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a double-blind double-dummy
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  双盲双模拟
     Me-thods A double-blind double-dummy randomized controlled multicenter clinical trial was designed.
     方法用随机双盲双模拟多中心临床试验设计,232例(试验组和对照组均为116例)托特罗定缓释片每日1次,每次4mg;
短句来源
     Methods A double-blind, double-dummy, randomized controlled trial was conducted.
     方法选择下尿路感染(下焦湿热证)患者96例进行随机、双盲双模拟、阳性药平行对照的临床试验。
短句来源
     METHODS: A double-blind double-dummy randomized controlled multicenter clinical trial was designed. 237 patients with bladder overactivity were enrolled, Patients received either tolterodine (2mg twice daily) or oxybutynin (5mg twice daily).
     方法:以盐酸奥昔布宁为对照,采用随机双盲双模拟多中心临床试验设计,对237例(托特罗定组114例,奥昔布宁组123例)膀胱过度活动症患者进行研究服药方法每日2次,每次托特罗定2mg或奥昔布宁5mg。
短句来源
     Cilnidipine capsule in treatment of essential hypertension:a double-blind,double-dummy,multicenter,randomized,controlled trial
     西尼地平胶囊治疗原发性高血压双盲双模拟随机对照多中心研究
短句来源
     A DOUBLE-BLIND, DOUBLE-DUMMY,CROSSOVER TRIAL OF KELUOQU IN THE MANAGEMENT OF CANCER PAIN
     克洛曲对癌痛的双盲双模拟自身交叉研究
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  “a double-blind double-dummy”译为未确定词的双语例句
     A double-blind,double-dummy,randomized,controlled study of entecavir versus lamivudine for treatment of chronic hepatitis B
     恩替卡韦与拉米夫定治疗慢性乙型肝炎随机、双盲、双模拟对照研究
短句来源
     Objective: To assess the efficacy and safety of argatroban in treatment of acute cerebral infarctionMethods: 48 patients with acute cerebral infarction (ACI) were followed up in a double-blind, double-dummy, positive-controlled, with randomized study for 14 days.
     方法:观察急性脑梗死患者48例,采用随机、双盲、双模拟、阳性对照研究。 将急性脑梗死患者随机分为阿加曲班注射液组和奥扎格雷钠组治疗,用药14天,总观察时间为28天。
短句来源
     OBJECTIVE: To evaluate the efficacy and safety of pioglitazone hydrochloride in the treatment of type 2diabetes mellitus patients, a double-blind double-dummy metformin-controlled trial was carried out.
     目的:以二甲双胍为对照,评价盐酸吡格列酮治疗2型糖尿病的疗效和安全性。
短句来源
     Methods This was a double - blind, double - dummy,randomized study controlled with clozapine. The period of trail was six weeks. The clinical efficacy was meassured with the Brief Psychotic Rating Scale (BPRS), the Scale for Assessment of Positive Symptoms (SAPS), the Scale for Assessment of Negative Symptoms (SANS) and the four- degree clinical effect criteria.
     方法 采用双盲、双模拟、氯氮平对照、随机入组方法,实验期六周,疗效评定采用简明精神病评定量表(BPRS)、阳性症状量表(SAPS)、阴性症状量表(SANS)及四级临床疗效评定标准,不良反应采用副作用量表(TESS)评定。
短句来源
     Methods A double-blind, double-dummy randomized, montelukast-controlled trial was performed.
     方法采用随机、双盲、双模拟、阳性药(孟鲁司特)对照的方法。
短句来源
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  相似匹配句对
     Methods The trial was a randomized,double-blind,double-dummy and control design.
     方法多中心(26个中心)、随机、双盲、双模拟的对照研究。
短句来源
     Methods A double-blind, double-dummy, randomized controlled trial was conducted.
     方法选择下尿路感染(下焦湿热证)患者96例进行随机、双盲双模拟、阳性药平行对照的临床试验。
短句来源
     The study was performed in a double-blind method.
     进行双盲法研究。
短句来源
     Methods 5 A double-blind, double dummy and randomized controlled method was adopted.
     方法 根据本研究的纳入与排除标准 ,选取慢性乙型肝炎肝纤维化 (气滞血瘀兼湿热未净证 )患者 4 6例 ,随机分为两组 ,进行随机双盲双模拟对照试验。
短句来源
     Methods:The study was designed as a randomized,double blind, double dummy and multi-center.
     方法:随机、双盲、双模拟、多种心研究方法。
短句来源
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  a double-blind double-dummy
Ten healthy subjects received single doses of physostigmine (0.75 mg SC), hyoscine (1.2 mg), temazepam (20 mg), flecainide (200 mg) or placebo in a double-blind double-dummy presentation.
      


