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   rb gene promoter 的翻译结果: 查询用时:0.105秒
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rb gene promoter
相关语句
  rb基因启动子
     The structure, function and mutation of Rb gene promoter in normal individuals and retinoblastoma patients
     正常人及视网膜母细胞瘤患者Rb基因启动子结构、功能和突变的研究
短句来源
     Though there was a increased tendency of the rate of methylation of Rb gene promoter, its rate of positive was very low, and there was no correlation with the extent of methylation and the expression of Rb (p > 0.05).
     而 Rb基因启动子区甲基化率虽然也呈增加趋势,但阳性率很低,并且基因甲基化程度与Rb蛋白表达也无明显相关性(p>0刀5)。
短句来源
     Results Eight from fifteen families showing low penetrance retinoblastoma were identified to have distinct Rb gene point mutations including Arg 661 →Trp 661 in five families, aberrant splicing in two families and a G→T mutation at ATF binding site of Rb gene promoter in one family. Conclusion The distribution of cases with low penetrance of retinoblastoma is not completely random.
     结果15个低外显率的RB家系中部份家系存在特殊类型的Rb基因点突变,其中5个家系有Arg661→Trp661突变,2个家系显示mRNA拼接位点异常,1个家系Rb基因启动子转录调控因子ATF结合位点改变。
短句来源
     Study on the status of methylation of Rb gene promoter in human esophageal cancer and effect of NMBzA on Rb gene promoter in monkey esophageal epithelium
     食管癌Rb基因启动子甲基化状态和甲基苄基亚硝胺对其影响的研究
短句来源
     2. The results, of methylation-specific PCR indicated that there was a increased tendency of the rate of methylation of p16, p27, Rb gene promoter in colorectal carcinogenisis, and there was a descending tendency the rate of methylation of cyclinDl gene promoter.
     2.甲基化特异性PCR结果显示:在大肠癌发生发展过程中 PI6、P27和 Rb基因启动子区甲基化率均呈增加趋势,cyclinD; 基因启动子区甲基化率呈下降趋势,p16、p27和CyClinD;
短句来源
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  相似匹配句对
     THE EXPRESSION OF Rb GENE IN RETINOBLASTOMA
     视网膜母细胞瘤Rb基因表达
短句来源
     RB Gene and Tumor Suppression .
     RB基因与肿瘤抑制
短句来源
     The gene of xylanase B from T.
     但编码该酶的基因xynB在大肠杆菌中的表达较困难。
短句来源
     As to the RYR gene.
     长白猪群中,未发现有该基因存在。
短句来源
     Aromatase promoter I .
     本研究克隆了芳香酶组织特异性启动子promoter Ⅰ.
短句来源
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Objective To elucidate the cause of abnormal Rb expression in esophageal cancer (EC). Methods Methylation of Rb gene promoter was examined with restriction endonuclease digestion and PCR amplification. Results Of the 30 specimens of EC, 10 (33.3%) had MspⅠ type hypermethylation of the Rb gene promoter while 12 (40.0%) had HpaⅡ type hypermethylation and one had both type of hypermethylation. In monkey fed with a single dose of NMBzA (30 mg/kg) on day 0, increasing hypermethylation of both...

Objective To elucidate the cause of abnormal Rb expression in esophageal cancer (EC). Methods Methylation of Rb gene promoter was examined with restriction endonuclease digestion and PCR amplification. Results Of the 30 specimens of EC, 10 (33.3%) had MspⅠ type hypermethylation of the Rb gene promoter while 12 (40.0%) had HpaⅡ type hypermethylation and one had both type of hypermethylation. In monkey fed with a single dose of NMBzA (30 mg/kg) on day 0, increasing hypermethylation of both types of the Rb gene promoter in esophageal epithelium was found on day 1,2 and 3 but reduced on day 5. Conclusion These data suggest that abnoromal expression of Rb gene may be related to hypermethylation of its promoter and carcinogen NMBzA can induce such hypermethylation in monkey esophageal epithelium.

目的分析Rb基因表达异常原因,研究Rb基因启动子甲基化状态和甲基苄基亚硝胺(NMBzA)对Rb基因启动子的影响。方法采用限制性核酸内切酶酶切和PCR扩增方法。结果33.3%的食管癌组织Rb基因启动子存在MspⅠ型高甲基化,40.0%的食管癌组织Rb基因启动子存在HpaⅡ型高甲基化。1例标本存在MspⅠ和HpaⅡ两种类型的高甲基化。恒河猴1次灌喂30mg/kgNMBzA后1,2,3天,其食管上皮Rb基因启动子HpaⅡ、MspⅠ类型甲基化逐渐增强;第5天其Rb基因启动子HpaⅡ、MspⅠ类型甲基化程度明显下降。结论食管癌组织中Rb基因表达异常可能与启动子高甲基化有关,NMBzA通过启动子甲基化对Rb基因调控产生影响。

Objective To investigate the possible cause and molecular mechanism of low penetrance in hereditary retinoblastoma kindred. Methods The DNAs from tumor or blood of affected and unaffected individuals in hereditary retinoblastoma families showing low penetrance were screened by SSCP analysis and further characterized by direct DNA sequencing. Results Eight from fifteen families showing low penetrance retinoblastoma were identified to have distinct Rb gene point mutations including Arg 661...

Objective To investigate the possible cause and molecular mechanism of low penetrance in hereditary retinoblastoma kindred. Methods The DNAs from tumor or blood of affected and unaffected individuals in hereditary retinoblastoma families showing low penetrance were screened by SSCP analysis and further characterized by direct DNA sequencing. Results Eight from fifteen families showing low penetrance retinoblastoma were identified to have distinct Rb gene point mutations including Arg 661 →Trp 661 in five families, aberrant splicing in two families and a G→T mutation at ATF binding site of Rb gene promoter in one family. Conclusion The distribution of cases with low penetrance of retinoblastoma is not completely random. The low penetrance in the families described here was associated with several distinct Rb gene point mutations which did not result in complete disruption of the gene product, and the reduced penetrance of retinoblastoma is probably the result of a residual function of these alleles in retinoblastoma precursor cells.

目的研究视网膜母细胞瘤患者(RB)低外显率的病因及其分子机理。方法收集RB先证者及其家庭成员的RB肿瘤与外周血,通过SSCP分析和DNA序列测定检测Rb基因点突变,结合家系调查分析突变的特征及其与RB表型变化的关系。结果15个低外显率的RB家系中部份家系存在特殊类型的Rb基因点突变,其中5个家系有Arg661→Trp661突变,2个家系显示mRNA拼接位点异常,1个家系Rb基因启动子转录调控因子ATF结合位点改变。结论RB低外显率并非完全随机发生的,与Rb基因突变的位置和性质有密切关系。

 
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