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   family diabetic history 在 内分泌腺及全身性疾病 分类中 的翻译结果: 查询用时:0.477秒
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泌尿科学
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family diabetic history
相关语句
  糖尿病家族史
    Results Conditional logistic regression analysis showed that family diabetic history (OR=4.13), hypertension (OR=1.87), hyperlipemia (OR=3.03), and low waist/hip ratio (OR=2.17) were the risk factors of type Ⅱdiabetes mellitus.
    结果 条件Logistic回归模型显示 ,糖尿病家族史 (OR =4 1 3 )、高血压 (OR =1 87)、高血脂 (OR =3 0 3 )和腰臀比 (OR =2 1 7)为Ⅱ型糖尿病的危险因素。
短句来源
    Compared with NPTDM,the patients with PTDM had statistical significance in age, body weight, renal function and family diabetic history(P<0.05 or P<0.01).
    PTDM患者与同期非PTDM患者相比,在年龄、体重、激素用量及肾功能异常、阳性糖尿病家族史方面有显著差异(P<0.05或P<0.01)。
短句来源
    Objective [ResultsObjective ]Conditional Logistic regression analysis showed that family diabetic history patrilineal index(OR=3 831); waist and hip ratio(OR=2 105)were the risk factors of type 2 diabetes mellitus.
    [结果 ]条件Logisitic回归模型显示 ,糖尿病家族史、父系遗传系数 (OR =3 831)和腰臀比 (OR =2 10 5 )为Ⅱ型糖尿病的危险因素。
短句来源
    Objective [ConclusionsObjective ]Intervention among urban population should be focus on the people with family diabetic history, particularly with the history of patrilineal inheritance and/or central type fatness
    [结论 \〗对具有糖尿病家族史特别是具有父系遗传史者与中心型肥胖者应加强干预工作。
短句来源
  “family diabetic history”译为未确定词的双语例句
    Methods Subjects in this study were 51 pedigree members who had family diabetic history,111 type 2 diabetic patients and 102 healthy controls from the Han nationality of Henan,China.
    方法 :在中国河南汉族人群中选择 12个DM家系 ,符合常染色体显性遗传规律 ,全部成员 197例 ,共收集到外周静脉血标本 5 1例 ; 111例 2型DM患者 (家系中患DM者不超过 2例 ) ;
短句来源
    Methods The subjects included in this study were 51 pedigree members(34 were diabetic,15 had onset younger than 25,17 had normal oral glucose tolerance test,OGTT),who had family diabetic history,111 type 2 diabetic patients,and 102 healthy controls.
    方法 在中国河南汉族人群中选择 12个糖尿病家系 ,共收集到外周静脉血标本 5 1例 (诊断为糖尿病者有 34例 ,发病年龄小于 2 5岁的 15例 ,17例口服葡萄糖耐量检测正常 ) ; 111例 2型糖尿病患者 ;
短句来源
    Conclusion CsA and tacrolimus are similar in terms of the effect on PTDM and the development of PTDM is related to steroid dose, age, body weight, renal function and family diabetic history.
    结论环孢素A和他克莫司对肾移植PTDM的作用相近,患者激素用量、体重、年龄、移植肾功能状况及糖尿病阳性家族史是PTDM的易发因素。
短句来源
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Objective To study the correlation between DM pedigree and leptin in Han nationality in Henan,China.Methods Subjects in this study were 51 pedigree members who had family diabetic history,111 type 2 diabetic patients and 102 healthy controls from the Han nationality of Henan,China.Serum leptin,Serum C-peptide were measured by radioimmunoassay.OGTT,plasma hemoglobin A 1C ,glutamic acid decarboxylase antibody and body mass index(BMI) were also measured.Results There was no significant difference...

Objective To study the correlation between DM pedigree and leptin in Han nationality in Henan,China.Methods Subjects in this study were 51 pedigree members who had family diabetic history,111 type 2 diabetic patients and 102 healthy controls from the Han nationality of Henan,China.Serum leptin,Serum C-peptide were measured by radioimmunoassay.OGTT,plasma hemoglobin A 1C ,glutamic acid decarboxylase antibody and body mass index(BMI) were also measured.Results There was no significant difference for leptin leptin levels between 51 pedigree members and 102 healthy controls (P>0.05).The leptin levels of male and female in 111 type 2 diabetic patients were significantly higher than those of 102 healthy controls(P<0.05).And the leptin was closely correlated to BMI(P<0.01) and 2h OGTT(P<0.01) in 111 type 2 diabetic subjects.Conclusion It is suggested that leptin didn't play an important role in the development of DM for pedigree members who had diabetic family history and increased serum leptin might be one of the risk factors related to type 2 DM.

