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   mouse writhing 的翻译结果: 查询用时:0.2秒
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mouse writhing
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  扭体
     In three analgesic experiments,Sin showed analgesic activity. In the experiment of mice hot plate ethod,the ED_(50) Values of po and sc Sin were 154.9mg/kg and 125.2 mg/kg,respectively. Sin po showedthe inhibitory effect on mouse writhing caused by i.pHAc with the ED_(50) value of 36.4 mg/kg.
     应用3种镇痛实验方法,青藤碱(Sin)皆呈现镇痛作用:小鼠热板法镇痛实验证明,Sin 口服和皮下注射的 ED_(50)分别为154.9mg/kg 和125.2mg/kg Sin 可抑制小鼠腹腔注射醋酸扭体反应,其 ED_(50)为36.4mg/kg;
短句来源
     Mouse writhing response, hot-plate test and rat tail-flick tests were used to study the influence of reserpine and pargyline on the normal pain threshold in mice and rats and on the analgesia of morphine. The results are as follows: The writhing response in mice was inhibited after ip of reserpine at a dose of 2 mg/kg, or pargyline 100 mg/kg.
     采用三种测痛方法,观察了利血平、优降宁对小鼠、大鼠正常痛阈和吗啡镇痛作用的影响,结果表明:ip利血平2 mg/kg,优降宁100 mg/kg均能明显抑制小鼠扭体反应;
短句来源
     Mouse writhing response testwas used to study the influence of IL on analgesia andits tolerance in mice. The writhing response in mice wasinhibited after sc IL at a dose of 25 or 50 mg/kg.
     对酒石酸锑钾性小鼠扭体反应,IL25、50 mg/kg sc 均有明显抑制作用;
短句来源
     Their antiinflammatory and analgesic activities in vivo were tested by xylene-induced mouse ear edema model and acetic acid-induced mouse writhing model po dose of 200 mg·kg -1 . RESULTS Seventeen new compounds (1-17) were synthesized.
     用二甲苯致小鼠耳肿胀法和小鼠醋酸扭体法测定这些化合物的 ( po 2 0 0mg·kg-1)抗炎及镇痛活性。 结果 合成了 17个新化合物 ( 1- 17)。
短句来源
     Methods The analgesic and anti-inflammatory effects and mechanism of ephedra asarum decoction were studied by the animal models of mouse writhing,mouse licking-foot,hot-plate,mouse's footpad swelling and the contraction of isolated guineapig ileum.
     方法 应用小鼠扭体、小鼠舔足、热板、小鼠足垫肿胀等动物模型和离体豚鼠回肠试验 ,对麻黄细辛汤的镇痛消炎作用及机理进行实验。
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  “mouse writhing”译为未确定词的双语例句
     Based on the SAR summarized, seventeen new compounds of 3H-1,2-dihydro-1-pyrrolizinone were designed and synthesized. Their chemical structures were confirmed by IR, ~1H-NMR, ~(13)C-NMR and MS. The anti-inflammatory and analgesic activities were tested on xylene-induced mouse ear edema and acetic acid-induced mouse writhing.
     本课题在我校有机教研室对吡里酮类化合物已发现的构效关系的基础上,设计合成了17个未见文献报道的吡里酮衍生物,并通过IR,~1H-NMR,~(13)C-NMR,MS确定了它们的结构。
短句来源
     The analgesic effect was determined with mouse writhing method and mouse hot plate method.
     用醋酸和热板两种方法致痛观察小鼠痛反应。
短句来源
  相似匹配句对
     Mouse
     鼠标
短句来源
     A STUDY ON DRUG-INDUCED “WRITHING” IN THE MOUSE
     药物所致小白鼠“扭体反应”
短句来源
     XT obviously inhibited the activities on mouse writhing induced by HOAc.
     XT明显抑制醋酸引起的小鼠扭体反应。
短句来源
     The Lion and the Mouse
     狮子与老鼠
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  mouse writhing
Differential effects of systemically administered nor-binaltorphimine (nor-BNI) on κ-opioid agonists in the mouse writhing assay
      
The mouse writhing assay is a useful test to evaluate mild analgesic non-steroidal anti-inflammatory agents.
      
