VEGF levels showed significant differences between the patients with normal serum Cr, serum calcium Bene-Jones protein λ, and urinary Bene-Jones protein λ and patients with abnormal ones (P<0.05).
     而VEGF水平在血肌苷、血轻链λ、尿轻链λ的异常组高于 其正常组(P<0.05)。
短句来源
  “尿轻链”译为未确定词的双语例句
     Isolation and Purification of Urine Light Chain from a Patient with Double Light Chain Disease
     双轻链病患者尿轻链的提取和纯化
短句来源
     Detecting of urinary free light cbain using ELISA method and its application to monoclonal gammapathies
     尿轻链酶联免疫测定在M蛋白病中的意义
短句来源
     the levels of light chain λ in serum and urine of type λ MM patients were higher than normal (P<0.05), and the levels of free chain in serum were much higher than in urine.
     λ型血清与尿λ轻链蛋白含量亦明显高于正常组 (P <0 .0 5 ) ,且血清中轻链蛋白高于尿轻链蛋白含量。
短句来源
     Proliferation of bone marrow plasmacyte and the quantity or urinary Benec-Jones protein are main causes of kidney lesion in multiple myeloma.
     骨髓浆细胞增殖及尿轻链蛋白产生可能是多发性骨髓瘤肾脏损害的主要原因。
短句来源
     Proliferation of bone marrow plasmacyte and urine Benec-Jones protein are main causes of kidney damage in multiple myeloma.
     骨髓浆细胞增殖及尿轻链蛋白产生可能是MM肾脏损害的主要原因。
短句来源
  相似匹配句对
     TYPING ANALYSIS OF LIGHT CHAIN URINE OF 110 CASES
     110例轻链尿分型分析
短句来源
     Urinic IgG kappa light chain had a positive correlation with proteinurine.
     尿kappa轻链与蛋白尿呈正相关。
短句来源
     The blood and urine osmolalities were determined at the same time.
     尿渗透压。
短句来源
     Indices in Renal Failure
     尿指数
短句来源
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Objective To investigate the clinical significance of the measurements of free light chain in serum and urine. Methods The levels of free light chain in serum and urine were measured in the cases of multiple myeloam (MM), light chain disease (LCD), dephropathy and systemic lupus erythematorsus (SLE) by mephelometry method. Results ①The levels of light chain κ in serum and urine of type κ MM patients were higher than that of normal healthy controls (P<0.05); the levels of light chain λ in serum and urine of...

Objective To investigate the clinical significance of the measurements of free light chain in serum and urine. Methods The levels of free light chain in serum and urine were measured in the cases of multiple myeloam (MM), light chain disease (LCD), dephropathy and systemic lupus erythematorsus (SLE) by mephelometry method. Results ①The levels of light chain κ in serum and urine of type κ MM patients were higher than that of normal healthy controls (P<0.05); the levels of light chain λ in serum and urine of type λ MM patients were higher than normal (P<0.05), and the levels of free chain in serum were much higher than in urine. ②The level of light chain κ in urine of type κ LCD was higher than normal (P< 0.05); the level of light chain λ in urine of type λ LCD was higher than normal (P<0.05), but the levels of light chain κ or λ in serum were as high as that of the normal. ③The levels of light chain κ or λ in urine of nephropathy were higher than normal (P<0.05), but the κ/λ ratio was normal, the levels of light chain κ or λ in serum were normal too. ④The levels of light chain κ or λ in urine of SLE patients were higher than normal (P<0.05). Conclusion The differences in the level of free light chains in serum and urine are of diagnostic importance to different diseases.

