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   family history of essential hypertension 在 心血管系统疾病 分类中 的翻译结果: 查询用时:0.504秒
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family history of essential hypertension
相关语句
  高血压家族史
    Objective To investigate the relationship between some vasoactive substances and the heredity of essential hypertension and the role of the vasoactive substances in the pathogenesis of essential hypertension by determining the plasma level of nitric oxide (NO), plasma renin activity(PRA) and angiotensin II (AT II) in healthy offsping with family history of essential hypertension.
    目的 研究具有原发性高血压家族史的健康子女血浆一氧化氮(Nitric Oxide,NO)、血浆肾素活性(Plasma Renin Activity,PRA)、血管紧张素Ⅱ(AngiotensinⅡ,ATⅡ)的水平变化,探讨NO与PRA、AT Ⅱ等血管活性物质与原发性高血压遗传的关系以及在原发性高血压发病机制中的作用。
短句来源
    Results (1)The levels of NO,PRA,AT II increased significantly in offsping with family history of essential hypertension compared to those in the control group (t= 2.782,2.841,3.418,P<0.01).
    结果 ①血浆NO、PRA、ATⅡ的水平在有原发性高血压家族史的研究组明显高于无原发性高血压家族史的正常对照组(t=2.782,2.841,3.418,P<0.01)。
短句来源
    TC and LDL c were positively correlated with 45 Ca 2+ influx in the patients with a family history of essential hypertension but not in those without.
    有家族史的EH病人TC、LDL-c与细胞45Ca2+内流呈正相关,无高血压家族史EH病人血脂与细胞离子转运无显著相关性。
短句来源
    Methods Totally, 74 normotensive people (38 men and 36 women), 51 patients with essential hypertension (27 men and 24 women) and 20 hypertensive patients with family history of essential hypertension (9 men and 11 women) were chosen, with mean ages of (54 ± 8) years, (57± 8)years and (38 ± 22) years, respectively.
    方法2002年4月至2003年9月选取原发性高血压患者51例,男27例,女24例,平均年龄(57±8)岁; 有高血压家族史的患者20例,女11例,男9例,平均年龄(38±22)。
短句来源
    Analysis of plasma endothelin concentration and related factors in adolescents with family history of essential hypertension
    有高血压家族史青少年血浆内皮素及相关因素分析
短句来源
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  “family history of essential hypertension”译为未确定词的双语例句
    CHANGES OF PLASMA CGRP,ADM, ATⅠAND ATⅡ LEVELS IN HEALTHY CHILDREN WITH A FAMILY HISTORY OF ESSENTIAL HYPERTENSION
    原发性高血压病人之健康子女血浆降钙素基因相关肽等水平变化的研究
短句来源
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  family history of essential hypertension
Children whose family members had essential hypertension had increased BMI compared with children without a family history of essential hypertension.
      
All essential hypertensive patients recruited reported the presence of a positive family history of essential hypertension.
      


Experimental study was done on the kidney function of sodium excretion in 109 healthy male children and youths from 8-21 years old. Urinary Na was measured after acute oral sodium loading. The result showed that the subjects with normal blood pressure and with family history of essential hypertension excreted less Na in their urine than the subjects without family history after loading. The response of sodium excretion to loading was slower and weaker in the subjects with family history....

Experimental study was done on the kidney function of sodium excretion in 109 healthy male children and youths from 8-21 years old. Urinary Na was measured after acute oral sodium loading. The result showed that the subjects with normal blood pressure and with family history of essential hypertension excreted less Na in their urine than the subjects without family history after loading. The response of sodium excretion to loading was slower and weaker in the subjects with family history. The result suggests that the children with family history of essential hypertension seem to have herecitary functional defect in the excretion of sodium after acute oral sodium loading before developing hypertension.

本文对109名8~21岁的健康男性儿童青少年进行了急性饮食盐负荷下肾脏排钠功能的研究。结果表明,有原发性高血压家族史的血压正常对象,相对于无家族史的对象负荷后尿排钠量少,负荷排钠反应慢且弱。结果提示:有原发性高血压家族史的儿童,可能在高血压病发病前就已存在遗传性肾脏排钠功能缺陷。

The excretion of urinary sodium of children, aged 5-6 years, with an approximate dayly salt intake, was compared between the group (151 members) with family history of essential hypertension and the other (137 members) without the history before and after salt loading, respectively. The results showed that the urinary sodium level (USL) of children with family history approximate to the USL of children without family history before salt loading, there was no significant difference....

