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retinoic acid induced
相关语句
  维甲酸诱导
    CLINICAL OBSERVATION ON RETINOIC ACID INDUCED DIFFERENTIATION THERAPY OF ACUTE PROMYELOCYTIC LEUKEMIA
    维甲酸诱导分化急性早幼粒细胞白血病一例的临床观察
短句来源
    RNA helicases Retinoic acid induced gene-I(RIG-Ⅰ) is a newly discovered pattern recognition receptor(PRR),acting as a cytoplasmic dsRNA receptor and inducer of IFN production,to activate antiviral immune responses.
    RNA解旋酶维甲酸诱导基因-Ⅰ(RIG-Ⅰ)是新发现的细胞内重要的模式识别受体,能识别胞内的dsRNA进而诱导IFN的产生,激活特异性免疫而发挥抗病毒作用。
短句来源
    Acute Promyelocytic Leukemia:Management of Bleeding Complication in all-Trans Retinoic Acid Induced Differentiation
    急性早幼粒细胞性白血病:全反式维甲酸诱导分化治疗中出血并发症的处理
短句来源
  “retinoic acid induced”译为未确定词的双语例句
    STUDY OF RETINOIC ACID INDUCED DIFFERENTIATION ON THE LEUKEMIA CELLS IN THE HUMAN PROMYELOCYTIC LEUKEMIA
    维甲酸对急性早幼粒细胞白血病白血病细胞诱导分化作用的研究
短句来源
    Study on Proteins Interacting with Retinoic Acid Induced Gene G by Yeast-Two-Hybrid Technique
    酵母双杂交研究与RIG-G相互作用的蛋白
短句来源
    Treatment with daunorubicin, dexamethasone and all-trans retinoic acid induced CYP3A5 activities in some leukemia cell lines.
    柔红霉素、地塞米松、全反式维甲酸的应用可诱导某些AL细胞株CYP3A5活性。
短句来源
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  retinoic acid induced
We have studied the retinoic acid response of five cell lines, compared to P19 cells, by observing three markers of retinoic acid induced P19 differentiation-cell morphology,RARα andWnt1 transcription.
      
3,4-Dihydroxyphenylalanine (DOPA) metabolism and retinoic acid induced differentiation in human neuroblastoma
      
During retinoic acid induced differentiation of mitotically synchronized PC13 EC cells, accumulation of H10 mRNA starts in the first cell cycle.
      
Histone H10 mRNA and protein accumulate early during retinoic acid induced differentiation of synchronized embryonal carcinoma c
      
Using explanted humeri of late fetal rats, retinoic acid induced a dose- and time-dependent regression of cartilage.
      
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Our recent studies showed that glucocorticoids play an important role in the processes responsible for proliferation and differentiation of a human megakaryoblastic leukemia cell line (HIMeg) and that the effects of glucocorticoids are mediated by glucocorticoid receptor(GR) in these cells.The regulation of GR expression in HIMeg cells by retinoic acid was further studied utilizing radioligand binding assay and molecular hybridization analysis.It was shown that retinoic acid could significantly...

Our recent studies showed that glucocorticoids play an important role in the processes responsible for proliferation and differentiation of a human megakaryoblastic leukemia cell line (HIMeg) and that the effects of glucocorticoids are mediated by glucocorticoid receptor(GR) in these cells.The regulation of GR expression in HIMeg cells by retinoic acid was further studied utilizing radioligand binding assay and molecular hybridization analysis.It was shown that retinoic acid could significantly increase the GR binding activities in a time-dependent manner,reaching a maximum of about 2-fold 24h following treatment.Dot blot hybridization analysis utilizing 32P-labeled GR cDNA fragment as a probe showed that GR mRNA was also up-regulated by retinoic acid,suggesting that the regulating effects of retinoic acid on GR occurred at least partially at GR mRNA levels. To explore further the possible consequence of retinoic acid-induced regulation of GR exp ression in HIMeg cells,the combined effects of glucocorticoids and retinoic acid on HIMeg cell proliferation were evaluated.It was found that the inhibitory effects of combinations of glucocorticoids and retinoic acid on HIMeg cell proliferation showed an additive property,suggesting that the regulation of GR expression by retinoic acid was of biological significance.

糖皮质激素对人原始巨核白血病细胞系(HIMeg)的增殖分化过程有调节作用,且由糖皮质激素受体(GR)介导。用放射配体结合分析法及分子杂交进一步研究了视黄酸对HIMeg细胞GR的表达调节作用。结果表明,视黄酸可使GR结合活性明显提高,且具有时间依赖性,24h后约提高2倍:以[32P]标记的GRcDNA片段为探针,用dotblot杂交分析表明,视黄酸亦可使GRmRNA水平升高,表明视黄酸对GR结合活性的影响至少部分地发生于mRNA水平。为进一步阐明视黄酸对GR调节的可能意义,还观察了糖皮质激素与视黄酸联合应用对HIMeg细胞增殖过程的影响,发现二者具有相加作用,提示视黄酸对GR的调节作用具有生物学意义。

Objective To investigate whether chemotherapeutic drugs can modulate the transcription and activities of CYP3A5 gene in some leukemia cell lines. Methods CYP3A5 mRNA and activities were detected in leukemia cell lines through RT-PCR and HPLC assay.Results Daunorubicin increased CYP3A5 mRNA level in K562/A02 cells and activated its transcription in HL-60/ADR cells. Dexamethasone induced a weak transcription of CYP3A5 gene after 24 hours and a strong transcription after 48 hours in Jurkat cells. All-trans...

