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retinoic acid induced
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  维甲酸诱导
     Results:After 15 days by retinoic acid induced,the masses of spongy bone and cortical bone of femurs of the rats were decreased and showed osteoporosis.
     结果 :维甲酸诱导 15d后 ,大鼠股骨松质骨和皮质骨骨量减少 ,呈现骨质疏松变化。
短句来源
     All trans retinoic acid induced differentiation in human gastric carcinoma cell line SGC 7901
     全反式维甲酸诱导人胃癌细胞株SGC-7901分化的研究
短句来源
     The transfer of human acetylcholinesterase gene to pancreatic cancer cells enhances the effect of all-trans retinoic acid induced cell apoptosis
     人乙酰胆碱酯酶基因转染增强全反式维甲酸诱导胰腺癌细胞凋亡
短句来源
     RNA helicases Retinoic acid induced gene-I(RIG-Ⅰ) is a newly discovered pattern recognition receptor(PRR),acting as a cytoplasmic dsRNA receptor and inducer of IFN production,to activate antiviral immune responses.
     RNA解旋酶维甲酸诱导基因-Ⅰ(RIG-Ⅰ)是新发现的细胞内重要的模式识别受体,能识别胞内的dsRNA进而诱导IFN的产生,激活特异性免疫而发挥抗病毒作用。
短句来源
     Results:After 15 days by retinoic acid induced,the masses of spongy bone and cortical bone of femurs from the rats were decreased,the osteoclast quantities in spongy bone were obviously increased and the osteoclast function became active,AKP and TRAP contents in serums were significantly increased.
     结果 :维甲酸诱导 15d后 ,大鼠股骨松质骨和皮质骨骨量减少 ,松质骨破骨细胞数明显增多 ,功能活跃 ,血清AKP、TRAP显著增高 ;
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  “retinoic acid induced”译为未确定词的双语例句
     Treatment with daunorubicin, dexamethasone and all-trans retinoic acid induced CYP3A5 activities in some leukemia cell lines.
     柔红霉素、地塞米松、全反式维甲酸的应用可诱导某些AL细胞株CYP3A5活性。
短句来源
     G CSF and retinoic acid induced the expression of ALP gene in the granulocytes of CML.
     G CSF和视黄醇对CML粒细胞中的ALP基因表达具有诱导作用
短句来源
     Expression and characterization of protein encoded by a retinoic acid induced novel gene RA28
     维甲酸激活基因RA28编码蛋白的表达及性质研究
短句来源
     OBSERVATION ON ULTRASTRUCTURAL CHANGES IN F9 MOUSE EMBRYONAL CARCINOMA CELLS DURING RETINOIC ACID INDUCED DIFFERENTIATION
     维生素A酸诱导小鼠F9胚胎性癌细胞分化的超微结构观察
短句来源
     STUDY OF RETINOIC ACID INDUCED DIFFERENTIATION ON THE LEUKEMIA CELLS IN THE HUMAN PROMYELOCYTIC LEUKEMIA
     维甲酸对急性早幼粒细胞白血病白血病细胞诱导分化作用的研究
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  相似匹配句对
     The Preparation of Cis-retinoic Acid
     异维A酸的制备方法
短句来源
     Retinoic acid in experimental myopia
     视黄醛在实验性近视中的作用
短句来源
     The rat's osteoporosis was induced by retinoic acid with 80mg.
     以维甲酸 80mg .
短句来源
     Skin Reactions Induced by Topical Retinoic Acid in Mice
     外用维A酸引起小鼠皮肤反应的研究
短句来源
     Studies on Differentiation of Colorectal Carcinoma Induced by Retinoic Acid
     维甲酸诱导大肠癌CCL-187细胞成熟分化的研究
短句来源
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  retinoic acid induced
We have studied the retinoic acid response of five cell lines, compared to P19 cells, by observing three markers of retinoic acid induced P19 differentiation-cell morphology,RARα andWnt1 transcription.
      
3,4-Dihydroxyphenylalanine (DOPA) metabolism and retinoic acid induced differentiation in human neuroblastoma
      
During retinoic acid induced differentiation of mitotically synchronized PC13 EC cells, accumulation of H10 mRNA starts in the first cell cycle.
      
Histone H10 mRNA and protein accumulate early during retinoic acid induced differentiation of synchronized embryonal carcinoma c
      
Using explanted humeri of late fetal rats, retinoic acid induced a dose- and time-dependent regression of cartilage.
      
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The changes of protein kinase C and its substrates in the cytosol and nuclei upon retinoic acid-induced differentiation of HL-60 cells were studies by incubation of [γ-32P]ATP with proteins in vitro. The activity of protein kinase C in the cytosol rose,and that in the nuclei declined after differentiation. The substrates of protein kinase C in the cytosol of HL-60 cells were 75 kD,67kD,47kD,40kD and 21kD proteins,and 35kD protein was the substrate of protein

本文观察视黄酸诱导HL-60细胞分化后胞浆及核中蛋白激酶C活性和底物的变化。视黄酸诱导分化后,胞浆中蛋白激酶C活性升高,而核中则降低;胞浆中蛋白激酶C的底物减少,而核中蛋白激酶C底物的种类没有改变,但21kD的蛋白激酶C底物的磷酸化明显减弱。进一步分析表明,21kD蛋白是0.75mol/L高氯酸可溶蛋白。结果提示胞浆和核中蛋白激酶C及其底物的变化,可能与视黄酸对HL-60细胞的诱导分化作用有关。

Our recent studies showed that glucocorticoids play an important role in the processes responsible for proliferation and differentiation of a human megakaryoblastic leukemia cell line (HIMeg) and that the effects of glucocorticoids are mediated by glucocorticoid receptor(GR) in these cells.The regulation of GR expression in HIMeg cells by retinoic acid was further studied utilizing radioligand binding assay and molecular hybridization analysis.It was shown that retinoic acid could significantly...