目的 探讨血液和尿液中游离轻链联合检测的临床应用。方法 利用速率散射比浊法对临床确诊的多发性骨髓瘤 (MM)、轻链病 (LCD)、肾病和系统性红斑狼疮 (SLE)患者血清和尿液中游离轻链进行联合测定。结果 ①MM患者κ型血清与尿κ轻链蛋白含量明显高于正常组 (P <0 .0 5 ) ;λ型血清与尿λ轻链蛋白含量亦明显高于正常组 (P <0 .0 5 ) ,且血清中轻链蛋白高于尿轻链蛋白含量。②LCD患者κ型仅尿κ轻链蛋白含量明显高于正常组 (P <0 .0 5 ) ;λ型尿λ轻链蛋白含量明显高于正常组 (P <0 .0 5 ) ,而血清中κ或λ轻链含量与正常组无明显差异。③肾病患者尿液κ或λ游离轻链含量明显高于正常组 (P <0 .0 5 ) ,但κ λ比值与正常组无明显差异 ,血清中κ或λ轻链蛋白含量与正常组无明显差异。④SLE患者尿κ或λ游离轻链含量明显高于正常组 (P <0 .0 5 )。结论 血清和尿中游离轻链含量的差异 ,对诊断上述疾病具有重要意义

Objective: To analyze the clinical characteristics and the correlative factors of kidney lesion in 44 cases of multiple myeloma (MM). Methods: From March 1994 to March 2004, 44 patients with MM were diagnosed by clinical characteritics and pathological methods. Analysis of statistics in clinical characteristics and results of laboratory of kidney lesion of this group of patients were carried out. Results: The incidence of kidney lesion was 40.9% (18/44), with 18 patients occurred in 44 cases. Renal insufficiency...

Objective: To analyze the clinical characteristics and the correlative factors of kidney lesion in 44 cases of multiple myeloma (MM). Methods: From March 1994 to March 2004, 44 patients with MM were diagnosed by clinical characteritics and pathological methods. Analysis of statistics in clinical characteristics and results of laboratory of kidney lesion of this group of patients were carried out. Results: The incidence of kidney lesion was 40.9% (18/44), with 18 patients occurred in 44 cases. Renal insufficiency (Scr>177.0 μmol/L) was the most frequent syndrome (77.8%), followed by nephrotic syndrome (16.7%) and syndrome of urinary abnormalities (5.56%). Free light chain was detected in serum of 13 (13/18) patients, in urine of 14 (14/18) patients, with λ chain as the dominant type. There was significant correlation between the quantity of bone marrow plasmacyte or urinary Bence-Jones protein and renal functional lesion (P<0.01, P<0.05). Anemia or multiple bone lesion was correlated with kidney damage. Conclusions: The most frequent clinical syndrome of MM with renal lesion is renal insufficiency. The λ chain is the dominant type in the serum or urine. Proliferation of bone marrow plasmacyte and the quantity or urinary Benec-Jones protein are main causes of kidney lesion in multiple myeloma.

目的了解多发性骨髓瘤(MM)肾损害患者临床特征及其发生的相关因素。方法对经临床、病理明确诊断的MM肾损害患者的临床特征及实验室检查进行统计学分析。结果MM肾损害的发生率为40.9%(18/44),临床症候群以肾功能不全(血肌酐>177 μmol/L)最为常见(77.8%),其次为肾病综合征(16.7%)、无症状尿检异常(5.56%)。血清轻链阳性率为72.2%(13/18),尿中轻链阳性率为77.8%(14/18例),均以λ链为主。骨髓浆细胞数量和尿本周蛋白(BJP)与肾功能损害之间有显著相关关系(P<0.01;P<0.05),贫血及多发性骨损害与肾脏损害有相关关系(P<0.05)。结论MM伴肾损害患者临床症候群以肾功能不全多见,血清与尿液中轻链以λ为主。骨髓浆细胞增殖及尿轻链蛋白产生可能是多发性骨髓瘤肾脏损害的主要原因。

Objective To investigate the clinical significance of the changes of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) level in multiple myeloma (MM), solid tumor fo- llowing bone metastasis. Methods Thirty- seven MM patients, including 7 in StageⅠ, 8 in StageⅡ, 22 in Stage Ⅲ, 8 solid tumor with bone metastasis patientsly, and 17 healthy controls were enrolled in this study. The serum VEGF and IL-6 levels were determined by ELISA. Results Serum VEGF and IL-6 concentrations in patients...

