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cooperation hospitals
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  合作医院
     With Beijing digital ophthalmology system network,the special technology can radiate to the community hospitals,multi-subjects cooperation hospitals and optometry center. Digital ophthalmology would benefit for the screening and early diagnosis for the preventable blindness.
     北京数字网络化眼科系统使专科技术向社区医院、跨学科合作医院、验光中心辐射,有利于可预防盲的筛查及早期诊断。
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  相似匹配句对
     It is the times for strategic cooperation for hospitals in China.
     我国医院的战略合作时代已经来临。
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     Cooperation and Communication
     合作与交流
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     Cooperation of Arthroscopy
     关节镜的手术配合
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     hospitals F, H, J and I were better;
     F、HJ、和I四家医院为良;
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     Strategy of Strengthening Management of Medical Cooperation Items in Military Hospitals
     加强军队医院医疗合作项目管理策略
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AIM: To analyze the features of clinical pathology and hereditary predisposition of primary colorectal cancer (CRC) patients. METHODS: A total of 594 primary CRC inpatients were continuously investigated in our hospital and cooperation hospitals. They were proved to be primary colorectal cancer by histopathological examination. The following data of all patients should be registered: sex, family history of colorectal cancer, site, number and histological type of primary cancer. Tumor sites were classified...

AIM: To analyze the features of clinical pathology and hereditary predisposition of primary colorectal cancer (CRC) patients. METHODS: A total of 594 primary CRC inpatients were continuously investigated in our hospital and cooperation hospitals. They were proved to be primary colorectal cancer by histopathological examination. The following data of all patients should be registered: sex, family history of colorectal cancer, site, number and histological type of primary cancer. Tumor sites were classified as proximal colon to the splenic flexure, distal colon to the splenic flexure and whole colorectum. Hereditary predisposition of CRC is that CRC patients have two or more first- or second-degree relatives (or both) with CRC. And hereditary predisposition of malignant tumor is that CRC patients have two or more first- or second-degree relatives (or both) with malignant tumor. Hereditary nonpolyposis colorectal cancer (HNPCC) was diagnosed by any of Amsterdam criteria, Amsterdam criteria Ⅱ and Japanese criteria of HNPCC. CRC patients were divided into seven groups by the age being diagnosed. RESULTS: The distribution of the age diagnosed as colorectal cancer was not normal distribution. The median diagnosed age of CRC patients was 65.1 years. There were more patients in -70 years group than other groups. In age of 70 years before, the proportion of patients was increasing with the increasing of age and more elder patients were found. But in more than 70 years old group, the proportion of patients was decreased by the increasing of patients' age. Most of colorectal caner were located distal to the splenic flexure, and rectal cancer was in 45.3% patients. There was no correlation between tumor site and the age in CRC (P >0.05). The most frequent histo-logical type was adenocarcinoma (87.5%). In addition, the proportion of mucoid adenocarcinoma and signet-ring cell carcinoma were 8.2% and 5.2%, respectively. The proportion of signet-ring cell carcinoma was higher in older groups (P<0.05). As to the proportion of multiple primary cancers, multiple primary CRCs, hereditary predisposition of cancer and hereditary predisposition of colorectal cancer were 13.1%, 10.1%, 17.2% and 5.2%, respectively. The incidence of HNPCC diagnosed by Amsterdam criteria, Amsterdam criteria Ⅱ and Japanese criteria of HNPCC were 0.5%, 2.9% and 2.4%, respectively. The correlation had been found between the occurrences of multiple primary cancers and multiple primary CRCs with familial history of malignant tumors (P <0.05), and there were more multiple primary cancers and multiple primary CRCs in CRC patients with familial history of malignant tumors. But obvious correlation was not found between the occurrence of multiple primary cancers and multiple primary CRCs with familial history of CRCs (P >0.05). CONCLUSION: Age of patients with colorectal cancer is not normal distribution, and the proportion of elder patients with colorectal cancer becomes higher in all CRC patients. Most of tumors locate distal to the splenic flexure and adenocarcinoma is the most common histological type. There are 17.2% colorectal cancer patients with hereditary cancer predisposition. The occurrences of multiple primary cancers and multiple primary CRCs are correlated with familial history of malignant tumors.

