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family diabetic history
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  糖尿病家族史
    Compared with NPTDM,the patients with PTDM had statistical significance in age, body weight, renal function and family diabetic history(P<0.05 or P<0.01).
    PTDM患者与同期非PTDM患者相比,在年龄、体重、激素用量及肾功能异常、阳性糖尿病家族史方面有显著差异(P<0.05或P<0.01)。
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    Conclusion CsA and tacrolimus are similar in terms of the effect on PTDM and the development of PTDM is related to steroid dose, age, body weight, renal function and family diabetic history.
    结论环孢素A和他克莫司对肾移植PTDM的作用相近,患者激素用量、体重、年龄、移植肾功能状况及糖尿病阳性家族史是PTDM的易发因素。
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Objective[WT5”BZ] To study the clinical rules of posttransplantation diabetes mellitus(PTDM). [WT5”HZ]Methods[WT5”BZ] 21 patients treated from Dec. 1992 to Sept. 1998 were analysed. [WT5”HZ]Results[WT5”BZ] The morbidity of PTDM was 16 3% of total patients in the corresponding period.Between the groups of PTDM and NON PTDM,there was statistical significance in age, kidney function and family diabetic history. It was not related to CSA bottom concentration and acute rejection. In this group 2 cases...

Objective[WT5”BZ] To study the clinical rules of posttransplantation diabetes mellitus(PTDM). [WT5”HZ]Methods[WT5”BZ] 21 patients treated from Dec. 1992 to Sept. 1998 were analysed. [WT5”HZ]Results[WT5”BZ] The morbidity of PTDM was 16 3% of total patients in the corresponding period.Between the groups of PTDM and NON PTDM,there was statistical significance in age, kidney function and family diabetic history. It was not related to CSA bottom concentration and acute rejection. In this group 2 cases were complicated by hyperosmolar nonketotic diabetic comas (9 5%) and 11 various infections (52 4%). [WT5”HZ]Conclusions[WT5”BZ] PTDM as a secondary diabetes due to antirejection drugs and allograft kidney function may cause serious consequences if it is treated improperly. [WT5”HZ]

目的 研究肾移植后糖尿病 (PTDM)的临床规律。 方法 总结 1992年 12月至 1998年 9月间经治的 2 1例PTDM患者与同期非PTDM患者 10 8例的资料比较。 结果 本组PTDM总发病率为 16 3%。统计显示 ,PTDM组与非PTDM组在年龄、肾功能异常率 (5 7.1%及 30 .5 % )及阳性糖尿病家族史方面有显著性差异 ,但与环孢霉素谷A浓度值及急性排异发生率无关。PTDM组并发高渗性非酮性糖尿病昏迷 2例 ,各类感染 11例 ,感染率 5 2 4%。 结论 PTDM是一种与抗排异药物及移植肾功能密切相关的继发性糖尿病 ,处理不当易致严重后果 ,需引起临床足够重视。

Objective To study the incidence and risk factors for post-transplant diabetes mellitus (PTDM) in kidney transplant recipients. Method Retrospective analysis of 217 cases of kidney transplant recipients was carried out. Immune maintenance therapy included myophenolate mofetil plus glucocorticoids in combination with cyclosporine A (Group Ⅰ, n=173) and tacrolimus (Group Ⅱ, n=44 ).There was a comparison between cases of PTDM and Non-PTDM(NPTDM). Results The morbidity of PTDM was 6.9% (15/217). The incidence for...

Objective To study the incidence and risk factors for post-transplant diabetes mellitus (PTDM) in kidney transplant recipients. Method Retrospective analysis of 217 cases of kidney transplant recipients was carried out. Immune maintenance therapy included myophenolate mofetil plus glucocorticoids in combination with cyclosporine A (Group Ⅰ, n=173) and tacrolimus (Group Ⅱ, n=44 ).There was a comparison between cases of PTDM and Non-PTDM(NPTDM). Results The morbidity of PTDM was 6.9% (15/217). The incidence for Group Ⅰ and Ⅱof 6.4%(11/173) and 9.1%(4/44) respectively were not statistically different(P>0.05). Compared with NPTDM,the patients with PTDM had statistical significance in age, body weight, renal function and family diabetic history(P<0.05 or P<0.01). Conclusion CsA and tacrolimus are similar in terms of the effect on PTDM and the development of PTDM is related to steroid dose, age, body weight, renal function and family diabetic history.

目的探讨肾移植术后糖尿病(PTDM)的发病情况及相关因素。方法回顾分析217例肾移植术后患者临床资料。按免疫抑制治疗方案分为两组,组Ⅰ:173例(环孢素A+骁悉+激素);组Ⅱ:44例(他克莫司+骁悉+激素);并比较PTDM与非PTDM患者临床资料。结果PTDM发病率6.9%(15/217),PTDM在组Ⅰ、组Ⅱ中的发病率分别为6.4%(11/173)及9.1%(4/44),两组比较无统计学差异(P>0.05);PTDM患者与同期非PTDM患者相比,在年龄、体重、激素用量及肾功能异常、阳性糖尿病家族史方面有显著差异(P<0.05或P<0.01)。结论环孢素A和他克莫司对肾移植PTDM的作用相近,患者激素用量、体重、年龄、移植肾功能状况及糖尿病阳性家族史是PTDM的易发因素。

 
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