Cefditoren pivoxil(ME1207) is a third-generation oral cephalosporins with a broad spectrum of antibacterial activity. A double-blind double-dummy randomized controlled multicenter clinical study of cefditoren pivoxil was conducted compared with cefixime. The objective of the study is to evaluate the safety and efficacy of Cefditoren pivoxil in the treatment of bacterial infections. A total of 400 patients was enrolled in the study. 100 patients received cefditoren pivoxil 200mg every 12 hours orally and...

Cefditoren pivoxil(ME1207) is a third-generation oral cephalosporins with a broad spectrum of antibacterial activity. A double-blind double-dummy randomized controlled multicenter clinical study of cefditoren pivoxil was conducted compared with cefixime. The objective of the study is to evaluate the safety and efficacy of Cefditoren pivoxil in the treatment of bacterial infections. A total of 400 patients was enrolled in the study. 100 patients received cefditoren pivoxil 200mg every 12 hours orally and 100 patients received cefixime 200mg every 12 hours orally were assessable for clinical efficacy. The duration was 7~14 days in both groups. The result showed that the overall efficacy rates were 94.0% for the cefditoren pivoxil group and 92.0% for the cefixime group, whereas the bacterial efficacy rates were 94.0% and 92.0%, respectively. 204 strains were isolated from the patients in the randomized controlled group, the bacterial clearance rates were 95.2% and 99.0%, respectively. The adverse drug reaction was evaluated in 103 cases of cefditoren pivoxil group and 107 cases of cefixime group. The adverse drug reaction rates were 8.7% and 6.5%, respectively. In the open group, 200 patients with bacterial infections received cefditoren pivoxil 200mg every 12 hours orally. For the total 300 patients treated by cefditoren pivoxil,the overall efficacy rate was 93.3%, the bacterial efficacy rate was 93.3% .308 strains were isolated from the 300 cases, bacterial clearance rates were 94.8%. The adverse drug reaction was evaluated in 316 cases and the adverse drug reaction rate was 7.6%. The results showed that cefditoren pivoxil was effective and safe for the treatment of bacterial infections.There were no statistical differences between the two groups(P>0.05).The disk diffusion test showed that the susceptible rates against staphylococcus aureus were 94.8% and 12.1%, respectitively(P<0.001). Against staphycoccus aureus, cefditoren was more activi (MIC90: 0.5 mg·L-1) than cefixime ( MIC90: 32 mg·L-1).

头孢妥仑酯是日本明治制果株式会社开发的新的酯型口服三代广谱头孢菌素,具有广谱抗菌活性,以头孢克肟为对照药,进行随机双盲双模拟多中心临床试验,目的是评价头孢妥仑酯治疗细菌性感染的安全有效性。给药方法随机双盲试验中,试验样品里、外包装仅标明“A”与“B”,两药剂量均为200mg,q12h,疗程7~14d。头孢妥仑酯开放组200mg,口服;q12h,疗程7~14d。随机双盲试验中头孢妥仑酯组及头孢克肟组分别各有100例可评价疗效,两组有效率分别为94.0%及92.0%。对各种致病菌感染的有效率分别为94.0%及92.0%,细菌清除率分别为95.2及99.0%。两组安全性评价分别为103例及107例,药物不良反应发生率分别为8.7%与6.5%。两组经统计学处理差异无显著性(P>0.05)。开放试验共治疗200例感染患者,则用头孢妥仑酯治疗的全部300例患者中,总有效率为93.3%,细菌学有效率为93.3%,细菌清除率为94.8%。316例患者可评价药物不良反应,总的药物不良反应发生率为7.6%。细菌敏感试验结果表明,头孢妥仑酯与头孢克肟对金黄色葡萄球菌的敏感率分别为94.8%和12.1%(P<0.001)。MIC9?