目的:了解原发性结直肠癌的临床病理特点和患者的遗传易感性. 方法:调查经组织病理学证实的结直肠癌患者594例,统计性别、年龄、家族恶性肿瘤史、个人恶性肿瘤史、肿瘤发生部位和数目、组织学类型等情况.肿瘤发生部位分为脾曲近侧结肠、脾曲远侧结肠和全结直肠.家族内有两个或更多个一级和/或二级亲属患有结直肠癌者,定义为具有结直肠癌遗传易感性;家族内有两个或更多个一级和/ 或二级亲属患有恶性肿瘤者,定义为具有恶性肿瘤遗传易感性.家族符合Amsterdam标准、Amsterdam标准Ⅱ和日本标准等中任何—个者均可诊断为遗传性非息肉病性结直肠癌(HNPCC).根据诊断肿瘤时的年龄大小将患者分为7组. 结果:结直肠癌患者的诊断年龄呈偏态分布,中位诊断年龄为65.1岁.-70岁组患者最多,在70岁以前(含70岁), 各年龄组患者的构成比随年龄增加而增大,发病呈高龄化趋势;但70岁以后即-80岁组和大于80岁组患者的构成比随年龄增加而降低.肿瘤发生部位以脾曲远侧结肠为主(73.6%),脾曲近侧结肠占25.9%,直肠占45.3%;肿瘤发生部位与患者的诊断年龄没有明显的相关性(P>0.05).组织学类型以腺癌为主(87.5%),黏液腺...

目的:了解原发性结直肠癌的临床病理特点和患者的遗传易感性. 方法:调查经组织病理学证实的结直肠癌患者594例,统计性别、年龄、家族恶性肿瘤史、个人恶性肿瘤史、肿瘤发生部位和数目、组织学类型等情况.肿瘤发生部位分为脾曲近侧结肠、脾曲远侧结肠和全结直肠.家族内有两个或更多个一级和/或二级亲属患有结直肠癌者,定义为具有结直肠癌遗传易感性;家族内有两个或更多个一级和/ 或二级亲属患有恶性肿瘤者,定义为具有恶性肿瘤遗传易感性.家族符合Amsterdam标准、Amsterdam标准Ⅱ和日本标准等中任何—个者均可诊断为遗传性非息肉病性结直肠癌(HNPCC).根据诊断肿瘤时的年龄大小将患者分为7组. 结果:结直肠癌患者的诊断年龄呈偏态分布,中位诊断年龄为65.1岁.-70岁组患者最多,在70岁以前(含70岁), 各年龄组患者的构成比随年龄增加而增大,发病呈高龄化趋势;但70岁以后即-80岁组和大于80岁组患者的构成比随年龄增加而降低.肿瘤发生部位以脾曲远侧结肠为主(73.6%),脾曲近侧结肠占25.9%,直肠占45.3%;肿瘤发生部位与患者的诊断年龄没有明显的相关性(P>0.05).组织学类型以腺癌为主(87.5%),黏液腺癌占8.2%,印戒细胞癌占2.5%;印戒细胞癌的构成比随年龄增大而增加(P<0.05). 多原发癌患者占13.1%,其中多原发结直肠癌占10.1%. 17.2%的患者具有恶性肿瘤遗传易感性,5.2%的患者具有结直肠癌遗传易感性;符合Amsterdam标准、Amsterdam 标准Ⅱ和日本标准的HNPCC的发生率分别为0.5%,2.9% 和2.4%.多原发癌、多原发结直肠癌均与患者的恶性肿瘤家族史相关(P<0.01),有恶性肿瘤家族史的结直肠癌患者,更易发生多原发癌和多原发结直肠癌.但多原发癌及多原发结直肠癌均与患者的结直肠癌家族史无明显的相关性(P>0.05). 结论:结直肠癌患者诊断年龄呈非正态分布曲线,发病呈老龄化趋势,部位以脾曲远侧结肠为主,组织学类型以腺癌为主;17.2%的患者具有恶性肿瘤遗传易感性;多原发癌及多原发结直肠癌的发生均与患者的恶性肿瘤家族史相关.