Objective To investigate the clinical significance of the changes of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) level in multiple myeloma (MM), solid tumor fo- llowing bone metastasis. Methods Thirty- seven MM patients, including 7 in StageⅠ, 8 in StageⅡ, 22 in Stage Ⅲ, 8 solid tumor with bone metastasis patientsly, and 17 healthy controls were enrolled in this study. The serum VEGF and IL-6 levels were determined by ELISA. Results Serum VEGF and IL-6 concentrations in patients with MM and solid tumor were significantly higher than those of the healthy controls (P<0.01), and the VEGF level was higher in MM than in solid tumor with bone metastasis. There was significant difference in VEGF and IL-6 levels in various clinical stages of MM. VEGF levels in StageⅢ were significantly higher than in StageⅠ(P<0.05) and IL-6 levels in StageⅡwere significantly higher than in StageⅠ(P<0.05). The levels of IL-6 showed great difference according to bone lesion scores (P<0.05). There was a positive correlation between IL-6 and serum calcium or C-reactive protein(P<0.01), and there was a positive correlation between VEGF and serum Cr or urinary Bene-Jones protein λ (P<0.01). The IL-6 levels had significant differences between patients with the normal serum CRP, serum calcium, and β 2-MG and patients with abnormal ones (P<0.05). VEGF levels showed significant differences between the patients with normal serum Cr, serum calcium Bene-Jones protein λ, and urinary Bene-Jones protein λ and patients with abnormal ones (P<0.05). Conclusion Serum VEGF and IL-6 levels are helpful to diagnose the clinical stages, and understand bone lesion and serevity of MM.

目的:探讨多发性骨髓瘤(MM)和实体瘤骨转移患者血清血管内皮生长因子(VEGF)和白细胞介素 (IL) 6水平变化的临床意义。方法:MM组37例,其中临床Ⅰ期7例,Ⅱ期8例,Ⅲ期22例;实体瘤骨转移阳性对 照组8例和正常对照组17例;用ELISA方法检测血清VEGF和IL 6的水平。结果:MM组和实体瘤骨转移组血清 VEGF和IL 6水平明显高于正常对照组(P<0.01),且MM组的VEGF水平明显高于实体瘤骨转移组(P<0.05)。 随着临床分期增加,VEGF和IL 6水平呈递增趋势,VEGF水平在Ⅲ期高于Ⅰ期组和Ⅱ期组(P<0.05),IL 6在Ⅱ期 组高于Ⅰ期组(P<0.05)。各骨损评分组间IL 6水平差异存在显著性(P<0.05)。VEGF与血肌苷,尿轻链λ存 在密切的关系(P<0.01);IL 6与血钙,C反应蛋白存在密切的关系(P<0.01)。IL 6水平在临床参数C反应蛋 白、血钙、β2微球蛋白异常组高于其正常组(P<0.05);而VEGF水平在血肌苷、血轻链λ、尿轻链λ的异常组高于 其正常组(P<0.05)。结论:检测血清VEGF和IL...

目的:探讨多发性骨髓瘤(MM)和实体瘤骨转移患者血清血管内皮生长因子(VEGF)和白细胞介素 (IL) 6水平变化的临床意义。方法:MM组37例,其中临床Ⅰ期7例,Ⅱ期8例,Ⅲ期22例;实体瘤骨转移阳性对 照组8例和正常对照组17例;用ELISA方法检测血清VEGF和IL 6的水平。结果:MM组和实体瘤骨转移组血清 VEGF和IL 6水平明显高于正常对照组(P<0.01),且MM组的VEGF水平明显高于实体瘤骨转移组(P<0.05)。 随着临床分期增加,VEGF和IL 6水平呈递增趋势,VEGF水平在Ⅲ期高于Ⅰ期组和Ⅱ期组(P<0.05),IL 6在Ⅱ期 组高于Ⅰ期组(P<0.05)。各骨损评分组间IL 6水平差异存在显著性(P<0.05)。VEGF与血肌苷,尿轻链λ存 在密切的关系(P<0.01);IL 6与血钙,C反应蛋白存在密切的关系(P<0.01)。IL 6水平在临床参数C反应蛋 白、血钙、β2微球蛋白异常组高于其正常组(P<0.05);而VEGF水平在血肌苷、血轻链λ、尿轻链λ的异常组高于 其正常组(P<0.05)。结论:检测血清VEGF和IL 6水平对于MM患者的诊断及鉴别诊断、临床分期、骨损程度和 病情的判断具有重要意义。

 
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