OBJECTIVE: To evaluate the efficacy and tolerability of tolterodine in patients with an overactive bladder. METHODS: A double-blind double-dummy randomized controlled multicenter clinical trial was designed. 237 patients with bladder overactivity were enrolled, Patients received either tolterodine (2mg twice daily) or oxybutynin (5mg twice daily). RESULTS: After 6 weeks' treatment, the mean decrease of frequency of micturition, the mean decrease of incontinence episodes among those with incontinence and...

OBJECTIVE: To evaluate the efficacy and tolerability of tolterodine in patients with an overactive bladder. METHODS: A double-blind double-dummy randomized controlled multicenter clinical trial was designed. 237 patients with bladder overactivity were enrolled, Patients received either tolterodine (2mg twice daily) or oxybutynin (5mg twice daily). RESULTS: After 6 weeks' treatment, the mean decrease of frequency of micturition, the mean decrease of incontinence episodes among those with incontinence and the volume increase of every micturition were statistically equivalent in those receiving tolterodine (n=109) and oxybutynin (n=108). In the tolterodine group, the total incidence of adverse event was 48.2% and the incidence of dry mouth, the most common adverse, was 32.5%. While in the oxybutynin group, the incidences were 65.0% and 55.3%, respectively. The incidences of adverse events and dryness were significantly lower in those on tolterodine than in those on oxybutynin. CONCLUSIONS: Tolterodine 2mg twice daily had the equivalent efficacy on patients with overactive bladder compared to oxybutynin 5mg twice daily, and the adverse-effection of tolterodine were lower than oxybutynin.

目的:评价国产酒石酸托特罗定治疗膀胱过度活动症的有效性和安全性。方法:以盐酸奥昔布宁为对照,采用随机双盲双模拟多中心临床试验设计,对237例(托特罗定组114例,奥昔布宁组123例)膀胱过度活动症患者进行研究服药方法每日2次,每次托特罗定2mg或奥昔布宁5mg。结果:治疗6周后,试验组(n=109)和对照组(n=108)24h平均排尿次数减少、尿失禁患者的中均尿失禁次数减少以及平均每次尿量增加比较无统计学差异(P>0.05)。试验组患者不良事件的总发生率48.2%,其中主要不良事件口干发生率为32.5%;而奥昔布宁组不良事件的总发生率为65.0%,口干发生率为55.3%,不良事件总发生率及口干发生率在两组间均有统计学差异(P<0.05)。结论:托特罗定是治疗膀胱过度活动症的有效药物,其疗效与奥昔布宁等效,但其药物不良反应明显低于奥昔布宁。

OBJECTIVE: To evaluate the efficacy and safety of pioglitazone hydrochloride in the treatment of type 2diabetes mellitus patients, a double-blind double-dummy metformin-controlled trial was carried out. METHODS:A randomized, double-blind, metformin-controlled, and multicenter clinical trial was conducted. A total of 227 patients with type 2 diabetes mellitus were enrolled in this study, in which 113 patients received pioglitazone 30mg once daily, and 114 patients received metfbrmin 250mg b.i.d, for...