BACKGROUND Beside direct trauma a series of secondary pathological changes would occur in local injured spinal cord area during spinal cord injury. It has been reported that recombinant human erythropoietin rhEPO could inhibit cell apoptosis and inflammatory reaction and possess neuroprotective role. OBJECTIVE To explore the neuroprotective role of rhEPO in spinal cord injury by observing the nerve cell apoptosis and related cytokine expression in traumatic spinal cord.DESIGN Randomized and controlled study.SETTING...

BACKGROUND Beside direct trauma a series of secondary pathological changes would occur in local injured spinal cord area during spinal cord injury. It has been reported that recombinant human erythropoietin rhEPO could inhibit cell apoptosis and inflammatory reaction and possess neuroprotective role. OBJECTIVE To explore the neuroprotective role of rhEPO in spinal cord injury by observing the nerve cell apoptosis and related cytokine expression in traumatic spinal cord.DESIGN Randomized and controlled study.SETTING Orthopedic Surgery Laboratory of Affiliated Cooperation Hospital of Tongji Medical College and Department of Pathology of Tongji Medical College Central China Science and Technology University.PARTICIPANTS The study was conduced at Orthopedic Surgery Laboratory of Affiliated Cooperation Hospital of Tongji Medical College Central China Science and Technology University and Department of Pathology of Tongji Medical College from September 2003 to May 2004. Thirty healthy female adult rats were randomly divided into 4 groups ① Six rats in blank control group only subjected to spinal cord exposure without injury. ② Eight rats in injury group were subjected to spinal cord injury without medication. ③ Eight rats in medication A group were treated with rhEPO. ④ Eight rats in medication B group were treated with rhEPO and β-aeacine sodium. METHODS ① Animal model preparation Spinal cord injury model was established on 24 rats by using improved Allen method. ② Administration Rats in medication A group were treated with rhEPO in dosage of 300 U/kg·d at postoperative 1 3 5 8 11 days while rats in medication B group were given additional β-aeacine sodium in dosage of 0.1 mg/kg once a day for consecutive 11 days. Rats in blank control group and injury group were injected with the same volume physical saline from tail veins. ③ Neurological function The neurological function was scored by the same examiner at 1 day and 12 days after model establishment. Behavioral observation Basing on improved Gale’s neurological functional behavioral analysis 0 score presented severer dysfunction and 6 scores represents normal. Slope test The gradient was determined by the grasping capability of rat which could reflect the recovery of neurological function. ④ Pathological examination Rat was put to death at postoperative 12 days traumatic spinal cord was made into slices for HE staining. ⑤ Expression of apoptosis cytokine bcl-2 bax and fas in nerve cells Specimen was collected for IHC stain and brown colored positive cells was counted for calculating positive expressing rate. ⑥ Apoptosis nerve cells In situ end-labeling techniques was used to calculate apoptosis index the number of apoptosis nucleus/total number. All data were analyzed by using paired chi-test. MAIN OUTCOME MEASURES ① Neurological functional behavioral score and results of slope test. ② Histological observation of traumatic spinal cord. ③ Expression of apoptosis nerve cell cytokines. ④ Examination of apoptostic nerve cells.RESULTS ① Neurological functional behavioral score and results of slope test There was no significant difference between 1 day and 12 days in blank control group while the gradient in traumatic group was significantly larger in 12 days than in 1 day P < 0.05. In both therapeutic A and B groups the behavioral scores and slope gradient were found significantly larger at 12 days than 1 day P < 0.05 and that of traumatic group P < 0.05. ② Histological observation of traumatic spinal cord Traumatic spinal cord became slim with a majority of necrosis and glial cell hyperplasia in it most of neurological tissues were found normal in medication A and B groups with the neural structure of medication B group better than A group. ③Expression of nerve cell apoptosis cytokines bax and fas positive cells in traumatic group were more than medication group A and B traumatic group of 25.75±3.37% and 41.37±2.83% vs medication group A of 19.87±3.56 and 26.00±3.29% vs medication group B of 12.00±2.97 and 17.50±2.20% P < 0.05 bcl-2 was significantly lower in medication group A and group B 9.75±1.83% 14.63±2.83% 21.63±5.34% P < 0.05. ④ Examination of apoptotic nerve cells Cell apoptosis index in traumatic group was significantly higher than medication group A and group B 50.75±5.39 34.75±3.01 24.00±3.46 P < 0.05. CONCLUSION Cell apoptosis is an important kind of neuronal death following spinal cord injury. rhEPO can inhibit nerve cell apoptosis and possess neuroprotective effect for traumatic spinal cord. stological obs?q>?