目的 :探讨中国河南汉族糖尿病 (DM )家系患者与瘦素 (leptin)水平的相关性。 方法 :在中国河南汉族人群中选择 12个DM家系 ,符合常染色体显性遗传规律 ,全部成员 197例 ,共收集到外周静脉血标本 5 1例 ;111例 2型DM患者 (家系中患DM者不超过 2例 ) ;10 2例健康献血者作对照。用放射免疫技术测定血清leptin、C肽 ;对糖化血红蛋白、谷氨酸脱羧酶抗体、葡萄糖耐量 (OGTT)、体重指数 (BMI)等指标进行检测。结果 :DM家系与正常人群的leptin比较无显著性差异(P >0 0 5 ) ;111例 2型DM中男性及女性患者分别与 10 2例正常人群男性及女性leptin水平比较均有显著性差异 (P <0 0 5 ) ;2型DM人群中leptin水平分别与餐后 2h血糖水平、BMI呈正相关。 结论 :leptin在中国河南汉族DM家系人群中可能不是主要致病原因 ,血清leptin增高可能是 2型DM的致病原因之一。

Objects To examine whether DM pedigree is associated with HNF 4α gene exon 4?exon 7,and if leptin is related to DM pedigree in Han nationality in Henan,China.Methods The subjects included in this study were 51 pedigree members(34 were diabetic,15 had onset younger than 25,17 had normal oral glucose tolerance test,OGTT),who had family diabetic history,111 type 2 diabetic patients,and 102 healthy controls.All subjects were from the Han nationality of Henan,China.Peripheral venous blood samples were...

Objects To examine whether DM pedigree is associated with HNF 4α gene exon 4?exon 7,and if leptin is related to DM pedigree in Han nationality in Henan,China.Methods The subjects included in this study were 51 pedigree members(34 were diabetic,15 had onset younger than 25,17 had normal oral glucose tolerance test,OGTT),who had family diabetic history,111 type 2 diabetic patients,and 102 healthy controls.All subjects were from the Han nationality of Henan,China.Peripheral venous blood samples were collected to extract genomic DNA by the standard phenol/choro form method.The HNF 4α gene fragement containing the exon4 (153 bp)and exon 7(200 bp) were amplified by polymerase chain reaction (PCR),then the PCR products were examined by single strand conformation polymorphism (SSCP).Serum leptin,Serum C peptide were measured by radioimmunoassay.OGTT,pLASMA hEMOGLOBIN A 1C (HbA 1C ),glutamic acid decarboxylase antibody (GAD Ab) and body mass index(BMI) were also measured.Results Among 51 pedigree members,HNF 4α gene exon 4 mutation was found in 4 members (three were diabetic patients,one was with normal OGTT).No mutation was found for HNF 4α gene exon 7.There was no significant difference for leptin levels between 51 pedigree members and 102 healthy controls ( P >0 05).For both male and female,the leptin levels of 111 type 2 diabetic patients were significantly higher than those of 102 healthy controls ( P <0.05).The results also indicated that leptin was closely correlated with BMI (r=0.917 for male, P <0.001;r=0.861 for female, P <0.001) and 2 h OGTT (r=0.890 for male, P <0.001;r=0.741 for female, P <0.001)in 111 type 2 diabetic subjects.Conclusions This study suggests that HNF 4α gene exon4 may be an important fragment to cause MODY 1.Whereas exon 7 fragment was not related to this disorder.There was no complete expression for HNF 4α gene exon 4 mutation.Leptin didn't play an important role in the development DM pedigree members who had diabetic family history.Increased serum leptin might be one of the risk factors related to type 2 DM.