Our recent studies showed that glucocorticoids play an important role in the processes responsible for proliferation and differentiation of a human megakaryoblastic leukemia cell line (HIMeg) and that the effects of glucocorticoids are mediated by glucocorticoid receptor(GR) in these cells.The regulation of GR expression in HIMeg cells by retinoic acid was further studied utilizing radioligand binding assay and molecular hybridization analysis.It was shown that retinoic acid could significantly increase the GR binding activities in a time-dependent manner,reaching a maximum of about 2-fold 24h following treatment.Dot blot hybridization analysis utilizing 32P-labeled GR cDNA fragment as a probe showed that GR mRNA was also up-regulated by retinoic acid,suggesting that the regulating effects of retinoic acid on GR occurred at least partially at GR mRNA levels. To explore further the possible consequence of retinoic acid-induced regulation of GR exp ression in HIMeg cells,the combined effects of glucocorticoids and retinoic acid on HIMeg cell proliferation were evaluated.It was found that the inhibitory effects of combinations of glucocorticoids and retinoic acid on HIMeg cell proliferation showed an additive property,suggesting that the regulation of GR expression by retinoic acid was of biological significance.

糖皮质激素对人原始巨核白血病细胞系(HIMeg)的增殖分化过程有调节作用,且由糖皮质激素受体(GR)介导。用放射配体结合分析法及分子杂交进一步研究了视黄酸对HIMeg细胞GR的表达调节作用。结果表明,视黄酸可使GR结合活性明显提高,且具有时间依赖性,24h后约提高2倍:以[32P]标记的GRcDNA片段为探针,用dotblot杂交分析表明,视黄酸亦可使GRmRNA水平升高,表明视黄酸对GR结合活性的影响至少部分地发生于mRNA水平。为进一步阐明视黄酸对GR调节的可能意义,还观察了糖皮质激素与视黄酸联合应用对HIMeg细胞增殖过程的影响,发现二者具有相加作用,提示视黄酸对GR的调节作用具有生物学意义。

Retinoic acid is a chemical teratogen which causes varieties of congenital cardiac malformations, such as overriding aorta, ventricular septal defect. In this study the changes of laminin (LN) and fibronectin (FN) in the development of cogenital heart malformations induced by excessive retinoic acid were observed by the immunohistochemical method. The results were as follows: 1. When endocardial cells transformed into endocardiac cushion cells, they lost laminin and fibronectin in their basal surfaces; The staining...

Retinoic acid is a chemical teratogen which causes varieties of congenital cardiac malformations, such as overriding aorta, ventricular septal defect. In this study the changes of laminin (LN) and fibronectin (FN) in the development of cogenital heart malformations induced by excessive retinoic acid were observed by the immunohistochemical method. The results were as follows: 1. When endocardial cells transformed into endocardiac cushion cells, they lost laminin and fibronectin in their basal surfaces; The staining for LN and FN became positively strong in the endocardiac jelly and myocardium. 2. The quantity of LN and FN within endocardiac jelly decreased after th formation and fusion of endocardiac cushion. 3. At 18 hours after the treatment the staining intensity for LN and FN in the endocardium, endocardiac jelly (EJ) and myocardium was weaker in the experimental group than in the control group, suggesting that LN and FN may be the medium to which the endocardiac cushion cells adhered and migrated. Excessive retinoic acid could reduce the quantity of laminin and fibronectin whithin endocardiac jelly during embryonic development, and thereby disturbed the normal adhesion and the migration of endocardiac cushion cells. It might be an important route by which excessive retinoic acid induced congenital cardiac malformation.

维生素A酸是常见的一类化学致畸因子,可引起各种心脏畸形,如主动脉骑跨、室间隔缺损等.实验采用免疫组织化学方法观察层粘连蛋白和纤维粘连蛋白在心脏正常和异常发育过程中的分布和变化规律,以探讨过量维生素A酸致心脏畸形发生的机理.结果显示:心内膜垫形成之前,心内膜细胞基底面呈层粘连蛋白和纤维粘连蛋白阳性;当内膜细胞转化为内膜垫细胞时,其基底面的层粘连蛋白和纤维粘连蛋白消失,心胶质和心肌膜中层粘连蛋白、纤维粘连蛋白免疫组化染色明显增强;心内膜垫形成并融合后,其染色又明显减弱.给孕鼠灌服过量的维生素A酸18小时后,各时间组胚胎心脏的心内膜、心胶质、心肌膜的层粘连蛋白和纤维粘连蛋白均出现了不同程度的减弱.这说明层粘连蛋白和纤维粘连蛋白是内膜垫细胞粘着和迁移的主要介导物质,维生素A酸抑制其两者的合成是引起心脏畸形的一个重要途径.

 
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