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double-strand breaks
相关语句
  双链断裂
    Double-strand Breaks of DNA Damage in Human Lymphocytes Induced by H_2O_2-Fe ̄(3+) System
    H_2O_2-Fe~(3+)所致人淋巴细胞DNA双链断裂损伤
短句来源
    DNA double-strand breaks induced by γ -ray
    γ射线诱导的肝癌细胞DNA双链断裂
短句来源
    A New Method for Calculating Yield of DNA Double-strand Breaks
    DNA双链断裂产额的新算法
短句来源
    γ-H2AX assay and its prospect of detecting DNA double-strand breaks caused by ionizing radiation
    γ-H2AX分析及其在监测电离辐射所致DNA双链断裂中的应用前景
短句来源
    Distribution of Fragmentations of Radiation Induced DNA Double-strand Breaks
    辐射致DNA双链断裂碎片分布研究
短句来源
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  双链损伤
    DNA-PK plays a major role in the repair of double-strand breaks (DSB) induced in DNA after exposure to ionizing radiation.
    DNA PK在DNA暴露于电离辐射后诱导的双链损伤修复中起主要作用。
短句来源
    Because γ-H2AX is a reliable marker to DNA double-strand breaks, γ-H2AX assay will make great future in detecting DNA double-strand breaks caused by ionizing radiation, especially in low levels of ionizing radiation.
    y-H2AX分析也将在监测电离辐射尤其是低剂量电离辐射所致的DNA双链损伤中拥有广阔的应用前景。
短句来源
  “double-strand breaks”译为未确定词的双语例句
    Comparison of Sensitivity to Heavy-Ion Induction of DNA Double-Strand Breaks between DNA and Intact Cells
    DNA和细胞对重离子辐照诱导DNA双链断裂的敏感性比较
短句来源
    DOSE-RATE EFFECTS ON THE INDUCTION OF DNA DOUBLE-STRAND BREAKS WITH HEAVY-ION IRRADIATION
    重离子辐照诱导DNA双链断裂的剂量率效应
短句来源
    Fragmentation in DNA double-strand breaks
    射线引起DNA双链断裂的统计分布
短句来源
    1. Normal human fibroblast cells GM0639 were irradiated by Gamma ray emitted from source ~(60)Co. The yields and distribution of double- strand breaks (DSB) were measured by the method of pulsed-field gel electrophoresis (PFGE) by subtracting the contributions of the background.
    方法 主要包括两个方面:一是以人正常成纤维细胞(GM0639)为研究对象,通过脉冲场凝胶电泳分离DSB碎片,扣除本底碎片分布的贡献,对~(60)Coγ射线不同辐射剂量诱导的DSB在比较宽的片段长度范围内进行定量和观察其碎片分布。
短句来源
    DNA single-and double-strand breaks of peripheral blood lymphocytes in mice induced by γ rays irradiation were detected by neutral and alkaline comet assay.
    分别应用中性单细胞凝胶电泳、碱性单细胞凝胶电泳技术检测了不同剂量γ射线外照射对小鼠外周血淋巴细胞DNA的损伤。
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  double-strand breaks
This review summarizes data about all known mechanisms of eukaryotic DNA repair including excision repair (base excision repair and nucleotide excision repair), mismatch repair, repair of double-strand breaks, and cross-link repair.
      
The incubation time necessary for the appearance of double-strand breaks in scDNA in the presence of TPT correlated with the time of formation of strong TPT-DNA complex.
      
This is the first demonstration that molecules of the camptothecin family can cause double-strand breaks in scDNA in the absence of the enzyme.
      
However, little is known about its system of homologous recombination underlying recombination repair of double-strand breaks.
      
Double-strand breaks occurred preferentially in 5'-CpG-3' dinucleotides.
      
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DNA strand breaks are the main biological effect of ionizing radia-tion. Single strand break is induced by a sinsle hit of irradiation and thus has lineardose response curve. Double strand break can be formed not only by a single hit, butalso by the overlap of two close single strand breaks located in the complemental stra-nds. The dose response curve of double strand breaks is linear -quadratic. DNA strandbreaks can be detected quantatively by various physicochemical methods. Cells...