目的 探讨中国河南汉族糖尿病家系患者与HNF 4α基因外显子 4、7是否关联以及与瘦素水平的关系。方法 在中国河南汉族人群中选择 12个糖尿病家系 ,共收集到外周静脉血标本 5 1例 (诊断为糖尿病者有 34例 ,发病年龄小于 2 5岁的 15例 ,17例口服葡萄糖耐量检测正常 ) ;111例 2型糖尿病患者 ;10 2例健康献血者作对照。抽取外周静脉血用经典的酚 氯仿法提取基因组DNA ,PCR扩增含HNF 4α基因外显子 4、7的片段 (分别为 15 3bp、2 0 0bp) ,将扩增产物进行单链构像多态性分析。用放射免疫分析技术测定血清瘦素、C肽。对糖化血红蛋白、谷氨酸脱羧酸抗体、口服葡萄糖耐量、体重指数等临床指标进行检测。结果 ① 5 1例糖尿病家系成员有 4例HNF 4α基因外显子 4 (突变率 7 8% )出现异常条带 ,其中 1例为口服葡萄糖耐量正常 ,而HNF 4α基因外显子 7未见异常条带。②糖尿病家系与正常人群的瘦素比较无显著性差异 (P >0 0 5 )。③ 111例 2型糖尿病男性及女性患者分别与 10 2例正常人人群男性及女性瘦素水平比较均有显著差异 (P <0 0 5 )。④...

目的 探讨中国河南汉族糖尿病家系患者与HNF 4α基因外显子 4、7是否关联以及与瘦素水平的关系。方法 在中国河南汉族人群中选择 12个糖尿病家系 ,共收集到外周静脉血标本 5 1例 (诊断为糖尿病者有 34例 ,发病年龄小于 2 5岁的 15例 ,17例口服葡萄糖耐量检测正常 ) ;111例 2型糖尿病患者 ;10 2例健康献血者作对照。抽取外周静脉血用经典的酚 氯仿法提取基因组DNA ,PCR扩增含HNF 4α基因外显子 4、7的片段 (分别为 15 3bp、2 0 0bp) ,将扩增产物进行单链构像多态性分析。用放射免疫分析技术测定血清瘦素、C肽。对糖化血红蛋白、谷氨酸脱羧酸抗体、口服葡萄糖耐量、体重指数等临床指标进行检测。结果 ① 5 1例糖尿病家系成员有 4例HNF 4α基因外显子 4 (突变率 7 8% )出现异常条带 ,其中 1例为口服葡萄糖耐量正常 ,而HNF 4α基因外显子 7未见异常条带。②糖尿病家系与正常人群的瘦素比较无显著性差异 (P >0 0 5 )。③ 111例 2型糖尿病男性及女性患者分别与 10 2例正常人人群男性及女性瘦素水平比较均有显著差异 (P <0 0 5 )。④ 2型糖尿病人群中瘦素水平分别与餐后 2小时血糖水平、体重指数呈正相关。结论 ①HNF 4α基因外显子 4可能是中国河南汉族糖尿病家系的主要致病基因片段 ,与外显子 7可能无

Objective Objective To understand the risk factor of type 2 diabetes mellitus in urban population ,and provide the information of formulating the intervention strategy of type 2 diabetes mellitus in similar communities.Objective [MethodsObjective ] 1∶1 matched case-control study of 71 type 2 diabetes mellitus cases was conducted.Objective [ResultsObjective ]Conditional Logistic regression analysis showed that family diabetic history patrilineal index(OR=3 831);waist and hip ratio(OR=2 105)were the...

Objective Objective To understand the risk factor of type 2 diabetes mellitus in urban population ,and provide the information of formulating the intervention strategy of type 2 diabetes mellitus in similar communities.Objective [MethodsObjective ] 1∶1 matched case-control study of 71 type 2 diabetes mellitus cases was conducted.Objective [ResultsObjective ]Conditional Logistic regression analysis showed that family diabetic history patrilineal index(OR=3 831);waist and hip ratio(OR=2 105)were the risk factors of type 2 diabetes mellitus.Objective [ConclusionsObjective ]Intervention among urban population should be focus on the people with family diabetic history, particularly with the history of patrilineal inheritance and/or central type fatness

[目的 ]探讨城市社区Ⅱ型糖尿病的危险因素 ,为该类社区人群Ⅱ型糖尿病干预对策与措施的制定提供依据。 [方法 ]用 71例Ⅱ型糖尿病患者进行 1 1配对病例对照研究。 [结果 ]条件Logisitic回归模型显示 ,糖尿病家族史、父系遗传系数 (OR =3 831)和腰臀比 (OR =2 10 5 )为Ⅱ型糖尿病的危险因素。 [结论 \〗对具有糖尿病家族史特别是具有父系遗传史者与中心型肥胖者应加强干预工作。

 
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