Subcutaneous BAY K 8644 increased morphine induced antinociception in the mouse writhing, hot-plate and tail-clip tests.
      
Our results show that the calcium-binding protein MRP-14 but not MRP-8 had a marked antinociceptive effect in the mouse writhing test.
      


Mouse writhing response, hot-plate test and rat tail-flick tests were used to study the influence of reserpine and pargyline on the normal pain threshold in mice and rats and on the analgesia of morphine. The results are as follows: The writhing response in mice was inhibited after ip of reserpine at a dose of 2 mg/kg, or pargyline 100 mg/kg. The paw lick latency in mouse hot-plate test was prolonged following reserpine (1 mg/kg, ip) but not influenced, by pargyline. The tail-flick...

Mouse writhing response, hot-plate test and rat tail-flick tests were used to study the influence of reserpine and pargyline on the normal pain threshold in mice and rats and on the analgesia of morphine. The results are as follows: The writhing response in mice was inhibited after ip of reserpine at a dose of 2 mg/kg, or pargyline 100 mg/kg. The paw lick latency in mouse hot-plate test was prolonged following reserpine (1 mg/kg, ip) but not influenced, by pargyline. The tail-flick latency in rats was affected by neither reserpine (6 mg/kg, ip) nor pargyline (75 mg/kg,ip). The analgesic effect of morphine was antagonized by reserpine (0.5 mg/kg and 1 mg/kg ip in mice or 2 mg/kg ip in rats), and potentiated by pargyline (35 mg/kg ip in mice, or 50 mg/kg ip in rats). The antagonistic effect of reserpine against morphine was reversed by pargyline, and this effect was found to be dependent on the sequence of the administration of reserpine and pargyline. The analgesic effect of morphine was potentiated by administering pargyline and reserpine at the same time or by giving pargyline half an hour before reserpine. But the analgesic effect of morphine was decreased when reserpine was given before pargyline.

采用三种测痛方法,观察了利血平、优降宁对小鼠、大鼠正常痛阈和吗啡镇痛作用的影响,结果表明:ip利血平2 mg/kg,优降宁100 mg/kg均能明显抑制小鼠扭体反应;ip利血平1 mg/kg能明显提高小鼠热板反应时间,但ip优降宁75 mg/kg无明显影响;ip利血平6 mg/kg,优降宁75 mg/kg对大鼠甩尾反应时间均无明显影响;利血平(小鼠0.5~1.0 mg/kg,大鼠2 mg/kg ip)能明显对抗吗啡镇痛作用;优降宁(小鼠35 mg/kg,大鼠50 mg/kg ip)能明显增强吗啡镇痛作用,并能“逆转”利血平对抗吗啡镇痛作用。其“逆转”作用的强弱取决于利血平、优降宁给药的先后次序。

Aconitum bulleyanum Diel is an herb which has been used as an anodyne in Yunnan province for a long time. Bulleyaconitine A (Bul), an active principle, was extracted from this herb. The analgesic action of Bul has been shown in this paper by using the following methods: mice writhing evoked by ip 0.7% acetic acid 10 ml/kg; mice hot plate (56℃); continuous pain stimuli elicited by sc formaldehyde in front paw~((8)) and-rat tail-flick response to light irradiation. The relative analgesic effect of...