背景:在脊髓损伤中,除了创伤造成的直接损伤外,脊髓局部还将发生一系列的继发性病理改变。有研究显示重组人红细胞生成素能抑制细胞凋亡和炎症反应,具有神经保护作用。目的:通过观察大鼠脊髓损伤段神经细胞凋亡及相关因子的表达,探讨重组人红细胞生成素对脊髓损伤的保护作用。设计:随机对照实验。单位:华中科技大学同济医学院附属协和医院骨外科实验室和同济医学院病理科。对象:实验于2003-09/2004-05在华中科技大学同济医学院附属协和医院骨外科实验室和同济医学院病理科进行。雌性成年SD 大鼠30只,随机分成4组,①空白组6只,只暴露脊髓,不损伤。②损伤组8只,脊髓损伤,不用药物。③治疗A 组8只,脊髓损伤,仅用重组人红细胞生成素。④治疗B组8只,脊髓损伤,联合应用重组人红细胞生成素和β-七叶皂甙钠。方法:①动物模型制作:24只大鼠应用改良的Allen 方法致脊髓中度损伤。②给药:治疗A 组于术后1,3,5,8,11d 应用重组人红细胞生成素300U /(kg·d)。治疗B 组应用重组人红细胞生成素剂量时间同治疗A组,β-七叶皂甙钠0.1m g/kg,1次/d,连用11d。空白组及损伤组尾静脉推注等容量生理盐水。③神经功能...