The excretion of urinary sodium of children, aged 5-6 years, with an approximate dayly salt intake, was compared between the group (151 members) with family history of essential hypertension and the other (137 members) without the history before and after salt loading, respectively. The results showed that the urinary sodium level (USL) of children with family history approximate to the USL of children without family history before salt loading, there was no significant difference. However, after salt loading the USL of the former was much lower than the latter, there was significant difference (p<0.0001). The multiple regression analysis of 24-hour urinary sodium after loading vs relevant factors as independent variables showed that the family history was an improtant factor which influence the excretion of urinary sodium. Dividing Children into several subgroups according to the difference of USL after and before salt loading, the comparision of percentages of children in each subgroup between the groups with and without family history showed that there was significant difference between the two groups (p<0.05) when the difference of USL was negative. Thus, we suggest that the negative difference of USL could serve as a criterion to screen the precursor of essential hypertension.

本文比较日摄盐量相近、有及无高血压家族史的5~6岁儿童的盐负荷前后尿钠排出量。结果表明,二组盐负荷前的尿钠量相近,差异无意义。后有家族史儿童的尿钠量明显较无家族史者为少。差异有高度显著意义(P<0.0001)。盐负荷后24小时尿钠与有关指标的逐步回归分析表明,家族史是影响尿钠排泄的重要因素。两组间盐负荷前后尿钠不同差值的人数分布比较表明,差值为负值时,二者间差异有显著意义(P<0.05)。建议以尿钠差值的负值作为原发性高血压先兆倾向的筛选标准。

Abstract Considerable evidence suggests that protein kinase C(PKC) activation participates in the regulation of vascular smooth muscle tone.We measured protein kinase C (PKC) activity in platelets in 62 essential hypertensive patietns(EH group), 20 normotensive subjects(NT group)and 20 normotensive offsprings with (FH ̄+group, n=10) and without (FH ̄- group , n=10) a family history of essential hypertension. The main findings were as followings. (1) PKC activities in the cytosol fraction of platelets were...

Abstract Considerable evidence suggests that protein kinase C(PKC) activation participates in the regulation of vascular smooth muscle tone.We measured protein kinase C (PKC) activity in platelets in 62 essential hypertensive patietns(EH group), 20 normotensive subjects(NT group)and 20 normotensive offsprings with (FH ̄+group, n=10) and without (FH ̄- group , n=10) a family history of essential hypertension. The main findings were as followings. (1) PKC activities in the cytosol fraction of platelets were not different between EH and NT group (P>0.05). Cytosol fraction stimulated with PKC activator phorbol-12-myristate-13-acetate (PMA)leads marked elevation in EH. (2) PKC activities in the membrane fraction of platelets in EH were increased (497. 95±103.90 pmol/min/mg protein) compared with NT (416. 87±73. 50 pmol/min/mg protein , P<0. 01),and the activity was the greatest in stage Ⅲ hypertension (553. 38±110. 49 pmol/min/mg protein).(3) The only difference between FH ̄- and FH ̄+ groups was that of the cytosol fraction stimulated with PMA,FH ̄+ group was increased compared with that in FH ̄-group (486. 86±74.41,404.35±83.10 pmol/min/mg protein,P<0.01) . These results suggest that PKC activation may be involved in the regulation of vascular smooth musle tone; the increased sensitivity to PMAmediated activity in FH ̄+ group may be responsible for a genetic predisposition to hypertension.

测定62例高血压病(EH)患者,20例正常对照者(NT),20例有和无高血压家族史的正常血压子女(FH+10例,FH-10例)的血小板各组份的基础蛋白激酶C(PKC)活性,并观察PKC激动剂phorbol-12-myristate-13-acetute(PMA)作用后的PKC激发变化。结果显示,EH组血小板质膜基础PKC活性及PMA刺激后血小板胞液PKC活性激发值均显著高于NT组,提示高血压时存在血小板PKC活性增加现象,尤其是FH+组对PMA的敏感性异常增加可能与该类子女的遗传易感性增加有关。

 
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