Objective To investigate whether chemotherapeutic drugs can modulate the transcription and activities of CYP3A5 gene in some leukemia cell lines. Methods CYP3A5 mRNA and activities were detected in leukemia cell lines through RT-PCR and HPLC assay.Results Daunorubicin increased CYP3A5 mRNA level in K562/A02 cells and activated its transcription in HL-60/ADR cells. Dexamethasone induced a weak transcription of CYP3A5 gene after 24 hours and a strong transcription after 48 hours in Jurkat cells. All-trans retinoic acid activated transcription of CYP3A5 gene after 24 hours in NB4 cells. CYP3A5 activity of K562 cells was significantly statistically higher than those of HL-60, NB4 and Jurkat cells. Treatment with daunorubicin increased CYP3A5 activity after 24 hours in K562 cells, and further increased a statistically significant higher activity after 48 hours, whereas there were no remarkable changes in NB4 and Jurkat cell lines. Jurkat cells treated with dexamethasone and NB4 cells treated with all-trans retinoic acid had both significantly increased the CYP3A5 activities, and the induction was time-dependent. Conclusion Treatment with daunorubicin, dexamethasone and all-trans retinoic acid induce the transcription and modutating activity of CYP3A5 gene in some leukemia cell lines.

目的 探讨化疗药对白血病细胞系CYP3A5基因转录及活性的调控。方法 采用RT -PCR、高压液相色谱法 (HPLC)检测药物干预后白血病细胞系CYP3A5基因的转录及活性。结果 K5 6 2 /A0 2细胞经柔红霉素作用后CYP3A5转录增强 ,HL -6 0 /ADR细胞则经诱导后出现CYP3A5转录。Jurkat细胞经地塞米松作用2 4h后出现微弱的CYP3A5转录 ,4 8h后转录明显增强。NB4细胞经全反式维甲酸作用 2 4~ 96h均诱导出现CYP3A5转录。K5 6 2细胞的CYP3A5活性显著高于HL- 6 0、NB4和Jurkat细胞。柔红霉素作用 2 4h后K5 6 2细胞的CYP3A5活性增高 ,4 8h后活性显著增高 ;而NB4和Jurkat细胞在柔红霉素作用 2 4h后CYP3A5活性无改变。地塞米松作用Jurkat细胞、全反式维甲酸作用NB4细胞均能诱导CYP3A5活性显著增高 ,并呈时间依赖性。结论 柔红霉素、地塞米松、全反式维甲酸的应用可诱导某些白血病细胞株CYP3A5基因的转录及活性。

Objective To develope HPLC assay to study CYP3A5 activities regulated by anticancer drugs in leukemia cell lines. Methods CYP3A5 activities of intact leukemia cell lines were detected through HPLC assay. Results 1×10 6 cells incubating with hydrocortisone (HC, final concentration 100 μmol/L) for 24 h were finally determined as the incubation conditions for assessing activities of HC 6β-hydroxylation in intact leukemia cell lines. CYP3A5 activity of K562 cells was statistically significantly higher than that...

Objective To develope HPLC assay to study CYP3A5 activities regulated by anticancer drugs in leukemia cell lines. Methods CYP3A5 activities of intact leukemia cell lines were detected through HPLC assay. Results 1×10 6 cells incubating with hydrocortisone (HC, final concentration 100 μmol/L) for 24 h were finally determined as the incubation conditions for assessing activities of HC 6β-hydroxylation in intact leukemia cell lines. CYP3A5 activity of K562 cells was statistically significantly higher than that of HL-60, NB4 and Jurkat cells. Treatment with daunorubicin increased CYP3A5 activity after 24 h in K562 cells, and further increased a statistically significantly higher activity after 48 h, while there were no remarkable changes in NB4 and Jurkat cell lines. Dexa- methasone induced a statistically significantly increased CYP3A5 activity after 24 h in Jurkat cells and statistically a even more significantly higher activity after 48 h. All-trans retinoic acid significantly increased CYP3A5 activity after 24 h in NB4 cells statistically, and induced a even more statistically significantly higher activity after 72 h. Conclusion Development of HPLC assay for measuring activities of HC 6β-hydroxylation in intact leukemia cell lines can be used to determine the localized CYP3A5 activities in leukemia cells.Treatment with daunorubicin, dexamethasone and all-trans retinoic acid induced CYP3A5 activities in some leukemia cell lines.

目的建立白血病(AL)细胞系CYP3A5活性检测方法,研究化疗药对其活性的调控。方法HPLC法检测药物干预后AL细胞系CYP3A5活性。结果以1×106细胞、氢化考的松终浓度100μmol/L、孵育24h为AL细胞体外培养条件下氢化考的松6β-羟化活性检测的孵育条件。K562细胞CYP3A5活性显著高于HL-60、NB4和Jurkat细胞。柔红霉素作用24h后K562细胞CYP3A5活性增高,48h后活性显著增高;而NB4与Jurkat细胞在其作用后活性无改变。地塞米松作用24h后Jurkat细胞CYP3A5活性显著增高,48h后活性又显著增高。全反式维甲酸作用24h后NB4细胞CYP3A5活性显著增高,72h后活性又显著增高。结论HPLC检测AL细胞体外培养条件下氢化考的松6β-羟化活性方法的建立可用于研究AL细胞CYP3A5活性。柔红霉素、地塞米松、全反式维甲酸的应用可诱导某些AL细胞株CYP3A5活性。

 
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