背景:在脊髓损伤中,除了创伤造成的直接损伤外,脊髓局部还将发生一系列的继发性病理改变。有研究显示重组人红细胞生成素能抑制细胞凋亡和炎症反应,具有神经保护作用。目的:通过观察大鼠脊髓损伤段神经细胞凋亡及相关因子的表达,探讨重组人红细胞生成素对脊髓损伤的保护作用。设计:随机对照实验。单位:华中科技大学同济医学院附属协和医院骨外科实验室和同济医学院病理科。对象:实验于2003-09/2004-05在华中科技大学同济医学院附属协和医院骨外科实验室和同济医学院病理科进行。雌性成年SD 大鼠30只,随机分成4组,①空白组6只,只暴露脊髓,不损伤。②损伤组8只,脊髓损伤,不用药物。③治疗A 组8只,脊髓损伤,仅用重组人红细胞生成素。④治疗B组8只,脊髓损伤,联合应用重组人红细胞生成素和β-七叶皂甙钠。方法:①动物模型制作:24只大鼠应用改良的Allen 方法致脊髓中度损伤。②给药:治疗A 组于术后1,3,5,8,11d 应用重组人红细胞生成素300U /(kg·d)。治疗B 组应用重组人红细胞生成素剂量时间同治疗A组,β-七叶皂甙钠0.1m g/kg,1次/d,连用11d。空白组及损伤组尾静脉推注等容量生理盐水。③神经功能判断:在造模后1和12d 分别由同一个实验者进行功能评分记录。行为观察:参照改良的Gale 神经功能行为分析法评估,0分为严重障碍,6分为正常。斜板试验:观察大鼠抓握能力决定斜板角度的大小,反映神经功能恢复情况。④组织学检查:大鼠术后12d 处死。取损伤段脊髓标本切片做苏木精-伊红染色。⑤神经细胞凋亡因子bcl-2,bax,fas检测:取标本做免疫组织化学染色,计数显微镜高倍视野内染色呈棕色的阳性细胞,计算阳性率。⑥凋亡神经细胞检测:采用原位末端标记法计算凋亡指数(凋亡细胞核数/总细胞核数)。各指标检测结果进行组内和组间比较。主要观察指标:①神经功能行为学评分及斜板实验结果。②损伤段脊髓组织学观察结果。③神经细胞凋亡因子检测结果。④凋亡神经细胞检测结果。结果:①神经功能行为学评分及斜板实验结果:1和12d 空白组无显著差异。损伤组12d 斜板角度显著大于1d 时(P <0.05)。治疗A 和B 组12d 行为评分及斜板角度值均显著大于1d 时(P <0.05),且显著大于损伤组P <0.05)。②损伤段脊髓组织学观察结果:损伤组损伤段变细,脊髓内有大部分坏死和大量胶质细胞增生;治疗A,B 组大多数神经组织正常,治疗B 组组织结构优于A 组。③神经细胞凋亡因子检测结果:损伤组bax,fas凋亡阳性细胞明显多于治疗A,B 组犤损伤组(25.75±3.37)%和(41.37±2.83)%,治疗A 组(19.87±3.56)和(26.00±3.29)%,治疗B 组(12.00±2.97)和(17.50±2.20)%,P <0.05犦;bcl-2显著低于治疗A ,B 组犤(9.75±1.83)%,(14.63±2.83)%,(21.63±5.34)%,P <0.05犦。④凋亡神经细胞检测结果:损伤组细胞凋亡指数明显高于治疗A ,B 组(50.75±5.39,34.75±3.01,24.00±3.46,P <0.05)。结论:细胞凋亡是脊髓损伤后神经元死亡的一种重要方式。重组人红细胞生成素能抑制脊髓神经细胞凋亡,对损伤脊髓的神经功能具有保护作用。

E-Health is an information technology entirely applied in medical sciences(from prevention,diagnosis and follow-up).Ophthalmology is a mainly image diagnosis subject.Most diagnosis instruments in ophthalmology can provide digital information.Comparing with the other subjects,telemedicine in ophthalmology have the predominance.By digital fundus photography,specialists consultation with telemedicine technology,systematic health can be evaluated from retinal microvessel changes.Therefore,the changes can be come...

E-Health is an information technology entirely applied in medical sciences(from prevention,diagnosis and follow-up).Ophthalmology is a mainly image diagnosis subject.Most diagnosis instruments in ophthalmology can provide digital information.Comparing with the other subjects,telemedicine in ophthalmology have the predominance.By digital fundus photography,specialists consultation with telemedicine technology,systematic health can be evaluated from retinal microvessel changes.Therefore,the changes can be come true from treatment to prevention,from diagnosis and treatment focus in the comprehensive hospitals to the special technology radiation to the communities,from diagnosis and treatment eye diseases to evaluation of systematic health.With Beijing digital ophthalmology system network,the special technology can radiate to the community hospitals,multi-subjects cooperation hospitals and optometry center.Digital ophthalmology would benefit for the screening and early diagnosis for the preventable blindness.

电子健康是信息技术在医疗保健领域(从预防、诊断到随诊)全方位的应用。眼科是以影像学诊断为主的学科,眼科诊断仪器已实现了数字化,与其他临床学科比较,眼科实现远程医疗最有优势。通过数码眼底照相、专家远程会诊,以视网膜微血管改变评估全身健康状况,实现从对疾病治疗到对疾病预防的转变;从大医院集中诊治到专科技术辐射到社区的转换;从诊治局部眼病向评估全身健康状况的转变。北京数字网络化眼科系统使专科技术向社区医院、跨学科合作医院、验光中心辐射,有利于可预防盲的筛查及早期诊断。

 
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