OBJECTIVE: To evaluate the efficacy and safety of pioglitazone hydrochloride in the treatment of type 2diabetes mellitus patients, a double-blind double-dummy metformin-controlled trial was carried out. METHODS:A randomized, double-blind, metformin-controlled, and multicenter clinical trial was conducted. A total of 227 patients with type 2 diabetes mellitus were enrolled in this study, in which 113 patients received pioglitazone 30mg once daily, and 114 patients received metfbrmin 250mg b.i.d, for 12 weeks. RESULTS:Comparing to the baseline, the fasting blood glucose (FBG), 2h postprandial blood glucose (P2hBG) and HbA1C levels in tow groups were significantly reduced after 12-week treatment (P<0.01). In pioglitazone group, the mean reductions of FBG, P2hBG and HbA1C levels were 1.42±1.93mmol.L-1 (13.41 ±18.65%), 4.42±3.96mmol.L-1(26.94±21.32%), 0.80±1.57% respectively, the efficacy rate of reduction of FBG and P2hBG were 75.82% and 86.24%. In metformin group, the mean reductions of FBG, P2hBG and HbA1C levels were 1.62±2.17mmol. L-1( 15.45±20.13%), 3.89±3.75mmol.L-1(24.27±21.54%), 0.89±1.39% respectively, the efficacy rate of reduction of FBG and 2hPBG were 82.42%,77.36%.,The differencesin reductions of FBG, P2hBG and HbA1C level between the groups were not statistically significant. The incidence of adverse effects in tow groups was similar. Hepatic function did not significantly change after treatment. CONCLUSION: This result provides an efficacy in glycemic control and a safety profile of pioglitazone in the treatment of type 2 diabetes mellitus.

目的:以二甲双胍为对照,评价盐酸吡格列酮治疗2型糖尿病的疗效和安全性。方法:采用多中心、随机、双盲双模拟、平行对照的试验设计,在5个中心共收集227例2型糖尿病病人,分为吡格列酮组(113例,服用盐酸吡格列酮30mg,每日1次),和二甲双胍组(114例,服用盐酸二甲双胍250mg,每日2次),治疗期12周。结果:用药12周后,与基础值相比,吡格列酮组空腹血糖下降1.42±1.93mmol.L-1(13.41±18.65%),餐后2h血糖下降4.42±3.96mmol.L-1(26.94%±21.32%),糖化血红蛋白下降0.80%±1.57%;二甲双胍组,空腹血糖下降1.62±2.17mmol·L(15.45±20.13%),餐后2h血糖下降值3.89±3.75mmol·L-1(24.27%±21.54%),糖化血红蛋白下降0.89%±1.39%。两组血糖和糖化血红蛋白下 降值与用药前比较均有显著性差异,但两组间比较无显著性差异。用药12周 后,吡格列酮组,降低空腹血糖显效率40.66%,有效率75.82%,降低餐后2h 血糖显效率51.38%,有效率86.24%;二甲双胍组,降低空腹血糖显效率53.85%,...

目的:以二甲双胍为对照,评价盐酸吡格列酮治疗2型糖尿病的疗效和安全性。方法:采用多中心、随机、双盲双模拟、平行对照的试验设计,在5个中心共收集227例2型糖尿病病人,分为吡格列酮组(113例,服用盐酸吡格列酮30mg,每日1次),和二甲双胍组(114例,服用盐酸二甲双胍250mg,每日2次),治疗期12周。结果:用药12周后,与基础值相比,吡格列酮组空腹血糖下降1.42±1.93mmol.L-1(13.41±18.65%),餐后2h血糖下降4.42±3.96mmol.L-1(26.94%±21.32%),糖化血红蛋白下降0.80%±1.57%;二甲双胍组,空腹血糖下降1.62±2.17mmol·L(15.45±20.13%),餐后2h血糖下降值3.89±3.75mmol·L-1(24.27%±21.54%),糖化血红蛋白下降0.89%±1.39%。两组血糖和糖化血红蛋白下 降值与用药前比较均有显著性差异,但两组间比较无显著性差异。用药12周 后,吡格列酮组,降低空腹血糖显效率40.66%,有效率75.82%,降低餐后2h 血糖显效率51.38%,有效率86.24%;二甲双胍组,降低空腹血糖显效率53.85%, 有效率82.42%,降低餐后2h血糖显效率46.23%,有效率77.36%。两组间比较 显效率和有效性均无统计学意义。两组药物不良反应发生率相似,未出现严重 肝功能异常病例。结论:吡格列酮可有效地降低2型糖尿病病人的空腹血糖、餐 ?

 
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