DNA strand breaks are the main biological effect of ionizing radia-tion. Single strand break is induced by a sinsle hit of irradiation and thus has lineardose response curve. Double strand break can be formed not only by a single hit, butalso by the overlap of two close single strand breaks located in the complemental stra-nds. The dose response curve of double strand breaks is linear -quadratic. DNA strandbreaks can be detected quantatively by various physicochemical methods. Cells are ableto repair both sinsle and double strand breaks. The mechanisms of repair, however,are not so clear as those of other repair models, excision repair, for example. The un-repaired strand breaks are lethal. Single strand repair is error-free. The biological ef-fects of repaied double strand kreaks remain unclear thus far. Dose rate has playsimportant role on the biological effects of ionizing radiations.

DNA链断裂是电离辐射的主要生物学效应之一,单链断裂由一次击中造成,所以与辐射剂量成线性关系,双链断裂可以一次击中造成,也可由两个位置相关的单链断裂迭加而成,所以与辐射剂量成线性——平方关系。已有各种理化方法能测定活细胞内的单链断裂和双链断裂数。细胞具有修复DNA链断裂的能力,但其机制远不如切除修复机制那么清楚。未修复的链断裂是致死的,被修复的单链断裂完全恢复DNA的正常结构与功能,被修复的双链断裂的生物学效应如何还不清楚。剂量率对辐射的生物学效应有重要影响。

The use of field inversion gel electrophoresis and Contour clamped homogeneous electric field electrophoresis to measure X ray induced DNA double strand breaks in mammalian cells was described in detail.The result indicated that by this method the DNA double strand breaks in SR-1 cells irradiated by X ray dose as low as 1.5 Gy could be observed distinctly.In the 1.5 to 20 Gy dose range,the dose response function for double strand breaks is linear.The protective effect of a free radical scavenger-DMSO...

The use of field inversion gel electrophoresis and Contour clamped homogeneous electric field electrophoresis to measure X ray induced DNA double strand breaks in mammalian cells was described in detail.The result indicated that by this method the DNA double strand breaks in SR-1 cells irradiated by X ray dose as low as 1.5 Gy could be observed distinctly.In the 1.5 to 20 Gy dose range,the dose response function for double strand breaks is linear.The protective effect of a free radical scavenger-DMSO on radiation induced DNA double strand breaks in SR-1 cells has also been identified by this method.

本文将反向交变电场和六角形电极电场这两种脉冲电场凝胶电泳技术应用于X线照射小鼠乳癌细胞SR-1所致DNA双链断裂的检测,在本实验条件下,用这种电泳都能检测到低至1.5Gy照射所产生的DNA双链断裂,并且用六角形电极电场电泳获得了DNA双链断裂程度与照射剂量之间的良好线性关系,此外,还用此方法观察了不同浓度自由基清除剂DMSO对X线照射SR-1细胞所致DNA双链断裂的保护作用,结果进一步证实本方法的可靠性。

Up to date, the fundamental theory in the field of single-and double-strand break of DNA induced by irradiation is still the target and hit theory, while the lack of DNA repair mechanism etc is the main shortage of that theory. And, Chadwick's theory is a semi-empirical one. In this paper, we from Hug and Kellerer's idea, have developed a stochastic dynamic theory of DNA's single-and double-strand break induced by irradiation, in which DNA rapairs are included, and a mathematical model of the stochastic...

Up to date, the fundamental theory in the field of single-and double-strand break of DNA induced by irradiation is still the target and hit theory, while the lack of DNA repair mechanism etc is the main shortage of that theory. And, Chadwick's theory is a semi-empirical one. In this paper, we from Hug and Kellerer's idea, have developed a stochastic dynamic theory of DNA's single-and double-strand break induced by irradiation, in which DNA rapairs are included, and a mathematical model of the stochastic dynamic differential equations has been given also. .

在辐射诱发DNA单链与双链断裂问题的研究中,迄今为止的主要理论——靶学说与击中理论,存在缺少修复机制等缺点,而Chadwick的理论仍属半经验性的.本文在Hug与Kellerer基本思想的基础上,发展了一个辐射诱发含修复DNA单、双链断裂的随机动力学理论,建立了随机动力学微分方程组数学模型.

 
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