Aconitum bulleyanum Diel is an herb which has been used as an anodyne in Yunnan province for a long time. Bulleyaconitine A (Bul), an active principle, was extracted from this herb. The analgesic action of Bul has been shown in this paper by using the following methods: mice writhing evoked by ip 0.7% acetic acid 10 ml/kg; mice hot plate (56℃); continuous pain stimuli elicited by sc formaldehyde in front paw~((8)) and-rat tail-flick response to light irradiation. The relative analgesic effect of Bul was found to be 1.8~3.25, 15.3~65.5 and 1208~7195 times as potent as 3-acetylaconitine, morphine and aspirin, respectively. The duration of analgesic effect of Bul assayed with pain stimuli of formaldehyde in mice was longer than that of morphine. No tolerance of analgesic effect was found after daily sc of Bul 0.15 mg/kg for 9 d in mice assayed with hot plate method. In nalorphine-challenge test, no jumping response was observed in mice treated with Bul 1.2 mg/kg, the maximal tolerance dose. Rats were given sc morphine 2.5 mg/kg bid for 120 d, withdrawal of morphine was followed by a decrease in body weight, which was used as a parameter of abstinence syndrome, Bul sc 0.1 mg/kg did not alter theoweight loss of morphine-treated rats. One male monkey developed physical dependence after se morphine of which the daily dose was increased progressively from 2.5 to 25 mg/kg in 21 d and then maintained for 120 d. Bul 30 μg/kg sc did not supress the withdrawal signs evoked by ip nalorphine 0.5 mg/kg. The results indicate that Bul induced no morphine-like tolerance nor physical dependence.The analgesic action of Bul was not antagonized by naloxone, but was eliminated by intraperitoneal injection of reserpine 3 mg/kg 3 h prior to Bul. The antagonistic action of reserpine to Bul could be reversed by icv 5-HT or ip 5-HTP given 3 h after reserpine. So, the analgesic effect of Bul may be related to the 5-HT level in brain.It was found that Bul exhibit strong local anesthetic activity when injected around the Sciatic erve in mice, the ED_(50) concentration of Bul (50% mice with signs of sciaric nerve block) was 0.0029%.

用扭体法、热板法、光热-甩尾法和甲醛致痛法证实Bul有明显镇痛作用。连续给药9 d,镇痛作用无耐受现象。小鼠跳跃反应试验阴性;Bul对吗啡依赖大鼠或猴的戒断症状,均无替代作用。Bul的镇痛作用不能被纳络酮翻转;利血平可取消Bul的镇痛作用,补充5-HT或5-HTP能翻转利血平取消Bul的镇痛作用。

Acemetacin ( ACM ) , a synthetic non-steroid antipyretic analgesics, was produced in China. ACM lOmg/kg ig markedly inhibited the increased vascular permeability induced by 0.7% HAc and the swelling of ear induced by croton oil in mice, ACM 20mg/kg ig inhibited the edema of the rat paw caused by carrageenin and the proliferation of granuloma caused by cotton pellet,ACM 40mg/kg it; prolonged the potential time induced by radiant heat in rats and reduced the tempreture of feverish rats. It inhibited the mouse...

Acemetacin ( ACM ) , a synthetic non-steroid antipyretic analgesics, was produced in China. ACM lOmg/kg ig markedly inhibited the increased vascular permeability induced by 0.7% HAc and the swelling of ear induced by croton oil in mice, ACM 20mg/kg ig inhibited the edema of the rat paw caused by carrageenin and the proliferation of granuloma caused by cotton pellet,ACM 40mg/kg it; prolonged the potential time induced by radiant heat in rats and reduced the tempreture of feverish rats. It inhibited the mouse writhing caused by HAc. In addition, ACM showed an inhibitory effect on platelet aggregation induced -with collgen. It is suggested that ACM induced the stomach ulcers

乙酰消炎痛为国内新合成的非甾体类解热镇痛药消炎痛的衍生物,对小鼠腹腔毛细血管渗透性增加和耳廓炎症、角叉菜胶性大鼠足肿胀及棉球肉芽肿均有明显的抑制作用。能延长辐射热诱发大鼠疼痛的潜伏期,抑制醋酸所致小鼠的扭体反应。对发热大鼠有降温作用,抑制胶原诱导的血小板聚集,对胃粘膜有损伤作用。

 
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