More particularly, Genetic Algorithms, Artificial Neural Networks and Fuzzy Logic methods seem to be the most promising tools to speed up and optimize the search for new leads and focused libraries.
At every iteration a quadratic programming which is obtained by quadratic approximation to Lagrangian function and linear approximations to constraints is solved to get a search direction for a merit function.
The efficient Fourier transform also makes possible the efficient calculation of convolution over SO(3) which has been used as the analytic engine for some new approaches to searching 3D databases (Funkhouser et al., ACM Trans.
By searching the appropriate base for uniform structure, it is shown that the topological transformation group is topologically equivalent to an isometric one if it is uniformly equicontinuous.
The algorithm uses the SAR range migration to resolve the PRF-ambiguity by searching for a PRF-ambiguity number that minimizes the intensity contrast in the range-Doppler domain.
The experimental results show that the method not only can correctly detect the fuzzy edge and exiguous edge but can evidently improve the searching efficiency of fuzzy clustering algorithm based on IEA.
Although yeast two-hybrid system is obviously advantageous in searching interacting proteins and setting up the network of proteins interaction, not all of proteins can use routine yeast two-hybrid method to search interacting proteins.
Consistent query answering is an approach to retrieving consistent answers over databases that might be inconsistent with respect to some given integrity constraints.
An algorithm for retrieving regularized estimates of the characteristics of spatially distributed scatterers (the phase velocity and absorption inhomogeneities) is developed.