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heavy primary dysmenorrhea
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  重度原发性痛经
     Methods Data of 499 female workers in a textile mill were collected. The associations of cytochrome P450 1A1 HincⅡ(CYP1A1 HincⅡ) and glutathion S transferase theta(GSTT1) polymorphisms with heavy primary dysmenorrhea were evaluated by Logistic regression, with adjustment for potential confounders.
     方法 收集某纺织厂 499名新婚女工的资料 ,采用L ogistic回归分析 ,评价 CYP1A1- Hinc 和 GSTT1多态性与重度原发性痛经的关系。
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     Conclusion The results suggested that GSTT1 polymorphism be associated with heavy primary dysmenorrhea.
     结论 重度原发性痛经与GSTT1遗传多态性相关
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Objective To investigate the genetic susceptibility to primary dysmenorrhea.Methods Data of 499 female workers in a textile mill were collected. The associations of cytochrome P450 1A1 HincⅡ(CYP1A1 HincⅡ) and glutathion S transferase theta(GSTT1) polymorphisms with heavy primary dysmenorrhea were evaluated by Logistic regression, with adjustment for potential confounders.Results The result showed variant of CYP1A1 HincⅡ genotypes slightly reduced the risk of primary dysmenorrhea, but...

Objective To investigate the genetic susceptibility to primary dysmenorrhea.Methods Data of 499 female workers in a textile mill were collected. The associations of cytochrome P450 1A1 HincⅡ(CYP1A1 HincⅡ) and glutathion S transferase theta(GSTT1) polymorphisms with heavy primary dysmenorrhea were evaluated by Logistic regression, with adjustment for potential confounders.Results The result showed variant of CYP1A1 HincⅡ genotypes slightly reduced the risk of primary dysmenorrhea, but its OR value was not statistically significant (CYP1A1 HincⅡ:OR=0.64,95% CI 0.35 1.17).The GSTT1 genotype variant increased the risk of primary dysmenorrhea (GSTT1:OR=1 83,95% CI 1.04 3.21). After potential confounders were adjusted, the data showed that CYP1A1 HincⅡ variant had the trend of decreasing the risk of dysmenorrhea (CYP1A1 HincⅡ:OR=0.58,95% CI 0 31 1.08), but its decreasing scope was still not statistically significant. The GSTT1 variant genotypes showed a significantly increased risk of dysmenorrhea (GSTT1:OR=2.01, 95% CI 1.12 3.62).Conclusion The results suggested that GSTT1 polymorphism be associated with heavy primary dysmenorrhea.

目的 研究原发性痛经的遗传易感性。方法 收集某纺织厂 499名新婚女工的资料 ,采用L ogistic回归分析 ,评价 CYP1A1- Hinc 和 GSTT1多态性与重度原发性痛经的关系。结果 在未调整环境因素时 CYP1A1- Hinc 变异基因型虽对痛经有缓解趋势 ,但差异无显著性 (CYP1A1- Hinc :OR=0 .6 495 % CI:0 .35~ 1.17)。而 GSTT1变异基因型可增加重度原发性痛经危险性 (GSTT1:OR=1.83,95 % CI:1.0 4~ 3.2 1)。调整潜在环境影响因素后 ,CY1A1- Hinc 变异基因型显示对原发性痛经有缓解趋势(CYP1A1- Hinc :OR=0 .5 8,95 % CI:0 .31~ 1.0 8) ,但差异仍无显著性。而 GSTT1变异基因型仍显示可增加重度原发性痛经的危险性 (GSTT1:OR=2 .0 1,95 % CI:1.12~ 3.6 2 )。结论 重度原发性痛经与GSTT1遗传多态性相关

 
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